HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

Protein

Protein (NP_963837)

Protein name

Galectin 8

Synonym(s)

Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)

HGNC gene name

LGALS8

HGNC name

galectin 8

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

galectin-like

Known lectin group

S-Type Lectins - Tandem repeat

Lectin fold

b-sandwich / ConA-like

Glycan specificity

Gal / Gal(b1-4)GlcNAc / Nter : NeuAc(a2-3)Gal(b1-4)GlcNAc

RefSeq accession

NP_963837

Gene ID

3964

UniProt accession

O00214

Ensembl protein ID

Undefined

UniRef cluster ID

O00214

LectomeXplore score

0.542

Reference

10.1111/j.1742-4658.2012.08753.x

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (317 amino acids) Download

MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-O00214-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand

Glycan ligands from structural data

Name

lactose, bGal14Glc, lactose 3-sulfate, Galb14Glc

IUPAC

Gal(b1-4)Glc

PDB

2YXS, 3AP4, 3AP6, 3VKL, 4BMB, 4BME, 5GZD, 5GZE, 5GZF, 5GZG, 5T7S

UniLectin3D

2YXS, 3AP4, 3AP6, 3VKL, 4BMB, 4BME, 5GZD, 5GZE, 5GZF, 5GZG, 5T7S

Parent structures

GlyConnect Structures

Name

bGal14bGlcNAc13bGal14Glc

IUPAC

Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc

PDB

5T7I

UniLectin3D

5T7I

Parent structures

GlyConnect Structures

Name

aNeuAc23bGal14GlcNAc

IUPAC

NeuAc(a2-3)Gal(b1-4)GlcNAc

PDB

3VKO

UniLectin3D

3VKO

Parent structures

GlyConnect Structures

Name

bGal13Glc

IUPAC

Gal(b1-3)Glc

PDB

5T7T

UniLectin3D

5T7T

Parent structures

GlyConnect Structures

Name

aNeuAc23bGal14Glc, aNeuAc3bGal14Glc

IUPAC

NeuAc(a2-3)Gal(b1-4)Glc

PDB

3AP7, 3VKM

UniLectin3D

3AP7, 3VKM

Parent structures

GlyConnect Structures

Name

Lacto-N-fucopentaose III

IUPAC

Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc

PDB

3AP9

UniLectin3D

3AP9

Parent structures

GlyConnect Structures

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for LGALS8 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Galectin-8 Is Upregulated in Keratinocytes by IL-17A and Promotes Proliferation by Regulating Mitosis in Psoriasis. [32805218]

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. [32915505]

Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts. [32449990]

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. [32814053]

A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1. [32209695]

Galectin-8: a complex sub-family of galectins (Review). [11494049]

Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. [10980616]

Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. [10852818]

Expression of Po66-CBP, a type-8 galectin, in different healthy, tumoral and peritumoral tissues. [10697573]

Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. [8692978]

UniProt Main References (6 PubMed Identifiers)

The DNA sequence and biological annotation of human chromosome 1. [16710414]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. [19268462]

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. [22246324]

PLA2G16 represents a switch between entry and clearance of Picornaviridae. [28077878]

Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. [21288902]

All isoforms of this gene containing a lectin domain

NP_006490.3, NP_963839.1, NP_963837.1, NP_963838.1, XP_011542490.1, XP_016856763.1, XP_016856764.1

RNA

RNA (Transcript ID: NM_201543.4)

RNA RefSeq ID

NM_201543.4

RNA name

galectin 8, transcript variant 2

Isoforms

All isoforms of LGALS8 containing a lectin domain

RNA Ensembl ID

Coding region

223..1176 (or 236526071.. 236548161)

