HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010].

Protein name

CBM13-ppGalNAc-T10

Synonym(s)

Polypeptide N-acetylgalactosaminyltransferase 10 (EC 2.4.1.41) (Polypeptide GalNAc transferase 10) (GalNAc-T10) (pp-GaNTase 10) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10)

HGNC gene name

GALNT10

HGNC name

polypeptide N-acetylgalactosaminyltransferase 10

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

Ricin-like

Known lectin group

R-Type Lectins

Lectin fold

b-trefoil

Glycan specificity

GalNAc / Mucin-type glycopeptide

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

Undefined

Reference

10.1074/jbc.M111.273722

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (603 amino acids) Download

MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAVAPAAGQGSHSRQKKTFFLGDGQKLKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAISHTSPVTLYDCHSMKGNQLWKYRKDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFNRN

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q86SR1-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for GALNT10 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

GALNT10 promotes the proliferation and metastatic ability of gastric cancer and reduces 5-fluorouracil sensitivity by activating HOXD13. [33275228]

Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer. [31853576]

Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma. [28122358]

Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study. [25898001]

Decreased expression of hepatocyte nuclear factor 4alpha (Hnf4alpha)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity. [25422324]

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. [23583978]

Genome-wide association of BMI in African Americans. [21701570]

Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. [19460755]

The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. [18562306]

Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10. [12417297]

UniProt Main References (5 PubMed Identifiers)

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The full-ORF clone resource of the German cDNA Consortium. [17974005]

Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. [12693554]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Structural basis of carbohydrate transfer activity by human UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase (pp-GalNAc-T10). [16650853]

RNA

RNA (Transcript ID: NM_198321.4)

RNA RefSeq ID

NM_198321.4

RNA name

polypeptide N-acetylgalactosaminyltransferase 10

Isoforms

All isoforms of GALNT10 containing a lectin domain

RNA Ensembl ID

ENST00000297107.11

Coding region

135..1946 (or 154190867.. 154416972)

