NCBI Summary
This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010].
Protein
Protein (NP_938080)
CBM13-ppGalNAc-T10
Polypeptide N-acetylgalactosaminyltransferase 10 (EC 2.4.1.41) (Polypeptide GalNAc transferase 10) (GalNAc-T10) (pp-GaNTase 10) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10)
GALNT10
polypeptide N-acetylgalactosaminyltransferase 10
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_938080
55568
Q86SR1
ENSP00000297107.6
Q86SR1
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (603 amino acids) Download
MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAVAPAAGQGSHSRQKKTFFLGDGQKLKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAISHTSPVTLYDCHSMKGNQLWKYRKDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFNRN
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q86SR1-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
Tn Antigen
GalNAc
2D7R
2D7R
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT10 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • GALNT10 promotes the proliferation and metastatic ability of gastric cancer and reduces 5-fluorouracil sensitivity by activating HOXD13. [33275228]
  • Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer. [31853576]
  • Prognostic role of N-Acetylgalactosaminyltransferase 10 in metastatic renal cell carcinoma. [28122358]
  • Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study. [25898001]
  • Decreased expression of hepatocyte nuclear factor 4alpha (Hnf4alpha)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity. [25422324]
  • A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. [23583978]
  • Genome-wide association of BMI in African Americans. [21701570]
  • Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. [19460755]
  • The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. [18562306]
  • Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10. [12417297]
UniProt Main References (5 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The full-ORF clone resource of the German cDNA Consortium. [17974005]
  • Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. [12693554]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Structural basis of carbohydrate transfer activity by human UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase (pp-GalNAc-T10). [16650853]
