NCBI Summary
Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].
Protein
Protein (NP_849142)
F-box protein 27
F-box only protein 27 (F-box/G-domain protein 5)
FBXO27
F-box protein 27
Undefined
Low evidence
F-box associated domain
F-Box Lectins
b-sandwich / Galactose-binding domain-like
Glycoproteins
NP_849142
126433
Q8NI29
ENSP00000292853.3
Q8NI29
Undefined
10.1074/jbc.M709508200
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (283 amino acids) Download
MGASVSRGRAARVPAPEPEPEEALDLSQLPPELLLVVLSHVPPRTLLGRCRQVCRGWRALVDGQALWLLILARDHGATGRALLHLARSCQSPARNARPCPLGRFCARRPIGRNLIRNPCGQEGLRKWMVQHGGDGWVVEENRTTVPGAPSQTCFVTSFSWCCKKQVLDLEEEGLWPELLDSGRIEICVSDWWGARHDSGCMYRLLVQLLDANQTVLDKFSAVPDPIPQWNNNACLHVTHVFSNIKMGVRFVSFEHRGQDTQFWAGHYGARVTNSSVIVRVRLS
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q8NI29-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

SWISS-MODEL structural models
SWISS-MODEL structural model
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for FBXO27 Gene
ProteomicsDB
References
NCBI References (7 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy. [28743755]
  • Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. [19028597]
  • Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. [18203720]
  • Systematic analysis and nomenclature of mammalian F-box proteins. [15520277]
  • A new subfamily of structurally related human F-box proteins. [12383498]
  • [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. [126433]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_178820.5)
NM_178820.5
F-box protein 27
All isoforms of FBXO27 containing a lectin domain
ENST00000292853.9
74..925 (or 39025411.. 39032227)
39024021.. 39032549
NCBI Matured mRNA sequence 2315 NTPDownload 
m7G-5')ppp(5'-GCGGCACAGCUAGGGCAUCCCGGCGAGGAGCGCCGCCAGGCCCCGGGCCACAGCCGGGCCUGGCGGGGGGACCAUGGGCGCCUCGGUCUCCAGGGGCCGGGCCGCCCGGGUCCCCGCGCCGGAGCCGGAACCCGAAGAGGCGCUGGACCUGAGCCAACUACCCCCAGAGCUGCUUCUGGUGGUGCUGAGCCACGUCCCCCCGCGCACGCUGCUCGGGCGCUGCCGCCAAGUGUGCCGGGGCUGGCGAGCCCUGGUGGACGGCCAGGCCCUGUGGCUGCUGAUCCUGGCCCGCGACCACGGCGCCACCGGCCGCGCGCUGCUGCACCUCGCCCGCAGCUGCCAGUCUCCCGCCCGUAACGCCAGGCCUUGCCCCCUGGGCCGCUUCUGCGCGCGCAGACCCAUCGGACGCAACCUUAUUCGCAACCCCUGCGGCCAAGAAGGCCUCCGAAAGUGGAUGGUGCAACACGGUGGGGACGGCUGGGUGGUGGAGGAAAACAGGACAACCGUGCCUGGGGCCCCUUCUCAGACGUGCUUCGUGACUUCAUUCAGCUGGUGUUGCAAGAAGCAGGUCUUGGACCUAGAGGAGGAGGGUCUGUGGCCAGAACUGCUGGAUAGUGGCAGGAUUGAGAUUUGUGUCUCUGACUGGUGGGGAGCCCGACACGACAGCGGCUGUAUGUACAGACUCCUCGUCCAACUUCUAGACGCCAACCAGACUGUUCUAGAUAAAUUCUCUGCUGUGCCUGAUCCCAUCCCGCAGUGGAACAACAAUGCCUGCCUUCACGUCACCCACGUGUUCUCCAACAUCAAGAUGGGCGUCCGCUUUGUGUCUUUCGAACACCGGGGCCAGGACACACAGUUCUGGGCUGGCCACUAUGGAGCCCGUGUGACCAACUCCAGUGUGAUCGUGCGAGUCCGUCUGUCCUAGUCCAGCACUACCCUUCUUGCAAGACAGCCUGACUGUGCCUUCCAGGGCCUGGGACCAUUGGCUGGGACCCCUCAUUAACCAACCAAGCACUUGUACCUCCCUGGCAUACUGAGAAUUCCUGGGUCCAAUCAAAGGCCCUGACGGGCCCUGUCUUCAGGUUCUAGAAACUACCAGAAGAAGCUUCUUCCAUCUUAUCUACCUACUGCAGCUGCUGCUUUGCGGGGGGGCCCUACUGUACUGAGGGGAAACCCACAAGUGAGCAUGGGGGAAUGCCCAUCCUGGAGAAGAAUUCUUGCCCUCCCCUCUCUUCUCCUCCCAACCAAAACCCUCCGAUCCAGCCCCAGGCCCCUCUGUACCAUCCCCUCCCCUCCGCACCACUGACCUCUUGUCUCCUGUUGUUUCUGCCACAGGGACUUCCUUGGUCCCUUCAGGGAAGCCCUCAACUCAUCUCUGAACUUAGAAUCUCAUCCUUAGGGCUCAGAGAGUCCCAGCCCUAAGGGUGUGAACCUCACCUCCUGGGGCUUCCGAGCUACAGGGCUGGGACCAGGUCAUGCAGCUGAAAGUCUACGUUAAAAAAAAAAAGUUUGGGCCAGGCACAGUGGCUCAUGCCUGUAAUCCCAGCACUUUGGGAGGCUGAGGCAGGCGGAUCACCUGAGGUCAGGAGUUCAAGACCAGCCUGGCCAACAUGGUGAAACCCCGUCUCUACUAAAAAUCCAAAAAAUUAGCCGGGCUUGGUGGUGUGCACCUGUAAUUCCAGCUACUCGGGAGGCUGAGGCAGGAGAAUUGCUUGAGCCCGGGAGGCAGAGGCUGCAGUGAACCAAGAUCAUGCCACUGCACUCCAGCCUGGGCAACACAGCGAGACUCCGUCUCAAAAAGAAAAAGUUUGGAUCAGGCAGGGUGGCUCACACCUGUAAUCCCUGCACUUUGGGAGGCCAAGGUGGGAGGAUCAGUUGAGCCCCAGAGUUCAAGACCAGCCUGGGCAAUGUAGUAAGACCCCCAUCGCUACAAAAAAUACAAAAGUUAGCCAGGUACAGUAGUACACACCUGUAGUCCAAGCUACUUGGGAGGCUGAAGUGGGAGGAUCAUUUGUGCCCAGGUUGAGGCUAUAGUGAGCCAUGAUCAUACCACUGCACUCCAGCCUGGGUGACAGAGCGAGACCCUGUCUCAAAAAAAAAAAAGAAUUUGGAGAUGGUUCUGCCCACUCUGGUUUCUCUGAAAAAACGAGGUAAUUCCCUGAGCCCAACCCUGAUCCUCAAGGACCUGUAAUUGUGUGGUAUUUAAAAUUAAAAUAACAUUAUUUUUAUUUUGACUUUUUUUCAAACAGUAAGAAUAAUAUAUCAGCAGCAUGUAUCUGCCAAUCAUAUGUAAUAAAUUUCUUAUUUUGCCAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 126433)
FBXO27
F-box protein 27
NC_000019.10
19  39025411.. 39032227
39025411.. 39032227
strand -
CCDS12527.1
MGI:2685007
ClinVar, dbVar
ENSG00000161243
Fbg5, Fbx27
uc002okh.5
INSDC: AF436061
18753
609099
OTTHUMG00000182719
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (852 bp)
5'-ATGGGCGCCTCGGTCTCCAGGGGCCGGGCCGCCCGGGTCCCCGCGCCGGAGCCGGAACCCGAAGAGGCGCTGGACCTGAGCCAACTACCCCCAGAGCTGCTTCTGGTGGTGCTGAGCCACGTCCCCCCGCGCACGCTGCTCGGGCGCTGCCGCCAAGTGTGCCGGGGCTGGCGAGCCCTGGTGGACGGCCAGGCCCTGTGGCTGCTGATCCTGGCCCGCGACCACGGCGCCACCGGCCGCGCGCTGCTGCACCTCGCCCGCAGCTGCCAGTCTCCCGCCCGTAACGCCAGGCCTTGCCCCCTGGGCCGCTTCTGCGCGCGCAGACCCATCGGACGCAACCTTATTCGCAACCCCTGCGGCCAAGAAGGCCTCCGAAAGTGGATGGTGCAACACGGTGGGGACGGCTGGGTGGTGGAGGAAAACAGGACAACCGTGCCTGGGGCCCCTTCTCAGACGTGCTTCGTGACTTCATTCAGCTGGTGTTGCAAGAAGCAGGTCTTGGACCTAGAGGAGGAGGGTCTGTGGCCAGAACTGCTGGATAGTGGCAGGATTGAGATTTGTGTCTCTGACTGGTGGGGAGCCCGACACGACAGCGGCTGTATGTACAGACTCCTCGTCCAACTTCTAGACGCCAACCAGACTGTTCTAGATAAATTCTCTGCTGTGCCTGATCCCATCCCGCAGTGGAACAACAATGCCTGCCTTCACGTCACCCACGTGTTCTCCAACATCAAGATGGGCGTCCGCTTTGTGTCTTTCGAACACCGGGGCCAGGACACACAGTTCTGGGCTGGCCACTATGGAGCCCGTGTGACCAACTCCAGTGTGATCGTGCGAGTCCGTCTGTCCTAG-3'
NCBI CDS gene sequence with introns (location: 39025411.. 39032227) (6817 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 39024021.. 39032549) (8529 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [39024021.. 39032549 + 1000]) (9529 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905