NCBI Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_060908)
F-box protein 6
F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)
FBXO6
F-box protein 6
Undefined
Low evidence
F-box associated domain
F-Box Lectins
b-sandwich / Galactose-binding domain-like
High mannose glycans
NP_060908
26270
Q9NRD1
ENSP00000365944.4
Q9NRD1
Undefined
10.1074/jbc.M709508200
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (293 amino acids) Download
MDAPHSKAALDSINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLMTLWKRKCLREGFITKDWDQPVADWKIFYFLRSLHRNLLRNPCAEEDMFAWQIDFNGGDRWKVESLPGAHGTDFPDPKVKKYFVTSYEMCLKSQLVDLVAEGYWEELLDTFRPDIVVKDWFAARADCGCTYQLKVQLASADYFVLASFEPPPVTIQQWNNATWTEVSYTFSDYPRGVRYILFQHGGRDTQYWAGWYGPRVTNSSIVVSPKMTRNQASSEAQPGQKHGQEEAAQSPYRAVVQIF
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9NRD1-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

SWISS-MODEL structural models
SWISS-MODEL structural model
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for FBXO6 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer. [33767133]
  • A reference map of the human binary protein interactome. [32296183]
  • Noncanonical Role of FBXO6 in Regulating Antiviral Immunity. [31308089]
  • Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer. [31140586]
  • A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. [30833792]
  • Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. [12939278]
  • A new subfamily of structurally related human F-box proteins. [12383498]
  • cDNA cloning and expression analysis of new members of the mammalian F-box protein family. [10945468]
  • A family of mammalian F-box proteins. [10531037]
  • Identification of a family of human F-box proteins. [10531035]
UniProt Main References (7 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. [18203720]
  • The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. [19716789]
  • Initial characterization of the human central proteome. [21269460]
  • Toward a comprehensive characterization of a human cancer cell phosphoproteome. [23186163]
RNA
RNA (Transcript ID: NM_018438.6)
NM_018438.6
F-box protein 6
All isoforms of FBXO6 containing a lectin domain
ENST00000376753.9
60..941 (or 11668659.. 11673851)
11664200.. 11674354
NCBI Matured mRNA sequence 1444 NTPDownload 
