NCBI Summary
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016].
Protein
Protein (NP_001315538)
CD2
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
CD2
CD2 molecule
CD2
Low evidence
I-type lectin
I-Type Lectins
b-sandwich / Ig-like
Sulfated
NP_001315538
914
P06729
Undefined
P06729
Undefined
10.4049/jimmunol.141.10.3498
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (377 amino acids) Download
MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPGGSILGQSNGLSAWTPPSHPTSLPFAEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P06729-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CD2 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases. [34552089]
  • Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells. [32398348]
  • Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin. [31324882]
  • MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer. [28409241]
  • A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis. [27385538]
  • The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. [1385321]
  • Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. [1377404]
  • The lymphocyte-specific tyrosine protein kinase p56lck is endocytosed in Jurkat cells stimulated via CD2. [1351089]
  • The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. [1346273]
  • Association of CD2 and CD45 on human T lymphocytes. [1970422]
UniProt Main References (15 PubMed Identifiers)
  • Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. [2894031]
  • Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. [2437578]
  • Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen. [3490670]
  • Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes. [2883656]
  • The structure of the human CD2 gene and its expression in transgenic mice. [2901953]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2). [2444890]
  • A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. [9857189]
  • Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. [23006327]
    • Show more
RNA
RNA (Transcript ID: NM_001328609.2)
NM_001328609.2
CD2 molecule, transcript variant 1
All isoforms of CD2 containing a lectin domain
64..1197 (or 116754493.. 116768783)
116754430.. 116769229
NCBI Matured mRNA sequence 1643 NTPDownload 
m7G-5')ppp(5'-AGUCUCACUUCAGUUCCUUUUGCAUGAAGAGCUCAGAAUCAAAAGAGGAAACCAACCCCUAAGAUGAGCUUUCCAUGUAAAUUUGUAGCCAGCUUCCUUCUGAUUUUCAAUGUUUCUUCCAAAGGUGCAGUCUCCAAAGAGAUUACGAAUGCCUUGGAAACCUGGGGUGCCUUGGGUCAGGACAUCAACUUGGACAUUCCUAGUUUUCAAAUGAGUGAUGAUAUUGACGAUAUAAAAUGGGAAAAAACUUCAGACAAGAAAAAGAUUGCACAAUUCAGAAAAGAGAAAGAGACUUUCAAGGAAAAAGAUACAUAUAAGCUAUUUAAAAAUGGAACUCUGAAAAUUAAGCAUCUGAAGACCGAUGAUCAGGAUAUCUACAAGGUAUCAAUAUAUGAUACAAAAGGAAAAAAUGUGUUGGAAAAAAUAUUUGAUUUGAAGAUUCAAGAGAGGGUCUCAAAACCAAAGAUCUCCUGGACUUGUAUCAACACAACCCUGACCUGUGAGGUAAUGAAUGGAACUGACCCCGAAUUAAACCUGUAUCAAGAUGGGAAACAUCUAAAACUUUCUCAGAGGGUCAUCACACACAAGUGGACCACCAGCCUGAGUGCAAAAUUCAAGUGCACAGCAGGGAACAAAGUCAGCAAGGAAUCCAGUGUCGAGCCUGUCAGCUGUCCAGGAGGCAGCAUCCUUGGCCAGAGUAAUGGGCUCUCUGCCUGGACCCCUCCCAGCCAUCCCACUUCUCUUCCUUUUGCAGAGAAAGGUCUGGACAUCUAUCUCAUCAUUGGCAUAUGUGGAGGAGGCAGCCUCUUGAUGGUCUUUGUGGCACUGCUCGUUUUCUAUAUCACCAAAAGGAAAAAACAGAGGAGUCGGAGAAAUGAUGAGGAGCUGGAGACAAGAGCCCACAGAGUAGCUACUGAAGAAAGGGGCCGGAAGCCCCACCAAAUUCCAGCUUCAACCCCUCAGAAUCCAGCAACUUCCCAACAUCCUCCUCCACCACCUGGUCAUCGUUCCCAGGCACCUAGUCAUCGUCCCCCGCCUCCUGGACACCGUGUUCAGCACCAGCCUCAGAAGAGGCCUCCUGCUCCGUCGGGCACACAAGUUCACCAGCAGAAAGGCCCGCCCCUCCCCAGACCUCGAGUUCAGCCAAAACCUCCCCAUGGGGCAGCAGAAAACUCAUUGUCCCCUUCCUCUAAUUAAAAAAGAUAGAAACUGUCUUUUUCAAUAAAAAGCACUGUGGAUUUCUGCCCUCCUGAUGUGCAUAUCCGUACUUCCAUGAGGUGUUUUCUGUGUGCAGAACAUUGUCACCUCCUGAGGCUGUGGGCCACAGCCACCUCUGCAUCUUCGAACUCAGCCAUGUGGUCAACAUCUGGAGUUUUUGGUCUCCUCAGAGAGCUCCAUCACACCAGUAAGGAGAAGCAAUAUAAGUGUGAUUGCAAGAAUGGUAGAGGACCGAGCACAGAAAUCUUAGAGAUUUCUUGUCCCCUCUCAGGUCAUGUGUAGAUGCGAUAAAUCAAGUGAUUGGUGUGCCUGGGUCUCACUACAAGCAGCCUAUCUGCUUAAGAGACUCUGGAGUUUCUUAUGUGCCCUGGUGGACACUUGCCCACCAUCCUGUGAGUAAAAGUGAAAUAAAAGCUUUGACUAGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 914)
CD2
CD2 molecule
NC_000001.11
1  116754493.. 116768783
116754493.. 116768783
strand +
MGI:88320
ClinVar, dbVar
ENSG00000116824
uc001egu.5
INSDC: BC033583
1639
186990
OTTHUMG00000022750
ENA, DDBJ, Monarch
CD2
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1134 bp)
5'-ATGAGCTTTCCATGTAAATTTGTAGCCAGCTTCCTTCTGATTTTCAATGTTTCTTCCAAAGGTGCAGTCTCCAAAGAGATTACGAATGCCTTGGAAACCTGGGGTGCCTTGGGTCAGGACATCAACTTGGACATTCCTAGTTTTCAAATGAGTGATGATATTGACGATATAAAATGGGAAAAAACTTCAGACAAGAAAAAGATTGCACAATTCAGAAAAGAGAAAGAGACTTTCAAGGAAAAAGATACATATAAGCTATTTAAAAATGGAACTCTGAAAATTAAGCATCTGAAGACCGATGATCAGGATATCTACAAGGTATCAATATATGATACAAAAGGAAAAAATGTGTTGGAAAAAATATTTGATTTGAAGATTCAAGAGAGGGTCTCAAAACCAAAGATCTCCTGGACTTGTATCAACACAACCCTGACCTGTGAGGTAATGAATGGAACTGACCCCGAATTAAACCTGTATCAAGATGGGAAACATCTAAAACTTTCTCAGAGGGTCATCACACACAAGTGGACCACCAGCCTGAGTGCAAAATTCAAGTGCACAGCAGGGAACAAAGTCAGCAAGGAATCCAGTGTCGAGCCTGTCAGCTGTCCAGGAGGCAGCATCCTTGGCCAGAGTAATGGGCTCTCTGCCTGGACCCCTCCCAGCCATCCCACTTCTCTTCCTTTTGCAGAGAAAGGTCTGGACATCTATCTCATCATTGGCATATGTGGAGGAGGCAGCCTCTTGATGGTCTTTGTGGCACTGCTCGTTTTCTATATCACCAAAAGGAAAAAACAGAGGAGTCGGAGAAATGATGAGGAGCTGGAGACAAGAGCCCACAGAGTAGCTACTGAAGAAAGGGGCCGGAAGCCCCACCAAATTCCAGCTTCAACCCCTCAGAATCCAGCAACTTCCCAACATCCTCCTCCACCACCTGGTCATCGTTCCCAGGCACCTAGTCATCGTCCCCCGCCTCCTGGACACCGTGTTCAGCACCAGCCTCAGAAGAGGCCTCCTGCTCCGTCGGGCACACAAGTTCACCAGCAGAAAGGCCCGCCCCTCCCCAGACCTCGAGTTCAGCCAAAACCTCCCCATGGGGCAGCAGAAAACTCATTGTCCCCTTCCTCTAATTAA-3'
NCBI CDS gene sequence with introns (location: 116754493.. 116768783) (14291 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 116754430.. 116769229) (14800 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [116754430 - 1000].. 116769229) (15800 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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