NCBI Summary
This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_059119)
CBM13-ppGalNAc-T7
N-acetylgalactosaminyltransferase 7 (EC 2.4.1.41) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7)
GALNT7
polypeptide N-acetylgalactosaminyltransferase 7
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_059119
51809
Q86SF2
ENSP00000265000.4
Q86SF2
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (657 amino acids) Download
MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q86SF2-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
GalNAc
GalNAc
6IWR
6IWR
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT7 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Long non-coding RNA TP73-AS1 contributes to glioma tumorigenesis by sponging the miR-103a/GALNT7 pathway. [32416102]
  • Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7. [30685086]
  • Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. [29970122]
  • miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer. [27619677]
  • GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma. [26503214]
  • MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7. [22399294]
  • miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. [21741600]
  • Defining the membrane proteome of NK cells. [19946888]
  • MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. [19844573]
  • A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates. [10544240]
UniProt Main References (4 PubMed Identifiers)
  • Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. [16303743]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. [11925450]
  • Initial characterization of the human central proteome. [21269460]
RNA
RNA (Transcript ID: NM_017423.3)
NM_017423.3
polypeptide N-acetylgalactosaminyltransferase 7, transcript variant 1
All isoforms of GALNT7 containing a lectin domain
ENST00000265000.9
26..1999 (or 173168836.. 173321717)
173168811.. 173323967
NCBI Matured mRNA sequence 4249 NTPDownload 