mRNA location

236523598.. 236552981

NCBI Matured mRNA sequence 5996 NTP Download

m⁷G-5')ppp(5'-CUAGACCUGGAGGCCUGGAACAGCCAGCCGCCCACGGACGCCAGAGCCGGGAACCCUGACGGCACUUAGCUGCUGACAAACAACCUGCUCCGUGGAGCGCCUGAAACACCAGUCUUUGGGGCCAGUGCCUCAGUUUCAAUCCAGGUAACCUUUAAAUGAAACUUGCCUAAAAUCUUAGGUCAUACACAGAAGAGACUCCAAUCGACAAGAAGCUGGAAAAGAAUGAUGUUGUCCUUAAACAACCUACAGAAUAUCAUCUAUAACCCGGUAAUCCCGUUUGUUGGCACCAUUCCUGAUCAGCUGGAUCCUGGAACUUUGAUUGUGAUACGUGGGCAUGUUCCUAGUGACGCAGACAGAUUCCAGGUGGAUCUGCAGAAUGGCAGCAGCAUGAAACCUCGAGCCGAUGUGGCCUUUCAUUUCAAUCCUCGUUUCAAAAGGGCCGGCUGCAUUGUUUGCAAUACUUUGAUAAAUGAAAAAUGGGGACGGGAAGAGAUCACCUAUGACACGCCUUUCAAAAGAGAAAAGUCUUUUGAGAUCGUGAUUAUGGUGCUGAAGGACAAAUUCCAGGUGGCUGUAAAUGGAAAACAUACUCUGCUCUAUGGCCACAGGAUCGGCCCAGAGAAAAUAGACACUCUGGGCAUUUAUGGCAAAGUGAAUAUUCACUCAAUUGGUUUUAGCUUCAGCUCGGACUUACAAAGUACCCAAGCAUCUAGUCUGGAACUGACAGAGAUAAGUAGAGAAAAUGUUCCAAAGUCUGGCACGCCCCAGCUUAGGCUGCCAUUCGCUGCAAGGUUGAACACCCCCAUGGGCCCUGGACGAACUGUCGUCGUUAAAGGAGAAGUGAAUGCAAAUGCCAAAAGCUUUAAUGUUGACCUACUAGCAGGAAAAUCAAAGGAUAUUGCUCUACACUUGAACCCACGCCUGAAUAUUAAAGCAUUUGUAAGAAAUUCUUUUCUUCAGGAGUCCUGGGGAGAAGAAGAGAGAAAUAUUACCUCUUUCCCAUUUAGUCCUGGGAUGUACUUUGAGAUGAUAAUUUAUUGUGAUGUUAGAGAAUUCAAGGUUGCAGUAAAUGGCGUACACAGCCUGGAGUACAAACACAGAUUUAAAGAGCUCAGCAGUAUUGACACGCUGGAAAUUAAUGGAGACAUCCACUUACUGGAAGUAAGGAGCUGGUAGCCUACCUACACAGCUGCUACAAAAACCAAAAUACAGAAUGGCUUCUGUGAUACUGGCCUUGCUGAAACGCAUCUCACUGUCAUUCUAUUGUUUAUAUUGUUAAAAUGAGCUUGUGCACCAUUAGGUCCUGCUGGGUGUUCUCAGUCCUUGCCAUGAAGUAUGGUGGUGUCUAGCACUGAAUGGGGAAACUGGGGGCAGCAACACUUAUAGCCAGUUAAAGCCACUCUGCCCUCUCUCCUACUUUGGCUGACUCUUCAAGAAUGCCAUUCAACAAGUAUUUAUGGAGUACCUACUAUAAUACAGUAGCUAACAUGUAUUGAGCACAGAUUUUUUUUGGUAAAACUGUGAAGAGCUAGGAUAUAUACUUGGUGAAACAAACCAGUAUGUUCCCUGUUCUCUUGAGCUUCGACUCUUCUGUGCGCUACUGCUGCGCACUGCUUUUUCUACAGGCAUUACAUCAACUCCUAAGGGGUCCUCUGGGAUUAGUUAUGCAGAUAUUAAAUCACCCGAAGACACUAACUUACAGAAGACACAACUCCUUCCCCAGUGAUCACUGUCAUAACCAGUGCUCUACCGUAUCCCAUCACUGAGGACUGAUGUUGACUGACAUCAUUUUCUUUAUCGUAAUAAACAUGUGGCUCUAUUAGCUGCAAGCUUUACCAAGUAAUUGGCAUGACAUCUGAGCACAGAAAUUAAGGCAAAAAACCAAAGCAAAACAAAUACAUGGUGCUGAAAUUAACUUGAUGCCAAGCCCAAGGCAGCUGAUUUCUGUGUAUUUGAACUUAGGGCAAAUCAGAGUCUACACAGACGCCUACAGAAAGUUUCAGGAAGAGGCAAGAUGCAUUCAAUUUGAAAGAUAUUUAUGGGCAACAAAGUAAGGUCAGGAUUAGACUUCAGGCAUUCAUAAGGCAGGCACUAUCAGAAAGUGUACGCCAACUAAGGGACCCACAAAGCAGGCAGAGGUAAUGCAGAAAUCUGUUUUGUUCCCAUGAAAUCACCAAUCAAGGCCUCCGUUCUUCUAAAGAUUAGUCCAUCAUCAUUAGCAACUGAGAUCAAAGCACUCUUCCACUUUACGUGAUUAAAAUCAAACCUGUAUCAGCAAGUUAAAUGGUUCCAUUUCUGUGAUUUUUCUAUUAUUUGAGGGGAGUUGGCAGAAGUUCCAUGUAUAUGGGAUCUUUACAGGUCAGAUCUUGUUACAGGAAAUUUCAAAGGUUUGGGAGUGGGGAGGGAAAAAAGCUCAGUCAGUGAGGAUCAUUUUAUCACAUUAGACUGGGGCAGAACUCUGCCAGGAUUUAGGAAUAUUUUCAGAACAGAUUUUAGAUAUUAUUUCUAUCCAUAUAUUGAAAAGAAUACCAUUGUCAAUCUUAUUUUUUUAAAAGUACUCAGUGUAGAAAUCGCUAGCCCUUAAUUCUUUUCCAGCUUUUCAUAUUAAUGUAUGCAGAGUCUCACCAAGCUCAAAGACACUGGUUGGGGGUGGAGGGUGCCACAGGGAAAGCUGUAGAAGGCAAGAAGACUCGAGAAUCCCCCAGAGUUAUUUUUCUCCAUAAAGACCAUCAGAGUGCUUAACUGAGCUGUUGGAGACUGUGAGGCAUUUAGGAAAAAAAUAGCCCACUCACAUCAUUCCUUGUAAGUCUUAAGUUCAUUUUCAUUUUACGUGGAGGAAAAAAAUUUAAAAAGCUAUUAGUAUUUAUUAAUGAAUUUUACUGAGACAUUUCUUAGAAAUAUGCACUUCUAUACUAGCAAGCUCUGUCUCUAAAAUGCAAGUUGGCCUUUUGCUUGCCACAUUUCUGCAUUAAACUUCUAUAUUAGCUUCAAAGGCUUUUAAACUCAAUGCGAACAUUCUACGGGAUGUUCUUAGAUGCCUUUAAAAAGGGGGCAGAUCUAAUUUUAUUUGAACCCUCACUUUCCAACUUCACCAUGACCCAGUACUAGAGAUUAGGGCACUUCAAAGCAUUGAAAAAAAUCUACUGAUACUUACUUUCUUAGACAAGUAGUUCUUAGUUAACCACCAAUGGAACUGGGUUCAUUCUGAAUCCUGGAGGAGCUUCCUCGUGCCACCCAGUGUUUCUGGGCCCUCUGUGUGAGCAGCCAGGUGUGAGCUGUUUUAGAAGCAGCGUGUUGCCUUCAUCUCUCCCGUUUCCCAAAAGAACAAAGGAUAAAGGUGACAGUCACACUCCUGGGUUAAAAAAAGCAUUCCAGAACCACUUCUCUUUAUGGGCACAACAAAGAAACGAAGGCUGAAGUUCGCCUACCCAAAAUGAAAAGUAGGCUUUACAGUCAAAAGUACUUCUGUUGAUUGCUAAAUAACUUCAUUUUCUUGAAAUAGAGCAACUUUGAGUGAAAUCUGCAACAUGGAUACCAUGUAUGUAAGAUACUGCUGUACAGAAGAGUUAAGGCUUACAGUGCAAAUGAGGCGUCAGCUUUGGGUGCUAAAAUUAACAAGUCUAAUAUUAUUACCAUCAAUCAGGAAGAGAAUAAUAAAUGUUUAAACAAACACAGCAGUCUGUAUAAAAAUACCGUGUAUCAUUUACUCUUUCUGCAGCUCUAUACGAUAGGCAGGAGAGGCUUAUGUGGCAGCACAAGCCAGGUGGGGAUUUUGUAAAGAAGUGAUAAAACAUUUGUAAGUAAUCCAAGUAGGUGUAUUAAGGCACCAAAAGUAACAUGGCACCCAACACCCAAAAAUAAAAAUAUGAAAUAUGAGUGUGAACUCUGAGUAGAGUAUGAAACACCACAGAAAGUCUUAGAAAUAGCUCUGGAGUGGCUCUCCCAGGACAGUUUCCAGUUGCUGAAUAGUCUUUUGGCACUGAUGUUCUACUUCUUCACAUUCAUCUAAAAAAAAAAAAAAAAAAUCAAAAUUAAAAUCUGAGUCAGUCCGCCUGCCUCGGUUCUCAUUAGUUUAAUUCUUAAUGCCUUGCACUUUCCGGCAAUCAUUCAAUCAAAAGAGUGAAAUGAAGCACAUUAACAAAGCAGGAGGCGCCACGGACCGCCUCCCUCCACACCGCUCCUUCCGCCUUCAUUCCUUGCCCACAGGCUUGCACUGGAAGCUGAAUAAGAAUCCCCAAAACUCAAACUUCCUAGGGAUGCCACCCCUUUAGUAGCUCACACCUCCCCCCUCCAAGAGCUAAGAAACAAAGGAGAAUGUACUUUUGUAGCUUAGAUAAGCAAUGAAUCAGUAAAGGACUGAUCUACUUGCUCCACCACCCCUCCCUUAAUAAUAACAUUUACUGUUAUUUCCUGGGCCUAAGACUCUAUGUUCCAGAACUGUCACAGCUCCCCAUGUCACACUCACUAGCUUGUGAUCUUUGUCAAAUAACUGAAAUCUUUUAAGCCUCUAGUUUCUUCCUUUGUAAAACAGAGAUAAAAUGUUGUGGUUUUUAAGUGAGAUAAUCCAAGUAAAGCACCUAACAUGGAGUAGUGAAUGAACAUCGGUUGCUACUAAAAGUGGACAUCCUACUGCAUCCUUAAUGCCACUAGGCAUUUCCAUACAAUCUGGGGACCAAAACUUCAAUCAUAUAAAUGUAUGAGGUUAAUUAAAAACACUACUGUAAUCUGCUUGUAUGAUCACAAACCACCACAAAAGAAAAGAUCGUGAAGAUUACACUGUAAACGGACUCUCAAAUGAUCAGGAGGUGGUCACUUCGCAACUUGCUCCCUCCACCCAACUCAAAACAGGAGCUCGAGCCUGCCUGUAUUUGAGACUGGAGCUGCCUGUAUGAGGACUGGAUCAACUGCUAGUCACGUUAUAUCCAAAUCUGCAUUAUCAUUGGGCACAUUUUCACAGAAUUUUACUGAAUUAUUCCUUAAUUGUUUAAUGGUUGGGAAUAGUUUGGGAAUUACCUUCCAUCAACUCUGCUAAGAAAGGAAUGGAUUCUGGUAGCAAGACAAUAUAAUUCUCCUUUAGUUUUUCAGCCAGUGCUAACACAGUAAUCAAAGCAGCAAAUCGAACCUGAAAGGGAUAAAAGAGCAAAGAAAUAAAAAGUAGUGUUACUGUAUUUAUUAUCUUAAGAGCUGUACUGACUUGAGACAAGCUCUAACUUUUUAAACAUUAGUUCACAUGCGUUUAUUCACUUCAUUAUGUUCAUUAAGCUUUCAUCUUAGAAUACCAGUUUCACCAUUUGGGAGCUGUUUGUAAUAUGUGCAACCUUAUAAAUAGUGUUUUCCAAACUGUGUCCCAGGACUGCAAAUCUUUAAUGUGAAAUGUCUUUUUAUAAUCUCUUCCUUUAAAAAAAACCAAUAAAAUAAAAUGCCGCAUGCAAACUCAAGUGUGUCACCAGAUUUUACUUCAUUGGCGCUCGCCAGCCCGCCAGGCUGGCAAUAAAGUGCCUCCAGCCACCUCUGGCAGGUCUCCUCACCCACAGCCCCUGACUGGUCACCACUAUAAUUGUAUGAGGGGCCAGGACAGUCGCUUGGGAUAAACUCCCAUCUCAGCACUGAAUAAAAAACAUUCUGUGUCACAAUAUCCUAGUUUUGGGGCUUUAAAAACGUCUAGGUGUUCCUCACAUGCCUUGUCUAUAAUAAGGAAAGCAAGCAGUAGUUGGGUAUUGUUAGCUUUUGAAACAAAAGCCCUACUGGUCUUCUAAUUUUGGAUAUUUUAAUUAAAGAAUAUCUGGACAGUACAAAGUGAAUUAUUAAAAAACCAUUUGUAACUACCUAGAUUCAAUCAGGAUUUCCUUGAUUUGUGCAAAGUAAAAUAUUACAAUAAAUUUGAUACUGCUACUUGUAUAAAAACCUAUGGUUUAAAAUGUGGGGGUUCAUCAUAAUAGUCUCAUUGUUAGCAUAUCCUAAUAAAGAAUUUGAACUAAUAAAUCCUAUUAAUAAAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 3964)

HGNC Gene symbol

LGALS8

HGNC Gene name

galectin 8

Chr. RefSeq ID

NC_000001.11

Chromosome N°

1 236526071.. 236548161

CDS location

236526071.. 236548161

DNA strand

strand +

CCDS ID

CCDS1612.1

Mouse ortholog gene

MGI:1928481

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000116977

HGNC other symbol

PCTA-1

UCSC ID

uc001hxy.3

GeneBank

INSDC: X91790

GeneCards

6569

MIM

606099

VEGA ID

OTTHUMG00000039953

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