Protein
Protein (NP_940910)
Killer cell lectin-like receptor G member 2
Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B)
KLRG2
killer cell lectin like receptor G2
Undefined
Very low evidence
C-type lectin
Undefined
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Uncharacterised
NP_940910
346689
A4D1S0
ENSP00000339356.4
A4D1S0
0.281
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (409 amino acids) Download
MEESWEAAPGGQAGAELPMEPVGSLVPTLEQPQVPAKVRQPEGPESSPSPAGAVEKAAGAGLEPSSKKKPPSPRPGSPRVPPLSLGYGVCPEPPSPGPALVKLPRNGEAPGAEPAPSAWAPMELQVDVRVKPVGAAGGSSTPSPRPSTRFLKVPVPESPAFSRHADPAHQLLLRAPSQGGTWGRRSPLAAARTESGCDAEGRASPAEGSAGSPGSPTCCRCKELGLEKEDAALLPRAGLDGDEKLPRAVTLTGLPMYVKSLYWALAFMAVLLAVSGVVIVVLASRAGARCQQCPPGWVLSEEHCYYFSAEAQAWEASQAFCSAYHATLPLLSHTQDFLGRYPVSRHSWVGAWRGPQGWHWIDEAPLPPQLLPEDGEDNLDINCGALEEGTLVAANCSTPRPWVCAKGTQ
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-A4D1S0-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.53, 1.95] ÅDownload
The location of the lectin domain structural model is: 288-406
We infer [1.53, 1.95] Å as the interval of error of this structural model.
Template 1: 6PWS chain: A, E1BIQ4, XP_005198961.1, sequence identity: 30.3%, coverage: 95.0%, location in sequence: 174-302, (162-290 in PDB).
Template 2: 3VYK chain: A, Q5YIR8, NP_001005860.1, sequence identity: 26.9%, coverage: 96.6%, location in sequence: 106-233, (106-233 in PDB).
Template 3: 6JJJ chain: A, P70194, NP_058031.2, sequence identity: 26.1%, coverage: 100.0%, location in sequence: 393-543, (393-543 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for KLRG2 Gene
ProteomicsDB
References
NCBI References (1 PubMed Identifiers)
  • Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. [20945404]
UniProt Main References (5 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence of human chromosome 7. [12853948]
  • Human chromosome 7: DNA sequence and biology. [12690205]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. [19413330]
All isoforms of this gene containing a lectin domain
NP_940910.1, XP_011514443.1, XP_005250368.1, XP_011514442.1
RNA
RNA (Transcript ID: NM_198508.4)
NM_198508.4
killer cell lectin like receptor G2
