HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008].

Protein name

CBM13-ppGalNAc-T7

Synonym(s)

N-acetylgalactosaminyltransferase 7 (EC 2.4.1.41) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7)

HGNC gene name

GALNT7

HGNC name

polypeptide N-acetylgalactosaminyltransferase 7

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

Ricin-like

Known lectin group

R-Type Lectins

Lectin fold

b-trefoil

Glycan specificity

GalNAc / Mucin-type glycopeptide

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

Undefined

Reference

10.1074/jbc.M111.273722

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (657 amino acids) Download

MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q86SF2-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for GALNT7 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Long non-coding RNA TP73-AS1 contributes to glioma tumorigenesis by sponging the miR-103a/GALNT7 pathway. [32416102]

Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7. [30685086]

Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. [29970122]

miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer. [27619677]

GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma. [26503214]

MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7. [22399294]

miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. [21741600]

Defining the membrane proteome of NK cells. [19946888]

MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. [19844573]

A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates. [10544240]

UniProt Main References (4 PubMed Identifiers)

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. [16303743]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. [11925450]

Initial characterization of the human central proteome. [21269460]

RNA

RNA (Transcript ID: NM_017423.3)

RNA RefSeq ID

NM_017423.3

RNA name

polypeptide N-acetylgalactosaminyltransferase 7, transcript variant 1

Isoforms

All isoforms of GALNT7 containing a lectin domain

RNA Ensembl ID

ENST00000265000.9

Coding region

26..1999 (or 173168836.. 173321717)

