NCBI Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_922938)
Dectin-1
C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
CLEC7A
C-type lectin domain containing 7A
CD369
Curated
C-type lectin
CLEC7A
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
b-glucans
NP_922938
64581
Q9BXN2
ENSP00000302569.8
Q9BXN2
0.354
10.2174/138945008783502430
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (247 amino acids) Download
MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWRLIAVILGILCLVILVIAVVLGTMAIWRSNSGSNTLENGYFLSRNKENHSQPTQSSLEDSVTPTKAVKTTGVLSSPCPPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDSSNELGFIVKQVSSQPDNSFWIGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSVIYDQLCSVPSYSICEKKFSM
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9BXN2-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.57, 2.03] ÅDownload
The location of the lectin domain structural model is: 97-244
We infer [1.57, 2.03] Å as the interval of error of this structural model.
Template 1: 4ZES chain: A, Q8WTT0, NP_569708.1, sequence identity: 27.0%, coverage: 92.6%, location in sequence: 67-213, (67-213 in PDB).
Template 2: 5VYB chain: A, Q6EIG7, NP_001007034.1, sequence identity: 25.7%, coverage: 93.2%, location in sequence: 63-209, (63-209 in PDB).
Template 3: 6JJJ chain: A, P70194, NP_058031.2, sequence identity: 23.6%, coverage: 93.9%, location in sequence: 393-543, (393-543 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC7A Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells. [34305908]
  • Interaction Between Dendritic Cells and Candida krusei beta-Glucan Partially Depends on Dectin-1 and It Promotes High IL-10 Production by T Cells. [33552998]
  • The relationship between dectin-1 and mast cells in patients with diarrhea-predominant irritable bowel syndrome. [32493087]
  • Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn's disease. [32476786]
  • Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response. [32234475]
  • Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1. [11470510]
  • Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells. [11491532]
  • Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. [10779524]
  • C-type lectin-like domains. [10508765]
  • Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. [7566098]
UniProt Main References (11 PubMed Identifiers)
  • A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. [11745369]
  • Characterization of the human beta -glucan receptor and its alternatively spliced isoforms. [11567029]
  • Molecular and functional characterization of human Dectin-1. [12423684]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The finished DNA sequence of human chromosome 12. [16541075]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM. [16870151]
  • Dectin-1 promotes fungicidal activity of human neutrophils. [17230442]
