Protein
Protein (NP_001123470)
C-type lectin domain family 12 member B
C-type lectin domain family 12 member B (Macrophage antigen H)
CLEC12B
C-type lectin domain family 12 member B
Undefined
Very low evidence
C-type lectin
Undefined
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Uncharacterised
NP_001123470
387837
Q2HXU8
ENSP00000344563.5
Q2HXU8
0.374
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (276 amino acids) Download
MSEEVTYATLTFQDSAGARNNRDGNNLRKRGHPAPSPIWRHAALGLVTLCLMLLIGLVTLGMMFLQISNDINSDSEKLSQLQKTIQQQQDNLSQQLGNSNNLSMEEEFLKSQISSVLKRQEQMAIKLCQELIIHTSDHRCNPCPKMWQWYQNSCYYFTTNEEKTWANSRKDCIDKNSTLVKIDSLEEKDFLMSQPLLMFSFFWLGLSWDSSGRSWFWEDGSVPSPSLFSTKELDQINGSKGCAYFQKGNIYISRCSAEIFWICEKTAAPVKTEDLD
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q2HXU8-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.55, 2.0] ÅDownload
The location of the lectin domain structural model is: 118-272
We infer [1.55, 2.0] Å as the interval of error of this structural model.
Template 1: 3WHD chain: C, Q8WXI8, NP_525126.2, sequence identity: 21.9%, coverage: 94.8%, location in sequence: 63-215, (63-215 in PDB).
Template 2: 6JJJ chain: A, P70194, NP_058031.2, sequence identity: 20.6%, coverage: 92.9%, location in sequence: 393-543, (393-543 in PDB).
Template 3: 1K9J chain: A, Q9H2X3, NP_055072.3, sequence identity: 28.4%, coverage: 81.3%, location in sequence: 267-394, (267-394 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC12B Gene
ProteomicsDB
References
NCBI References (4 PubMed Identifiers)
  • Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells. [34020140]
  • Pinpointing a potential role for CLEC12B in cancer predisposition through familial exome sequencing. [30350915]
  • Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis. [24091439]
  • Identification of CLEC12B, an inhibitory receptor on myeloid cells. [17562706]
UniProt Main References (3 PubMed Identifiers)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • CLEC12B Decreases Melanoma Proliferation by Repressing Signal Transducer and Activator of Transcription 3. [34310951]
All isoforms of this gene containing a lectin domain
NP_001306170.1, XP_016874784.1, XP_011518960.1, NP_001123470.1, NP_001306171.1, NP_995324.2, NP_001374067.1
RNA
RNA (Transcript ID: NM_001129998.3)
NM_001129998.3
C-type lectin domain family 12 member B, transcript variant 1
All isoforms of CLEC12B containing a lectin domain
ENST00000338896.11
134..964 (or 10010760.. 10018481)
10010627.. 10018796
NCBI Matured mRNA sequence 1279 NTPDownload 
