NCBI Summary
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008].
Protein
Protein (NP_997228)
DNGR - C-type lectin domain containing 9A
C-type lectin domain family 9 member A (CD antigen CD370)
CLEC9A
C-type lectin domain containing 9A
Very low evidence
C-type lectin
Undefined
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
MHEEEIYTSLQWDSPAPDTYQKCLSSNKCSGACCLVMVISCVFCMGLLTASIFLGVKLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFITGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNSLLSSNCSTWKYFICEKYALRSSV
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study. [34415004]
- The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens. [33349708]
- CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra. [29065139]
- A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy. [27250027]
- BDCA3(+)CLEC9A(+) human dendritic cell function and development. [24910448]
- Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. [19219027]
- The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. [18669894]
- CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. [18408006]
- Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. [18497879]
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
UniProt Main References (1 PubMed Identifiers)
- The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. [22483802]
RNA
RNA (Transcript ID: NM_207345.4)
m7G-5')ppp(5'-GUACCCGGCUGUGGCAAUCUGUGGUGAAGUUGAAAUGCUUUUCUGCUAGACUGGCAACAUGUUUUGAUUCUUCUCAAAUAACUCGCAAGCUCUUGUGAAGCACAACGGCCUACCUUGUCCUGAAGAAAACAUACUCUAAGGCCCACAGAUGAUUAAACCCAGCCAUUUAUGUGACAAUAGCAUUUUUAUUUUUCUUAUCAAGAUCUGGGUAUUUGAUCCACACAAUGGUAAAGAUUCCCAUGUUAGCCAAGAUCUAAAUGAUUCAAACUGAUGAUACUCUCUGCAGAAGAGGUGACUAUAAACGCAGCCCCUGUGAUGCCAACUGGACAUAUUAUGGAGAUAGCUGCUAUGGGUUCUUCAAACACAACUUGACAUGGAAAGAGAGUGAGCAGUACUGCACUGACAUGAAGGCUACUCUCCUGAAGACUGACAACCAGAACAUUCUGUGGAUAGAAGUCAAGGGCUCCAAUGUCUCCCAAGACGAAAGAAUCCCAAGUCUCAUUUGGAGGAAUGCUAUCACUAACUAGGAUUCCUGGAGCUAAAACAUUAUAGGAGUUACUUGUUCCAGCCUCCUGUGUGGACUGCUUUCCUAUCAAAGCACCUUAGACAUGCACGAGGAAGAAAUAUACACCUCUCUUCAGUGGGAUAGCCCAGCACCAGACACUUACCAGAAAUGUCUGUCUUCCAACAAAUGUUCAGGAGCAUGCUGUCUUGUGAUGGUGAUUUCAUGUGUUUUCUGCAUGGGAUUAUUAACAGCAUCCAUUUUCUUGGGCGUCAAGUUGUUGCAGGUGUCCACCAUUGCGAUGCAGCAGCAAGAAAAACUCAUCCAACAAGAGAGGGCACUGCUAAACUUUACAGAAUGGAAGAGAAGCUGUGCCCUUCAGAUGAAAUAUUGCCAAGCCUUCAUGCAAAACUCAUUAAGUUCAGCCCAUAACAGCAGUCCUUGUCCAAACAAUUGGAUUCAGAACAGAGAAAGUUGUUACUAUGUCUCUGAAAUUUGGAGCAUUUGGCACACCAGUCAAGAGAAUUGUUUAAAGGAAGGUUCCACGCUGCUACAAAUAGAGAGCAAAGAAGAAAUGGAUUUUAUCACUGGCAGCUUGAGGAAGAUUAAAGGAAGCUAUGAUUACUGGGUGGGGUUGUCUCAGGAUGGACACAGCGGACGCUGGCUUUGGCAAGAUGGCUCCUCUCCUUCUCCUGGCCUGUUGCCAGCAGAGAGAUCCCAGUCAGCUAACCAAGUCUGUGGAUACGUGAAAAGCAAUUCCCUUCUUUCGUCUAACUGCAGCACGUGGAAGUAUUUUAUCUGUGAGAAGUAUGCGUUGAGAUCCUCUGUCUGAAAGAAAUUGUGUUCAAAGUGUUCUAUUACACUGUUAUUUGGAGCAUGCCAUUGGAAAACCCACCCCCACCCCCCCUCAAAAAAACAGAACAGUAAACCAAAAUGUGGGCCAUGAAAUUAGCAACCUGGGACUCAAUAAUACACUUGGGAAUAUUCUUCCACACCGUCCAGAUUUCAUUUGAUGUUGUUCACAUUGCAAGAGUAAAACUUAUUUAGAGCUACAGAAGACAAAACCCUGAAGAGUUAAGAACAAACGCAAGGAAAUAAUUUUUAUUGUUUAAAGCCCGGAAUGACUGUAACUUUCACACAAGGUACGCAUCUAUGUUUUUGGGGGAGGUGAUGUAGUUACAGCUGACUAAUAUUUUUAAAAUAAAUAAAUAAAUUUGGCCUUUAAAACUCA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 283420)
C-type lectin domain containing 9A
strand +
UNQ9341, HEEE9341, CD370, DNGR-1
NCBI CDS gene sequence (726 bp)
5'-ATGCACGAGGAAGAAATATACACCTCTCTTCAGTGGGATAGCCCAGCACCAGACACTTACCAGAAATGTCTGTCTTCCAACAAATGTTCAGGAGCATGCTGTCTTGTGATGGTGATTTCATGTGTTTTCTGCATGGGATTATTAACAGCATCCATTTTCTTGGGCGTCAAGTTGTTGCAGGTGTCCACCATTGCGATGCAGCAGCAAGAAAAACTCATCCAACAAGAGAGGGCACTGCTAAACTTTACAGAATGGAAGAGAAGCTGTGCCCTTCAGATGAAATATTGCCAAGCCTTCATGCAAAACTCATTAAGTTCAGCCCATAACAGCAGTCCTTGTCCAAACAATTGGATTCAGAACAGAGAAAGTTGTTACTATGTCTCTGAAATTTGGAGCATTTGGCACACCAGTCAAGAGAATTGTTTAAAGGAAGGTTCCACGCTGCTACAAATAGAGAGCAAAGAAGAAATGGATTTTATCACTGGCAGCTTGAGGAAGATTAAAGGAAGCTATGATTACTGGGTGGGGTTGTCTCAGGATGGACACAGCGGACGCTGGCTTTGGCAAGATGGCTCCTCTCCTTCTCCTGGCCTGTTGCCAGCAGAGAGATCCCAGTCAGCTAACCAAGTCTGTGGATACGTGAAAAGCAATTCCCTTCTTTCGTCTAACTGCAGCACGTGGAAGTATTTTATCTGTGAGAAGTATGCGTTGAGATCCTCTGTCTGA-3'
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