NCBI Summary
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012].
Protein
Protein (NP_006030)
Endo180 (Mannose receptor C type 2)
C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280)
MRC2
mannose receptor C type 2
Curated
C-type lectin
Undefined
C-type - Macrophage Mannose Receptor MMR
a/b mixed / C-type lectin-like
Man, Fuc, GlcNAc
0.379
MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGGQVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTTASLGMYECDREALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCKKKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDEVMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDDDIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFFEHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRFRWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQPPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNVTFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLLQKPLRWHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGSCPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQSYEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWRPGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQSIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Mathematical modelling of the role of Endo180 network in the development of metastatic bone disease in prostate cancer. [32072971]
- Interleukin-1 alpha derived from ultraviolet B-exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180. [31376337]
- Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins. [30366943]
- Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180. [29061505]
- HIV-1 Tat represses transcription from the mannose receptor promoter. [11120831]
- Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. [10683150]
- A urokinase receptor-associated protein with specific collagen binding properties. [10636902]
- Cloning of human chromosome 17-specific cDNAs using representational difference analysis and human-mouse hybrid cells. [9192860]
- Characterization of a novel member of the macrophage mannose receptor type C lectin family. [8702911]
- A novel, specific pro-urokinase complex on monocyte-like cells, detected by transglutaminase-catalyzed cross-linking. [7904248]