m7G-5')ppp(5'-GAGACAGCUUCAGGACACGCAGGCCGCAGCGAGGGCCCGGGCCCUGGGGAUCCCAGGCCAUGGAUGCUCCCCACUCCAAAGCAGCCCUGGACAGCAUUAACGAGCUGCCCGAGAACAUCCUGCUGGAGCUGUUCACGCACGUGCCCGCCCGCCAGCUGCUGCUGAACUGCCGCCUGGUCUGCAGCCUCUGGCGGGACCUCAUCGACCUCAUGACCCUCUGGAAACGCAAGUGCCUGCGAGAGGGCUUCAUCACCAAGGACUGGGACCAGCCCGUGGCCGACUGGAAAAUCUUCUACUUCCUACGGAGCCUGCAUAGGAACCUCCUGCGCAACCCGUGUGCUGAAGAGGAUAUGUUUGCAUGGCAAAUUGAUUUCAAUGGUGGGGACCGCUGGAAGGUGGAGAGCCUCCCUGGAGCCCACGGGACAGAUUUUCCUGACCCCAAAGUCAAGAAGUAUUUUGUCACAUCCUACGAAAUGUGCCUCAAGUCCCAGCUGGUGGACCUUGUAGCCGAGGGCUACUGGGAGGAGCUACUAGACACAUUCCGGCCGGACAUCGUGGUUAAGGACUGGUUUGCUGCCAGAGCCGACUGUGGCUGCACCUACCAACUCAAAGUGCAGCUGGCCUCGGCUGACUACUUCGUGUUGGCCUCCUUCGAGCCCCCACCUGUGACCAUCCAACAGUGGAACAAUGCCACAUGGACAGAGGUCUCCUACACCUUCUCAGACUACCCCCGGGGUGUCCGCUACAUCCUCUUCCAGCAUGGGGGCAGGGACACCCAGUACUGGGCAGGCUGGUAUGGGCCCCGAGUCACCAACAGCAGCAUUGUCGUCAGCCCCAAGAUGACCAGGAACCAGGCCUCCUCCGAGGCUCAGCCUGGGCAGAAGCAUGGACAGGAGGAGGCUGCCCAAUCGCCCUACCGAGCUGUUGUCCAGAUUUUCUGACAGCUGUCCAUCCUGUGUCUGGGUCAGCCAGAGGUUCCUCCAGGCAGGAGCUGAGCAUGGGGUGGGCAGUGAGGUCCCUGUACCAGCGACUCCUGCCCCGGUUCAACCCUACCAGCUUGUGGUAACUUACUGUCACAUAGCUCUGACGUUUUGUUGUAAUAAAUGUUUUCAGGCCGGGCACUGUGGCUCACGCCUGUAAUCCCAGCACUUUGGGAGACCGAGGCAGGUGGAUCACGAGGUCAGGAGAUAGAGACCAUCCUGGCCAACACGGUGAAACCCUGUCUCUACUAAAAAUACAAAAAAUUAGCCGGGCGUGGUGGCGGGCGCCUGUAGUCCCAGCUACUCGGGAGGCUGAUGCAGAAGAAUGGCGUGAACCCGGAAGGCAGAGCUUGCAGUGAGCCGAGAUCACGCCACUGCACUCCAGCCUGGGUGACAGAGCGAGACUCUGGCUCAUAAAAUAAUAAUAAUAAUAAAUAAAUAAAAAAUAAAUGUUUUCAGUAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 26270)
FBXO6
F-box protein 6
NC_000001.11
1  11668659.. 11673851
11668659.. 11673851
strand +
CCDS133.1
MGI:1354743
ClinVar, dbVar
ENSG00000116663
FBX6, FBG2, FBS2, Fbx6b
uc001aso.4
INSDC: AF129536
13585
605647
OTTHUMG00000002229
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (882 bp)
5'-ATGGATGCTCCCCACTCCAAAGCAGCCCTGGACAGCATTAACGAGCTGCCCGAGAACATCCTGCTGGAGCTGTTCACGCACGTGCCCGCCCGCCAGCTGCTGCTGAACTGCCGCCTGGTCTGCAGCCTCTGGCGGGACCTCATCGACCTCATGACCCTCTGGAAACGCAAGTGCCTGCGAGAGGGCTTCATCACCAAGGACTGGGACCAGCCCGTGGCCGACTGGAAAATCTTCTACTTCCTACGGAGCCTGCATAGGAACCTCCTGCGCAACCCGTGTGCTGAAGAGGATATGTTTGCATGGCAAATTGATTTCAATGGTGGGGACCGCTGGAAGGTGGAGAGCCTCCCTGGAGCCCACGGGACAGATTTTCCTGACCCCAAAGTCAAGAAGTATTTTGTCACATCCTACGAAATGTGCCTCAAGTCCCAGCTGGTGGACCTTGTAGCCGAGGGCTACTGGGAGGAGCTACTAGACACATTCCGGCCGGACATCGTGGTTAAGGACTGGTTTGCTGCCAGAGCCGACTGTGGCTGCACCTACCAACTCAAAGTGCAGCTGGCCTCGGCTGACTACTTCGTGTTGGCCTCCTTCGAGCCCCCACCTGTGACCATCCAACAGTGGAACAATGCCACATGGACAGAGGTCTCCTACACCTTCTCAGACTACCCCCGGGGTGTCCGCTACATCCTCTTCCAGCATGGGGGCAGGGACACCCAGTACTGGGCAGGCTGGTATGGGCCCCGAGTCACCAACAGCAGCATTGTCGTCAGCCCCAAGATGACCAGGAACCAGGCCTCCTCCGAGGCTCAGCCTGGGCAGAAGCATGGACAGGAGGAGGCTGCCCAATCGCCCTACCGAGCTGTTGTCCAGATTTTCTGA-3'
NCBI CDS gene sequence with introns (location: 11668659.. 11673851) (5193 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 11664200.. 11674354) (10155 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [11664200 - 1000].. 11674354) (11155 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905