Protein
Protein (NP_940918)
CBM13-ppGalNAc-T18
Polypeptide N-acetylgalactosaminyltransferase 18 (EC 2.4.1.41) (Polypeptide GalNAc transferase 18) (GalNAc-T18) (Polypeptide GalNAc transferase-like protein 4) (GalNAc-T-like protein 4) (pp-GaNTase-like protein 4) (Polypeptide N-acetylgalactosaminyltransferase-like protein 4) (Protein-UDP acetylgalactosaminyltransferase-like protein 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4)
GALNT18
polypeptide N-acetylgalactosaminyltransferase 18
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_940918
374378
Q6P9A2
ENSP00000227756.4
Q6P9A2
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (607 amino acids) Download
MVCTRKTKTLVSTCVILSGMTNIICLLYVGWVTNYIASVYVRGQEPAPDKKLEEDKGDTLKIIERLDHLENVIKQHIQEAPAKPEEAEAEPFTDSSLFAHWGQELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSGCRNLSFPDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPPHLLKEIILVDDNSSNEELKEKLTEYVDKVNSQKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYDNFEIEEYPLAAQGFDWELWCRYLNPPKAWWKLENSTAPIRSPALIGCFIVDRQYFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTEDLTAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLDQGPDTENVPIMYICHGMTPQNVYYTSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGPIQNRKSKRCLELQENSDLEFGFQLVLQKCSGQHWSITNVLRSLAS
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q6P9A2-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.49, 1.89] ÅDownload
The location of the lectin domain structural model is: 257-602
We infer [1.49, 1.89] Å as the interval of error of this structural model.
Template: 1XHB chain: A, O08912, NP_001153876.1, sequence identity: 33.2%, coverage: 94.8%, location in sequence: 95-553, (95-553 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT18 Gene
ProteomicsDB
References
NCBI References (6 PubMed Identifiers)
  • Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. [22491018]
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. [22186971]
  • Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases. [22171061]
  • A genome-wide association search for type 2 diabetes genes in African Americans. [22238593]
  • Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. [20080650]
  • Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. [19240061]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_198516.3)
NM_198516.3
polypeptide N-acetylgalactosaminyltransferase 18, transcript variant 1
All isoforms of GALNT18 containing a lectin domain
ENST00000227756.5
413..2236 (or 11271144.. 11621593)
11270877.. 11622005
NCBI Matured mRNA sequence 2503 NTPDownload 