All isoforms of KLRG2 containing a lectin domain
ENST00000340940.5
32..1261 (or 139453587.. 139483642)
139452690.. 139483673
NCBI Matured mRNA sequence 2158 NTPDownload 
m7G-5')ppp(5'-CUCAGCGUCUCCGGGUGGCGGGGCGCGCGGGAUGGAGGAGUCUUGGGAGGCUGCGCCCGGAGGCCAAGCCGGGGCAGAGCUCCCAAUGGAGCCCGUGGGAAGCCUGGUCCCCACGCUGGAGCAGCCGCAGGUGCCCGCGAAGGUGCGACAACCUGAAGGUCCCGAAAGCAGCCCAAGUCCGGCCGGGGCCGUGGAGAAGGCGGCGGGCGCAGGCCUGGAGCCCUCGAGCAAGAAAAAGCCGCCUUCGCCUCGCCCCGGGUCCCCGCGCGUGCCGCCGCUCAGCCUGGGCUACGGGGUCUGCCCCGAGCCGCCGUCACCGGGCCCUGCCUUGGUCAAGCUGCCCCGGAAUGGCGAGGCGCCCGGGGCUGAGCCUGCGCCCAGCGCCUGGGCGCCCAUGGAGCUGCAGGUAGAUGUGCGCGUGAAGCCCGUGGGCGCGGCCGGUGGCAGCAGCACGCCAUCGCCCAGGCCCUCCACGCGCUUCCUCAAGGUGCCGGUGCCCGAGUCCCCUGCCUUCUCCCGCCACGCGGACCCGGCGCACCAGCUCCUGCUGCGCGCACCAUCCCAGGGCGGCACGUGGGGCCGCCGCUCGCCGCUGGCUGCAGCCCGGACGGAGAGCGGCUGCGACGCAGAGGGCCGGGCCAGCCCCGCGGAAGGAAGCGCCGGCUCCCCGGGCUCCCCCACGUGCUGCCGCUGCAAGGAGCUGGGGCUGGAGAAGGAGGAUGCGGCGCUGUUGCCCCGCGCGGGGUUGGACGGCGACGAGAAGCUGCCCCGGGCCGUAACGCUUACGGGGCUACCCAUGUACGUGAAGUCCCUGUACUGGGCCCUGGCGUUCAUGGCUGUGCUCCUGGCAGUCUCUGGGGUUGUCAUUGUGGUCCUGGCCUCAAGAGCAGGAGCCAGAUGCCAGCAGUGCCCCCCAGGCUGGGUGUUGUCCGAGGAGCACUGUUACUACUUCUCUGCAGAAGCGCAGGCCUGGGAAGCCAGCCAGGCUUUCUGCUCAGCCUACCACGCUACCCUCCCCCUGCUAAGCCACACCCAGGACUUCCUGGGCAGAUACCCAGUCUCCAGGCACUCCUGGGUGGGGGCCUGGCGAGGCCCCCAGGGCUGGCACUGGAUCGACGAGGCCCCACUCCCGCCCCAGCUACUCCCUGAGGACGGCGAGGACAAUCUGGAUAUCAACUGUGGGGCCCUGGAGGAAGGCACGCUGGUGGCUGCAAACUGCAGCACUCCAAGACCCUGGGUCUGUGCCAAGGGGACCCAGUGAUCUGGGCUCUGCCUGGUCCUCAGCCUGCCAGGCAGAUGCAGCACCCCCUACAGGGGAGGCCAGUUGAGAGCUUGGGCAGCCUCUUCCUGGACCCAGUUAUCCAGGUCUUCAUGCUCUGCUCAAGGGGGCCACAUGAGCGAGCCUAGGAGCUGGACUUCAACCCAGGAAGAUGCAUCCGAGGGAAAGGAGAUUUUCUAUGGCCUCAGGCCUGAGUGCCAAUAUUAGUCUCCAGCUUCUGUGGAUGAUCGGUUUGAUGACAUUGGGAUGGUUGUUUAGCAUUUCUGUGCCUUGGUUUCAUUAAAAUGACAAUUUCCCCCUAGAGGAAAAAGACAGGGUUAACAACCACAGCGGAUUCCAAUCUGGGUUCUCAUUCCGGCUCAUGGAAAUGAGUCUGCCGUUGUUCAGUGGCAGUGGGACUUGGCAGGGAUAACGUCAUUGCUGUGAAUUCUACUUCAGGCAGCUGGGUGUACAUCGGACACAGCCUACCGGCAGCCUCUGGAAAAUUAACCAAGGAAAAGGAGCGGUCAGCCCUGGAAAGAGGGGAGAGCAAGGUUUUCCUUCCCCACCCUGAGAGUUGGCAAAGGGUUGGCAGACAGGAAGGUUCUGGGUGGAGAUCCCGCAUGUGGGCUGGCCAGCCCCUGGCACGCUGAUGCCCAAGGGUGAGACAAGGCAGAGAGGACAGGGCCACCUGGCAGGAGAAGCCAGGAGAGCACCCCAGCUUGGUAGGUGGAAGCUGAGGAGUCUGAGUGAAAAAGGAAAUCAGAGAAAUGCAGGCACGUUCCAGGCAGCUCUUCUACCCACAGCUGCAGAGACGACCAACCUGAAGAUGUCUCCAUGCUGGGGUGCAGUGAAGACCUUCAGGCUGGAGGAUGUGGCUGACAGAGUUGUGUAGUUCCU-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 346689)