m7G-5')ppp(5'-GGGGCAGUAGAGUGUGUCUGGGUCAGCUGAGUGACUACAUCAAAGCUCCCAGCCUUGAAAAACACAUGCUGUUCCCAGGCCUCAAGAUAUUGAAACAUUAAUUAGAUAAUUUAAAGUAGCGUUUUCUUCUACAAUGUCUGAAGAAGUGACCUACGCGACACUCACAUUUCAGGAUUCUGCUGGAGCAAGGAAUAACCGAGAUGGAAAUAACCUAAGAAAAAGAGGGCAUCCAGCUCCAUCUCCCAUUUGGCGUCAUGCUGCUCUGGGUCUGGUAACUCUUUGCCUGAUGUUGCUGAUUGGGCUGGUGACAUUGGGGAUGAUGUUUUUGCAGAUAUCUAAUGACAUUAACUCAGAUUCAGAGAAAUUGAGUCAACUUCAGAAAACCAUCCAACAGCAGCAGGAUAACUUAUCCCAGCAACUGGGCAACUCCAACAACUUGUCCAUGGAGGAGGAAUUUCUCAAGUCACAGAUCUCCAGUGUACUGAAGAGGCAGGAACAAAUGGCCAUCAAACUGUGCCAAGAGCUAAUCAUUCAUACUUCAGACCACAGAUGUAAUCCAUGUCCUAAGAUGUGGCAAUGGUACCAAAAUAGUUGCUACUAUUUUACAACAAAUGAGGAGAAAACCUGGGCUAACAGUAGAAAGGACUGCAUAGACAAGAACUCCACCCUAGUGAAGAUAGACAGUUUGGAAGAAAAGGAUUUUCUUAUGUCACAGCCAUUACUCAUGUUUUCGUUCUUUUGGCUGGGAUUAUCAUGGGACUCCUCUGGCAGAAGUUGGUUCUGGGAAGAUGGCUCUGUUCCCUCUCCAUCCUUAUUUAGUACUAAAGAACUUGACCAGAUCAAUGGAUCCAAAGGAUGUGCUUAUUUUCAAAAAGGAAAUAUUUAUAUUUCUCGCUGUAGUGCUGAAAUUUUUUGGAUUUGCGAGAAGACAGCUGCCCCAGUGAAGACUGAGGAUUUGGAUUAGUAUGCUUCUUCCAAAUUCUCCAAGAAGUAAGAGACUUGUGAGUAAGCUCAUAUGAGGAAAGAGGAAACUACGGUACCAGAGCCAAACCAGCUUUUAAAAUGACUGUGUAUUUACAUUAUCAGACAAAUGAACUUGUUUAACAGAACAUUCUCCAGUUCCUUGUCUGACGUCUUCUGAUUUGAUGUUAUUAUUCGGUCUUAAAAUUAUACCUGGGGACAAAGGGGAAUAGCCAUACUAUGGCCCUAUGAUUGUCUCAGAAUCAUUUCACUGAAUUUCUUUGCUUUCUCAAAUAAAGACUCCUUUCUUUCAUUAUUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 387837)
CLEC12B
C-type lectin domain family 12 member B
NC_000012.12
12  10010760.. 10018481
10010760.. 10018481
strand +
CCDS44830.1
MGI:1918433
ClinVar, dbVar
ENSG00000256660
uc001qwz.3
INSDC: AK128243
31966
617573
OTTHUMG00000168397
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (831 bp)
5'-ATGTCTGAAGAAGTGACCTACGCGACACTCACATTTCAGGATTCTGCTGGAGCAAGGAATAACCGAGATGGAAATAACCTAAGAAAAAGAGGGCATCCAGCTCCATCTCCCATTTGGCGTCATGCTGCTCTGGGTCTGGTAACTCTTTGCCTGATGTTGCTGATTGGGCTGGTGACATTGGGGATGATGTTTTTGCAGATATCTAATGACATTAACTCAGATTCAGAGAAATTGAGTCAACTTCAGAAAACCATCCAACAGCAGCAGGATAACTTATCCCAGCAACTGGGCAACTCCAACAACTTGTCCATGGAGGAGGAATTTCTCAAGTCACAGATCTCCAGTGTACTGAAGAGGCAGGAACAAATGGCCATCAAACTGTGCCAAGAGCTAATCATTCATACTTCAGACCACAGATGTAATCCATGTCCTAAGATGTGGCAATGGTACCAAAATAGTTGCTACTATTTTACAACAAATGAGGAGAAAACCTGGGCTAACAGTAGAAAGGACTGCATAGACAAGAACTCCACCCTAGTGAAGATAGACAGTTTGGAAGAAAAGGATTTTCTTATGTCACAGCCATTACTCATGTTTTCGTTCTTTTGGCTGGGATTATCATGGGACTCCTCTGGCAGAAGTTGGTTCTGGGAAGATGGCTCTGTTCCCTCTCCATCCTTATTTAGTACTAAAGAACTTGACCAGATCAATGGATCCAAAGGATGTGCTTATTTTCAAAAAGGAAATATTTATATTTCTCGCTGTAGTGCTGAAATTTTTTGGATTTGCGAGAAGACAGCTGCCCCAGTGAAGACTGAGGATTTGGATTAG-3'
NCBI CDS gene sequence with introns (location: 10010760.. 10018481) (7722 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 10010627.. 10018796) (8170 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [10010627 - 1000].. 10018796) (9170 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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