RNA
RNA (Transcript ID: NM_198321.4)
NM_198321.4
polypeptide N-acetylgalactosaminyltransferase 10
All isoforms of GALNT10 containing a lectin domain
ENST00000297107.11
135..1946 (or 154190867.. 154416972)
154190733.. 154420984
NCBI Matured mRNA sequence 5958 NTPDownload 
m7G-5')ppp(5'-GAGUUGGAGCGGGGCCGGCGCCGCAGCCGCUUCUGCUGGCUGAGCUGCUGCCGCCGCCGGGCGGACGGGCGGACGCGCGGAGCUGGGGGCGGCGCGGCGGGGCCGGCGGGGCGCGGCGGGGCUGACCGGCCCCGAUGAGGCGGAAGGAGAAGCGGCUCCUGCAGGCGGUGGCGCUGGUGCUGGCGGCCCUGGUCCUCCUGCCCAACGUGGGGCUUUGGGCGCUGUACCGCGAGCGGCAGCCCGACGGCACCCCUGGGGGAUCGGGGGCGGCGGUGGCGCCGGCGGCGGGACAGGGCUCACACAGUCGACAAAAGAAAACGUUUUUCUUGGGAGAUGGGCAGAAGCUGAAGGACUGGCAUGACAAGGAGGCCAUCCGGAGGGACGCUCAGCGCGUAGGAAAUGGAGAACAAGGAAGACCUUACCCCAUGACCGAUGCUGAGAGAGUGGAUCAGGCAUACCGAGAAAAUGGAUUUAACAUCUACGUCAGUGAUAAAAUCUCCUUGAAUCGCUCUCUCCCAGAUAUCCGGCACCCAAACUGCAACAGCAAGCGCUACCUGGAGACACUUCCCAACACAAGCAUCAUCAUCCCCUUCCACAACGAGGGCUGGUCCUCCCUCCUCCGCACCGUCCACAGUGUGCUCAAUCGCUCGCCUCCAGAGCUGGUCGCCGAGAUUGUACUGGUCGACGACUUCAGUGAUCGAGAGCACCUGAAGAAGCCUCUUGAAGACUACAUGGCCCUUUUCCCCAGUGUGAGGAUUCUUCGAACCAAGAAACGGGAAGGGCUGAUAAGGACCCGAAUGCUGGGGGCCUCAGUGGCAACUGGGGAUGUCAUCACAUUCUUGGAUUCACACUGUGAAGCCAAUGUCAACUGGCUUCCCCCCUUGCUUGACCGCAUUGCUCGGAACCGCAAGACCAUUGUGUGCCCGAUGAUUGAUGUAAUUGACCAUGACGACUUUCGGUACGAGACACAGGCAGGGGAUGCCAUGCGGGGAGCCUUUGACUGGGAGAUGUACUACAAGCGGAUCCCGAUCCCUCCAGAACUGCAGAAAGCUGACCCCAGCGACCCAUUUGAGUCUCCCGUGAUGGCCGGUGGACUGUUCGCCGUGGAUCGGAAGUGGUUCUGGGAACUCGGCGGGUAUGACCCAGGCUUGGAGAUCUGGGGAGGGGAGCAGUAUGAAAUCUCCUUCAAGGUGUGGAUGUGUGGGGGCCGCAUGGAGGACAUCCCCUGCUCCAGGGUGGGCCAUAUCUACAGGAAGUAUGUGCCCUACAAGGUCCCGGCCGGAGUCAGCCUGGCCCGGAACCUUAAGCGGGUGGCCGAAGUGUGGAUGGAUGAGUACGCAGAGUACAUUUACCAGCGCCGGCCUGAAUACCGCCACCUCUCCGCUGGGGAUGUCGCAGUCCAGAAAAAGCUCCGCAGCUCCCUUAACUGCAAGAGUUUCAAGUGGUUUAUGACGAAGAUAGCCUGGGACCUGCCCAAAUUCUACCCACCCGUGGAGCCCCCGGCUGCAGCUUGGGGGGAGAUCCGAAAUGUGGGCACAGGGCUGUGUGCAGACACAAAGCACGGGGCCUUGGGCUCCCCACUAAGGCUAGAGGGCUGCGUCCGAGGCCGUGGGGAGGCUGCCUGGAACAACAUGCAGGUAUUCACCUUCACCUGGAGAGAGGACAUCCGGCCUGGAGACCCCCAGCACACCAAGAAGUUCUGCUUUGAUGCCAUUUCCCACACCAGCCCUGUCACGCUGUACGACUGCCACAGCAUGAAGGGCAACCAGCUGUGGAAAUACCGCAAAGACAAGACCCUGUACCACCCUGUCAGUGGCAGCUGCAUGGACUGCAGUGAAAGUGACCAUAGGAUCUUCAUGAACACCUGCAACCCAUCCUCUCUCACCCAGCAGUGGCUGUUUGAACACACCAACUCAACAGUCUUGGAAAAAUUCAAUAGGAACUGAGCCCUCAUGUCCCCUUGGCAGGCCCCCCAGGGUCUGGCACUCACUGCAGACUUCCUCUUUCAAGGGAGGCAGGGCCCCUGUGGGCACUAGGUGUAAAAGGUGCUGGCCAAAUGGUUCAGGGUGAAGAGGGCUCUUGAUUCAGGGGCUGGGGUCUGCCUGGUCCUUGAGCCCCUGAGUUGUGGGGGUAGGGUGAAGAGCAUAUCCCACAAGAGGCCCCACAGGGAGCAGAGACUGCUUUAAUCCCUGCUGACAUCACGGAAAAGCAACAGAGCCUUUUCAACUUUGUCACUAUGUCCCCUUGAACAUUAUGUGGGAGAACACCAAGGUAGCCUAGGCCACCCAAAAGUGAGUCCUGCGAGGUUGCCCAGCCCUCAGAUGGCUCUCCUACAUGAUGGUGCUUUAGAAACAAAGGUAAAAUUUGCCUGUUUGGGGCAGCUUUUAGUAUCGAUGCCACUCAUCUGCAGCAGAAGAGAAAGAAGUCCUCUUGGGGCUUUUUAGUUUCUGCCGUCCUGGGGGGAACAUUGCAGUUACUGCACAGCUUCUGUUCUCUGUCACAACCCCAGGUGAUUUGGUCCGGUCAAAGGCCAUACUUGGGGCCCUAAGAGUGUUCAGUAUUGAAUGCUGAUCAGCUGCCAGGUGAGGAGUCAGAAGAGGGAGCCCCCCUAGACAUUUCUUUGCAGCUAUGGACAUGCGGGAUAUCUCCCCCUGCUCUCUGGGUAUUUGAAAUGUCAAUUUUAGCACUCUCCAGGCACAAGGACAGCCCAGCACCAGCUUUACAGGGCAGUGUUUCAGAUGGCCCUGAGCCCACGGAAAAGGCCAGGUAGACCUCCAAACUAGAAAUGCUGGCUGAUUUGCCCUGAUCCAUGCUUCCAUUUCCCUGUCUCUCUUCCCCAGGCAAUUACUGGCCUCAAAAGAGGAACAGAGGUGCUGCGAGGUGCUCACCUCACAGAGUCUGGAGGCCUCCAGGAUCAACUGUGGGCAAAGUGCCUGCCUCUGACCUCAUCAUGGUUCUAGUUCUCAUACAGAACUCCAGAAUUUUUAAAGAACUCUAUAAUUGGAUUGCAAACUAGGAUGCUACAUAGGAUUCUGGUAUUCCACAUCCAAUAUGGAUUUCUAGAAUGCUGUGAUUAAAGGAGCCAGCCAGGUGUAAUACAGUCAAGGCAGCCCCCAGCCUAGAGACAAUCUGUGAAAUCCAAAGUUGGUGGUGUUGGGAAAGCAGGGGGACAUGUGUCCCUCAGCUCAGCAGAGGCUGUGGUACAACAUGGUCCUUGGUGAAGACCUGCACCCCUGGAACCUCCCACCAUCAUCACAACUGUAGUCUCAUUUGCAGUGGAGAAAAGAACCCGACGUCCCACAGCCAGAUAUACACCCAGCUCCAUGCCAGCCCUUCAUGUUUACCUUUUGCUUUGUUAAUUACAUGUCAGACUCCUAGAGGGCCUCCAGACUAAUAGGAAGCAUUUCUGUAACCAACCUGCCACCCACUGAUUCAGAAAUGGAAAUCACAUUCCACAAUCUAUGGCUUCCACCAGCUAGCCCAGGAAAUACUUGAAAUCAGCAUUCCAAUUAGUGUUGAGUCUCUUGAUUGUGUCAUUUACCAAUUAAAUAACUGAGACCUAAGUCUGGGAACAGAGCCACGAAUCUGCCUUUGAGAUGCUGGCAGAUCUCAAGGCCAUCAAUUAUUGGGGGAGGGAGGGACAAACACUCCCAAUCAUCCACCAGUCAGACUGAAUGUGUAGCUGGCGAGGAAUUACUUCCACUUCUGGCCCAGCACAAGCCCUGCUUUGGCCACCUGUCUGCAAGAGAGGCGGCCCCUGUGCUUGCAACGCUUACGUGUUGAUCCCAGUGUCCUUUUCCAAAUGAGUGCUGUAGCUUUAGAAGUGGCCCUCUAUAGAAAGAAGUCAAAAGAUGAGGCCCCUUCUAGAAUCUAGGAUAACAAGAGUGUUGACAGUUUGAGGAGUCGAAUUGAGAUUCAUCAUCAAAGAGCAAUGCAGCGUCGUUAAAAUAAAAACUGUGCCUUUUAAAAAGAAAAAUGCAAAUAUAGAGCAAAUCCCUAAACUUGAACCAUUUCCUAGUGCCUUGCUAGACAAACAUAAAGGGGCAGGGUUGUGGGGAGGGGAACGUUUUUGGUGGUGUGUGCAGUUCCUACUGGAUGAGUGUGUGUUUCUUAAUGUCUCAUUUCAAGCAGGAGAUGUUGGGUCUGGAGCAAGAUCUGAGACUGAGAUGUCCCCCAAGGGUGACAGGUCAGAUUUAUUUCAGUCAGUGCAAGUCACACUCCAAACUAAAGGCUGGGCAGUGCGUUUAGUCUGUGGCCUAGAAGACCUCAUCAGCCCCCGAGAGGAGGCCUUGCAUUACCUCACUGGGACCUGUUUGGGGGCCAUCCCUGCGGUCCACCCUCUGAACCCCCAGCAUGUUUGUCCUGUUUCUCACCAUUGGGUUAAGGGGUGCCGAGCACUAGCUAGACUUCCACAUAGUCCCACCCCAAGUGGGCGGCAGUGUUCCUGGCAUGACCAGGAUUCCUGUGAAAGCAGGAGCAGCAGCAAGCCGUCCCGGGCCUGCCUUUCCCAUCCUUUGGUUCUCCUUUCCAGUCUGGGUUCACACCCUGAAAAGGGAUGGGUGUGUCCUCUGAGCACUCUGGCAUUUGUCAUUGCUGAGCCCAUAUCAGUAGGUCCUGGGACUUGACAAAGUAUGUGGGAGGGGAAGGAAGGACAGAACUUGACUGGCUCCAUUUCAUGGACCAACUGAUCAAUUGCCAGUACUAAGCCACUCAUUGUUAUGGCUUCCUUUUUGAAAACCACCUGUCUCAAGGAUUCAGGUUUCUGCUCACAUCCCCAGCUGAUGCUCAAUAAAACUCAGCCAGGAGCAUAUGGAGAUGCUGACAGCCAGGUAAUGGGUGAGACUGUGGGGUCCCUUUUCCUCUAAAGCCUUUACUCUGAGGAUAAGGUCACAAAGUAGGGUGUGACUUGAAAGUAUCGUGACCAUGUGGCCCACCAGCAGCCUUUCCAAAGGGGAACUCCAGAGACAUUUCAUAAUGCAAACAGCACUGUUGCUUUAAGAACAAGGCCUUUGGAGGUGGCUAAACUUGCACGCACGUGUGUGAAAAGCCAUCCCAUCUUCUGCCUCCAGUUGGAGCUUUCAGCUGUUAAAACAGUCAGAAACUAUUGAUUCUUCCCUUUAGGAAAAAAUGCUCAGGCAGAACGGGGUACAUCCACAGGAGGAAUCGGACGAGAGGAUGUGACAUUCGGUCCAGGAGAGAAAGAGCAGUUUCUGUUAAAGAUGUAACAAAUGGAUUUCCAAAGUCUACAUGACAUUCACUUUUCAAACUUCCCACCAGUUGAAUUUCUUUUUUUCCUUAAGAAACAGGUGAUGUCUUGGAAAACAGCUCCUUAUGUCUCUCUGUGCAUCUCCAUUUUCCUAGUCUCUGGAGUCUCAAAAAGAGUGGCAAAGCACUUUACAGUAGUAACUGAGGAAUCAGAGUCUCUGCUUCAGCGAUAUCUAGUUUGUACAGUUGGGUGAUCUUUUGUAAUUCCUAGGAGGUAAUGCAUUUUUAAUGUUUUCUGAAGCUUUGUAAGUGUGAGAGAGGGACAAGAAGUGCAGUUCUGUUCUGGAAUUCCUUAUUGCUUUCAACGGACACUCUUUGUGAAAAAUCCAAGUAAUAUUUUAGUUCAAACUUGAUCUUGAGCCAAGGCCCACUGCCACCUCUGGGAUGGGAGUCGGACCUACAUACCAAGUGACAAGUUCACCUUAACAUCUGCUUCCAGAAUGGCUUUGAUUCAGCCGUGCCAGGCAACAGAACAGGGUCAGACUCCUGCUCUGUUAUUGGCUUGAAGACUAGGAUCCCAAAGGGGUUGGAGGCAGGGAAUAUUUGAAAAUUCAGACUGGAAUUCCAGGCCAAAAGCUCAAGACCACCAGCCUCUCCUCCUGCCUGGAAAAAUAAGCCUUUGUGAAAGACUGAUUUACCAUGUACAAUUGUGAUUGUGAACGUUGUUGAGUAAACCUCCAGACUUUCUCUAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 55568)
GALNT10
polypeptide N-acetylgalactosaminyltransferase 10
NC_000005.10
5  154190867.. 154416972
154190867.. 154416972
strand +
CCDS4325.1
MGI:1890480
ClinVar, dbVar
ENSG00000164574
GalNAc-T10
uc003lvh.4
INSDC: AK023782
19873
608043