KLRG2
killer cell lectin like receptor G2
NC_000007.14
7  139453587.. 139483642
139453587.. 139483642
strand -
CCDS5854.1
MGI:1921503
ClinVar, dbVar
ENSG00000188883
FLJ44186, CLEC15B
uc003vvb.4
INSDC: AK126174
24778
OTTHUMG00000157705
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1230 bp)
5'-ATGGAGGAGTCTTGGGAGGCTGCGCCCGGAGGCCAAGCCGGGGCAGAGCTCCCAATGGAGCCCGTGGGAAGCCTGGTCCCCACGCTGGAGCAGCCGCAGGTGCCCGCGAAGGTGCGACAACCTGAAGGTCCCGAAAGCAGCCCAAGTCCGGCCGGGGCCGTGGAGAAGGCGGCGGGCGCAGGCCTGGAGCCCTCGAGCAAGAAAAAGCCGCCTTCGCCTCGCCCCGGGTCCCCGCGCGTGCCGCCGCTCAGCCTGGGCTACGGGGTCTGCCCCGAGCCGCCGTCACCGGGCCCTGCCTTGGTCAAGCTGCCCCGGAATGGCGAGGCGCCCGGGGCTGAGCCTGCGCCCAGCGCCTGGGCGCCCATGGAGCTGCAGGTAGATGTGCGCGTGAAGCCCGTGGGCGCGGCCGGTGGCAGCAGCACGCCATCGCCCAGGCCCTCCACGCGCTTCCTCAAGGTGCCGGTGCCCGAGTCCCCTGCCTTCTCCCGCCACGCGGACCCGGCGCACCAGCTCCTGCTGCGCGCACCATCCCAGGGCGGCACGTGGGGCCGCCGCTCGCCGCTGGCTGCAGCCCGGACGGAGAGCGGCTGCGACGCAGAGGGCCGGGCCAGCCCCGCGGAAGGAAGCGCCGGCTCCCCGGGCTCCCCCACGTGCTGCCGCTGCAAGGAGCTGGGGCTGGAGAAGGAGGATGCGGCGCTGTTGCCCCGCGCGGGGTTGGACGGCGACGAGAAGCTGCCCCGGGCCGTAACGCTTACGGGGCTACCCATGTACGTGAAGTCCCTGTACTGGGCCCTGGCGTTCATGGCTGTGCTCCTGGCAGTCTCTGGGGTTGTCATTGTGGTCCTGGCCTCAAGAGCAGGAGCCAGATGCCAGCAGTGCCCCCCAGGCTGGGTGTTGTCCGAGGAGCACTGTTACTACTTCTCTGCAGAAGCGCAGGCCTGGGAAGCCAGCCAGGCTTTCTGCTCAGCCTACCACGCTACCCTCCCCCTGCTAAGCCACACCCAGGACTTCCTGGGCAGATACCCAGTCTCCAGGCACTCCTGGGTGGGGGCCTGGCGAGGCCCCCAGGGCTGGCACTGGATCGACGAGGCCCCACTCCCGCCCCAGCTACTCCCTGAGGACGGCGAGGACAATCTGGATATCAACTGTGGGGCCCTGGAGGAAGGCACGCTGGTGGCTGCAAACTGCAGCACTCCAAGACCCTGGGTCTGTGCCAAGGGGACCCAGTGA-3'
NCBI CDS gene sequence with introns (location: 139453587.. 139483642) (30056 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 139452690.. 139483673) (30984 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [139452690.. 139483673 + 1000]) (31984 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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