NCBI Summary
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008].
Protein
Protein (NP_997228)
DNGR - C-type lectin domain containing 9A
C-type lectin domain family 9 member A (CD antigen CD370)
CLEC9A
C-type lectin domain containing 9A
CD370
Very low evidence
C-type lectin
Undefined
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Uncharacterised
NP_997228
283420
Q6UXN8
ENSP00000348074.1
Q6UXN8
0.346
Undefined
PFAM, InterPro
Protein sequence and protein families (fasta) (241 amino acids) Download
MHEEEIYTSLQWDSPAPDTYQKCLSSNKCSGACCLVMVISCVFCMGLLTASIFLGVKLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFITGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNSLLSSNCSTWKYFICEKYALRSSV
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q6UXN8-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Homodimer. Source: UniProt
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study. [34415004]
  • The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens. [33349708]
  • CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra. [29065139]
  • A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy. [27250027]
  • BDCA3(+)CLEC9A(+) human dendritic cell function and development. [24910448]
  • Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. [19219027]
  • The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. [18669894]
  • CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. [18408006]
  • Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. [18497879]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
UniProt Main References (1 PubMed Identifiers)
  • The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. [22483802]
RNA
RNA (Transcript ID: NM_207345.4)
NM_207345.4
C-type lectin domain containing 9A
All isoforms of CLEC9A containing a lectin domain
ENST00000355819.6
609..1334 (or 10052688.. 10065632)
10030682.. 10066031
NCBI Matured mRNA sequence 1733 NTPDownload 
m7G-5')ppp(5'-GUACCCGGCUGUGGCAAUCUGUGGUGAAGUUGAAAUGCUUUUCUGCUAGACUGGCAACAUGUUUUGAUUCUUCUCAAAUAACUCGCAAGCUCUUGUGAAGCACAACGGCCUACCUUGUCCUGAAGAAAACAUACUCUAAGGCCCACAGAUGAUUAAACCCAGCCAUUUAUGUGACAAUAGCAUUUUUAUUUUUCUUAUCAAGAUCUGGGUAUUUGAUCCACACAAUGGUAAAGAUUCCCAUGUUAGCCAAGAUCUAAAUGAUUCAAACUGAUGAUACUCUCUGCAGAAGAGGUGACUAUAAACGCAGCCCCUGUGAUGCCAACUGGACAUAUUAUGGAGAUAGCUGCUAUGGGUUCUUCAAACACAACUUGACAUGGAAAGAGAGUGAGCAGUACUGCACUGACAUGAAGGCUACUCUCCUGAAGACUGACAACCAGAACAUUCUGUGGAUAGAAGUCAAGGGCUCCAAUGUCUCCCAAGACGAAAGAAUCCCAAGUCUCAUUUGGAGGAAUGCUAUCACUAACUAGGAUUCCUGGAGCUAAAACAUUAUAGGAGUUACUUGUUCCAGCCUCCUGUGUGGACUGCUUUCCUAUCAAAGCACCUUAGACAUGCACGAGGAAGAAAUAUACACCUCUCUUCAGUGGGAUAGCCCAGCACCAGACACUUACCAGAAAUGUCUGUCUUCCAACAAAUGUUCAGGAGCAUGCUGUCUUGUGAUGGUGAUUUCAUGUGUUUUCUGCAUGGGAUUAUUAACAGCAUCCAUUUUCUUGGGCGUCAAGUUGUUGCAGGUGUCCACCAUUGCGAUGCAGCAGCAAGAAAAACUCAUCCAACAAGAGAGGGCACUGCUAAACUUUACAGAAUGGAAGAGAAGCUGUGCCCUUCAGAUGAAAUAUUGCCAAGCCUUCAUGCAAAACUCAUUAAGUUCAGCCCAUAACAGCAGUCCUUGUCCAAACAAUUGGAUUCAGAACAGAGAAAGUUGUUACUAUGUCUCUGAAAUUUGGAGCAUUUGGCACACCAGUCAAGAGAAUUGUUUAAAGGAAGGUUCCACGCUGCUACAAAUAGAGAGCAAAGAAGAAAUGGAUUUUAUCACUGGCAGCUUGAGGAAGAUUAAAGGAAGCUAUGAUUACUGGGUGGGGUUGUCUCAGGAUGGACACAGCGGACGCUGGCUUUGGCAAGAUGGCUCCUCUCCUUCUCCUGGCCUGUUGCCAGCAGAGAGAUCCCAGUCAGCUAACCAAGUCUGUGGAUACGUGAAAAGCAAUUCCCUUCUUUCGUCUAACUGCAGCACGUGGAAGUAUUUUAUCUGUGAGAAGUAUGCGUUGAGAUCCUCUGUCUGAAAGAAAUUGUGUUCAAAGUGUUCUAUUACACUGUUAUUUGGAGCAUGCCAUUGGAAAACCCACCCCCACCCCCCCUCAAAAAAACAGAACAGUAAACCAAAAUGUGGGCCAUGAAAUUAGCAACCUGGGACUCAAUAAUACACUUGGGAAUAUUCUUCCACACCGUCCAGAUUUCAUUUGAUGUUGUUCACAUUGCAAGAGUAAAACUUAUUUAGAGCUACAGAAGACAAAACCCUGAAGAGUUAAGAACAAACGCAAGGAAAUAAUUUUUAUUGUUUAAAGCCCGGAAUGACUGUAACUUUCACACAAGGUACGCAUCUAUGUUUUUGGGGGAGGUGAUGUAGUUACAGCUGACUAAUAUUUUUAAAAUAAAUAAAUAAAUUUGGCCUUUAAAACUCA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 283420)
CLEC9A
C-type lectin domain containing 9A
NC_000012.12
12  10052688.. 10065632
10052688.. 10065632
strand +
CCDS8611.1
MGI:2444608
ClinVar, dbVar
ENSG00000197992
UNQ9341, HEEE9341, CD370, DNGR-1
uc001qxa.4
INSDC:
26705
612252
OTTHUMG00000168398
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (726 bp)
5'-ATGCACGAGGAAGAAATATACACCTCTCTTCAGTGGGATAGCCCAGCACCAGACACTTACCAGAAATGTCTGTCTTCCAACAAATGTTCAGGAGCATGCTGTCTTGTGATGGTGATTTCATGTGTTTTCTGCATGGGATTATTAACAGCATCCATTTTCTTGGGCGTCAAGTTGTTGCAGGTGTCCACCATTGCGATGCAGCAGCAAGAAAAACTCATCCAACAAGAGAGGGCACTGCTAAACTTTACAGAATGGAAGAGAAGCTGTGCCCTTCAGATGAAATATTGCCAAGCCTTCATGCAAAACTCATTAAGTTCAGCCCATAACAGCAGTCCTTGTCCAAACAATTGGATTCAGAACAGAGAAAGTTGTTACTATGTCTCTGAAATTTGGAGCATTTGGCACACCAGTCAAGAGAATTGTTTAAAGGAAGGTTCCACGCTGCTACAAATAGAGAGCAAAGAAGAAATGGATTTTATCACTGGCAGCTTGAGGAAGATTAAAGGAAGCTATGATTACTGGGTGGGGTTGTCTCAGGATGGACACAGCGGACGCTGGCTTTGGCAAGATGGCTCCTCTCCTTCTCCTGGCCTGTTGCCAGCAGAGAGATCCCAGTCAGCTAACCAAGTCTGTGGATACGTGAAAAGCAATTCCCTTCTTTCGTCTAACTGCAGCACGTGGAAGTATTTTATCTGTGAGAAGTATGCGTTGAGATCCTCTGTCTGA-3'
NCBI CDS gene sequence with introns (location: 10052688.. 10065632) (12945 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 10030682.. 10066031) (35350 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [10030682 - 1000].. 10066031) (36350 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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