NCBI Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_036300)
F-box protein 2
F-box only protein 2 (FBG1) (Fbs1)
FBXO2
F-box protein 2
Undefined
Curated
F-box
F-Box Lectins
b-sandwich / Galactose-binding domain-like
Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
NP_036300
26232
Q9UK22
ENSP00000346240.4
Q9UK22
Undefined
10.1271/bbb.70074
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (296 amino acids) Download
MDGDGDPESVGQPEEASPEEQPEEASAEEERPEDQQEEEAAAAAAYLDELPEPLLLRVLAALPAAELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGGVEEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDESVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRSDAGCLYELTVKLLSEHENVLAEFSSGQVAVPQDSDGGGWMEISHTFTDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9UK22-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for FBXO2 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain. [32931479]
  • A reference map of the human binary protein interactome. [32296183]
  • FBXO2, a novel marker for metastasis in human gastric cancer. [29269301]
  • Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease. [28341977]
  • An engineered high affinity Fbs1 carbohydrate binding protein for selective capture of N-glycans and N-glycopeptides. [28534482]
  • E3 ubiquitin ligase that recognizes sugar chains. [12140560]
  • A family of mammalian F-box proteins. [10531037]
  • Identification of a family of human F-box proteins. [10531035]
  • A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest. [9857061]
  • Organ of Corti-specific polypeptides: OCP-I and OCP-II. [7458746]
UniProt Main References (4 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Initial characterization of the human central proteome. [21269460]
RNA
RNA (Transcript ID: NM_012168.6)
NM_012168.6
F-box protein 2
All isoforms of FBXO2 containing a lectin domain
ENST00000354287.5
90..980 (or 11648694.. 11654340)
11648387.. 11654429
NCBI Matured mRNA sequence 1287 NTPDownload 
m7G-5')ppp(5'-AGACGCGGACAGCGCCGGGACUCGCCGCCCCGGGACUCGCGCAGCCCGCAGCGCUCCGGCUCCUCCUCUCGCGACCGCCCUCCGCAGCGAUGGACGGAGACGGUGACCCAGAGAGCGUGGGCCAGCCCGAGGAGGCAAGCCCGGAGGAGCAGCCAGAGGAGGCGAGUGCUGAGGAGGAGCGGCCGGAGGACCAGCAGGAGGAGGAGGCGGCGGCCGCCGCCGCGUACCUGGACGAGCUGCCCGAGCCGCUGCUGCUGCGCGUGCUGGCCGCACUGCCGGCCGCCGAGCUGGUGCAGGCCUGCCGCCUGGUGUGCCUGCGCUGGAAGGAGCUGGUGGACGGCGCCCCGCUGUGGCUGCUCAAGUGCCAGCAGGAGGGGCUGGUGCCCGAGGGCGGCGUGGAGGAGGAGCGCGACCACUGGCAGCAGUUCUACUUCCUGAGCAAGCGGCGCCGCAACCUUCUGCGUAACCCGUGUGGGGAAGAGGACUUGGAAGGCUGGUGUGACGUGGAGCAUGGUGGGGACGGCUGGAGGGUGGAGGAGCUGCCUGGAGACAGUGGGGUGGAGUUCACCCACGAUGAGAGCGUCAAGAAGUACUUCGCCUCCUCCUUUGAGUGGUGUCGCAAAGCACAGGUCAUUGACCUGCAGGCUGAGGGCUACUGGGAGGAGCUGCUGGACACGACUCAGCCGGCCAUCGUGGUGAAGGACUGGUACUCGGGCCGCAGCGACGCUGGUUGCCUCUACGAGCUCACCGUUAAGCUACUGUCCGAGCACGAGAACGUGCUGGCUGAGUUCAGCAGCGGGCAGGUGGCAGUGCCCCAAGACAGUGACGGCGGGGGCUGGAUGGAGAUCUCCCACACCUUCACCGACUACGGGCCGGGCGUCCGCUUCGUCCGCUUCGAGCACGGGGGGCAGGACUCCGUCUACUGGAAGGGCUGGUUCGGGGCCCGGGUGACCAACAGCAGCGUGUGGGUAGAACCCUGAGCGACCCUGCCUCCACUCUCCCCCAGCUGCCUGGAGGGGCAAAGGUCGAGGGUAGAUAGGCCUUAACUUAGUCCAUAGCGUCCUCACCUUCCCCAAGCCACACAUCCUCCUCCCAUCCCUUGCUCCGAUCCCAGCCCCUGAGCAGGGAGAGAGAAGUUUUGUUGGCAUAGGUUUGCUUAGGUAGCCGGCUUCUAGAAUGUAGAUCCGUGAGGGCGUGAGCUUGGACUGGACCCACUGCUGAUUCCCUGCACCUAGCACAGUGCUUGCCACAAAGUGGGCUCUCAAUAAAUAUUAUUUGUCCAAGGAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 26232)
FBXO2
F-box protein 2
NC_000001.11
1  11648694.. 11654340
11648694.. 11654340
strand -
CCDS130.1
MGI:2446216
ClinVar, dbVar
ENSG00000116661
FBX2, Nfb42, Fbs1, Fbg1
uc001asj.4
INSDC: AF174594
13581
607112
OTTHUMG00000002072
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (891 bp)
5'-ATGGACGGAGACGGTGACCCAGAGAGCGTGGGCCAGCCCGAGGAGGCAAGCCCGGAGGAGCAGCCAGAGGAGGCGAGTGCTGAGGAGGAGCGGCCGGAGGACCAGCAGGAGGAGGAGGCGGCGGCCGCCGCCGCGTACCTGGACGAGCTGCCCGAGCCGCTGCTGCTGCGCGTGCTGGCCGCACTGCCGGCCGCCGAGCTGGTGCAGGCCTGCCGCCTGGTGTGCCTGCGCTGGAAGGAGCTGGTGGACGGCGCCCCGCTGTGGCTGCTCAAGTGCCAGCAGGAGGGGCTGGTGCCCGAGGGCGGCGTGGAGGAGGAGCGCGACCACTGGCAGCAGTTCTACTTCCTGAGCAAGCGGCGCCGCAACCTTCTGCGTAACCCGTGTGGGGAAGAGGACTTGGAAGGCTGGTGTGACGTGGAGCATGGTGGGGACGGCTGGAGGGTGGAGGAGCTGCCTGGAGACAGTGGGGTGGAGTTCACCCACGATGAGAGCGTCAAGAAGTACTTCGCCTCCTCCTTTGAGTGGTGTCGCAAAGCACAGGTCATTGACCTGCAGGCTGAGGGCTACTGGGAGGAGCTGCTGGACACGACTCAGCCGGCCATCGTGGTGAAGGACTGGTACTCGGGCCGCAGCGACGCTGGTTGCCTCTACGAGCTCACCGTTAAGCTACTGTCCGAGCACGAGAACGTGCTGGCTGAGTTCAGCAGCGGGCAGGTGGCAGTGCCCCAAGACAGTGACGGCGGGGGCTGGATGGAGATCTCCCACACCTTCACCGACTACGGGCCGGGCGTCCGCTTCGTCCGCTTCGAGCACGGGGGGCAGGACTCCGTCTACTGGAAGGGCTGGTTCGGGGCCCGGGTGACCAACAGCAGCGTGTGGGTAGAACCCTGA-3'
NCBI CDS gene sequence with introns (location: 11648694.. 11654340) (5647 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 11648387.. 11654429) (6043 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [11648387.. 11654429 + 1000]) (7043 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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