Protein
Protein (XP_016880141)
CLEC4H2 - Asialoglycoprotein receptor 2
Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)
ASGR2
asialoglycoprotein receptor 2
Undefined
Curated
C-type lectin
CLEC4H2
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
Gal, GalNAc
XP_016880141
433
P07307
Undefined
P07307
0.424
10.1074/jbc.273.31.19502
PFAM, InterPro
Protein sequence and protein families (fasta) (311 amino acids) Download
MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVNWVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDSDGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVCEKRRNATGEVA
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P07307-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2

(Microbial infection) Interacts with hepatitis E virus capsid protein ORF2
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
UniProt Main References (9 PubMed Identifiers)
  • Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. [3863106]
  • Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver. [1371982]
  • DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. [16625196]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. [11543633]
  • Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]
  • Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2. [27155063]
All isoforms of this gene containing a lectin domain
XP_006721587.2, XP_024306525.1, NP_550435.1, XP_005256705.1, XP_006721589.1, NP_550436.1, XP_016880140.1, XP_011522165.1, XP_011522167.1, XP_011522168.1, NP_001188281.1, XP_024306524.1, NP_001172.1, NP_550434.1, XP_016880141.1, XP_016880142.1, XP_011522166.1, XP_024306523.1, XP_011522164.2
RNA
RNA (Transcript ID: XM_017024652.2)
XM_017024652.2
asialoglycoprotein receptor 2, transcript variant X7
All isoforms of ASGR2 containing a lectin domain
753..1688 (or 7101575.. 7114240)
7101322.. 7115538
NCBI Matured mRNA sequence 1941 NTPDownload 
m7G-5')ppp(5'-CAUUUUGCUUUGCCAGUUUCUCUACUCACCUGGGCCACCACCUAGAGCAAGUUGCCUCAUCUCUCCGAGGCUCCGCUUCCGAACCCUGUGAAAUGGGAGUAACAGAAGUCCUGCCUCGUGGGGGUGUUGUGCUGUGAUAAAUGAAGAAACACCUUGGAGAAUUUAGGGCAGUGGCUGGGCCUGAGGACAGUGUUUGUGUUGCCUGGGCUGGGGCAGGGUCUGGGCCGGACGGGGCUCUCUGAGGUUGGAUUCCUCCUGCGAGGAGAGCUGUUUUUCUGCAAAGCCCCUUCCUCCUCCUGCUGAAGCUUCUGGAUUUGAGAGGCUUUACUCUCCAGGAGAGUGAAGCGAGUUGGGCCAGAGCUGAGAGUCUGGUGGCCGAGCCCACAGGAAGCUGGGGUCUGUGGUUCAGAUGCCGGAUUGGGCAAGAGUAGAGAACUGGUCGCUGUGAUCCUGGUCAGGGAUAUUUGGAGACACCCACAGUUCUGUCCCAGGCCAGGAGGUGCCAGGUUAGAGCUUGGACACUCAGACCCUCCAGUGCAGGCCUUGCCCGGACCAGCCCCUCCUCCACUCUCCUCUCCCCUGUGAGCUCCACCUGCCCCAGUUCUCCUGGCUUUAACCCCUCCUUGGCCAAGGCCAGGGUUGCCUGCGGGAGCCAGGUGUCCGCUCUCCACACCUUUCACAGCCCCAGCCCUCAGAGCAACCUCAGCCCAGCCCAGCCCAGCUCCAGCUCCAGCUCCAGCCCGGGCCCCAUCAUGGCCAAGGACUUUCAAGAUAUCCAGCAGCUGAGCUCGGAGGAAAAUGACCAUCCUUUCCAUCAAGGUGAGGGGCCAGGCACUCGCAGGCUGAAUCCCAGGAGAGGAAAUCCAUUUUUGAAAGGGCCACCUCCUGCCCAGCCCCUGGCACAGCGUCUCUGCUCCAUGGUCUGCUUCAGUCUGCUUGCCCUGAGCUUCAACAUCCUGCUGCUGGUGGUCAUCUGUGUGACUGGGUCCCAAAGUGAGGGUCACGGGGGUGCACAGCUGCAAGCCGAGCUGCGGAGCCUGAAGGAAGCUUUCAGCAACUUCUCCUCGAGCACCCUGACGGAGGUCCAGGCAAUCAGCACCCACGGAGGCAGCGUGGGUGACAAGAUCACAUCCCUAGGAGCCAAGCUGGAGAAACAGCAGCAGGACCUGAAAGCAGAUCACGAUGCCCUGCUCUUCCAUCUGAAGCACUUCCCCGUGGACCUGCGCUUCGUGGCCUGCCAGAUGGAGCUCCUCCACAGCAACGGCUCCCAAAGGACCUGCUGCCCCGUCAACUGGGUGGAGCACCAAGGCAGCUGCUACUGGUUCUCUCACUCCGGGAAGGCCUGGGCUGAGGCGGAGAAGUACUGCCAGCUGGAGAACGCACACCUGGUGGUCAUCAACUCCUGGGAGGAGCAGAAAUUCAUUGUACAACACACGAACCCCUUCAAUACCUGGAUAGGUCUCACGGACAGUGAUGGCUCUUGGAAAUGGGUGGAUGGCACAGACUAUAGGCACAACUACAAGAACUGGGCUGUCACUCAGCCAGAUAAUUGGCACGGGCACGAGCUGGGUGGAAGUGAAGACUGUGUUGAAGUCCAGCCGGAUGGCCGCUGGAACGAUGACUUCUGCCUGCAGGUGUACCGCUGGGUGUGUGAGAAAAGGCGGAAUGCCACCGGCGAGGUGGCCUGACCCCAGCACACCUCUGGCUAACCCAUACCCCACACCUGCCCAGCUCUGGCUUCUCUGUUGAGGAUUUUGAGGAAAGGAAGAAACACUGAGACAGGGGUAUGGGGAAGAGCUGAGCAAAGAGAGAAAGGAGGUAGUUUAAGAGUCCCUGACCCUGGAGGACUGAGAUCCCACCUCCUUCUGUAAUUCAUUGUAAUUAUUAUAAUCGUCAGCCUCUUCAAUGGCGUAGGAAAGAAGAAACAAAUGCUUGAAUCUC-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 433)
ASGR2
asialoglycoprotein receptor 2
NC_000017.11
17  7101575.. 7114240
7101575.. 7114240
strand -
MGI:88082
ClinVar, dbVar
ENSG00000161944
CLEC4H2
uc002geq.4
INSDC: M11025
743
108361
OTTHUMG00000102158
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (936 bp)
5'-ATGGCCAAGGACTTTCAAGATATCCAGCAGCTGAGCTCGGAGGAAAATGACCATCCTTTCCATCAAGGTGAGGGGCCAGGCACTCGCAGGCTGAATCCCAGGAGAGGAAATCCATTTTTGAAAGGGCCACCTCCTGCCCAGCCCCTGGCACAGCGTCTCTGCTCCATGGTCTGCTTCAGTCTGCTTGCCCTGAGCTTCAACATCCTGCTGCTGGTGGTCATCTGTGTGACTGGGTCCCAAAGTGAGGGTCACGGGGGTGCACAGCTGCAAGCCGAGCTGCGGAGCCTGAAGGAAGCTTTCAGCAACTTCTCCTCGAGCACCCTGACGGAGGTCCAGGCAATCAGCACCCACGGAGGCAGCGTGGGTGACAAGATCACATCCCTAGGAGCCAAGCTGGAGAAACAGCAGCAGGACCTGAAAGCAGATCACGATGCCCTGCTCTTCCATCTGAAGCACTTCCCCGTGGACCTGCGCTTCGTGGCCTGCCAGATGGAGCTCCTCCACAGCAACGGCTCCCAAAGGACCTGCTGCCCCGTCAACTGGGTGGAGCACCAAGGCAGCTGCTACTGGTTCTCTCACTCCGGGAAGGCCTGGGCTGAGGCGGAGAAGTACTGCCAGCTGGAGAACGCACACCTGGTGGTCATCAACTCCTGGGAGGAGCAGAAATTCATTGTACAACACACGAACCCCTTCAATACCTGGATAGGTCTCACGGACAGTGATGGCTCTTGGAAATGGGTGGATGGCACAGACTATAGGCACAACTACAAGAACTGGGCTGTCACTCAGCCAGATAATTGGCACGGGCACGAGCTGGGTGGAAGTGAAGACTGTGTTGAAGTCCAGCCGGATGGCCGCTGGAACGATGACTTCTGCCTGCAGGTGTACCGCTGGGTGTGTGAGAAAAGGCGGAATGCCACCGGCGAGGTGGCCTGA-3'
NCBI CDS gene sequence with introns (location: 7101575.. 7114240) (12666 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 7101322.. 7115538) (14217 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [7101322.. 7115538 + 1000]) (15217 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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