mRNA location

173168811.. 173323967

NCBI Matured mRNA sequence 4249 NTP Download

m⁷G-5')ppp(5'-GUGAGUCUCUCGCCGCCGGAGGAAGAUGAGGCUGAAGAUUGGGUUCAUCUUACGCAGUUUGCUGGUGGUGGGAAGCUUCCUGGGGCUAGUGGUCCUCUGGUCUUCCCUGACCCCGCGGCCGGACGACCCAAGCCCGCUGAGCAGGAUGAGGGAAGACAGAGAUGUCAAUGACCCCAUGCCCAACCGAGGCGGCAAUGGACUAGCUCCUGGGGAGGACAGAUUCAAACCUGUGGUACCAUGGCCUCAUGUUGAAGGAGUAGAAGUGGACUUAGAGUCUAUUAGAAGAAUAAACAAGGCCAAAAAUGAACAAGAGCACCAUGCUGGAGGAGAUUCCCAGAAAGAUAUCAUGCAGAGGCAGUAUCUCACAUUUAAGCCUCAGACAUUCACCUACCAUGAUCCUGUGCUUCGCCCAGGGAUCCUCGGUAACUUUGAACCCAAAGAACCUGAGCCUCCUGGAGUGGUUGGUGGCCCUGGAGAGAAAGCCAAGCCAUUGGUUUUGGGACCAGAAUUCAAACAAGCAAUUCAAGCCAGCAUUAAAGAGUUUGGAUUUAACAUGGUGGCAAGUGACAUGAUCUCACUGGACCGCAGCGUCAAUGACUUACGCCAAGAAGAAUGCAAGUAUUGGCAUUAUGAUGAAAACUUGCUCACUUCGAGCGUUGUCAUUGUCUUCCAUAAUGAAGGAUGGUCAACCCUCAUGAGAACAGUCCACAGUGUAAUUAAAAGGACUCCAAGGAAAUAUUUAGCAGAAAUUGUGUUAAUUGACGAUUUCAGUAAUAAAGAACACUUAAAAGAAAAACUGGAUGAAUAUAUUAAGCUGUGGAAUGGCCUAGUGAAGGUAUUUCGAAAUGAAAGAAGGGAAGGUUUAAUUCAAGCACGAAGUAUUGGUGCUCAGAAGGCUAAACUUGGACAGGUUUUGAUAUACCUUGAUGCCCACUGUGAGGUGGCAGUUAACUGGUAUGCACCACUUGUAGCUCCCAUAUCUAAGGACAGAACCAUUUGCACUGUGCCGCUUAUAGAUGUCAUAAAUGGCAACACAUAUGAAAUUAUACCCCAAGGGGGUGGUGAUGAAGAUGGGUAUGCCCGAGGAGCAUGGGAUUGGAGUAUGCUCUGGAAACGGGUGCCUCUGACCCCUCAAGAGAAGAGACUGAGAAAGACAAAAACUGAACCGUAUCGGUCCCCAGCCAUGGCUGGGGGAUUAUUUGCCAUUGAACGAGAGUUCUUCUUUGAAUUGGGUCUCUAUGAUCCAGGUCUCCAGAUUUGGGGUGGUGAAAACUUUGAGAUCUCAUACAAGAUAUGGCAGUGUGGUGGCAAAUUAUUAUUUGUUCCUUGUUCUCGUGUUGGACAUAUCUACCGUCUUGAGGGCUGGCAAGGAAAUCCUCCGCCCAUUUAUGUUGGGUCUUCUCCAACUCUGAAGAAUUAUGUUAGAGUUGUGGAGGUUUGGUGGGAUGAAUAUAAAGACUACUUCUAUGCUAGUCGUCCUGAAUCGCAGGCAUUACCAUAUGGGGAUAUAUCGGAGCUGAAAAAAUUUCGAGAAGAUCACAACUGCAAAAGUUUUAAGUGGUUCAUGGAAGAAAUAGCUUAUGAUAUCACCUCACACUACCCUUUGCCACCCAAAAAUGUUGACUGGGGAGAAAUCAGAGGCUUCGAAACUGCUUACUGCAUUGAUAGCAUGGGAAAAACAAAUGGAGGCUUUGUUGAACUAGGACCCUGCCACAGGAUGGGAGGGAAUCAGCUUUUCAGAAUCAAUGAAGCAAAUCAACUCAUGCAGUAUGACCAGUGUUUGACAAAGGGAGCUGAUGGAUCAAAAGUUAUGAUUACACACUGUAAUCUAAAUGAAUUUAAGGAAUGGCAGUACUUCAAGAACCUGCACAGAUUUACUCAUAUUCCUUCAGGAAAGUGUUUAGAUCGCUCAGAGGUCCUGCAUCAAGUAUUCAUCUCCAAUUGUGACUCCAGUAAAACGACUCAAAAAUGGGAAAUGAAUAACAUCCAUAGUGUUUAGAGAGAAAAAAAUAAACCAAUAACCUACCUACUGACAAGUAAAUUUAUACAGGACUGAAAACCGCCUGAAACCUGCUGCAACUAUUGUUAUUAACUCUGUAUAGCUCCAAACCUGGAACCUCCUGAUCAGUUUGAAGGACAUUGAUAAACUGUGAUUUUACAAUAACAUUAUCAUCUGCAGUUACUGUUUACAAGACUGCUUUUACCUUAAACUUUGUAGAUGUUUACAUCUUUUUGUUGUGUUUUAAGAUGAUGUUGGUAAUUUGUGCCUUUAGCUCUGUUUUAUUAGACAGAGUUAAAGCAUGUUGUCUUCUUUGGGAUUACACUCAGGGGUCUGAAAGGCAGUUUGAUUUUUAUUUUUAACACACUUGAAAAAAGGUUGGAGUAGCCAGACUUUCAUAUAUAACUUGGUGAUUAUCAACCUGUUGUGUCUUUAUUUAAUUUUACAUCUUUUUGAAGCACUGCCACAGGUUAUUAGCCAAGGUGGCCUUCCUUCACAGUCAUGCUGCUUUUUUGAAAGGUGAAUUUCAACACAUUUAGUGCCUCUUUCAUUUCUCAGUAUAUAUUUCAAGAGCUUGUGAUGAAAUCUAUAGGAUGGUAAUGAUGGACUUGUCACCUGUAUGGGGAAUACUUUUACUACUCAGAAAUGAAUUUAUGUGCUGCCAUUUGCUAUAAAGUUGAACUUUGUAUGGCUUGAAAAAGAAAUGACAAUAUGGAACAUCCCAAGGCUGUCCCAUAGGGUUGGAAGUUGUGUAGCAUUCACUCCCUUACCUACUGGCAUUCCCAGUGCCCUCUGUCCAUACCUACUUCUAGGAUUGCAAAGGAGUCUUCCAACUAGAGAAAAAUUGUCCACUGACAUUUGGGAUUUACUUUUCUCCAAUACCUGCCAAUACAGAAAACUAUUAUCAGUUGUUAUUGUUAUCCCUUGAAAGCGAGGGUGACAAAAACAACAAAACACCGUUAUAAACACAUCAAAGGUUCAUUCUGACUGAGGUAAGACUUUCCAAGCCCUUGUUAGAUUAGGCCUUAUAAAACUUGUGUGCAUUAUAACCUAAGCUGUGCAACCUGUGAAGCCAAGAGUGAACUGAUGUUUCAUUUAUAUUUUCAUCCAAAUGACAUUAUCUGCACGUUUUUAAAAUUUAAAAACAAAGGACUAUUUAAAAAUACAGUUUAUUAACAAACGUGAACUACUUUCUGUUACAUUAGGUGUUCCCUAGUGUUUCUUAAUUUCUUUUUAGAAAGUGUAUUUUUAUUAGUAUUUUUCCGGUGAACAGAAGAUUUGUUUGGAUUUAAACAUUUACUAAGACAGUACCUAUUAGGAAAACCAAAUAUUGCAAAUGGUCAAUUCGAUUUUAAUUUCUCAAAAGAUACUCUGUUAUCCAGAAGAUUAAAAUGCCUACAUUGAGUGCUUAAAAAAAAAAAAACAACUGUGAUGAUGUGAGCAGAAUGGCAAGUAAGUUAAGCAUUUUUGAUCCUGUAAUCAUGGUAUCAUUACAAUGAAAGGAAUUCACAAACUACUGCCAGAGGAAGUUUGUUUUUUAAUUUAAGAGGGAAAUAUAACCUAUAAAUUUGUUUCUUCCAAGCUUAGCUCUUAAAUUUGGAGACUCAAAGUUAAACAUCCUCAACAGAGUUUUAUUUAUAAUUUUGAAUUGUCAAUUUGUAUUUUGCUACUGAUCUGUGAUCAACCAUUUUAACUUUCAUCUCUAGGGAUGUUUAACAUUUAUAAUUGCAAAAUAAACCAACUAUAAAAAAAGAAACUAAGAGAGAAUUGGUACUUUAAUUACUUGUGUGUUUGCAAAUAGGCUCCAUUUUCCAUGUUGAGUAGAUUAUAACCUUAUUAACUAUGCAUAGGCCUAAGAAAGGUGGCAAUGAACUGUGCAUGUAAAUUUUAAAUGGGUACUUUGUGCAAUUCGUUAAAAGAAGAUACUCUAUGAAUAUGAUUCUAUAUAUUGAAAUCAGAAAACCUACCAAACAAAAACAUCAGAAGCUGCUGCCAUAAUGACUAUUUUCUACUGUAGGCUGCUUUGGAAAUAAUUCCCAUAUCCUUGCUUUGUAAGUUGGUAAUAUCACUAUGCAUUUCUACACAUUUUAUAAAUUUGAUUUAUGCAGAUUUUGAUACACUGUAUGUUUCUGUAGAAAUUGUAUAAAUAUUCAAAAUUUUAUUAGGAUAAAUUUGAGAAACUUACGUAUAUCUUAAUUCUGGGUUGCUUGUUUUUUAGGUGACAAAAAUAAAAUAUUGUAUUUUAAUUCA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 51809)

