NCBI Summary
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_963837)
Galectin 8
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
LGALS8
galectin 8
Undefined
Curated
Galectin
S-Type Lectins - Tandem repeat
b-sandwich / ConA-like
Gal / Gal(b1-4)GlcNAc / Nter : NeuAc(a2-3)Gal(b1-4)GlcNAc
NP_963837
3964
O00214
Undefined
O00214
0.542
10.1111/j.1742-4658.2012.08753.x
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (317 amino acids) Download
MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-O00214-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
lactose, bGal14Glc, lactose 3-sulfate, Galb14Glc
Gal(b1-4)Glc
2YXS, 3AP4, 3AP6, 3VKL, 4BMB, 4BME, 5GZD, 5GZE, 5GZF, 5GZG, 5T7S
2YXS, 3AP4, 3AP6, 3VKL, 4BMB, 4BME, 5GZD, 5GZE, 5GZF, 5GZG, 5T7S
GlyConnect Structures
bGal14bGlcNAc13bGal14Glc
Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc
5T7I
5T7I
GlyConnect Structures
aNeuAc23bGal14GlcNAc
NeuAc(a2-3)Gal(b1-4)GlcNAc
3VKO
3VKO
GlyConnect Structures
bGal13Glc
Gal(b1-3)Glc
5T7T
5T7T
GlyConnect Structures
aNeuAc23bGal14Glc, aNeuAc3bGal14Glc
NeuAc(a2-3)Gal(b1-4)Glc
3AP7, 3VKM
3AP7, 3VKM
GlyConnect Structures
Lacto-N-fucopentaose III
Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc
3AP9
3AP9
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS8 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Galectin-8 Is Upregulated in Keratinocytes by IL-17A and Promotes Proliferation by Regulating Mitosis in Psoriasis. [32805218]
  • Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. [32915505]
  • Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts. [32449990]
  • Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. [32814053]
  • A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1. [32209695]
  • Galectin-8: a complex sub-family of galectins (Review). [11494049]
  • Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. [10980616]
  • Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. [10852818]
  • Expression of Po66-CBP, a type-8 galectin, in different healthy, tumoral and peritumoral tissues. [10697573]
  • Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. [8692978]