m7G-5')ppp(5'-GUGAGUCUCUCGCCGCCGGAGGAAGAUGAGGCUGAAGAUUGGGUUCAUCUUACGCAGUUUGCUGGUGGUGGGAAGCUUCCUGGGGCUAGUGGUCCUCUGGUCUUCCCUGACCCCGCGGCCGGACGACCCAAGCCCGCUGAGCAGGAUGAGGGAAGACAGAGAUGUCAAUGACCCCAUGCCCAACCGAGGCGGCAAUGGACUAGCUCCUGGGGAGGACAGAUUCAAACCUGUGGUACCAUGGCCUCAUGUUGAAGGAGUAGAAGUGGACUUAGAGUCUAUUAGAAGAAUAAACAAGGCCAAAAAUGAACAAGAGCACCAUGCUGGAGGAGAUUCCCAGAAAGAUAUCAUGCAGAGGCAGUAUCUCACAUUUAAGCCUCAGACAUUCACCUACCAUGAUCCUGUGCUUCGCCCAGGGAUCCUCGGUAACUUUGAACCCAAAGAACCUGAGCCUCCUGGAGUGGUUGGUGGCCCUGGAGAGAAAGCCAAGCCAUUGGUUUUGGGACCAGAAUUCAAACAAGCAAUUCAAGCCAGCAUUAAAGAGUUUGGAUUUAACAUGGUGGCAAGUGACAUGAUCUCACUGGACCGCAGCGUCAAUGACUUACGCCAAGAAGAAUGCAAGUAUUGGCAUUAUGAUGAAAACUUGCUCACUUCGAGCGUUGUCAUUGUCUUCCAUAAUGAAGGAUGGUCAACCCUCAUGAGAACAGUCCACAGUGUAAUUAAAAGGACUCCAAGGAAAUAUUUAGCAGAAAUUGUGUUAAUUGACGAUUUCAGUAAUAAAGAACACUUAAAAGAAAAACUGGAUGAAUAUAUUAAGCUGUGGAAUGGCCUAGUGAAGGUAUUUCGAAAUGAAAGAAGGGAAGGUUUAAUUCAAGCACGAAGUAUUGGUGCUCAGAAGGCUAAACUUGGACAGGUUUUGAUAUACCUUGAUGCCCACUGUGAGGUGGCAGUUAACUGGUAUGCACCACUUGUAGCUCCCAUAUCUAAGGACAGAACCAUUUGCACUGUGCCGCUUAUAGAUGUCAUAAAUGGCAACACAUAUGAAAUUAUACCCCAAGGGGGUGGUGAUGAAGAUGGGUAUGCCCGAGGAGCAUGGGAUUGGAGUAUGCUCUGGAAACGGGUGCCUCUGACCCCUCAAGAGAAGAGACUGAGAAAGACAAAAACUGAACCGUAUCGGUCCCCAGCCAUGGCUGGGGGAUUAUUUGCCAUUGAACGAGAGUUCUUCUUUGAAUUGGGUCUCUAUGAUCCAGGUCUCCAGAUUUGGGGUGGUGAAAACUUUGAGAUCUCAUACAAGAUAUGGCAGUGUGGUGGCAAAUUAUUAUUUGUUCCUUGUUCUCGUGUUGGACAUAUCUACCGUCUUGAGGGCUGGCAAGGAAAUCCUCCGCCCAUUUAUGUUGGGUCUUCUCCAACUCUGAAGAAUUAUGUUAGAGUUGUGGAGGUUUGGUGGGAUGAAUAUAAAGACUACUUCUAUGCUAGUCGUCCUGAAUCGCAGGCAUUACCAUAUGGGGAUAUAUCGGAGCUGAAAAAAUUUCGAGAAGAUCACAACUGCAAAAGUUUUAAGUGGUUCAUGGAAGAAAUAGCUUAUGAUAUCACCUCACACUACCCUUUGCCACCCAAAAAUGUUGACUGGGGAGAAAUCAGAGGCUUCGAAACUGCUUACUGCAUUGAUAGCAUGGGAAAAACAAAUGGAGGCUUUGUUGAACUAGGACCCUGCCACAGGAUGGGAGGGAAUCAGCUUUUCAGAAUCAAUGAAGCAAAUCAACUCAUGCAGUAUGACCAGUGUUUGACAAAGGGAGCUGAUGGAUCAAAAGUUAUGAUUACACACUGUAAUCUAAAUGAAUUUAAGGAAUGGCAGUACUUCAAGAACCUGCACAGAUUUACUCAUAUUCCUUCAGGAAAGUGUUUAGAUCGCUCAGAGGUCCUGCAUCAAGUAUUCAUCUCCAAUUGUGACUCCAGUAAAACGACUCAAAAAUGGGAAAUGAAUAACAUCCAUAGUGUUUAGAGAGAAAAAAAUAAACCAAUAACCUACCUACUGACAAGUAAAUUUAUACAGGACUGAAAACCGCCUGAAACCUGCUGCAACUAUUGUUAUUAACUCUGUAUAGCUCCAAACCUGGAACCUCCUGAUCAGUUUGAAGGACAUUGAUAAACUGUGAUUUUACAAUAACAUUAUCAUCUGCAGUUACUGUUUACAAGACUGCUUUUACCUUAAACUUUGUAGAUGUUUACAUCUUUUUGUUGUGUUUUAAGAUGAUGUUGGUAAUUUGUGCCUUUAGCUCUGUUUUAUUAGACAGAGUUAAAGCAUGUUGUCUUCUUUGGGAUUACACUCAGGGGUCUGAAAGGCAGUUUGAUUUUUAUUUUUAACACACUUGAAAAAAGGUUGGAGUAGCCAGACUUUCAUAUAUAACUUGGUGAUUAUCAACCUGUUGUGUCUUUAUUUAAUUUUACAUCUUUUUGAAGCACUGCCACAGGUUAUUAGCCAAGGUGGCCUUCCUUCACAGUCAUGCUGCUUUUUUGAAAGGUGAAUUUCAACACAUUUAGUGCCUCUUUCAUUUCUCAGUAUAUAUUUCAAGAGCUUGUGAUGAAAUCUAUAGGAUGGUAAUGAUGGACUUGUCACCUGUAUGGGGAAUACUUUUACUACUCAGAAAUGAAUUUAUGUGCUGCCAUUUGCUAUAAAGUUGAACUUUGUAUGGCUUGAAAAAGAAAUGACAAUAUGGAACAUCCCAAGGCUGUCCCAUAGGGUUGGAAGUUGUGUAGCAUUCACUCCCUUACCUACUGGCAUUCCCAGUGCCCUCUGUCCAUACCUACUUCUAGGAUUGCAAAGGAGUCUUCCAACUAGAGAAAAAUUGUCCACUGACAUUUGGGAUUUACUUUUCUCCAAUACCUGCCAAUACAGAAAACUAUUAUCAGUUGUUAUUGUUAUCCCUUGAAAGCGAGGGUGACAAAAACAACAAAACACCGUUAUAAACACAUCAAAGGUUCAUUCUGACUGAGGUAAGACUUUCCAAGCCCUUGUUAGAUUAGGCCUUAUAAAACUUGUGUGCAUUAUAACCUAAGCUGUGCAACCUGUGAAGCCAAGAGUGAACUGAUGUUUCAUUUAUAUUUUCAUCCAAAUGACAUUAUCUGCACGUUUUUAAAAUUUAAAAACAAAGGACUAUUUAAAAAUACAGUUUAUUAACAAACGUGAACUACUUUCUGUUACAUUAGGUGUUCCCUAGUGUUUCUUAAUUUCUUUUUAGAAAGUGUAUUUUUAUUAGUAUUUUUCCGGUGAACAGAAGAUUUGUUUGGAUUUAAACAUUUACUAAGACAGUACCUAUUAGGAAAACCAAAUAUUGCAAAUGGUCAAUUCGAUUUUAAUUUCUCAAAAGAUACUCUGUUAUCCAGAAGAUUAAAAUGCCUACAUUGAGUGCUUAAAAAAAAAAAAACAACUGUGAUGAUGUGAGCAGAAUGGCAAGUAAGUUAAGCAUUUUUGAUCCUGUAAUCAUGGUAUCAUUACAAUGAAAGGAAUUCACAAACUACUGCCAGAGGAAGUUUGUUUUUUAAUUUAAGAGGGAAAUAUAACCUAUAAAUUUGUUUCUUCCAAGCUUAGCUCUUAAAUUUGGAGACUCAAAGUUAAACAUCCUCAACAGAGUUUUAUUUAUAAUUUUGAAUUGUCAAUUUGUAUUUUGCUACUGAUCUGUGAUCAACCAUUUUAACUUUCAUCUCUAGGGAUGUUUAACAUUUAUAAUUGCAAAAUAAACCAACUAUAAAAAAAGAAACUAAGAGAGAAUUGGUACUUUAAUUACUUGUGUGUUUGCAAAUAGGCUCCAUUUUCCAUGUUGAGUAGAUUAUAACCUUAUUAACUAUGCAUAGGCCUAAGAAAGGUGGCAAUGAACUGUGCAUGUAAAUUUUAAAUGGGUACUUUGUGCAAUUCGUUAAAAGAAGAUACUCUAUGAAUAUGAUUCUAUAUAUUGAAAUCAGAAAACCUACCAAACAAAAACAUCAGAAGCUGCUGCCAUAAUGACUAUUUUCUACUGUAGGCUGCUUUGGAAAUAAUUCCCAUAUCCUUGCUUUGUAAGUUGGUAAUAUCACUAUGCAUUUCUACACAUUUUAUAAAUUUGAUUUAUGCAGAUUUUGAUACACUGUAUGUUUCUGUAGAAAUUGUAUAAAUAUUCAAAAUUUUAUUAGGAUAAAUUUGAGAAACUUACGUAUAUCUUAAUUCUGGGUUGCUUGUUUUUUAGGUGACAAAAAUAAAAUAUUGUAUUUUAAUUCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 51809)
GALNT7
polypeptide N-acetylgalactosaminyltransferase 7
NC_000004.12
4  173168836.. 173321717
173168836.. 173321717
strand +
CCDS3815.1
MGI:1349449
ClinVar, dbVar
ENSG00000109586
GALNAC-T7
uc003isz.4
INSDC: AJ002744
4129
605005
OTTHUMG00000160817
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1974 bp)