OTTHUMG00000130145
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1812 bp)
5'-ATGAGGCGGAAGGAGAAGCGGCTCCTGCAGGCGGTGGCGCTGGTGCTGGCGGCCCTGGTCCTCCTGCCCAACGTGGGGCTTTGGGCGCTGTACCGCGAGCGGCAGCCCGACGGCACCCCTGGGGGATCGGGGGCGGCGGTGGCGCCGGCGGCGGGACAGGGCTCACACAGTCGACAAAAGAAAACGTTTTTCTTGGGAGATGGGCAGAAGCTGAAGGACTGGCATGACAAGGAGGCCATCCGGAGGGACGCTCAGCGCGTAGGAAATGGAGAACAAGGAAGACCTTACCCCATGACCGATGCTGAGAGAGTGGATCAGGCATACCGAGAAAATGGATTTAACATCTACGTCAGTGATAAAATCTCCTTGAATCGCTCTCTCCCAGATATCCGGCACCCAAACTGCAACAGCAAGCGCTACCTGGAGACACTTCCCAACACAAGCATCATCATCCCCTTCCACAACGAGGGCTGGTCCTCCCTCCTCCGCACCGTCCACAGTGTGCTCAATCGCTCGCCTCCAGAGCTGGTCGCCGAGATTGTACTGGTCGACGACTTCAGTGATCGAGAGCACCTGAAGAAGCCTCTTGAAGACTACATGGCCCTTTTCCCCAGTGTGAGGATTCTTCGAACCAAGAAACGGGAAGGGCTGATAAGGACCCGAATGCTGGGGGCCTCAGTGGCAACTGGGGATGTCATCACATTCTTGGATTCACACTGTGAAGCCAATGTCAACTGGCTTCCCCCCTTGCTTGACCGCATTGCTCGGAACCGCAAGACCATTGTGTGCCCGATGATTGATGTAATTGACCATGACGACTTTCGGTACGAGACACAGGCAGGGGATGCCATGCGGGGAGCCTTTGACTGGGAGATGTACTACAAGCGGATCCCGATCCCTCCAGAACTGCAGAAAGCTGACCCCAGCGACCCATTTGAGTCTCCCGTGATGGCCGGTGGACTGTTCGCCGTGGATCGGAAGTGGTTCTGGGAACTCGGCGGGTATGACCCAGGCTTGGAGATCTGGGGAGGGGAGCAGTATGAAATCTCCTTCAAGGTGTGGATGTGTGGGGGCCGCATGGAGGACATCCCCTGCTCCAGGGTGGGCCATATCTACAGGAAGTATGTGCCCTACAAGGTCCCGGCCGGAGTCAGCCTGGCCCGGAACCTTAAGCGGGTGGCCGAAGTGTGGATGGATGAGTACGCAGAGTACATTTACCAGCGCCGGCCTGAATACCGCCACCTCTCCGCTGGGGATGTCGCAGTCCAGAAAAAGCTCCGCAGCTCCCTTAACTGCAAGAGTTTCAAGTGGTTTATGACGAAGATAGCCTGGGACCTGCCCAAATTCTACCCACCCGTGGAGCCCCCGGCTGCAGCTTGGGGGGAGATCCGAAATGTGGGCACAGGGCTGTGTGCAGACACAAAGCACGGGGCCTTGGGCTCCCCACTAAGGCTAGAGGGCTGCGTCCGAGGCCGTGGGGAGGCTGCCTGGAACAACATGCAGGTATTCACCTTCACCTGGAGAGAGGACATCCGGCCTGGAGACCCCCAGCACACCAAGAAGTTCTGCTTTGATGCCATTTCCCACACCAGCCCTGTCACGCTGTACGACTGCCACAGCATGAAGGGCAACCAGCTGTGGAAATACCGCAAAGACAAGACCCTGTACCACCCTGTCAGTGGCAGCTGCATGGACTGCAGTGAAAGTGACCATAGGATCTTCATGAACACCTGCAACCCATCCTCTCTCACCCAGCAGTGGCTGTTTGAACACACCAACTCAACAGTCTTGGAAAAATTCAATAGGAACTGA-3'
NCBI CDS gene sequence with introns (location: 154190867.. 154416972) (226106 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 154190733.. 154420984) (230252 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [154190733 - 1000].. 154420984) (231252 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
Cite How to cite