NCBI Summary
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Protein
Protein (NP_004224)
CD83
CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein HB15) (CD antigen CD83)
CD83
CD83 molecule
CD83
Curated
I-type lectin
I-Type Lectins
b-sandwich / Ig-like
NeuAc
NP_004224
9308
Q01151
ENSP00000368450.3
Q01151
Undefined
10.4049/jimmunol.166.6.3865
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (205 amino acids) Download
MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVPYTVSWVKLLEGGEERMETPQEDHLRGQHYHQKGQNGSFDAPNERPYSLKIRNTTSCNSGTYRCTLQDPDGQRNLSGKVILRVTGCPAQRKEETFKKYRAEIVLLLALVIFYLTLIIFTCKFARLQSIFPDFSKAGMERAFLPVTSPNKHLGLVTPHKTELV
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q01151-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CD83 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses. [33455090]
  • Difference in Presence and Number of CD83+ Dendritic Cells in Patients with Ulcerative Colitis and Crohn's Disease. [32572123]
  • Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses. [32529460]
  • A reference map of the human binary protein interactome. [32296183]
  • Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells. [31293592]
  • Fine mapping of 39 ESTs on human chromosome 6p23-p25. [9417921]
  • CD84 leukocyte antigen is a new member of the Ig superfamily. [9310491]
  • Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. [7706722]
  • Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes. [8422464]
  • A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. [1378080]
UniProt Main References (5 PubMed Identifiers)
  • The DNA sequence and analysis of human chromosome 6. [14574404]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
  • A quantitative atlas of mitotic phosphorylation. [18669648]
  • Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. [19349973]
RNA
RNA (Transcript ID: NM_004233.4)
NM_004233.4
CD83 molecule, transcript variant 1
All isoforms of CD83 containing a lectin domain
ENST00000379153.4
41..658 (or 14117812.. 14135236)
14117772.. 14136906
NCBI Matured mRNA sequence 2328 NTPDownload 
m7G-5')ppp(5'-ACAGCUCUGCAGCUCGUGGCAGCGGCGCAGCGCUCCAGCCAUGUCGCGCGGCCUCCAGCUUCUGCUCCUGAGCUGCGCCUACAGCCUGGCUCCCGCGACGCCGGAGGUGAAGGUGGCUUGCUCCGAAGAUGUGGACUUGCCCUGCACCGCCCCCUGGGAUCCGCAGGUUCCCUACACGGUCUCCUGGGUCAAGUUAUUGGAGGGUGGUGAAGAGAGGAUGGAGACACCCCAGGAAGACCACCUCAGGGGACAGCACUAUCAUCAGAAGGGGCAAAAUGGUUCUUUCGACGCCCCCAAUGAAAGGCCCUAUUCCCUGAAGAUCCGAAACACUACCAGCUGCAACUCGGGGACAUACAGGUGCACUCUGCAGGACCCGGAUGGGCAGAGAAACCUAAGUGGCAAGGUGAUCUUGAGAGUGACAGGAUGCCCUGCACAGCGUAAAGAAGAGACUUUUAAGAAAUACAGAGCGGAGAUUGUCCUGCUGCUGGCUCUGGUUAUUUUCUACUUAACACUCAUCAUUUUCACUUGUAAGUUUGCACGGCUACAGAGUAUCUUCCCAGAUUUUUCUAAAGCUGGCAUGGAACGAGCUUUUCUCCCAGUUACCUCCCCAAAUAAGCAUUUAGGGCUAGUGACUCCUCACAAGACAGAACUGGUAUGAGCAGGAUUUCUGCAGGUUCUUCUUCCUGAAGCUGAGGCUCAGGGGUGUGCCUGUCUGUUACACUGGAGGAGAGAAGAAUGAGCCUACGCUGAAGAUGGCAUCCUGUGAAGUCCUUCACCUCACUGAAAACAUCUGGAAGGGGAUCCCACCCCAUUUUCUGUGGGCAGGCCUCGAAAACCAUCACAUGACCACAUAGCAUGAGGCCACUGCUGCUUCUCCAUGGCCACCUUUUCAGCGAUGUAUGCAGCUAUCUGGUCAACCUCCUGGACAUUUUUUCAGUCAUAUAAAAGCUAUGGUGAGAUGCAGCUGGAAAAGGGUCUUGGGAAAUAUGAAUGCCCCCAGCUGGCCCGUGACAGACUCCUGAGGACAGCUGUCCUCUUCUGCAUCUUGGGGACAUCUCUUUGAAUUUUCUGUGUUUUGCUGUACCAGCCCAGAUGUUUUACGUCUGGGAGAAAUUGACAGAUCAAGCUGUGAGACAGUGGGAAAUAUUUAGCAAAUAAUUUCCUGGUGUGAAGGUCCUGCUAUUACUAAGGAGUAAUCUGUGUACAAAGAAAUAACAAGUCGAUGAACUAUUCCCCAGCAGGGUCUUUUCAUCUGGGAAAGACAUCCAUAAAGAAGCAAUAAAGAAGAGUGCCACAUUUAUUUUUAUAUCUAUAUGUACUUGUCAAAGAAGGUUUGUGUUUUUCUGCUUUUGAAAUCUGUAUCUGUAGUGAGAUAGCAUUGUGAACUGACAGGCAGCCUGGACAUAGAGAGGGAGAAGAAGUCAGAGAGGGUGACAAGAUAGAGAGCUAUUUAAUGGCCGGCUGGAAAUGCUGGGCUGACGGUGCAGUCUGGGUGCUCGCCCACUUGUCCCACUAUCUGGGUGCAUGAUCUUGAGCAAGUUCCUUCUGGUGUCUGCUUUCUCCAUUGUAAACCACAAGGCUGUUGCAUGGGCUAAUGAAGAUCAUAUACGUGAAAAUUAUUUGAAAACAUAUAAAGCACUAUACAGAUUCGAAACUCCAUUGAGUCAUUAUCCUUGCUAUGAUGAUGGUGUUUUGGGGAUGAGAGGGUGCUAUCCAUUUCUCAUGUUUUCCAUUGUUUGAAACAAAGAAGGUUACCAAGAAGCCUUUCCUGUAGCCUUCUGUAGGAAUUCUUUUGGGGAAGUGAGGAAGCCAGGUCCACGGUCUGUUCUUGAAGCAGUAGCCUAACACACUCCAAGAUAUGGACACACGGGAGCCGCUGGCAGAAGGGACUUCACGAAGUGUUGCAUGGAUGUUUUAGCCAUUGUUGGCUUUCCCUUAUCAAACUUGGGCCCUUCCCUUCUUGGUUUCCAAAGGCAUUUUAUUGCUUGAGUUAUAUGUUCACUGUCCCCCUAAUAUUAGGGAGUAAAACGGAUACCAAGUUGAUUUAGUGUUUUUACCUCUGUCUUGGCUUUCAUGUUAUUAAACGUAUGCAUGUGAAGAAAGGGUGUUUUUCUGUUUUAUAUUCAACUCAUAAGACUUUGGGAUAGGAAAAAUGAGUAAUGGUUACUAGGCUUAAUACCUGGGUGAUUACAUAAUCUGUACAAUGAACCCCCAUGAUGUAAGUUUACCUAUGUAACAAACCUGCACUUAUACCCAUGAACUUAAAAUGAAAGUUAAAAAUAAAAAACAUAUACAAAUAAAAAAAUCCCGACUUUGGGAUGAGUGCUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 9308)
CD83
CD83 molecule
NC_000006.12
6  14117812.. 14135236
14117812.. 14135236
strand +
CCDS4532.1
MGI:1328316
ClinVar, dbVar
ENSG00000112149
HB15, BL11
uc003nbi.4
INSDC: Z11697
1703
604534
OTTHUMG00000014283
ENA, DDBJ, Monarch
CD83
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (618 bp)
5'-ATGTCGCGCGGCCTCCAGCTTCTGCTCCTGAGCTGCGCCTACAGCCTGGCTCCCGCGACGCCGGAGGTGAAGGTGGCTTGCTCCGAAGATGTGGACTTGCCCTGCACCGCCCCCTGGGATCCGCAGGTTCCCTACACGGTCTCCTGGGTCAAGTTATTGGAGGGTGGTGAAGAGAGGATGGAGACACCCCAGGAAGACCACCTCAGGGGACAGCACTATCATCAGAAGGGGCAAAATGGTTCTTTCGACGCCCCCAATGAAAGGCCCTATTCCCTGAAGATCCGAAACACTACCAGCTGCAACTCGGGGACATACAGGTGCACTCTGCAGGACCCGGATGGGCAGAGAAACCTAAGTGGCAAGGTGATCTTGAGAGTGACAGGATGCCCTGCACAGCGTAAAGAAGAGACTTTTAAGAAATACAGAGCGGAGATTGTCCTGCTGCTGGCTCTGGTTATTTTCTACTTAACACTCATCATTTTCACTTGTAAGTTTGCACGGCTACAGAGTATCTTCCCAGATTTTTCTAAAGCTGGCATGGAACGAGCTTTTCTCCCAGTTACCTCCCCAAATAAGCATTTAGGGCTAGTGACTCCTCACAAGACAGAACTGGTATGA-3'
NCBI CDS gene sequence with introns (location: 14117812.. 14135236) (17425 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 14117772.. 14136906) (19135 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [14117772 - 1000].. 14136906) (20135 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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