Protein
Protein (NP_001092082)
SIGLEC-14
Sialic acid-binding Ig-like lectin 14 (Siglec-14)
SIGLEC14
sialic acid binding Ig like lectin 14
Undefined
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)GalNAc
NP_001092082
100049587
Q08ET2
Undefined
Q08ET2
0.555
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (396 amino acids) Download
MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQRSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRAERPG
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q08ET2-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [0.28, 0.77] ÅDownload
The location of the lectin domain structural model is: 19-146
We infer [0.28, 0.77] Å as the interval of error of this structural model.
Template 1: 2ZG1 chain: A, O15389, NP_003821.1, sequence identity: 95.3%, coverage: 95.3%, location in sequence: 20-141, (25-146 in PDB).
Template 2: 2N7B chain: A, Q9NYZ4, NP_055257.2, sequence identity: 59.4%, coverage: 94.5%, location in sequence: 26-152, (10-136 in PDB).
Template 3: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 56.2%, coverage: 96.1%, location in sequence: 18-141, (18-141 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for SIGLEC14 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages. [31805552]
  • Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses. [30377253]
  • The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes. [28454648]
  • Human gingiva transcriptome during wound healing. [28005267]
  • Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. [26459514]
  • Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. [24799499]
  • Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. [23519826]
  • Deletion polymorphism of SIGLEC14 and its functional implications. [19369701]
  • Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. [17012248]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
UniProt Main References (2 PubMed Identifiers)
  • Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. [17012248]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
All isoforms of this gene containing a lectin domain
NP_001092082.1, XP_016881602.1
RNA
RNA (Transcript ID: NM_001098612.3)
NM_001098612.3
sialic acid binding Ig like lectin 14
All isoforms of SIGLEC14 containing a lectin domain
67..1257 (or 51643355.. 51646759)
51639478.. 51646825