m7G-5')ppp(5'-GCUGUUCUCCUAGCAGCGCGGGCCGGUCGGACCGCCAAGGCAGCCGGCGCUGGCGAUGGGAAGCGGCGUGGCCGCCGACACAGGCAGUGGCAAAGUUUCCCAGACGUACACAUCUGGACGCGCGGCUGCCGGCUACCCGUGACCCCUCUAGGAAGGGUUCAGGGAUUUUUAAUUUGGAAAAAAAUCCACCUGGUUUCCUUUGUCAAGGUCUCUCCGGGUGGCCAGCGGCAGGAGCUGCAAACUUGGGCACGGCGGCUACACCGGCAGCGGACCGGGCUUUGGAGAACCUCGGGACUCAGGUGCUGAGGUGCCCAGCGGCUCCGGACGUGCUACGGGGUGCGAGCGCGGGGGAGUUCGGGGCGCACGACAAGGAAGGGCCCCCGGGAGCUCUAUAUGGAGGAAGGAGCCCAGAAUGGUGUGCACCAGGAAGACCAAAACUUUGGUGUCCACUUGCGUGAUCCUGAGCGGCAUGACUAACAUCAUCUGCCUGCUCUACGUGGGCUGGGUCACCAACUACAUCGCCAGCGUGUAUGUGCGGGGGCAGGAGCCGGCGCCCGACAAGAAGCUGGAGGAAGACAAAGGGGACACUCUGAAGAUUAUUGAGCGGCUGGACCACCUGGAGAAUGUCAUCAAGCAGCACAUUCAAGAGGCUCCUGCCAAGCCUGAGGAGGCAGAGGCCGAGCCCUUCACAGACUCCUCUCUGUUUGCACACUGGGGCCAGGAGCUCAGCCCCGAAGGCCGGCGCGUGGCCCUGAAGCAAUUCCAGUACUACGGCUACAACGCCUACCUCAGCGACCGCCUGCCCCUGGACCGGCCCCUGCCUGACCUCAGACCCAGUGGGUGCCGUAACCUCUCAUUUCCUGACAGCCUGCCAGAGGUGAGCAUCGUGUUCAUCUUCGUCAAUGAAGCGCUUUCAGUGCUGCUGCGCUCCAUCCACUCGGCCAUGGAACGCACGCCCCCACAUCUGCUCAAGGAGAUCAUUCUGGUGGAUGACAACAGCAGUAACGAGGAACUGAAGGAGAAGCUGACCGAAUAUGUGGACAAGGUGAACAGCCAGAAGCCAGGCUUCAUCAAAGUCGUGCGUCACAGCAAGCAGGAAGGCCUCAUCCGCUCCAGGGUCAGUGGCUGGAGGGCGGCCACUGCCCCUGUGGUGGCACUCUUUGAUGCCCACGUGGAGUUCAAUGUGGGCUGGGCUGAACCUGUACUCACCCGCAUCAAGGAGAACCGGAAGCGGAUCAUCUCGCCAUCCUUUGAUAACAUCAAAUAUGACAACUUUGAGAUAGAAGAGUACCCGCUGGCUGCCCAGGGCUUUGACUGGGAGCUGUGGUGCCGCUACCUAAAUCCCCCCAAGGCCUGGUGGAAGCUGGAGAACUCCACAGCGCCAAUCAGGAGCCCUGCCCUCAUUGGCUGCUUCAUUGUGGACCGGCAGUACUUCCAGGAGAUCGGCCUGCUGGACGAAGGCAUGGAAGUCUACGGGGGCGAGAAUGUGGAGCUUGGGAUCAGGGUGUGGCAGUGUGGCGGGAGUGUGGAGGUCCUGCCCUGCUCACGGAUUGCCCACAUUGAGCGAGCCCACAAGCCCUACACAGAGGACCUCACCGCCCAUGUCCGCAGGAACGCUCUCAGGGUGGCUGAAGUCUGGAUGGAUGAAUUUAAAAGCCACGUCUACAUGGCAUGGAACAUACCGCAGGAGGACUCAGGAAUUGACAUUGGGGACAUCACUGCAAGGAAGGCUCUCAGGAAACAGCUGCAGUGCAAGACCUUCCGGUGGUACCUGGUCAGCGUGUACCCAGAGAUGAGGAUGUACUCCGACAUCAUUGCCUAUGGAGUGCUGCAGAAUUCUCUGAAGACUGAUUUGUGUCUUGACCAGGGGCCAGAUACAGAGAAUGUCCCCAUCAUGUACAUCUGCCAUGGGAUGACGCCUCAGAACGUGUACUACACGAGCAGUCAGCAGAUCCAUGUGGGCAUUCUGAGCCCCACCGUGGAUGAUGAUGACAACCGAUGCCUGGUGGACGUCAACAGCCGGCCCCGGCUCAUCGAAUGCAGCUACGCCAAAGCCAAGAGGAUGAAGCUUCACUGGCAGUUCUCUCAGGGAGGACCCAUCCAGAACCGCAAGUCUAAGCGCUGUCUGGAGCUGCAGGAGAAUAGCGACCUGGAGUUCGGCUUCCAGCUGGUGUUGCAGAAGUGCUCGGGCCAGCACUGGAGCAUCACCAACGUCCUGAGGAGCCUCGCGUCCUGACCCACCGGGGCCACUUCCGGCUGCCUCUUUGCUACUGUGUAGCACCUGCUGCAACGUUGCCUGCUGUCCACGUGGGGUUGUUUGGAGUCUGGGGAACCAGGUUAGUGGGCCCCCAAGAAGAGCUUUUUAUUUCCUAUUCAAUUUUCAUGGAGUUUAUAGAAAGAUGCUGAUUGGUAGGUGAUGGUAUGAUAUCAAACUAUUUUGCAGUUGUAAAUAGGGGACAGAUGGAAAAUAUUUAUAACUGACAAUAAAAUAUUAUUAAGAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 374378)