mRNA location

154190733.. 154420984

NCBI Matured mRNA sequence 5958 NTP Download

m⁷G-5')ppp(5'-GAGUUGGAGCGGGGCCGGCGCCGCAGCCGCUUCUGCUGGCUGAGCUGCUGCCGCCGCCGGGCGGACGGGCGGACGCGCGGAGCUGGGGGCGGCGCGGCGGGGCCGGCGGGGCGCGGCGGGGCUGACCGGCCCCGAUGAGGCGGAAGGAGAAGCGGCUCCUGCAGGCGGUGGCGCUGGUGCUGGCGGCCCUGGUCCUCCUGCCCAACGUGGGGCUUUGGGCGCUGUACCGCGAGCGGCAGCCCGACGGCACCCCUGGGGGAUCGGGGGCGGCGGUGGCGCCGGCGGCGGGACAGGGCUCACACAGUCGACAAAAGAAAACGUUUUUCUUGGGAGAUGGGCAGAAGCUGAAGGACUGGCAUGACAAGGAGGCCAUCCGGAGGGACGCUCAGCGCGUAGGAAAUGGAGAACAAGGAAGACCUUACCCCAUGACCGAUGCUGAGAGAGUGGAUCAGGCAUACCGAGAAAAUGGAUUUAACAUCUACGUCAGUGAUAAAAUCUCCUUGAAUCGCUCUCUCCCAGAUAUCCGGCACCCAAACUGCAACAGCAAGCGCUACCUGGAGACACUUCCCAACACAAGCAUCAUCAUCCCCUUCCACAACGAGGGCUGGUCCUCCCUCCUCCGCACCGUCCACAGUGUGCUCAAUCGCUCGCCUCCAGAGCUGGUCGCCGAGAUUGUACUGGUCGACGACUUCAGUGAUCGAGAGCACCUGAAGAAGCCUCUUGAAGACUACAUGGCCCUUUUCCCCAGUGUGAGGAUUCUUCGAACCAAGAAACGGGAAGGGCUGAUAAGGACCCGAAUGCUGGGGGCCUCAGUGGCAACUGGGGAUGUCAUCACAUUCUUGGAUUCACACUGUGAAGCCAAUGUCAACUGGCUUCCCCCCUUGCUUGACCGCAUUGCUCGGAACCGCAAGACCAUUGUGUGCCCGAUGAUUGAUGUAAUUGACCAUGACGACUUUCGGUACGAGACACAGGCAGGGGAUGCCAUGCGGGGAGCCUUUGACUGGGAGAUGUACUACAAGCGGAUCCCGAUCCCUCCAGAACUGCAGAAAGCUGACCCCAGCGACCCAUUUGAGUCUCCCGUGAUGGCCGGUGGACUGUUCGCCGUGGAUCGGAAGUGGUUCUGGGAACUCGGCGGGUAUGACCCAGGCUUGGAGAUCUGGGGAGGGGAGCAGUAUGAAAUCUCCUUCAAGGUGUGGAUGUGUGGGGGCCGCAUGGAGGACAUCCCCUGCUCCAGGGUGGGCCAUAUCUACAGGAAGUAUGUGCCCUACAAGGUCCCGGCCGGAGUCAGCCUGGCCCGGAACCUUAAGCGGGUGGCCGAAGUGUGGAUGGAUGAGUACGCAGAGUACAUUUACCAGCGCCGGCCUGAAUACCGCCACCUCUCCGCUGGGGAUGUCGCAGUCCAGAAAAAGCUCCGCAGCUCCCUUAACUGCAAGAGUUUCAAGUGGUUUAUGACGAAGAUAGCCUGGGACCUGCCCAAAUUCUACCCACCCGUGGAGCCCCCGGCUGCAGCUUGGGGGGAGAUCCGAAAUGUGGGCACAGGGCUGUGUGCAGACACAAAGCACGGGGCCUUGGGCUCCCCACUAAGGCUAGAGGGCUGCGUCCGAGGCCGUGGGGAGGCUGCCUGGAACAACAUGCAGGUAUUCACCUUCACCUGGAGAGAGGACAUCCGGCCUGGAGACCCCCAGCACACCAAGAAGUUCUGCUUUGAUGCCAUUUCCCACACCAGCCCUGUCACGCUGUACGACUGCCACAGCAUGAAGGGCAACCAGCUGUGGAAAUACCGCAAAGACAAGACCCUGUACCACCCUGUCAGUGGCAGCUGCAUGGACUGCAGUGAAAGUGACCAUAGGAUCUUCAUGAACACCUGCAACCCAUCCUCUCUCACCCAGCAGUGGCUGUUUGAACACACCAACUCAACAGUCUUGGAAAAAUUCAAUAGGAACUGAGCCCUCAUGUCCCCUUGGCAGGCCCCCCAGGGUCUGGCACUCACUGCAGACUUCCUCUUUCAAGGGAGGCAGGGCCCCUGUGGGCACUAGGUGUAAAAGGUGCUGGCCAAAUGGUUCAGGGUGAAGAGGGCUCUUGAUUCAGGGGCUGGGGUCUGCCUGGUCCUUGAGCCCCUGAGUUGUGGGGGUAGGGUGAAGAGCAUAUCCCACAAGAGGCCCCACAGGGAGCAGAGACUGCUUUAAUCCCUGCUGACAUCACGGAAAAGCAACAGAGCCUUUUCAACUUUGUCACUAUGUCCCCUUGAACAUUAUGUGGGAGAACACCAAGGUAGCCUAGGCCACCCAAAAGUGAGUCCUGCGAGGUUGCCCAGCCCUCAGAUGGCUCUCCUACAUGAUGGUGCUUUAGAAACAAAGGUAAAAUUUGCCUGUUUGGGGCAGCUUUUAGUAUCGAUGCCACUCAUCUGCAGCAGAAGAGAAAGAAGUCCUCUUGGGGCUUUUUAGUUUCUGCCGUCCUGGGGGGAACAUUGCAGUUACUGCACAGCUUCUGUUCUCUGUCACAACCCCAGGUGAUUUGGUCCGGUCAAAGGCCAUACUUGGGGCCCUAAGAGUGUUCAGUAUUGAAUGCUGAUCAGCUGCCAGGUGAGGAGUCAGAAGAGGGAGCCCCCCUAGACAUUUCUUUGCAGCUAUGGACAUGCGGGAUAUCUCCCCCUGCUCUCUGGGUAUUUGAAAUGUCAAUUUUAGCACUCUCCAGGCACAAGGACAGCCCAGCACCAGCUUUACAGGGCAGUGUUUCAGAUGGCCCUGAGCCCACGGAAAAGGCCAGGUAGACCUCCAAACUAGAAAUGCUGGCUGAUUUGCCCUGAUCCAUGCUUCCAUUUCCCUGUCUCUCUUCCCCAGGCAAUUACUGGCCUCAAAAGAGGAACAGAGGUGCUGCGAGGUGCUCACCUCACAGAGUCUGGAGGCCUCCAGGAUCAACUGUGGGCAAAGUGCCUGCCUCUGACCUCAUCAUGGUUCUAGUUCUCAUACAGAACUCCAGAAUUUUUAAAGAACUCUAUAAUUGGAUUGCAAACUAGGAUGCUACAUAGGAUUCUGGUAUUCCACAUCCAAUAUGGAUUUCUAGAAUGCUGUGAUUAAAGGAGCCAGCCAGGUGUAAUACAGUCAAGGCAGCCCCCAGCCUAGAGACAAUCUGUGAAAUCCAAAGUUGGUGGUGUUGGGAAAGCAGGGGGACAUGUGUCCCUCAGCUCAGCAGAGGCUGUGGUACAACAUGGUCCUUGGUGAAGACCUGCACCCCUGGAACCUCCCACCAUCAUCACAACUGUAGUCUCAUUUGCAGUGGAGAAAAGAACCCGACGUCCCACAGCCAGAUAUACACCCAGCUCCAUGCCAGCCCUUCAUGUUUACCUUUUGCUUUGUUAAUUACAUGUCAGACUCCUAGAGGGCCUCCAGACUAAUAGGAAGCAUUUCUGUAACCAACCUGCCACCCACUGAUUCAGAAAUGGAAAUCACAUUCCACAAUCUAUGGCUUCCACCAGCUAGCCCAGGAAAUACUUGAAAUCAGCAUUCCAAUUAGUGUUGAGUCUCUUGAUUGUGUCAUUUACCAAUUAAAUAACUGAGACCUAAGUCUGGGAACAGAGCCACGAAUCUGCCUUUGAGAUGCUGGCAGAUCUCAAGGCCAUCAAUUAUUGGGGGAGGGAGGGACAAACACUCCCAAUCAUCCACCAGUCAGACUGAAUGUGUAGCUGGCGAGGAAUUACUUCCACUUCUGGCCCAGCACAAGCCCUGCUUUGGCCACCUGUCUGCAAGAGAGGCGGCCCCUGUGCUUGCAACGCUUACGUGUUGAUCCCAGUGUCCUUUUCCAAAUGAGUGCUGUAGCUUUAGAAGUGGCCCUCUAUAGAAAGAAGUCAAAAGAUGAGGCCCCUUCUAGAAUCUAGGAUAACAAGAGUGUUGACAGUUUGAGGAGUCGAAUUGAGAUUCAUCAUCAAAGAGCAAUGCAGCGUCGUUAAAAUAAAAACUGUGCCUUUUAAAAAGAAAAAUGCAAAUAUAGAGCAAAUCCCUAAACUUGAACCAUUUCCUAGUGCCUUGCUAGACAAACAUAAAGGGGCAGGGUUGUGGGGAGGGGAACGUUUUUGGUGGUGUGUGCAGUUCCUACUGGAUGAGUGUGUGUUUCUUAAUGUCUCAUUUCAAGCAGGAGAUGUUGGGUCUGGAGCAAGAUCUGAGACUGAGAUGUCCCCCAAGGGUGACAGGUCAGAUUUAUUUCAGUCAGUGCAAGUCACACUCCAAACUAAAGGCUGGGCAGUGCGUUUAGUCUGUGGCCUAGAAGACCUCAUCAGCCCCCGAGAGGAGGCCUUGCAUUACCUCACUGGGACCUGUUUGGGGGCCAUCCCUGCGGUCCACCCUCUGAACCCCCAGCAUGUUUGUCCUGUUUCUCACCAUUGGGUUAAGGGGUGCCGAGCACUAGCUAGACUUCCACAUAGUCCCACCCCAAGUGGGCGGCAGUGUUCCUGGCAUGACCAGGAUUCCUGUGAAAGCAGGAGCAGCAGCAAGCCGUCCCGGGCCUGCCUUUCCCAUCCUUUGGUUCUCCUUUCCAGUCUGGGUUCACACCCUGAAAAGGGAUGGGUGUGUCCUCUGAGCACUCUGGCAUUUGUCAUUGCUGAGCCCAUAUCAGUAGGUCCUGGGACUUGACAAAGUAUGUGGGAGGGGAAGGAAGGACAGAACUUGACUGGCUCCAUUUCAUGGACCAACUGAUCAAUUGCCAGUACUAAGCCACUCAUUGUUAUGGCUUCCUUUUUGAAAACCACCUGUCUCAAGGAUUCAGGUUUCUGCUCACAUCCCCAGCUGAUGCUCAAUAAAACUCAGCCAGGAGCAUAUGGAGAUGCUGACAGCCAGGUAAUGGGUGAGACUGUGGGGUCCCUUUUCCUCUAAAGCCUUUACUCUGAGGAUAAGGUCACAAAGUAGGGUGUGACUUGAAAGUAUCGUGACCAUGUGGCCCACCAGCAGCCUUUCCAAAGGGGAACUCCAGAGACAUUUCAUAAUGCAAACAGCACUGUUGCUUUAAGAACAAGGCCUUUGGAGGUGGCUAAACUUGCACGCACGUGUGUGAAAAGCCAUCCCAUCUUCUGCCUCCAGUUGGAGCUUUCAGCUGUUAAAACAGUCAGAAACUAUUGAUUCUUCCCUUUAGGAAAAAAUGCUCAGGCAGAACGGGGUACAUCCACAGGAGGAAUCGGACGAGAGGAUGUGACAUUCGGUCCAGGAGAGAAAGAGCAGUUUCUGUUAAAGAUGUAACAAAUGGAUUUCCAAAGUCUACAUGACAUUCACUUUUCAAACUUCCCACCAGUUGAAUUUCUUUUUUUCCUUAAGAAACAGGUGAUGUCUUGGAAAACAGCUCCUUAUGUCUCUCUGUGCAUCUCCAUUUUCCUAGUCUCUGGAGUCUCAAAAAGAGUGGCAAAGCACUUUACAGUAGUAACUGAGGAAUCAGAGUCUCUGCUUCAGCGAUAUCUAGUUUGUACAGUUGGGUGAUCUUUUGUAAUUCCUAGGAGGUAAUGCAUUUUUAAUGUUUUCUGAAGCUUUGUAAGUGUGAGAGAGGGACAAGAAGUGCAGUUCUGUUCUGGAAUUCCUUAUUGCUUUCAACGGACACUCUUUGUGAAAAAUCCAAGUAAUAUUUUAGUUCAAACUUGAUCUUGAGCCAAGGCCCACUGCCACCUCUGGGAUGGGAGUCGGACCUACAUACCAAGUGACAAGUUCACCUUAACAUCUGCUUCCAGAAUGGCUUUGAUUCAGCCGUGCCAGGCAACAGAACAGGGUCAGACUCCUGCUCUGUUAUUGGCUUGAAGACUAGGAUCCCAAAGGGGUUGGAGGCAGGGAAUAUUUGAAAAUUCAGACUGGAAUUCCAGGCCAAAAGCUCAAGACCACCAGCCUCUCCUCCUGCCUGGAAAAAUAAGCCUUUGUGAAAGACUGAUUUACCAUGUACAAUUGUGAUUGUGAACGUUGUUGAGUAAACCUCCAGACUUUCUCUAAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 55568)

HGNC Gene symbol

GALNT10

HGNC Gene name

polypeptide N-acetylgalactosaminyltransferase 10

Chr. RefSeq ID

NC_000005.10

Chromosome N°

5 154190867.. 154416972

CDS location

154190867.. 154416972

DNA strand

strand +

CCDS ID

CCDS4325.1

Mouse ortholog gene

MGI:1890480

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000164574

HGNC other symbol

GalNAc-T10

UCSC ID

uc003lvh.4

GeneBank

INSDC: AK023782

GeneCards

19873

MIM

608043

VEGA ID

OTTHUMG00000130145