NCBI Matured mRNA sequence 5134 NTPDownload 
m7G-5')ppp(5'-AUUUGGAGCAUUUCCUUCCCUGACAGCCGGACCUGGGACUGGGCUGGGGCCCUGGCGGAUGGAGACAUGCUGCCCCUGCUGCUGCUGCCCCUGCUGUGGGGGGGGUCCCUGCAGGAGAAGCCAGUGUACGAGCUGCAAGUGCAGAAGUCGGUGACGGUGCAGGAGGGCCUGUGCGUCCUUGUGCCCUGCUCCUUCUCUUACCCCUGGAGAUCCUGGUAUUCCUCUCCCCCACUCUACGUCUACUGGUUCCGGGACGGGGAGAUCCCAUACUACGCUGAGGUUGUGGCCACAAACAACCCAGACAGAAGAGUGAAGCCAGAGACCCAGGGCCGAUUCCGCCUCCUUGGGGAUGUCCAGAAGAAGAACUGCUCCCUGAGCAUCGGAGAUGCCAGAAUGGAGGACACGGGAAGCUAUUUCUUCCGCGUGGAGAGAGGAAGGGAUGUAAAAUAUAGCUACCAACAGAAUAAGCUGAACUUGGAGGUGACAGCCCUGAUAGAGAAACCCGACAUCCACUUUCUGGAGCCUCUGGAGUCCGGCCGCCCCACAAGGCUGAGCUGCAGCCUUCCAGGAUCCUGUGAAGCGGGACCACCUCUCACAUUCUCCUGGACGGGGAAUGCCCUCAGCCCCCUGGACCCCGAGACCACCCGCUCCUCGGAGCUCACCCUCACCCCCAGGCCCGAGGACCAUGGCACCAACCUCACCUGUCAGGUGAAACGCCAAGGAGCUCAGGUGACCACGGAGAGAACUGUCCAGCUCAAUGUCUCCUAUGCUCCACAGAACCUCGCCAUCAGCAUCUUCUUCAGAAAUGGCACAGGCACAGCCCUGCGGAUCCUGAGCAAUGGCAUGUCGGUGCCCAUCCAGGAGGGCCAGUCCCUGUUCCUCGCCUGCACAGUUGACAGCAACCCCCCUGCCUCACUGAGCUGGUUCCGGGAGGGAAAAGCCCUCAAUCCUUCCCAGACCUCAAUGUCUGGGACCCUGGAGCUGCCUAACAUAGGAGCUAGAGAGGGAGGGGAAUUCACCUGCCGGGUUCAGCAUCCGCUGGGCUCCCAGCACCUGUCCUUCAUCCUUUCUGUGCAGAGAAGCUCCUCUUCCUGCAUAUGUGUAACUGAGAAACAGCAGGGCUCCUGGCCCCUCGUCCUCACCCUGAUCAGGGGGGCUCUCAUGGGGGCUGGCUUCCUCCUCACCUAUGGCCUCACCUGGAUCUACUAUACCAGGUGUGGAGGCCCCCAGCAGAGCAGGGCUGAGAGGCCUGGCUGAGCCCCUCCCGCUCAAGACAGAACUGAGGUGUGGACACUUAGCCCUGUGGGACACAUGCAGGACAUCACUGUCAGCUUCUUUCUGGAAGCUCACAUCCCACUGACUACCCCUCUUUUCCUUCCUGCCCCAUACCCCUUCUACUUAUUCCCCUCUGCUUGUGAGUCUUGCCCCACCACACCUGCAUCCCCAUCUGCACCCCAUCCCCUCUCCACCUGCCCUUCUCUUCCCUCUCCAUCCACCAUCUCCAGCCCUGUGAAGGGAAUGUACUUUCGGUCUUAUACCCCCAUUACCCAUUACCCAAAAGUUACCUUUUUUUUUUUUUUUUUUUUUUGAGACAGAGUCUCACUCUGUUGCACAGGCUGGAGUUCAGUGGCACAAUCUCCGUUCACUGCAACCUCCACCUCUGGGGUUCAAGCAAUUCUCCUGCCUCAGCCUCCCUAGUAGCUGGGAUUACAGGUGCCUGCCACCACAUCCAGUUAAUUUUUUUUUUUUGUAUGUUAGUAGAGAUGGGGUUUUACCAUGUUGGCCAGGUCUCGAACUCCUGACCUCAAGCAAUCCACUGCAUUGGCCUCCCAAAGUGCUGGCAUUACAGGUAUGAGCCACCGUGCCUGGCUGCCAAAAGUUACCUUCUUAACACUUGAAUUUCUGGUCUCCUCAGCUUCCCUAUCCAUAUAGGCACAGAGAGGCAGCAUUUGUUUUCCAGUUAAAACUCUACCUCAUUGUGAUUAUUAUCCAAUACAAUUGUUACAAAAUAAGUAAAACUUUUAUGAAACAAUACAACAUAACUGAUUUUACUCUUUAAUGCCUCUGUGAGAGUUUGUAGACAAAAAUUAUGUCUUUUUUUUUUUUCUUUGAGACAGAGUUUCUAUCUUGUUGCCCAGGCUGGAGUGCAAUGGCAAAAUCUCAGCUCACUGCAACUUCUGCCUCCCAGGUUCAAGUGAUUCUCCUUCUGUCCAUAUACAAGAAGGCAAUACCUGUAUUGUCAGGUUCUGUGCAUCGUAUAACUGGAACCAAACAUAUUUGCUUUAGGGUCUGCUUUCAUUUCUUCAGUGUGGUUUUCCCAGUUUAUCCACGUUGUUACACGUAUCAAUAGCUCAUUCUCAGUUUUGGUGGGGUUUUUUUUGCUUUUAAUAUCGUACAGUCAGCCUUCUGUAUCCACUGGUUCUGCAUUUUCCCUUUAAUCACUUUUGCUGCACCACAAAAGUUUUGUUAUGUUGUAUUUUUAUAUUAGUUCAAAAUAUUUCCUUCUUUCCCCUGAGAUUUCCUUUGAAUUCACGGAUUGCUUAGAAGUGUGUUGUUUAAUUUCUAAGUGAUUGCAGAUUUUACUGGUUUUUUAUUUUUAAACAAAUUGUUACUACUUUCUUUUUAAGUUCCAUUUUAAUAAAUACACAUGCUUGAUAUGAUUUUUUUUAACUUUUAAGUUCAGGGGGCACAAGUGCAGGUUUGUUACAUAGGUAAAGUGUCAUGGGAGUUUGUUGUACAGAUUAUUGCAUCACCCAGAUAUUAAGCCUAGUACCCAUUAGUUAUUUUCCUCAUCCUCUCCCUCCUCCCACCUUCCACCCUUUGAAAGGCCCCAGUGUGUGUUGCUCACCUCUAUGUAUCCAUGUGUUCUCAUCAUUUAGCUCCCACUUACAAGUGAGAACAUGUGGUAUUUGGUUUUCUCUUCUUGUGAUAGUUUGCUGAGGAUAAUGGUCUCCAGCUCCACUCAUGUCCCUGCAAAGGACAUAAUCUCAUUCUUUUUUAUGGCUGCUUAGUAUUCCAUGGUGUAUAUGUACCACAUUUUCUCUAUCCAGUCUACCACUGAUAGGCAGUUAGGUUGAUUCCAUGUCAUUGCUAUUGUGAAUAGUGCUGCAGUGAAUGUAUGCAUGCAUGUGUCUUUGUAAUAGAAUGAUUUAUAUUCCUUUGGGUAUAUGCCUAGGAAUGGGAUUGCUGAGUCGAAUGGUAUUUCUAUGUUUAGGUCUUUGAGGAAUCGCCACACUGUCUUCCACAAUGGCUGAACUAACUUUCACUUUCACCAACCGUGAGAGUCUUUUAUAUUGGUUAAGUUUGCUUGAUGACACUGGUCUAUCUUGGUGAAUGCUCCAUGUGUGCUUAGAAAGAAUGUGUAUUGCCCUGUUAUGGGACGAAUAUUAAAUGGCAAUUAGACAUAGUUGUCCAAUGGUGUUCAGUUUUAUAGCUGGUAACUUUUUUGUCUACCAGCUCAGUCUAUUACUGAGAGAGGAAUGUUGAAGUCUCUGAUCCUAAUGUUGGAUUUGUCAGUUUCUCCUCUCAGUUUCAUCAGUUUUUGCUGCAUGUAUUUUUAAACUCUGUCGUUAGGUGCAUACAUAUUAAGAAUUCUCAUGUCUUCUUAAAGAAUCAACUUAAAAAAAAUUUUUUUUUGAGACAGAGUUUCGCUCUUUUUGCCCAGGCUGGAGUGCAAUGGCGCGAUCUUGGCUCACUGCAACCUCCGCCUCCCAGGUACAAGUGAUUCUCCUGCCUCAGCCUCCCAAAUAGCUUGGAUUACAGGCACGCACCAUCACGCCUGGCUAGUUUUUUUUGUAUUUAGUAGAGACAAGGUUUCACCAUGUAAGUCAGGCUGGUCCUGAACUCCUGACUUCAGGUGAUCCACCCGCCUCAGCCUCCAAAGUGCUGGGAUUAUAGGCGUGAGCCACCGCAGUUGGCUGAAUCAACUGUUUUACAUUAUGUAACAUCACUUUUUGUUCCUGUGAUUUUCUUUGCUCUUAAGUGUACUUUGUCUGCUAUUAACAUAGCCAUUCCAGUUUUCUUUUGACUAGUAUUUGCAUAGUAUGCAUUUUCACAUCCUUUAAGUCCUAGCCUCACCUCAUUAUAUUUGAAAUGGAAAGCAUUUAUACUCAGAAGCUGGAGUUCCUUUUCCCUAGCUCUUCCCUUUCCAGAAUUGUUACCUGUUGUUUCAGUGUUCCUAGUUGCCCUGGGCUUCAUCCCUUGUUUCUCAGUCCAGAAAGAUGGAAGGAGUUGUAUUAGAAUUUUAGCAGCCACUUUCUGCACUGUAGCUCUGACCUACCAUUGGAAUAAAGCUAUUUAUUCCUUGUUGGUGCCUUUCCCCAAAUAUUGACUCCCGUUCCAGAAUCUAUUUUCUUUUAUCCCAUUUCCCAAGUAGUUUUUUUUCCCCAUUCAAAGCUUAUAACUUGUAAGGAUUUUUUGUUUGUUUGUUUUGUUGUGUUGUGGUGAGUUCACUCUGCUAGGAGCUUACUCCUUCAUAAUAAAAGCACGACUCCUUCUCUUUCGUUUUGAAGGAUAAUUUUCCAAAAUGUAGAAUUCUAGCUUUGCAUUUUUCUUUUAACCUUUUGGAGAUGUCAUUCCACUUUGGAGGGCGGGUGAGUUUCUCAUGACAAUUCAGUCAUCAUUUUCUUAUUGUGGUUCCAUUUAAGGCAAUAUCUGUUUAUGUCUUGCUGCUUUUAUAAUUUCUUCAUUCUUUUUCAUGAAUUUAACUUUUAUAAACUUCAGGUGUUUUUCUUUUAAUUUCCCUAAGUGCAUGUAGCAAAGAGAGUGCAAUAUUUGCUUUUUUUCUAUAUGCUUUAACUCUUGAUAUACUUUAUUUAUGCUAUAAUAGAAAUGUGUGUCUUCCCAAAAUUUAUAUGUUGAAAUCUUAAACCUCAAGGUGAUGGUAUUAAAAGGUUGGGGCUUUUUGGAAAGUGAUUAACCCAUAAUGGUGCCAUCCUUCAUGAAUGGGAUUAGUGUUCUCAUAAAAGAAACAGAAGGAAGUGUGUUUUCCUCUUCUGCCAUGUGAGGAUACCACGAAAAGAUACUAUCUGGGAAGCAAAUAAUUCUCUCCAGACACUGAAUCCGCUGGCACCUUGAUCUUGGACUUCCCGACCUCCAGAAUUAUGAGAAAUAAAUUUCUGUUGUUUAUAAAUCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 100049587)
SIGLEC14
sialic acid binding Ig like lectin 14
NC_000019.10
19  51643355.. 51646759
51643355.. 51646759
strand -
CCDS42604.1
MGI:2681107
ClinVar, dbVar
ENSG00000254415
uc002pxf.5
INSDC: AY854038
32926
618132
OTTHUMG00000165511
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1191 bp)
5'-ATGCTGCCCCTGCTGCTGCTGCCCCTGCTGTGGGGGGGGTCCCTGCAGGAGAAGCCAGTGTACGAGCTGCAAGTGCAGAAGTCGGTGACGGTGCAGGAGGGCCTGTGCGTCCTTGTGCCCTGCTCCTTCTCTTACCCCTGGAGATCCTGGTATTCCTCTCCCCCACTCTACGTCTACTGGTTCCGGGACGGGGAGATCCCATACTACGCTGAGGTTGTGGCCACAAACAACCCAGACAGAAGAGTGAAGCCAGAGACCCAGGGCCGATTCCGCCTCCTTGGGGATGTCCAGAAGAAGAACTGCTCCCTGAGCATCGGAGATGCCAGAATGGAGGACACGGGAAGCTATTTCTTCCGCGTGGAGAGAGGAAGGGATGTAAAATATAGCTACCAACAGAATAAGCTGAACTTGGAGGTGACAGCCCTGATAGAGAAACCCGACATCCACTTTCTGGAGCCTCTGGAGTCCGGCCGCCCCACAAGGCTGAGCTGCAGCCTTCCAGGATCCTGTGAAGCGGGACCACCTCTCACATTCTCCTGGACGGGGAATGCCCTCAGCCCCCTGGACCCCGAGACCACCCGCTCCTCGGAGCTCACCCTCACCCCCAGGCCCGAGGACCATGGCACCAACCTCACCTGTCAGGTGAAACGCCAAGGAGCTCAGGTGACCACGGAGAGAACTGTCCAGCTCAATGTCTCCTATGCTCCACAGAACCTCGCCATCAGCATCTTCTTCAGAAATGGCACAGGCACAGCCCTGCGGATCCTGAGCAATGGCATGTCGGTGCCCATCCAGGAGGGCCAGTCCCTGTTCCTCGCCTGCACAGTTGACAGCAACCCCCCTGCCTCACTGAGCTGGTTCCGGGAGGGAAAAGCCCTCAATCCTTCCCAGACCTCAATGTCTGGGACCCTGGAGCTGCCTAACATAGGAGCTAGAGAGGGAGGGGAATTCACCTGCCGGGTTCAGCATCCGCTGGGCTCCCAGCACCTGTCCTTCATCCTTTCTGTGCAGAGAAGCTCCTCTTCCTGCATATGTGTAACTGAGAAACAGCAGGGCTCCTGGCCCCTCGTCCTCACCCTGATCAGGGGGGCTCTCATGGGGGCTGGCTTCCTCCTCACCTATGGCCTCACCTGGATCTACTATACCAGGTGTGGAGGCCCCCAGCAGAGCAGGGCTGAGAGGCCTGGCTGA-3'
NCBI CDS gene sequence with introns (location: 51643355.. 51646759) (3405 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51639478.. 51646825) (7348 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51639478.. 51646825 + 1000]) (8348 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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