UniProt Main References (6 PubMed Identifiers)
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. [19268462]
  • Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. [22246324]
  • PLA2G16 represents a switch between entry and clearance of Picornaviridae. [28077878]
  • Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. [21288902]
All isoforms of this gene containing a lectin domain
NP_006490.3, NP_963839.1, NP_963837.1, NP_963838.1, XP_011542490.1, XP_016856763.1, XP_016856764.1
RNA
RNA (Transcript ID: NM_201543.4)
NM_201543.4
galectin 8, transcript variant 2
All isoforms of LGALS8 containing a lectin domain
223..1176 (or 236526071.. 236548161)
236523598.. 236552981
NCBI Matured mRNA sequence 5996 NTPDownload 
m7G-5')ppp(5'-CUAGACCUGGAGGCCUGGAACAGCCAGCCGCCCACGGACGCCAGAGCCGGGAACCCUGACGGCACUUAGCUGCUGACAAACAACCUGCUCCGUGGAGCGCCUGAAACACCAGUCUUUGGGGCCAGUGCCUCAGUUUCAAUCCAGGUAACCUUUAAAUGAAACUUGCCUAAAAUCUUAGGUCAUACACAGAAGAGACUCCAAUCGACAAGAAGCUGGAAAAGAAUGAUGUUGUCCUUAAACAACCUACAGAAUAUCAUCUAUAACCCGGUAAUCCCGUUUGUUGGCACCAUUCCUGAUCAGCUGGAUCCUGGAACUUUGAUUGUGAUACGUGGGCAUGUUCCUAGUGACGCAGACAGAUUCCAGGUGGAUCUGCAGAAUGGCAGCAGCAUGAAACCUCGAGCCGAUGUGGCCUUUCAUUUCAAUCCUCGUUUCAAAAGGGCCGGCUGCAUUGUUUGCAAUACUUUGAUAAAUGAAAAAUGGGGACGGGAAGAGAUCACCUAUGACACGCCUUUCAAAAGAGAAAAGUCUUUUGAGAUCGUGAUUAUGGUGCUGAAGGACAAAUUCCAGGUGGCUGUAAAUGGAAAACAUACUCUGCUCUAUGGCCACAGGAUCGGCCCAGAGAAAAUAGACACUCUGGGCAUUUAUGGCAAAGUGAAUAUUCACUCAAUUGGUUUUAGCUUCAGCUCGGACUUACAAAGUACCCAAGCAUCUAGUCUGGAACUGACAGAGAUAAGUAGAGAAAAUGUUCCAAAGUCUGGCACGCCCCAGCUUAGGCUGCCAUUCGCUGCAAGGUUGAACACCCCCAUGGGCCCUGGACGAACUGUCGUCGUUAAAGGAGAAGUGAAUGCAAAUGCCAAAAGCUUUAAUGUUGACCUACUAGCAGGAAAAUCAAAGGAUAUUGCUCUACACUUGAACCCACGCCUGAAUAUUAAAGCAUUUGUAAGAAAUUCUUUUCUUCAGGAGUCCUGGGGAGAAGAAGAGAGAAAUAUUACCUCUUUCCCAUUUAGUCCUGGGAUGUACUUUGAGAUGAUAAUUUAUUGUGAUGUUAGAGAAUUCAAGGUUGCAGUAAAUGGCGUACACAGCCUGGAGUACAAACACAGAUUUAAAGAGCUCAGCAGUAUUGACACGCUGGAAAUUAAUGGAGACAUCCACUUACUGGAAGUAAGGAGCUGGUAGCCUACCUACACAGCUGCUACAAAAACCAAAAUACAGAAUGGCUUCUGUGAUACUGGCCUUGCUGAAACGCAUCUCACUGUCAUUCUAUUGUUUAUAUUGUUAAAAUGAGCUUGUGCACCAUUAGGUCCUGCUGGGUGUUCUCAGUCCUUGCCAUGAAGUAUGGUGGUGUCUAGCACUGAAUGGGGAAACUGGGGGCAGCAACACUUAUAGCCAGUUAAAGCCACUCUGCCCUCUCUCCUACUUUGGCUGACUCUUCAAGAAUGCCAUUCAACAAGUAUUUAUGGAGUACCUACUAUAAUACAGUAGCUAACAUGUAUUGAGCACAGAUUUUUUUUGGUAAAACUGUGAAGAGCUAGGAUAUAUACUUGGUGAAACAAACCAGUAUGUUCCCUGUUCUCUUGAGCUUCGACUCUUCUGUGCGCUACUGCUGCGCACUGCUUUUUCUACAGGCAUUACAUCAACUCCUAAGGGGUCCUCUGGGAUUAGUUAUGCAGAUAUUAAAUCACCCGAAGACACUAACUUACAGAAGACACAACUCCUUCCCCAGUGAUCACUGUCAUAACCAGUGCUCUACCGUAUCCCAUCACUGAGGACUGAUGUUGACUGACAUCAUUUUCUUUAUCGUAAUAAACAUGUGGCUCUAUUAGCUGCAAGCUUUACCAAGUAAUUGGCAUGACAUCUGAGCACAGAAAUUAAGGCAAAAAACCAAAGCAAAACAAAUACAUGGUGCUGAAAUUAACUUGAUGCCAAGCCCAAGGCAGCUGAUUUCUGUGUAUUUGAACUUAGGGCAAAUCAGAGUCUACACAGACGCCUACAGAAAGUUUCAGGAAGAGGCAAGAUGCAUUCAAUUUGAAAGAUAUUUAUGGGCAACAAAGUAAGGUCAGGAUUAGACUUCAGGCAUUCAUAAGGCAGGCACUAUCAGAAAGUGUACGCCAACUAAGGGACCCACAAAGCAGGCAGAGGUAAUGCAGAAAUCUGUUUUGUUCCCAUGAAAUCACCAAUCAAGGCCUCCGUUCUUCUAAAGAUUAGUCCAUCAUCAUUAGCAACUGAGAUCAAAGCACUCUUCCACUUUACGUGAUUAAAAUCAAACCUGUAUCAGCAAGUUAAAUGGUUCCAUUUCUGUGAUUUUUCUAUUAUUUGAGGGGAGUUGGCAGAAGUUCCAUGUAUAUGGGAUCUUUACAGGUCAGAUCUUGUUACAGGAAAUUUCAAAGGUUUGGGAGUGGGGAGGGAAAAAAGCUCAGUCAGUGAGGAUCAUUUUAUCACAUUAGACUGGGGCAGAACUCUGCCAGGAUUUAGGAAUAUUUUCAGAACAGAUUUUAGAUAUUAUUUCUAUCCAUAUAUUGAAAAGAAUACCAUUGUCAAUCUUAUUUUUUUAAAAGUACUCAGUGUAGAAAUCGCUAGCCCUUAAUUCUUUUCCAGCUUUUCAUAUUAAUGUAUGCAGAGUCUCACCAAGCUCAAAGACACUGGUUGGGGGUGGAGGGUGCCACAGGGAAAGCUGUAGAAGGCAAGAAGACUCGAGAAUCCCCCAGAGUUAUUUUUCUCCAUAAAGACCAUCAGAGUGCUUAACUGAGCUGUUGGAGACUGUGAGGCAUUUAGGAAAAAAAUAGCCCACUCACAUCAUUCCUUGUAAGUCUUAAGUUCAUUUUCAUUUUACGUGGAGGAAAAAAAUUUAAAAAGCUAUUAGUAUUUAUUAAUGAAUUUUACUGAGACAUUUCUUAGAAAUAUGCACUUCUAUACUAGCAAGCUCUGUCUCUAAAAUGCAAGUUGGCCUUUUGCUUGCCACAUUUCUGCAUUAAACUUCUAUAUUAGCUUCAAAGGCUUUUAAACUCAAUGCGAACAUUCUACGGGAUGUUCUUAGAUGCCUUUAAAAAGGGGGCAGAUCUAAUUUUAUUUGAACCCUCACUUUCCAACUUCACCAUGACCCAGUACUAGAGAUUAGGGCACUUCAAAGCAUUGAAAAAAAUCUACUGAUACUUACUUUCUUAGACAAGUAGUUCUUAGUUAACCACCAAUGGAACUGGGUUCAUUCUGAAUCCUGGAGGAGCUUCCUCGUGCCACCCAGUGUUUCUGGGCCCUCUGUGUGAGCAGCCAGGUGUGAGCUGUUUUAGAAGCAGCGUGUUGCCUUCAUCUCUCCCGUUUCCCAAAAGAACAAAGGAUAAAGGUGACAGUCACACUCCUGGGUUAAAAAAAGCAUUCCAGAACCACUUCUCUUUAUGGGCACAACAAAGAAACGAAGGCUGAAGUUCGCCUACCCAAAAUGAAAAGUAGGCUUUACAGUCAAAAGUACUUCUGUUGAUUGCUAAAUAACUUCAUUUUCUUGAAAUAGAGCAACUUUGAGUGAAAUCUGCAACAUGGAUACCAUGUAUGUAAGAUACUGCUGUACAGAAGAGUUAAGGCUUACAGUGCAAAUGAGGCGUCAGCUUUGGGUGCUAAAAUUAACAAGUCUAAUAUUAUUACCAUCAAUCAGGAAGAGAAUAAUAAAUGUUUAAACAAACACAGCAGUCUGUAUAAAAAUACCGUGUAUCAUUUACUCUUUCUGCAGCUCUAUACGAUAGGCAGGAGAGGCUUAUGUGGCAGCACAAGCCAGGUGGGGAUUUUGUAAAGAAGUGAUAAAACAUUUGUAAGUAAUCCAAGUAGGUGUAUUAAGGCACCAAAAGUAACAUGGCACCCAACACCCAAAAAUAAAAAUAUGAAAUAUGAGUGUGAACUCUGAGUAGAGUAUGAAACACCACAGAAAGUCUUAGAAAUAGCUCUGGAGUGGCUCUCCCAGGACAGUUUCCAGUUGCUGAAUAGUCUUUUGGCACUGAUGUUCUACUUCUUCACAUUCAUCUAAAAAAAAAAAAAAAAAAUCAAAAUUAAAAUCUGAGUCAGUCCGCCUGCCUCGGUUCUCAUUAGUUUAAUUCUUAAUGCCUUGCACUUUCCGGCAAUCAUUCAAUCAAAAGAGUGAAAUGAAGCACAUUAACAAAGCAGGAGGCGCCACGGACCGCCUCCCUCCACACCGCUCCUUCCGCCUUCAUUCCUUGCCCACAGGCUUGCACUGGAAGCUGAAUAAGAAUCCCCAAAACUCAAACUUCCUAGGGAUGCCACCCCUUUAGUAGCUCACACCUCCCCCCUCCAAGAGCUAAGAAACAAAGGAGAAUGUACUUUUGUAGCUUAGAUAAGCAAUGAAUCAGUAAAGGACUGAUCUACUUGCUCCACCACCCCUCCCUUAAUAAUAACAUUUACUGUUAUUUCCUGGGCCUAAGACUCUAUGUUCCAGAACUGUCACAGCUCCCCAUGUCACACUCACUAGCUUGUGAUCUUUGUCAAAUAACUGAAAUCUUUUAAGCCUCUAGUUUCUUCCUUUGUAAAACAGAGAUAAAAUGUUGUGGUUUUUAAGUGAGAUAAUCCAAGUAAAGCACCUAACAUGGAGUAGUGAAUGAACAUCGGUUGCUACUAAAAGUGGACAUCCUACUGCAUCCUUAAUGCCACUAGGCAUUUCCAUACAAUCUGGGGACCAAAACUUCAAUCAUAUAAAUGUAUGAGGUUAAUUAAAAACACUACUGUAAUCUGCUUGUAUGAUCACAAACCACCACAAAAGAAAAGAUCGUGAAGAUUACACUGUAAACGGACUCUCAAAUGAUCAGGAGGUGGUCACUUCGCAACUUGCUCCCUCCACCCAACUCAAAACAGGAGCUCGAGCCUGCCUGUAUUUGAGACUGGAGCUGCCUGUAUGAGGACUGGAUCAACUGCUAGUCACGUUAUAUCCAAAUCUGCAUUAUCAUUGGGCACAUUUUCACAGAAUUUUACUGAAUUAUUCCUUAAUUGUUUAAUGGUUGGGAAUAGUUUGGGAAUUACCUUCCAUCAACUCUGCUAAGAAAGGAAUGGAUUCUGGUAGCAAGACAAUAUAAUUCUCCUUUAGUUUUUCAGCCAGUGCUAACACAGUAAUCAAAGCAGCAAAUCGAACCUGAAAGGGAUAAAAGAGCAAAGAAAUAAAAAGUAGUGUUACUGUAUUUAUUAUCUUAAGAGCUGUACUGACUUGAGACAAGCUCUAACUUUUUAAACAUUAGUUCACAUGCGUUUAUUCACUUCAUUAUGUUCAUUAAGCUUUCAUCUUAGAAUACCAGUUUCACCAUUUGGGAGCUGUUUGUAAUAUGUGCAACCUUAUAAAUAGUGUUUUCCAAACUGUGUCCCAGGACUGCAAAUCUUUAAUGUGAAAUGUCUUUUUAUAAUCUCUUCCUUUAAAAAAAACCAAUAAAAUAAAAUGCCGCAUGCAAACUCAAGUGUGUCACCAGAUUUUACUUCAUUGGCGCUCGCCAGCCCGCCAGGCUGGCAAUAAAGUGCCUCCAGCCACCUCUGGCAGGUCUCCUCACCCACAGCCCCUGACUGGUCACCACUAUAAUUGUAUGAGGGGCCAGGACAGUCGCUUGGGAUAAACUCCCAUCUCAGCACUGAAUAAAAAACAUUCUGUGUCACAAUAUCCUAGUUUUGGGGCUUUAAAAACGUCUAGGUGUUCCUCACAUGCCUUGUCUAUAAUAAGGAAAGCAAGCAGUAGUUGGGUAUUGUUAGCUUUUGAAACAAAAGCCCUACUGGUCUUCUAAUUUUGGAUAUUUUAAUUAAAGAAUAUCUGGACAGUACAAAGUGAAUUAUUAAAAAACCAUUUGUAACUACCUAGAUUCAAUCAGGAUUUCCUUGAUUUGUGCAAAGUAAAAUAUUACAAUAAAUUUGAUACUGCUACUUGUAUAAAAACCUAUGGUUUAAAAUGUGGGGGUUCAUCAUAAUAGUCUCAUUGUUAGCAUAUCCUAAUAAAGAAUUUGAACUAAUAAAUCCUAUUAAUAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 3964)
LGALS8
galectin 8
NC_000001.11
1  236526071.. 236548161
236526071.. 236548161
strand +
CCDS1612.1
MGI:1928481
ClinVar, dbVar
ENSG00000116977
PCTA-1
uc001hxy.3
INSDC: X91790
6569
606099
OTTHUMG00000039953
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (954 bp)
5'-ATGATGTTGTCCTTAAACAACCTACAGAATATCATCTATAACCCGGTAATCCCGTTTGTTGGCACCATTCCTGATCAGCTGGATCCTGGAACTTTGATTGTGATACGTGGGCATGTTCCTAGTGACGCAGACAGATTCCAGGTGGATCTGCAGAATGGCAGCAGCATGAAACCTCGAGCCGATGTGGCCTTTCATTTCAATCCTCGTTTCAAAAGGGCCGGCTGCATTGTTTGCAATACTTTGATAAATGAAAAATGGGGACGGGAAGAGATCACCTATGACACGCCTTTCAAAAGAGAAAAGTCTTTTGAGATCGTGATTATGGTGCTGAAGGACAAATTCCAGGTGGCTGTAAATGGAAAACATACTCTGCTCTATGGCCACAGGATCGGCCCAGAGAAAATAGACACTCTGGGCATTTATGGCAAAGTGAATATTCACTCAATTGGTTTTAGCTTCAGCTCGGACTTACAAAGTACCCAAGCATCTAGTCTGGAACTGACAGAGATAAGTAGAGAAAATGTTCCAAAGTCTGGCACGCCCCAGCTTAGGCTGCCATTCGCTGCAAGGTTGAACACCCCCATGGGCCCTGGACGAACTGTCGTCGTTAAAGGAGAAGTGAATGCAAATGCCAAAAGCTTTAATGTTGACCTACTAGCAGGAAAATCAAAGGATATTGCTCTACACTTGAACCCACGCCTGAATATTAAAGCATTTGTAAGAAATTCTTTTCTTCAGGAGTCCTGGGGAGAAGAAGAGAGAAATATTACCTCTTTCCCATTTAGTCCTGGGATGTACTTTGAGATGATAATTTATTGTGATGTTAGAGAATTCAAGGTTGCAGTAAATGGCGTACACAGCCTGGAGTACAAACACAGATTTAAAGAGCTCAGCAGTATTGACACGCTGGAAATTAATGGAGACATCCACTTACTGGAAGTAAGGAGCTGGTAG-3'
NCBI CDS gene sequence with introns (location: 236526071.. 236548161) (22091 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 236523598.. 236552981) (29384 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [236523598 - 1000].. 236552981) (30384 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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