NCBI Summary
The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Protein
Protein (NP_001267)
Hcgp-39
Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)
CHI3L1
chitinase 3 like 1
Undefined
Curated
chi-lectin (TIM)
Chilectins
a/b barrel / TIM
GlcNAc(b1-4)GlcNAc / Chitooligosaccharides
NP_001267
1116
P36222
ENSP00000255409.3
P36222
Undefined
10.1074/jbc.M303137200
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (383 amino acids) Download
MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P36222-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
chito-octasaccharide
GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc
1HJW, 1NWT
1HJW, 1NWT
GlyConnect Structures
bGlcNAc14GlcNAc
GlcNAc(b1-4)GlcNAc
1NWS
1NWS
GlyConnect Structures
bGlcNAc14bGlcNAc14bGlcNAc14GlcNAc
GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc
1HJV
1HJV
GlyConnect Structures
chitopentaose
GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc
1NWU
1NWU
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CHI3L1 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Comprehensive Analysis of CD163 as a Prognostic Biomarker and Associated with Immune Infiltration in Glioblastoma Multiforme. [34395626]
  • Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival. [33828170]
  • YKL-39 as a Potential New Target for Anti-Angiogenic Therapy in Cancer. [32038607]
  • M2 Macrophage Marker Chitinase 3-Like 2 (CHI3L2) Associates With Progression of Conventional Renal Cell Carcinoma. [31810965]
  • Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy. [29728799]
  • Two closely related human members of chitinase-like family, CHI3L1 and CHI3L2, activate ERK1/2 in 293 and U373 cells but have the different influence on cell proliferation. [22211103]
  • Human colostrum: identification of minor proteins in the aqueous phase by proteomics. [16502470]
  • Transcriptome analysis of human gastric cancer. [16341674]
  • Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. [12435396]
  • Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. [8702629]
UniProt Main References (14 PubMed Identifiers)
  • Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. [8245017]
  • Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. [9244440]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period. [2375755]
  • Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. [9492324]
  • Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. [16472595]
  • Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. [17160890]
  • Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. [19414556]
  • The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury. [20558631]
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RNA
RNA (Transcript ID: NM_004000.3)
NM_004000.3
chitinase 3 like 2, transcript variant 1
All isoforms of CHI3L1 containing a lectin domain
ENST00000369748.9
18..1190 (or 203179445.. 203186623)
111227713.. 111243440
NCBI Matured mRNA sequence 1416 NTPDownload 
