NCBI Summary
This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. There are no human mRNAs or ESTs supporting the full-length exon combination of this RefSeq; it is predicted based on partial human and homologous transcript alignments from zebrafish and chicken, and on human RNA-Seq alignments from the ENCODE project.
Protein
Protein (NP_001243649)
C-type lectin domain family 19 member A
C-type lectin domain family 19 member A
CLEC19A
C-type lectin domain containing 19A
Undefined
Very low evidence
C-type lectin
Undefined
Undefined
a/b mixed / C-type lectin-like
Uncharacterised
NP_001243649
728276
Q6UXS0
ENSP00000490375.1
G1R003
0.346
Undefined
neXtProt, PFAM, InterPro
Information and mainly modelling of this lectin is based on the longer isoform currently unreviewed in UniProt A0A1B0GV53 but reviewed in RefSeq NP_001243649. The extension of the C-terminal region produces a more consistent carbohydrate-binding domain.
Protein sequence and protein families (fasta) (186 amino acids) Download
MQRWTLWAAAFLTLHSAQAFPQTDISISPALPELPLPSLCPLFWMEFKGHCYRFFPLNKTWAEADLYCSEFSVGRKSAKLASIHSWEENVFVYDLVNSCVPGIPADVWTGLHDHRQEGQFEWTDGSSYDYSYWDGSQPDDGVHADPEEEDCVQIWYRPTSALRSWNDNTCSRKFPFVCKIPSLTIH
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q6UXS0-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.48, 1.88] ÅDownload
The location of the lectin domain structural model is: 38-183
We infer [1.48, 1.88] Å as the interval of error of this structural model.
Template 1: 3L9J chain: C, P05452, NP_003269.2, sequence identity: 21.9%, coverage: 91.1%, location in sequence: 67-201, (46-180 in PDB).
Template 2: 6PY1 chain: A, Q8IUN9, NP_878910.1, sequence identity: 33.6%, coverage: 87.0%, location in sequence: 179-308, (179-308 in PDB).
Template 3: 6YAU chain: A, P07306, NP_001662.1, sequence identity: 33.6%, coverage: 86.3%, location in sequence: 153-281, (152-280 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC19A Gene
References
NCBI References (2 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
UniProt Main References (1 PubMed Identifiers)
  • The sequence and analysis of duplication-rich human chromosome 16. [15616553]
RNA
RNA (Transcript ID: NM_001256720.2)
NM_001256720.2
C-type lectin domain containing 19A
All isoforms of CLEC19A containing a lectin domain
ENST00000636231.2
122..682 (or 19285852.. 19309083)
19285731.. 19310947
NCBI Matured mRNA sequence 2546 NTPDownload 
m7G-5')ppp(5'-AGUCUGUCCCAGCUCCUGCCAGGCUCCAUCUGACCCUAGGAGAGCAAUCCUGGACCCAAGCUCCAGCCAAAAAGCCUCUCUCCUCCACUCAGGCUGGGAGGUUGCUUUCUAGGAGCUCAGGAUGCAAAGGUGGACACUGUGGGCUGCAGCCUUCCUGACCCUCCACUCUGCACAGGCCUUUCCACAAACAGACAUCAGUAUCAGUCCAGCCCUGCCAGAGCUGCCCCUGCCUUCCCUGUGCCCCCUGUUCUGGAUGGAGUUCAAAGGCCACUGCUAUCGAUUCUUCCCUCUCAAUAAGACCUGGGCUGAGGCCGACCUCUACUGUUCUGAGUUCUCUGUGGGCAGGAAGUCCGCCAAGCUGGCCUCCAUCCACAGCUGGGAGGAGAAUGUCUUUGUAUAUGACCUCGUGAACAGCUGUGUUCCCGGCAUCCCAGCUGACGUCUGGACAGGCCUUCAUGAUCACAGACAGGAAGGGCAGUUUGAAUGGACUGAUGGCUCAUCCUAUGACUACAGCUACUGGGAUGGCAGCCAGCCAGAUGAUGGCGUCCACGCGGACCCAGAAGAAGAGGACUGCGUGCAGAUAUGGUACAGGCCUACCAGUGCUCUGAGGUCAUGGAAUGAUAACACCUGCAGCCGGAAGUUCCCCUUUGUCUGCAAAAUCCCAUCUCUGACCAUUCAUUGAUCCUGUCUUGUCCUACUGGUGUGAGCUCAACUCUAGUAUCAUCUUGUAGCUGUAACCAGUGUAGAAUUGACAUUGAAUACAUGUAAAACAUACAUAGGAAGUAAAUCUCUUGGACAGAGAUUUUAAACAAGCAGAUCUUAAUUAUACAGGGUGGUCACUUGGCCAAGUGUCAGGAAAGCCAGCUCAAAUUGGCUUAAUUUUUUAAAGUGUUUUUUUUUUUAAAUUGACCCAAGUAACAAAAAUCCAGGGGUUGUUCUGAUUCAGAGUUGAAUCUCACUGGCCUGGCUCGGGUCACGUGCCCAUCCCUGAAGCAAUCACUUUGGCAUAUGCUAAGUGGCUAGCUCCUGCUUAGCUGUACAUCUUUGGACAAAAUGGGGUGGAAGUCACAUUAUCAGAGGCGCUGGGAGUGGGGGAAAAUGCGGGGGGGUGUUGGUCAAAGCAUACAAACUUUUGGAAAUAAGAUUAAUAAGUUUGGGAGGCUUAAUGUACAGCGUGAUGACUAUAGUUAAUAAUAAUGUAUUGUAUUCCUGAAAUUUGCUACGAGAGUAAUUUUUUUUUUUGAGACAGAGUCUCACUCUGUUGCCCAGGCUGAAGUGCAAUGAUGCAAUCACAGCUCACUGCAGCCUCAACCUCCUGGGCUCAGGUGAUCCUUCCACCUCCAGUCCCCAGAGUAGGUGGGACUACAGGACGCUACAGGCGCAUGCCACCACAUCUAGCUAACUUUUGUAUUUUUUUUUUUAAAUAGAGACGAGGUUUCAUCAUGUCAUCCAAGCUGGUUUCGAACUCCUGGGCUCAAGGGAUCCACCCACCUCAGCCUCCCAAAGUACUGGGAUUACAGGCAUGAGCCACUGCGCCUAGCCAAGAAUACAUCUUAAAUAUUCCCGUCAACACAUGGGCUCAAAGAUGAGGCUGGUUCUUCAAAGGAAAACAAAAAGAUUACCAAACUCAUAAAUUGCUGGUGGGAAUGUAAAAUAGUGAAGCCACUGUGGAAAAGUUUGGCAGUUCCUCAAAAAGUUAAACAUAGAAUUACAUCUAAGCCAGCAAUUCCACUCCUAGAUCUCGACCUAAGAGAAUCGGAAACAGGUAUUUAAAUAUAAGUGGUCGGCCAGGUGUAGUGGCUCAUGCCUGUAAUCCCAGCACUUUGGGAAGCUGAGGAGAGAGGAUCACUUGAGCCCAGGAGUUGAAGAUCAGCCUGGGCAACAUAGUAAGACCCCAUCUCCAUAAGAAAAAUUUUUUAAUUAGCCAAGCAUGGUGAUGCACAUCUGUAGUCCCAGCUGUUUGGGAGGCUGAGAUGGGAGGAUCACUUGAGCCCAGGAUAUCAAGGCUGCAAUGGACCAUGAUUGUGCUUCUGCACUCCAGCCUGGGUGACAGAGCAAGACCCUGUCUCAAAAAACAAAAACAAAAAAAUGUGAUCACAGCAGCAUUAUUGAUAAAAACCACAAAAAAAAUGAAGACAACCCAAGUGCUCACCAACAGAUGAAUGACUAAACAAAUGUGGUCUAUUCAUAGGGUGGAAUAUUAUUCAAGCAUAAAAAGGAAUGAAGUAACGAUAGAUACUACAACCUGAAUGAACCUGAAAAACAUUAUGCUUCCAGUCACAAAAGACCACAUGUUGUAUGAUUCCAUAUAUAUGAAAUAUCCAGAAUAGGCAAGUCUAUAGAGAUGGAAAGUGGAUUAGUGGUUGCCAGGGGAUGUGUGGAGGGGGAAUAGAAAGUGAGUGCUAAUAGGUAUGGGAUUACUUUGUGAGGUGACAAAAAUUAUCUGCAAUUAGAUAGUGGUAAUGGCUGCACAAUAUUGUAAAUGUACAAGAAGCCACUGAACUGUACAUUUUAAAAUAAUAGUUAAAAUGAUAAAUUUUACAUUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 728276)
CLEC19A
C-type lectin domain containing 19A
NC_000016.10
16  19285852.. 19309083
19285852.. 19309083
strand +
CCDS81953.1
ClinVar, dbVar
ENSG00000261210
uc002dga.6
INSDC:
34522
OTTHUMG00000177218
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (561 bp)
5'-ATGCAAAGGTGGACACTGTGGGCTGCAGCCTTCCTGACCCTCCACTCTGCACAGGCCTTTCCACAAACAGACATCAGTATCAGTCCAGCCCTGCCAGAGCTGCCCCTGCCTTCCCTGTGCCCCCTGTTCTGGATGGAGTTCAAAGGCCACTGCTATCGATTCTTCCCTCTCAATAAGACCTGGGCTGAGGCCGACCTCTACTGTTCTGAGTTCTCTGTGGGCAGGAAGTCCGCCAAGCTGGCCTCCATCCACAGCTGGGAGGAGAATGTCTTTGTATATGACCTCGTGAACAGCTGTGTTCCCGGCATCCCAGCTGACGTCTGGACAGGCCTTCATGATCACAGACAGGAAGGGCAGTTTGAATGGACTGATGGCTCATCCTATGACTACAGCTACTGGGATGGCAGCCAGCCAGATGATGGCGTCCACGCGGACCCAGAAGAAGAGGACTGCGTGCAGATATGGTACAGGCCTACCAGTGCTCTGAGGTCATGGAATGATAACACCTGCAGCCGGAAGTTCCCCTTTGTCTGCAAAATCCCATCTCTGACCATTCATTGA-3'
NCBI CDS gene sequence with introns (location: 19285852.. 19309083) (23232 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 19285731.. 19310947) (25217 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [19285731 - 1000].. 19310947) (26217 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
Cite How to cite