GALNT18
polypeptide N-acetylgalactosaminyltransferase 18
NC_000011.10
11  11271144.. 11621593
11271144.. 11621593
strand -
CCDS7807.1
MGI:2446239
ClinVar, dbVar
ENSG00000110328
MGC71806, GALNT15, GalNAc-T18
uc001mjo.3
INSDC: AK055111
30488
615136
OTTHUMG00000165707
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1824 bp)
5'-ATGGTGTGCACCAGGAAGACCAAAACTTTGGTGTCCACTTGCGTGATCCTGAGCGGCATGACTAACATCATCTGCCTGCTCTACGTGGGCTGGGTCACCAACTACATCGCCAGCGTGTATGTGCGGGGGCAGGAGCCGGCGCCCGACAAGAAGCTGGAGGAAGACAAAGGGGACACTCTGAAGATTATTGAGCGGCTGGACCACCTGGAGAATGTCATCAAGCAGCACATTCAAGAGGCTCCTGCCAAGCCTGAGGAGGCAGAGGCCGAGCCCTTCACAGACTCCTCTCTGTTTGCACACTGGGGCCAGGAGCTCAGCCCCGAAGGCCGGCGCGTGGCCCTGAAGCAATTCCAGTACTACGGCTACAACGCCTACCTCAGCGACCGCCTGCCCCTGGACCGGCCCCTGCCTGACCTCAGACCCAGTGGGTGCCGTAACCTCTCATTTCCTGACAGCCTGCCAGAGGTGAGCATCGTGTTCATCTTCGTCAATGAAGCGCTTTCAGTGCTGCTGCGCTCCATCCACTCGGCCATGGAACGCACGCCCCCACATCTGCTCAAGGAGATCATTCTGGTGGATGACAACAGCAGTAACGAGGAACTGAAGGAGAAGCTGACCGAATATGTGGACAAGGTGAACAGCCAGAAGCCAGGCTTCATCAAAGTCGTGCGTCACAGCAAGCAGGAAGGCCTCATCCGCTCCAGGGTCAGTGGCTGGAGGGCGGCCACTGCCCCTGTGGTGGCACTCTTTGATGCCCACGTGGAGTTCAATGTGGGCTGGGCTGAACCTGTACTCACCCGCATCAAGGAGAACCGGAAGCGGATCATCTCGCCATCCTTTGATAACATCAAATATGACAACTTTGAGATAGAAGAGTACCCGCTGGCTGCCCAGGGCTTTGACTGGGAGCTGTGGTGCCGCTACCTAAATCCCCCCAAGGCCTGGTGGAAGCTGGAGAACTCCACAGCGCCAATCAGGAGCCCTGCCCTCATTGGCTGCTTCATTGTGGACCGGCAGTACTTCCAGGAGATCGGCCTGCTGGACGAAGGCATGGAAGTCTACGGGGGCGAGAATGTGGAGCTTGGGATCAGGGTGTGGCAGTGTGGCGGGAGTGTGGAGGTCCTGCCCTGCTCACGGATTGCCCACATTGAGCGAGCCCACAAGCCCTACACAGAGGACCTCACCGCCCATGTCCGCAGGAACGCTCTCAGGGTGGCTGAAGTCTGGATGGATGAATTTAAAAGCCACGTCTACATGGCATGGAACATACCGCAGGAGGACTCAGGAATTGACATTGGGGACATCACTGCAAGGAAGGCTCTCAGGAAACAGCTGCAGTGCAAGACCTTCCGGTGGTACCTGGTCAGCGTGTACCCAGAGATGAGGATGTACTCCGACATCATTGCCTATGGAGTGCTGCAGAATTCTCTGAAGACTGATTTGTGTCTTGACCAGGGGCCAGATACAGAGAATGTCCCCATCATGTACATCTGCCATGGGATGACGCCTCAGAACGTGTACTACACGAGCAGTCAGCAGATCCATGTGGGCATTCTGAGCCCCACCGTGGATGATGATGACAACCGATGCCTGGTGGACGTCAACAGCCGGCCCCGGCTCATCGAATGCAGCTACGCCAAAGCCAAGAGGATGAAGCTTCACTGGCAGTTCTCTCAGGGAGGACCCATCCAGAACCGCAAGTCTAAGCGCTGTCTGGAGCTGCAGGAGAATAGCGACCTGGAGTTCGGCTTCCAGCTGGTGTTGCAGAAGTGCTCGGGCCAGCACTGGAGCATCACCAACGTCCTGAGGAGCCTCGCGTCCTGA-3'
NCBI CDS gene sequence with introns (location: 11271144.. 11621593) (350450 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 11270877.. 11622005) (351129 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [11270877.. 11622005 + 1000]) (352129 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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