m7G-5')ppp(5'-AGAAGCUGGCCAAGGAUAUGGGAGCAACCACCAUGGACCAGAAGUCUCUCUGGGCAGGUGUAGUGGUCUUGCUGCUUCUCCAGGGAGGAUCUGCCUACAAACUGGUUUGCUACUUUACCAACUGGUCCCAGGACCGGCAGGAACCAGGAAAAUUCACCCCUGAGAAUAUUGACCCCUUCCUAUGCUCUCAUCUCAUCUAUUCAUUCGCCAGCAUCGAAAACAACAAGGUUAUCAUCAAGGACAAGAGUGAAGUGAUGCUCUACCAGACCAUCAACAGUCUCAAAACCAAGAAUCCCAAACUGAAAAUUCUCUUGUCCAUUGGAGGGUACCUGUUUGGUUCCAAAGGGUUCCACCCUAUGGUGGAUUCUUCUACAUCACGCUUGGAAUUCAUUAACUCCAUAAUCCUGUUUCUGAGGAACCAUAACUUUGAUGGACUGGAUGUAAGCUGGAUCUACCCAGAUCAGAAAGAAAACACUCAUUUCACUGUGCUGAUUCAUGAGUUAGCAGAAGCCUUUCAGAAGGACUUCACAAAAUCCACCAAGGAAAGGCUUCUCUUGACUGCGGGCGUAUCUGCAGGGAGGCAAAUGAUUGAUAACAGCUAUCAAGUUGAGAAACUGGCAAAAGAUCUGGAUUUCAUCAACCUCCUGUCCUUUGACUUCCAUGGGUCUUGGGAAAAGCCCCUUAUCACUGGCCACAACAGCCCUCUGAGCAAGGGGUGGCAGGACAGAGGGCCAAGCUCCUACUACAAUGUGGAAUAUGCUGUGGGGUACUGGAUACAUAAGGGAAUGCCAUCAGAGAAGGUGGUCAUGGGCAUCCCCACAUAUGGGCACUCCUUCACACUGGCCUCUGCAGAAACCACCGUGGGGGCCCCUGCCUCUGGCCCUGGAGCUGCUGGACCCAUCACAGAGUCUUCAGGCUUCCUGGCCUAUUAUGAGAUCUGCCAGUUCCUGAAAGGAGCCAAGAUCACGCGGCUCCAGGAUCAGCAGGUUCCCUACGCAGUCAAGGGGAACCAGUGGGUGGGCUAUGAUGAUGUGAAGAGUAUGGAGACCAAGGUUCAGUUCUUAAAGAAUUUAAACCUGGGAGGAGCCAUGAUCUGGUCUAUUGACAUGGAUGACUUCACUGGCAAAUCCUGCAACCAGGGCCCUUACCCUCUUGUCCAAGCAGUCAAGAGAAGCCUUGGCUCCCUGUGAAGGAUUAACUUACAGAGAAGCAGGCAAGAUGACCUUGCUGCCUGGGGCCUGCUCUCUCCCAGGAAUUCUCAUGUGGGAUUCCCCUUGCCAGGCUGGCCUUUGGAUCUCUCUUCCAAGCCUUUCCUGACUUCCUCUUAGAUCAUAGAUUGGACCUGGUUUUGUUUUCCUGCAGCUGUUGACUUGUUGCCCUGAAGUACAAUAAAAAAAAUUCAUUUUGCUCCAGUAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 1116)
CHI3L1
chitinase 3 like 1
NC_000001.11
1  203179445.. 203186623
203179445.. 203186623
strand -
CCDS1435.1
MGI:1340899
ClinVar, dbVar
ENSG00000133048
GP39, YKL40, YK-40
uc001gzi.3
INSDC: BC008568
1932
601525
OTTHUMG00000042122
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1152 bp)
5'-ATGGGTGTGAAGGCGTCTCAAACAGGCTTTGTGGTCCTGGTGCTGCTCCAGTGCTGCTCTGCATACAAACTGGTCTGCTACTACACCAGCTGGTCCCAGTACCGGGAAGGCGATGGGAGCTGCTTCCCAGATGCCCTTGACCGCTTCCTCTGTACCCACATCATCTACAGCTTTGCCAATATAAGCAACGATCACATCGACACCTGGGAGTGGAATGATGTGACGCTCTACGGCATGCTCAACACACTCAAGAACAGGAACCCCAACCTGAAGACTCTCTTGTCTGTCGGAGGATGGAACTTTGGGTCTCAAAGATTTTCCAAGATAGCCTCCAACACCCAGAGTCGCCGGACTTTCATCAAGTCAGTACCGCCATTTCTGCGCACCCATGGCTTTGATGGGCTGGACCTTGCCTGGCTCTACCCTGGACGGAGAGACAAACAGCATTTTACCACCCTAATCAAGGAAATGAAGGCCGAATTTATAAAGGAAGCCCAGCCAGGGAAAAAGCAGCTCCTGCTCAGCGCAGCACTGTCTGCGGGGAAGGTCACCATTGACAGCAGCTATGACATTGCCAAGATATCCCAACACCTGGATTTCATTAGCATCATGACCTACGATTTTCATGGAGCCTGGCGTGGGACCACAGGCCATCACAGTCCCCTGTTCCGAGGTCAGGAGGATGCAAGTCCTGACAGATTCAGCAACACTGACTATGCTGTGGGGTACATGTTGAGGCTGGGGGCTCCTGCCAGTAAGCTGGTGATGGGCATCCCCACCTTCGGGAGGAGCTTCACTCTGGCTTCTTCTGAGACTGGTGTTGGAGCCCCAATCTCAGGACCGGGAATTCCAGGCCGGTTCACCAAGGAGGCAGGGACCCTTGCCTACTATGAGATCTGTGACTTCCTCCGCGGAGCCACAGTCCATAGAATCCTCGGCCAGCAGGTCCCCTATGCCACCAAGGGCAACCAGTGGGTAGGATACGACGACCAGGAAAGCGTCAAAAGCAAGGTGCAGTACCTGAAGGACAGGCAGCTGGCGGGCGCCATGGTATGGGCCCTGGACCTGGATGACTTCCAGGGCTCCTTCTGTGGCCAGGATCTGCGCTTCCCTCTCACCAATGCCATCAAGGATGCACTCGCTGCAACGTAG-3'
NCBI CDS gene sequence with introns (location: 203179445.. 203186623) (7179 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 111227713.. 111243440) (15728 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [111227713.. 111243440 + 1000]) (16728 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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