5'-ATGAGGCTGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGGCTAGTGGTCCTCTGGTCTTCCCTGACCCCGCGGCCGGACGACCCAAGCCCGCTGAGCAGGATGAGGGAAGACAGAGATGTCAATGACCCCATGCCCAACCGAGGCGGCAATGGACTAGCTCCTGGGGAGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTGGACTTAGAGTCTATTAGAAGAATAAACAAGGCCAAAAATGAACAAGAGCACCATGCTGGAGGAGATTCCCAGAAAGATATCATGCAGAGGCAGTATCTCACATTTAAGCCTCAGACATTCACCTACCATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCTGAGCCTCCTGGAGTGGTTGGTGGCCCTGGAGAGAAAGCCAAGCCATTGGTTTTGGGACCAGAATTCAAACAAGCAATTCAAGCCAGCATTAAAGAGTTTGGATTTAACATGGTGGCAAGTGACATGATCTCACTGGACCGCAGCGTCAATGACTTACGCCAAGAAGAATGCAAGTATTGGCATTATGATGAAAACTTGCTCACTTCGAGCGTTGTCATTGTCTTCCATAATGAAGGATGGTCAACCCTCATGAGAACAGTCCACAGTGTAATTAAAAGGACTCCAAGGAAATATTTAGCAGAAATTGTGTTAATTGACGATTTCAGTAATAAAGAACACTTAAAAGAAAAACTGGATGAATATATTAAGCTGTGGAATGGCCTAGTGAAGGTATTTCGAAATGAAAGAAGGGAAGGTTTAATTCAAGCACGAAGTATTGGTGCTCAGAAGGCTAAACTTGGACAGGTTTTGATATACCTTGATGCCCACTGTGAGGTGGCAGTTAACTGGTATGCACCACTTGTAGCTCCCATATCTAAGGACAGAACCATTTGCACTGTGCCGCTTATAGATGTCATAAATGGCAACACATATGAAATTATACCCCAAGGGGGTGGTGATGAAGATGGGTATGCCCGAGGAGCATGGGATTGGAGTATGCTCTGGAAACGGGTGCCTCTGACCCCTCAAGAGAAGAGACTGAGAAAGACAAAAACTGAACCGTATCGGTCCCCAGCCATGGCTGGGGGATTATTTGCCATTGAACGAGAGTTCTTCTTTGAATTGGGTCTCTATGATCCAGGTCTCCAGATTTGGGGTGGTGAAAACTTTGAGATCTCATACAAGATATGGCAGTGTGGTGGCAAATTATTATTTGTTCCTTGTTCTCGTGTTGGACATATCTACCGTCTTGAGGGCTGGCAAGGAAATCCTCCGCCCATTTATGTTGGGTCTTCTCCAACTCTGAAGAATTATGTTAGAGTTGTGGAGGTTTGGTGGGATGAATATAAAGACTACTTCTATGCTAGTCGTCCTGAATCGCAGGCATTACCATATGGGGATATATCGGAGCTGAAAAAATTTCGAGAAGATCACAACTGCAAAAGTTTTAAGTGGTTCATGGAAGAAATAGCTTATGATATCACCTCACACTACCCTTTGCCACCCAAAAATGTTGACTGGGGAGAAATCAGAGGCTTCGAAACTGCTTACTGCATTGATAGCATGGGAAAAACAAATGGAGGCTTTGTTGAACTAGGACCCTGCCACAGGATGGGAGGGAATCAGCTTTTCAGAATCAATGAAGCAAATCAACTCATGCAGTATGACCAGTGTTTGACAAAGGGAGCTGATGGATCAAAAGTTATGATTACACACTGTAATCTAAATGAATTTAAGGAATGGCAGTACTTCAAGAACCTGCACAGATTTACTCATATTCCTTCAGGAAAGTGTTTAGATCGCTCAGAGGTCCTGCATCAAGTATTCATCTCCAATTGTGACTCCAGTAAAACGACTCAAAAATGGGAAATGAATAACATCCATAGTGTTTAG-3'
NCBI CDS gene sequence with introns (location: 173168836.. 173321717) (152882 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 173168811.. 173323967) (155157 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [173168811 - 1000].. 173323967) (156157 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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