NCBI Summary
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Protein
Protein (NP_004224)
CD83
CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein HB15) (CD antigen CD83)
CD83
CD83 molecule
CD83
Curated
I-type lectin
I-Type Lectins
b-sandwich / Ig-like
NeuAc
NP_004224
9308
Q01151
ENSP00000368450.3
Q01151
Undefined
10.4049/jimmunol.166.6.3865
PFAM, InterPro
Protein sequence and protein families (fasta) (205 amino acids) Download
MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVPYTVSWVKLLEGGEERMETPQEDHLRGQHYHQKGQNGSFDAPNERPYSLKIRNTTSCNSGTYRCTLQDPDGQRNLSGKVILRVTGCPAQRKEETFKKYRAEIVLLLALVIFYLTLIIFTCKFARLQSIFPDFSKAGMERAFLPVTSPNKHLGLVTPHKTELV
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q01151-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Monomer. Homodimer (PubMed:28315353). Homotrimer (PubMed:28315353). Interacts with MARCHF1; this interaction antagonizes MARCHF1-mediated MHC II and CD86 down-regulation (PubMed:21220452)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses. [33455090]
  • Difference in Presence and Number of CD83+ Dendritic Cells in Patients with Ulcerative Colitis and Crohn's Disease. [32572123]
  • Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses. [32529460]
  • A reference map of the human binary protein interactome. [32296183]
  • Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells. [31293592]
  • Fine mapping of 39 ESTs on human chromosome 6p23-p25. [9417921]
  • CD84 leukocyte antigen is a new member of the Ig superfamily. [9310491]
  • Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. [7706722]
  • Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes. [8422464]
  • A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. [1378080]
UniProt Main References (5 PubMed Identifiers)
  • The DNA sequence and analysis of human chromosome 6. [14574404]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
  • A quantitative atlas of mitotic phosphorylation. [18669648]
  • Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. [19349973]
RNA
RNA (Transcript ID: NM_004233.4)
NM_004233.4
CD83 molecule, transcript variant 1
All isoforms of CD83 containing a lectin domain
ENST00000379153.4
41..658 (or 14117812.. 14135236)
14117772.. 14136906
NCBI Matured mRNA sequence 2328 NTPDownload 
m7G-5')ppp(5'-ACAGCUCUGCAGCUCGUGGCAGCGGCGCAGCGCUCCAGCCAUGUCGCGCGGCCUCCAGCUUCUGCUCCUGAGCUGCGCCUACAGCCUGGCUCCCGCGACGCCGGAGGUGAAGGUGGCUUGCUCCGAAGAUGUGGACUUGCCCUGCACCGCCCCCUGGGAUCCGCAGGUUCCCUACACGGUCUCCUGGGUCAAGUUAUUGGAGGGUGGUGAAGAGAGGAUGGAGACACCCCAGGAAGACCACCUCAGGGGACAGCACUAUCAUCAGAAGGGGCAAAAUGGUUCUUUCGACGCCCCCAAUGAAAGGCCCUAUUCCCUGAAGAUCCGAAACACUACCAGCUGCAACUCGGGGACAUACAGGUGCACUCUGCAGGACCCGGAUGGGCAGAGAAACCUAAGUGGCAAGGUGAUCUUGAGAGUGACAGGAUGCCCUGCACAGCGUAAAGAAGAGACUUUUAAGAAAUACAGAGCGGAGAUUGUCCUGCUGCUGGCUCUGGUUAUUUUCUACUUAACACUCAUCAUUUUCACUUGUAAGUUUGCACGGCUACAGAGUAUCUUCCCAGAUUUUUCUAAAGCUGGCAUGGAACGAGCUUUUCUCCCAGUUACCUCCCCAAAUAAGCAUUUAGGGCUAGUGACUCCUCACAAGACAGAACUGGUAUGAGCAGGAUUUCUGCAGGUUCUUCUUCCUGAAGCUGAGGCUCAGGGGUGUGCCUGUCUGUUACACUGGAGGAGAGAAGAAUGAGCCUACGCUGAAGAUGGCAUCCUGUGAAGUCCUUCACCUCACUGAAAACAUCUGGAAGGGGAUCCCACCCCAUUUUCUGUGGGCAGGCCUCGAAAACCAUCACAUGACCACAUAGCAUGAGGCCACUGCUGCUUCUCCAUGGCCACCUUUUCAGCGAUGUAUGCAGCUAUCUGGUCAACCUCCUGGACAUUUUUUCAGUCAUAUAAAAGCUAUGGUGAGAUGCAGCUGGAAAAGGGUCUUGGGAAAUAUGAAUGCCCCCAGCUGGCCCGUGACAGACUCCUGAGGACAGCUGUCCUCUUCUGCAUCUUGGGGACAUCUCUUUGAAUUUUCUGUGUUUUGCUGUACCAGCCCAGAUGUUUUACGUCUGGGAGAAAUUGACAGAUCAAGCUGUGAGACAGUGGGAAAUAUUUAGCAAAUAAUUUCCUGGUGUGAAGGUCCUGCUAUUACUAAGGAGUAAUCUGUGUACAAAGAAAUAACAAGUCGAUGAACUAUUCCCCAGCAGGGUCUUUUCAUCUGGGAAAGACAUCCAUAAAGAAGCAAUAAAGAAGAGUGCCACAUUUAUUUUUAUAUCUAUAUGUACUUGUCAAAGAAGGUUUGUGUUUUUCUGCUUUUGAAAUCUGUAUCUGUAGUGAGAUAGCAUUGUGAACUGACAGGCAGCCUGGACAUAGAGAGGGAGAAGAAGUCAGAGAGGGUGACAAGAUAGAGAGCUAUUUAAUGGCCGGCUGGAAAUGCUGGGCUGACGGUGCAGUCUGGGUGCUCGCCCACUUGUCCCACUAUCUGGGUGCAUGAUCUUGAGCAAGUUCCUUCUGGUGUCUGCUUUCUCCAUUGUAAACCACAAGGCUGUUGCAUGGGCUAAUGAAGAUCAUAUACGUGAAAAUUAUUUGAAAACAUAUAAAGCACUAUACAGAUUCGAAACUCCAUUGAGUCAUUAUCCUUGCUAUGAUGAUGGUGUUUUGGGGAUGAGAGGGUGCUAUCCAUUUCUCAUGUUUUCCAUUGUUUGAAACAAAGAAGGUUACCAAGAAGCCUUUCCUGUAGCCUUCUGUAGGAAUUCUUUUGGGGAAGUGAGGAAGCCAGGUCCACGGUCUGUUCUUGAAGCAGUAGCCUAACACACUCCAAGAUAUGGACACACGGGAGCCGCUGGCAGAAGGGACUUCACGAAGUGUUGCAUGGAUGUUUUAGCCAUUGUUGGCUUUCCCUUAUCAAACUUGGGCCCUUCCCUUCUUGGUUUCCAAAGGCAUUUUAUUGCUUGAGUUAUAUGUUCACUGUCCCCCUAAUAUUAGGGAGUAAAACGGAUACCAAGUUGAUUUAGUGUUUUUACCUCUGUCUUGGCUUUCAUGUUAUUAAACGUAUGCAUGUGAAGAAAGGGUGUUUUUCUGUUUUAUAUUCAACUCAUAAGACUUUGGGAUAGGAAAAAUGAGUAAUGGUUACUAGGCUUAAUACCUGGGUGAUUACAUAAUCUGUACAAUGAACCCCCAUGAUGUAAGUUUACCUAUGUAACAAACCUGCACUUAUACCCAUGAACUUAAAAUGAAAGUUAAAAAUAAAAAACAUAUACAAAUAAAAAAAUCCCGACUUUGGGAUGAGUGCUA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 9308)
CD83
CD83 molecule
NC_000006.12
6  14117812.. 14135236
14117812.. 14135236
strand +
CCDS4532.1
MGI:1328316
ClinVar, dbVar
ENSG00000112149
HB15, BL11
uc003nbi.4
INSDC: Z11697
1703
604534
OTTHUMG00000014283
ENA, DDBJ, Monarch
CD83
Gene-related data
NCBI CDS gene sequence (618 bp)
5'-ATGTCGCGCGGCCTCCAGCTTCTGCTCCTGAGCTGCGCCTACAGCCTGGCTCCCGCGACGCCGGAGGTGAAGGTGGCTTGCTCCGAAGATGTGGACTTGCCCTGCACCGCCCCCTGGGATCCGCAGGTTCCCTACACGGTCTCCTGGGTCAAGTTATTGGAGGGTGGTGAAGAGAGGATGGAGACACCCCAGGAAGACCACCTCAGGGGACAGCACTATCATCAGAAGGGGCAAAATGGTTCTTTCGACGCCCCCAATGAAAGGCCCTATTCCCTGAAGATCCGAAACACTACCAGCTGCAACTCGGGGACATACAGGTGCACTCTGCAGGACCCGGATGGGCAGAGAAACCTAAGTGGCAAGGTGATCTTGAGAGTGACAGGATGCCCTGCACAGCGTAAAGAAGAGACTTTTAAGAAATACAGAGCGGAGATTGTCCTGCTGCTGGCTCTGGTTATTTTCTACTTAACACTCATCATTTTCACTTGTAAGTTTGCACGGCTACAGAGTATCTTCCCAGATTTTTCTAAAGCTGGCATGGAACGAGCTTTTCTCCCAGTTACCTCCCCAAATAAGCATTTAGGGCTAGTGACTCCTCACAAGACAGAACTGGTATGA-3'
NCBI CDS gene sequence with introns (location: 14117812.. 14135236) (17425 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 14117772.. 14136906) (19135 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [14117772 - 1000].. 14136906) (20135 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
Cite How to cite