UniProt Main References (10 PubMed Identifiers)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. [9734811]
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. [16625196]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. [12068012]
- Characterization of sugar binding by the mannose receptor family member, Endo180. [12399458]
- Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. [12972549]
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]
- A strategy for precise and large scale identification of core fucosylated glycoproteins. [19139490]
- In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. [20388717]
- N-terminome analysis of the human mitochondrial proteome. [25944712]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_006039.5)
m7G-5')ppp(5'-AUCACUUCGUCCCGACCCGGAGGAGGACGCGAGCCCCUUGCGGGCGGUCAUCACAGCCCAGCCUCGGGGCUGCCACAGCGCGUUGCGCCUGUGCGCCCUCGGUCCCCGCGUCCACUGAGCGCCGCGCUCGGGGAUGGGGCCCGGCCGGCCGGCCCCCGCGCCCUGGCCUCGUCACCUGCUGCGCUGCGUCCUGCUCCUCGGGUGCCUGCACCUCGGCCGUCCCGGCGCCCCUGGGGACGCCGCCCUCCCGGAACCCAACGUCUUCCUCAUCUUCAGCCAUGGACUGCAGGGCUGCCUGGAGGCCCAGGGCGGGCAGGUCAGAGUCACCCCGGCUUGCAAUACCAGCCUCCCUGCCCAGCGCUGGAAGUGGGUCUCCCGAAACCGGCUAUUCAACCUGGGUACCAUGCAGUGCCUGGGCACAGGCUGGCCAGGCACCAACACCACGGCCUCCCUGGGCAUGUAUGAGUGUGACCGGGAAGCACUGAAUCUUCGCUGGCAUUGUCGUACACUGGGUGACCAGCUGUCCUUGCUCCUGGGGGCCCGCACCAGCAACAUAUCCAAGCCUGGCACCCUUGAGCGUGGUGACCAGACCCGCAGUGGCCAGUGGCGCAUCUACGGCAGCGAGGAGGACCUAUGUGCUCUGCCCUACCACGAGGUCUACACCAUCCAGGGAAACUCCCACGGAAAGCCGUGCACCAUCCCCUUCAAAUAUGACAACCAGUGGUUCCACGGCUGCACCAGCACGGGCCGCGAGGAUGGUCACCUGUGGUGUGCCACCACCCAGGACUACGGCAAAGACGAGCGCUGGGGCUUCUGCCCCAUCAAGAGUAACGACUGCGAGACCUUCUGGGACAAGGACCAGCUGACUGACAGCUGCUACCAGUUUAACUUCCAGUCCACGCUGUCGUGGAGGGAGGCCUGGGCCAGCUGCGAGCAGCAGGGUGCGGAUCUGCUGAGCAUCACGGAGAUCCACGAGCAGACCUACAUCAACGGCCUCCUCACUGGGUACAGCUCCACCCUGUGGAUCGGCUUGAAUGACUUGGACACGAGCGGAGGCUGGCAGUGGUCGGACAACUCGCCCCUCAAGUACCUCAACUGGGAGAGUGACCAGCCGGACAACCCCAGUGAGGAGAACUGUGGAGUGAUCCGCACUGAGUCCUCGGGCGGCUGGCAGAACCGUGACUGCAGCAUCGCGCUGCCCUAUGUGUGCAAGAAGAAGCCCAACGCCACGGCCGAGCCCACCCCUCCAGACAGGUGGGCCAAUGUGAAGGUGGAGUGCGAGCCGAGCUGGCAGCCCUUCCAGGGCCACUGCUACCGCCUGCAGGCCGAGAAGCGCAGCUGGCAGGAGUCCAAGAAGGCAUGUCUACGGGGCGGUGGCGACCUGGUCAGCAUCCACAGCAUGGCGGAGCUGGAAUUCAUCACCAAGCAGAUCAAGCAAGAGGUGGAGGAGCUGUGGAUCGGCCUCAACGAUUUGAAACUGCAGAUGAAUUUUGAGUGGUCUGACGGGAGCCUUGUGAGCUUCACCCACUGGCACCCCUUUGAGCCCAACAACUUCCGGGACAGUCUGGAGGACUGUGUCACCAUCUGGGGCCCGGAAGGCCGCUGGAACGACAGUCCCUGUAACCAGUCCUUGCCAUCCAUCUGCAAGAAGGCAGGCCAGCUGAGCCAGGGGGCCGCCGAGGAGGACCAUGGCUGCCGGAAGGGUUGGACGUGGCACAGCCCAUCCUGCUACUGGCUGGGAGAAGACCAAGUGACCUACAGUGAGGCCCGGCGCCUGUGCACUGACCAUGGCUCUCAGCUGGUCACCAUCACCAACAGGUUCGAGCAGGCCUUCGUCAGCAGCCUCAUCUACAACUGGGAGGGCGAGUACUUCUGGACGGCCCUGCAGGACCUCAACAGCACCGGCUCCUUCUUCUGGCUCAGUGGGGAUGAAGUCAUGUACACCCACUGGAACCGGGACCAGCCCGGGUACAGCCGUGGGGGCUGCGUGGCGCUGGCCACUGGCAGCGCCAUGGGGCUGUGGGAGGUGAAGAACUGUACCUCGUUCCGGGCCCGCUACAUCUGCCGGCAGAGCCUGGGCACUCCAGUGACGCCGGAGCUGCCGGGGCCAGAUCCCACGCCCAGCCUCACUGGCUCCUGUCCCCAGGGCUGGGCCUCGGACACCAAACUCCGGUAUUGCUAUAAGGUGUUCAGCUCAGAGCGGCUGCAGGACAAGAAGAGCUGGGUCCAGGCCCAGGGGGCCUGCCAGGAGCUGGGGGCCCAGCUGCUGAGCCUGGCCAGCUACGAGGAGGAGCACUUUGUGGCCAACAUGCUCAACAAGAUCUUCGGUGAAUCAGAACCCGAGAUCCACGAGCAGCACUGGUUCUGGAUCGGCCUGAACCGUCGGGAUCCCAGAGGGGGUCAGAGUUGGCGCUGGAGCGACGGCGUAGGGUUCUCUUACCACAAUUUCGACCGGAGCCGGCACGACGACGACGACAUCCGAGGCUGUGCGGUGCUGGACCUGGCCUCCCUGCAGUGGGUGGCCAUGCAGUGCGACACACAGCUGGACUGGAUCUGCAAGAUCCCCAGAGGUACGGACGUGCGGGAGCCCGACGACAGCCCUCAAGGCCGACGGGAAUGGCUGCGCUUCCAGGAGGCCGAGUACAAGUUCUUUGAGCACCACUCCACGUGGGCGCAGGCGCAGCGCAUCUGCACGUGGUUCCAGGCCGAGCUGACCUCGGUGCACAGCCAGGCGGAGCUAGACUUCCUGAGCCACAACUUGCAGAAGUUCUCCCGGGCCCAGGAGCAGCACUGGUGGAUCGGCCUGCACACCUCUGAGAGCGAUGGGCGCUUCAGAUGGACAGAUGGUUCCAUUAUAAACUUCAUCUCCUGGGCACCAGGCAAACCUCGGCCUGUCGGCAAGGACAAGAAGUGCGUGUACAUGACAGCCAGCCGAGAGGACUGGGGGGACCAGAGGUGCCUGACAGCCUUGCCCUACAUCUGCAAGCGCAGCAACGUCACCAAAGAAACGCAGCCCCCAGACCUGCCAACUACAGCCCUGGGGGGCUGCCCCUCUGACUGGAUCCAGUUCCUCAACAAGUGUUUUCAGGUCCAGGGCCAGGAACCCCAGAGCCGGGUGAAGUGGUCAGAGGCACAGUUCUCCUGUGAACAGCAAGAGGCCCAGCUGGUCACCAUCACAAACCCCUUAGAGCAAGCAUUCAUCACAGCCAGCCUGCCCAAUGUGACCUUUGACCUUUGGAUUGGCCUCCAUGCCUCGCAGAGGGACUUCCAGUGGGUGGAGCAGGAGCCUUUGAUGUAUGCCAACUGGGCACCUGGGGAGCCCUCUGGCCCUAGCCCUGCUCCCAGUGGCAACAAACCGACCAGCUGUGCAGUGGUCCUGCACAGCCCCUCAGCCCACUUCACUGGCCGCUGGGACGAUCGGAGCUGCACGGAGGAGACCCAUGGCUUCAUCUGCCAGAAGGGCACGGACCCCUCCCUGAGCCCGUCCCCAGCAGCGCUGCCCCCCGCCCCGGGCACUGAGCUCUCCUACCUCAACGGCACCUUCCGGCUGCUUCAGAAGCCGCUGCGCUGGCACGAUGCCCUCCUGCUGUGUGAGAGCCGCAAUGCCAGCCUGGCCUACGUGCCCGACCCCUACACCCAGGCCUUCCUCACGCAGGCUGCCCGAGGGCUGCGCACGCCGCUCUGGAUUGGGCUGGCUGGCGAGGAGGGCUCUCGGCGGUACUCCUGGGUCUCAGAGGAGCCGCUGAACUACGUGGGCUGGCAGGACGGGGAGCCGCAGCAGCCGGGGGGCUGUACCUACGUAGAUGUGGACGGGGCCUGGCGCACCACCAGCUGUGACACCAAGCUGCAGGGGGCUGUGUGUGGGGUUAGCAGUGGGCCCCCUCCUCCCCGAAGAAUAAGCUACCAUGGCAGCUGUCCCCAGGGACUGGCAGACUCCGCGUGGAUUCCCUUCCGGGAGCACUGCUAUUCUUUCCACAUGGAGCUGCUGCUGGGCCACAAGGAGGCGCGACAGCGCUGCCAGAGAGCGGGUGGGGCCGUCCUGUCUAUCCUGGAUGAGAUGGAGAAUGUGUUUGUCUGGGAGCACCUGCAGAGCUAUGAGGGCCAGAGUCGGGGCGCCUGGCUGGGCAUGAACUUCAACCCCAAAGGAGGCACUCUGGUCUGGCAGGACAACACAGCUGUGAACUACUCCAACUGGGGGCCCCCGGGCUUGGGCCCCAGCAUGCUGAGCCACAACAGCUGCUACUGGAUUCAGAGCAACAGCGGGCUAUGGCGCCCCGGCGCUUGCACCAACAUCACCAUGGGUGUCGUCUGCAAGCUUCCUCGUGCUGAGCAGAGCAGCUUCUCCCCAUCAGCGCUUCCAGAGAACCCAGCGGCCCUGGUGGUGGUGCUGAUGGCGGUGCUGCUGCUCCUGGCCUUGCUGACCGCAGCCCUCAUCCUUUACCGGAGGCGCCAGAGCAUCGAGCGCGGGGCCUUUGAGGGUGCCCGCUACAGCCGCAGCAGCUCCAGCCCCACCGAGGCCACUGAGAAGAACAUCCUGGUGUCAGACAUGGAAAUGAAUGAGCAACAAGAAUAGAGCCAGGCGCGUGGGCAGGGCCAGGGCGGGAGGAGCUGGGGAGCUGGGGCCCUGGGUCAGUCUGGCCCCCCACCAGCUGCCUGUCCAGUUGGCCUAUGGAAGGGUGCCCUUGGGAGUCGCUGUUGGGAGCCGGAGCUGGGCAGAGCCUGGGCUGGUGGGGUGCCACCCUCCCACAAGGGCUGGGCUGAGACCCAGCUGAGUGCAGCGUGGCGUUUCCCUUUCUGGGGGGGCCUGAGGUCUUGUCACCUGGUCCUGUGCCCCCACAGGAACCAGAGGUAGGAUGGGAGGGGGAACGAGAGCCUCUUUCUCCCCAGAGCCCCCGGCCCAGGCCUGUUGAUCCGCGCCCCAGGACCCCCUUCUUUGCAGAGCCCGAGGAGCCUCCCCUGUCCCCUCGGGCAGAUCUGUUGUGUCUCUCUUCCCACCUGGCAGCCUCAGCUCUGUGCCCCUCACCCUGCUCCCUCUCGCCCCUUCUCUCCCACCCCUUCCUUCUGAGCCGGGCCCUGGGGAUUGGGGAGCCCUCUUGUUCCUGAUGAGGGUCAGCUGAGGGGGCUGAGCAUCCAUCACUCCUGUGCCUGCUGGGGUGGCUGUGGGGCGUGGCAGGAGGGGCCUAGGUGGGUUGGGCCUGAGAACCAGGGCACGGGUGUGGUGUCUGCUGGGCUGGAGAUAAGACUGGGGAGAGACACCCCAACCUCCCAGGGUGGGAGCUGGGCCGGGCUGGGAUGUCAUCUCCUGCCGGGCGGGGGAGGGCUCUGCCCCUGGAAGAGUCCCCUGUGGGGACCAAAAUAAGUUCCCUAACAUCUCCAGCUCCUGGCUCUGGUUUGGAGCAAGGGGAAGGGUUGCCAGAGUCCUGGGGGCCCCAGAGGAGCAGGAGUCUGGGAGGGCCCAGAGUUCACCCUCUAGUGGAUCCAGGAGGAGCAGCACCCGAGCCCUGGAGUGGCCCAGUACCCUUCCAAGAGGCCACAGUCCCAGCCAGGACAAAGUAUGCGGCCCAUCCUGGUGCGACAGCGUGGGACAAUGUGAACAUGGACUCGAAGACAUGGCCCUUUCUCUGUAGUUGAUUUUUUAAAUGUGCCAUUAUUGUUUUUAAAAAAAAAGGAAAAAAGAAAAGCAAACAAAUAAAACACCUUUAAGAGGCUUGAAAGAGAA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 9902)
mannose receptor C type 2
strand +
KIAA0709, ENDO180, CLEC13E, CD280
NCBI CDS gene sequence (4440 bp)