HGNC Gene symbol

GALNT7

HGNC Gene name

polypeptide N-acetylgalactosaminyltransferase 7

Chr. RefSeq ID

NC_000004.12

Chromosome N°

4 173168836.. 173321717

CDS location

173168836.. 173321717

DNA strand

strand +

CCDS ID

CCDS3815.1

Mouse ortholog gene

MGI:1349449

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000109586

HGNC other symbol

GALNAC-T7

UCSC ID

uc003isz.4

GeneBank

INSDC: AJ002744

GeneCards

4129

MIM

605005

VEGA ID

OTTHUMG00000160817

Other links

ENA, DDBJ, Monarch

NCBI CDS Gene viewer

More about the NCBI sViewer.

NCBI CDS gene sequence (1974 bp)

5'-ATGAGGCTGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGGCTAGTGGTCCTCTGGTCTTCCCTGACCCCGCGGCCGGACGACCCAAGCCCGCTGAGCAGGATGAGGGAAGACAGAGATGTCAATGACCCCATGCCCAACCGAGGCGGCAATGGACTAGCTCCTGGGGAGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTGGACTTAGAGTCTATTAGAAGAATAAACAAGGCCAAAAATGAACAAGAGCACCATGCTGGAGGAGATTCCCAGAAAGATATCATGCAGAGGCAGTATCTCACATTTAAGCCTCAGACATTCACCTACCATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCTGAGCCTCCTGGAGTGGTTGGTGGCCCTGGAGAGAAAGCCAAGCCATTGGTTTTGGGACCAGAATTCAAACAAGCAATTCAAGCCAGCATTAAAGAGTTTGGATTTAACATGGTGGCAAGTGACATGATCTCACTGGACCGCAGCGTCAATGACTTACGCCAAGAAGAATGCAAGTATTGGCATTATGATGAAAACTTGCTCACTTCGAGCGTTGTCATTGTCTTCCATAATGAAGGATGGTCAACCCTCATGAGAACAGTCCACAGTGTAATTAAAAGGACTCCAAGGAAATATTTAGCAGAAATTGTGTTAATTGACGATTTCAGTAATAAAGAACACTTAAAAGAAAAACTGGATGAATATATTAAGCTGTGGAATGGCCTAGTGAAGGTATTTCGAAATGAAAGAAGGGAAGGTTTAATTCAAGCACGAAGTATTGGTGCTCAGAAGGCTAAACTTGGACAGGTTTTGATATACCTTGATGCCCACTGTGAGGTGGCAGTTAACTGGTATGCACCACTTGTAGCTCCCATATCTAAGGACAGAACCATTTGCACTGTGCCGCTTATAGATGTCATAAATGGCAACACATATGAAATTATACCCCAAGGGGGTGGTGATGAAGATGGGTATGCCCGAGGAGCATGGGATTGGAGTATGCTCTGGAAACGGGTGCCTCTGACCCCTCAAGAGAAGAGACTGAGAAAGACAAAAACTGAACCGTATCGGTCCCCAGCCATGGCTGGGGGATTATTTGCCATTGAACGAGAGTTCTTCTTTGAATTGGGTCTCTATGATCCAGGTCTCCAGATTTGGGGTGGTGAAAACTTTGAGATCTCATACAAGATATGGCAGTGTGGTGGCAAATTATTATTTGTTCCTTGTTCTCGTGTTGGACATATCTACCGTCTTGAGGGCTGGCAAGGAAATCCTCCGCCCATTTATGTTGGGTCTTCTCCAACTCTGAAGAATTATGTTAGAGTTGTGGAGGTTTGGTGGGATGAATATAAAGACTACTTCTATGCTAGTCGTCCTGAATCGCAGGCATTACCATATGGGGATATATCGGAGCTGAAAAAATTTCGAGAAGATCACAACTGCAAAAGTTTTAAGTGGTTCATGGAAGAAATAGCTTATGATATCACCTCACACTACCCTTTGCCACCCAAAAATGTTGACTGGGGAGAAATCAGAGGCTTCGAAACTGCTTACTGCATTGATAGCATGGGAAAAACAAATGGAGGCTTTGTTGAACTAGGACCCTGCCACAGGATGGGAGGGAATCAGCTTTTCAGAATCAATGAAGCAAATCAACTCATGCAGTATGACCAGTGTTTGACAAAGGGAGCTGATGGATCAAAAGTTATGATTACACACTGTAATCTAAATGAATTTAAGGAATGGCAGTACTTCAAGAACCTGCACAGATTTACTCATATTCCTTCAGGAAAGTGTTTAGATCGCTCAGAGGTCCTGCATCAAGTATTCATCTCCAATTGTGACTCCAGTAAAACGACTCAAAAATGGGAAATGAATAACATCCATAGTGTTTAG-3'

NCBI CDS gene sequence with introns (location: 173168836.. 173321717) (152882 bp)Download

NCBI Gene Viewer (CDS + introns)

NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 173168811.. 173323967) (155157 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions)

NCBI gene sequence (location: [173168811 - 1000].. 173323967) (156157 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)