5'-ATGGGGCCCGGCCGGCCGGCCCCCGCGCCCTGGCCTCGTCACCTGCTGCGCTGCGTCCTGCTCCTCGGGTGCCTGCACCTCGGCCGTCCCGGCGCCCCTGGGGACGCCGCCCTCCCGGAACCCAACGTCTTCCTCATCTTCAGCCATGGACTGCAGGGCTGCCTGGAGGCCCAGGGCGGGCAGGTCAGAGTCACCCCGGCTTGCAATACCAGCCTCCCTGCCCAGCGCTGGAAGTGGGTCTCCCGAAACCGGCTATTCAACCTGGGTACCATGCAGTGCCTGGGCACAGGCTGGCCAGGCACCAACACCACGGCCTCCCTGGGCATGTATGAGTGTGACCGGGAAGCACTGAATCTTCGCTGGCATTGTCGTACACTGGGTGACCAGCTGTCCTTGCTCCTGGGGGCCCGCACCAGCAACATATCCAAGCCTGGCACCCTTGAGCGTGGTGACCAGACCCGCAGTGGCCAGTGGCGCATCTACGGCAGCGAGGAGGACCTATGTGCTCTGCCCTACCACGAGGTCTACACCATCCAGGGAAACTCCCACGGAAAGCCGTGCACCATCCCCTTCAAATATGACAACCAGTGGTTCCACGGCTGCACCAGCACGGGCCGCGAGGATGGTCACCTGTGGTGTGCCACCACCCAGGACTACGGCAAAGACGAGCGCTGGGGCTTCTGCCCCATCAAGAGTAACGACTGCGAGACCTTCTGGGACAAGGACCAGCTGACTGACAGCTGCTACCAGTTTAACTTCCAGTCCACGCTGTCGTGGAGGGAGGCCTGGGCCAGCTGCGAGCAGCAGGGTGCGGATCTGCTGAGCATCACGGAGATCCACGAGCAGACCTACATCAACGGCCTCCTCACTGGGTACAGCTCCACCCTGTGGATCGGCTTGAATGACTTGGACACGAGCGGAGGCTGGCAGTGGTCGGACAACTCGCCCCTCAAGTACCTCAACTGGGAGAGTGACCAGCCGGACAACCCCAGTGAGGAGAACTGTGGAGTGATCCGCACTGAGTCCTCGGGCGGCTGGCAGAACCGTGACTGCAGCATCGCGCTGCCCTATGTGTGCAAGAAGAAGCCCAACGCCACGGCCGAGCCCACCCCTCCAGACAGGTGGGCCAATGTGAAGGTGGAGTGCGAGCCGAGCTGGCAGCCCTTCCAGGGCCACTGCTACCGCCTGCAGGCCGAGAAGCGCAGCTGGCAGGAGTCCAAGAAGGCATGTCTACGGGGCGGTGGCGACCTGGTCAGCATCCACAGCATGGCGGAGCTGGAATTCATCACCAAGCAGATCAAGCAAGAGGTGGAGGAGCTGTGGATCGGCCTCAACGATTTGAAACTGCAGATGAATTTTGAGTGGTCTGACGGGAGCCTTGTGAGCTTCACCCACTGGCACCCCTTTGAGCCCAACAACTTCCGGGACAGTCTGGAGGACTGTGTCACCATCTGGGGCCCGGAAGGCCGCTGGAACGACAGTCCCTGTAACCAGTCCTTGCCATCCATCTGCAAGAAGGCAGGCCAGCTGAGCCAGGGGGCCGCCGAGGAGGACCATGGCTGCCGGAAGGGTTGGACGTGGCACAGCCCATCCTGCTACTGGCTGGGAGAAGACCAAGTGACCTACAGTGAGGCCCGGCGCCTGTGCACTGACCATGGCTCTCAGCTGGTCACCATCACCAACAGGTTCGAGCAGGCCTTCGTCAGCAGCCTCATCTACAACTGGGAGGGCGAGTACTTCTGGACGGCCCTGCAGGACCTCAACAGCACCGGCTCCTTCTTCTGGCTCAGTGGGGATGAAGTCATGTACACCCACTGGAACCGGGACCAGCCCGGGTACAGCCGTGGGGGCTGCGTGGCGCTGGCCACTGGCAGCGCCATGGGGCTGTGGGAGGTGAAGAACTGTACCTCGTTCCGGGCCCGCTACATCTGCCGGCAGAGCCTGGGCACTCCAGTGACGCCGGAGCTGCCGGGGCCAGATCCCACGCCCAGCCTCACTGGCTCCTGTCCCCAGGGCTGGGCCTCGGACACCAAACTCCGGTATTGCTATAAGGTGTTCAGCTCAGAGCGGCTGCAGGACAAGAAGAGCTGGGTCCAGGCCCAGGGGGCCTGCCAGGAGCTGGGGGCCCAGCTGCTGAGCCTGGCCAGCTACGAGGAGGAGCACTTTGTGGCCAACATGCTCAACAAGATCTTCGGTGAATCAGAACCCGAGATCCACGAGCAGCACTGGTTCTGGATCGGCCTGAACCGTCGGGATCCCAGAGGGGGTCAGAGTTGGCGCTGGAGCGACGGCGTAGGGTTCTCTTACCACAATTTCGACCGGAGCCGGCACGACGACGACGACATCCGAGGCTGTGCGGTGCTGGACCTGGCCTCCCTGCAGTGGGTGGCCATGCAGTGCGACACACAGCTGGACTGGATCTGCAAGATCCCCAGAGGTACGGACGTGCGGGAGCCCGACGACAGCCCTCAAGGCCGACGGGAATGGCTGCGCTTCCAGGAGGCCGAGTACAAGTTCTTTGAGCACCACTCCACGTGGGCGCAGGCGCAGCGCATCTGCACGTGGTTCCAGGCCGAGCTGACCTCGGTGCACAGCCAGGCGGAGCTAGACTTCCTGAGCCACAACTTGCAGAAGTTCTCCCGGGCCCAGGAGCAGCACTGGTGGATCGGCCTGCACACCTCTGAGAGCGATGGGCGCTTCAGATGGACAGATGGTTCCATTATAAACTTCATCTCCTGGGCACCAGGCAAACCTCGGCCTGTCGGCAAGGACAAGAAGTGCGTGTACATGACAGCCAGCCGAGAGGACTGGGGGGACCAGAGGTGCCTGACAGCCTTGCCCTACATCTGCAAGCGCAGCAACGTCACCAAAGAAACGCAGCCCCCAGACCTGCCAACTACAGCCCTGGGGGGCTGCCCCTCTGACTGGATCCAGTTCCTCAACAAGTGTTTTCAGGTCCAGGGCCAGGAACCCCAGAGCCGGGTGAAGTGGTCAGAGGCACAGTTCTCCTGTGAACAGCAAGAGGCCCAGCTGGTCACCATCACAAACCCCTTAGAGCAAGCATTCATCACAGCCAGCCTGCCCAATGTGACCTTTGACCTTTGGATTGGCCTCCATGCCTCGCAGAGGGACTTCCAGTGGGTGGAGCAGGAGCCTTTGATGTATGCCAACTGGGCACCTGGGGAGCCCTCTGGCCCTAGCCCTGCTCCCAGTGGCAACAAACCGACCAGCTGTGCAGTGGTCCTGCACAGCCCCTCAGCCCACTTCACTGGCCGCTGGGACGATCGGAGCTGCACGGAGGAGACCCATGGCTTCATCTGCCAGAAGGGCACGGACCCCTCCCTGAGCCCGTCCCCAGCAGCGCTGCCCCCCGCCCCGGGCACTGAGCTCTCCTACCTCAACGGCACCTTCCGGCTGCTTCAGAAGCCGCTGCGCTGGCACGATGCCCTCCTGCTGTGTGAGAGCCGCAATGCCAGCCTGGCCTACGTGCCCGACCCCTACACCCAGGCCTTCCTCACGCAGGCTGCCCGAGGGCTGCGCACGCCGCTCTGGATTGGGCTGGCTGGCGAGGAGGGCTCTCGGCGGTACTCCTGGGTCTCAGAGGAGCCGCTGAACTACGTGGGCTGGCAGGACGGGGAGCCGCAGCAGCCGGGGGGCTGTACCTACGTAGATGTGGACGGGGCCTGGCGCACCACCAGCTGTGACACCAAGCTGCAGGGGGCTGTGTGTGGGGTTAGCAGTGGGCCCCCTCCTCCCCGAAGAATAAGCTACCATGGCAGCTGTCCCCAGGGACTGGCAGACTCCGCGTGGATTCCCTTCCGGGAGCACTGCTATTCTTTCCACATGGAGCTGCTGCTGGGCCACAAGGAGGCGCGACAGCGCTGCCAGAGAGCGGGTGGGGCCGTCCTGTCTATCCTGGATGAGATGGAGAATGTGTTTGTCTGGGAGCACCTGCAGAGCTATGAGGGCCAGAGTCGGGGCGCCTGGCTGGGCATGAACTTCAACCCCAAAGGAGGCACTCTGGTCTGGCAGGACAACACAGCTGTGAACTACTCCAACTGGGGGCCCCCGGGCTTGGGCCCCAGCATGCTGAGCCACAACAGCTGCTACTGGATTCAGAGCAACAGCGGGCTATGGCGCCCCGGCGCTTGCACCAACATCACCATGGGTGTCGTCTGCAAGCTTCCTCGTGCTGAGCAGAGCAGCTTCTCCCCATCAGCGCTTCCAGAGAACCCAGCGGCCCTGGTGGTGGTGCTGATGGCGGTGCTGCTGCTCCTGGCCTTGCTGACCGCAGCCCTCATCCTTTACCGGAGGCGCCAGAGCATCGAGCGCGGGGCCTTTGAGGGTGCCCGCTACAGCCGCAGCAGCTCCAGCCCCACCGAGGCCACTGAGAAGAACATCCTGGTGTCAGACATGGAAATGAATGAGCAACAAGAATAG-3'
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