  • Human dectin-1 deficiency and mucocutaneous fungal infections. [19864674]
    • Show more
All isoforms of this gene containing a lectin domain
NP_922941.1, NP_072092.2, NP_922938.1, XP_016875311.1, XP_016875312.1, XP_006719198.1, XP_024304900.1, NP_922939.1, XP_024304901.1, NP_922940.1
RNA
RNA (Transcript ID: NM_197947.3)
NM_197947.3
C-type lectin domain containing 7A, transcript variant 1
All isoforms of CLEC7A containing a lectin domain
ENST00000304084.13
118..861 (or 10118458.. 10130082)
10116777.. 10130199
NCBI Matured mRNA sequence 2542 NTPDownload 
m7G-5')ppp(5'-AGUACCUAGCCCACAUGAUUUGACUCAGAGAUUCUCUUUUGUCCACAGACAGUCAUCUCAGGAGCAGAAAGAAAAGAGCUCCCAAAUGCUAUAUCUAUUCAGGGGCUCUCAAGAACAAUGGAAUAUCAUCCUGAUUUAGAAAAUUUGGAUGAAGAUGGAUAUACUCAAUUACACUUCGACUCUCAAAGCAAUACCAGGAUAGCUGUUGUUUCAGAGAAAGGAUCGUGUGCUGCAUCUCCUCCUUGGCGCCUCAUUGCUGUAAUUUUGGGAAUCCUAUGCUUGGUAAUACUGGUGAUAGCUGUGGUCCUGGGUACCAUGGCUAUUUGGAGAUCCAAUUCAGGAAGCAACACAUUGGAGAAUGGCUACUUUCUAUCAAGAAAUAAAGAGAACCACAGUCAACCCACACAAUCAUCUUUAGAAGACAGUGUGACUCCUACCAAAGCUGUCAAAACCACAGGGGUUCUUUCCAGCCCUUGUCCUCCUAAUUGGAUUAUAUAUGAGAAGAGCUGUUAUCUAUUCAGCAUGUCACUAAAUUCCUGGGAUGGAAGUAAAAGACAAUGCUGGCAACUGGGCUCUAAUCUCCUAAAGAUAGACAGCUCAAAUGAAUUGGGAUUUAUAGUAAAACAAGUGUCUUCCCAACCUGAUAAUUCAUUUUGGAUAGGCCUUUCUCGGCCCCAGACUGAGGUACCAUGGCUCUGGGAGGAUGGAUCAACAUUCUCUUCUAACUUAUUUCAGAUCAGAACCACAGCUACCCAAGAAAACCCAUCUCCAAAUUGUGUAUGGAUUCACGUGUCAGUCAUUUAUGACCAACUGUGUAGUGUGCCCUCAUAUAGUAUUUGUGAGAAGAAGUUUUCAAUGUAAGAGGAAGGGUGGAGAAGGAGAGAGAAAUAUGUGAGGUAGUAAGGAGGACAGAAAACAGAACAGAAAAGAGUAACAGCUGAGGUCAAGAUAAAUGCAGAAAAUGUUUAGAGAGCUUGGCCAACUGUAAUCUUAACCAAGAAAUUGAAGGGAGAGGCUGUGAUUUCUGUAUUUGUCGACCUACAGGUAGGCUAGUAUUAUUUUUCUAGUUAGUAGAUCCCUAGACAUGGAAUCAGGGCAGCCAAGCUUGAGUUUUUAUUUUUUAUUUAUUUAUUUUUUUGAGAUAGGGUCUCACUUUGUUACCCAGGCUGGAGUGCAGUGGCACAAUCUCGACUCACUGCAGCUAUCUCUCGCCUCAGCCCCUCAAGUAGCUGGGACUACAGGUGCAUGCCACCAUGCCAGGCUAAUUUUUGGUGUUUUUUGUAGAGACUGGGUUUUGCCAUGUUGACCAAGCUGGUCUCUAACUCCUGGGCUUAAGUGAUCUGCCCGCCUUGGCCUCCCAAAGUGCUGGGAUUACAGAUGUGAGCCACCACACCUGGCCCCAAGCUUGAAUUUUCAUUCUGCCAUUGACUUGGCAUUUACCUUGGGUAAGCCAUAAGCGAAUCUUAAUUUCUGGCUCUAUCAGAGUUGUUUCAUGCUCAACAAUGCCAUUGAAGUGCACGGUGUGUUGCCACGAUUUGACCCUCAACUUCUAGCAGUAUAUCAGUUAUGAACUGAGGGUGAAAUAUAUUUCUGAAUAGCUAAAUGAAGAAAUGGGAAAAAAUCUUCACCACAGUCAGAGCAAUUUUAUUAUUUUCAUCAGUAUGAUCAUAAUUAUGAUUAUCAUCUUAGUAAAAAGCAGGAACUCCUACUUUUUCUUUAUCAAUUAAAUAGCUCAGAGAGUACAUCUGCCAUAUCUCUAAUAGAAUCUUUUUUUUUUUUUUUUUUUUUGAGACAGAGUUUCGCUCUUGUUGCCCAGGCUGGAGUGCAACGGCACGAUCUCGGCUCACCGCAACCUCCGCCCCCUGGGUUCAAGCAAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGAUUACAGUCAGGCACCACCACACCCGGCUAAUUUUGUAUUUUUUUAGUAGAGACAGGGUUUCUCCAUGUCGGUCAGGGUAGUCCCGAACUCCUGACCUCAAGUGAUCUGCCUGCCUCGGCCUCCCAAGUGCUGGGAUUACAGGCGUGAGCCACUGCACCCAGCCUAGAAUCUUGUAUAAUAUGUAAUUGUAGGGAAACUGCUCUCAUAGGAAAGUUUUCUGCUUUUUAAAUACAAAAAUACAUAAAAAUACAUAAAAUCUGAUGAUGAAUAUAAAAAAGUAACCAACCUCAUUGGAACAAGUAUUAACAUUUUGGAAUAUGUUUUAUUAGUUUUGUGAUGUACUGUUUUACAAUUUUUACCAUUUUUUUCAGUAAUUACUGUAAAAUGGUAUUAUUGGAAUGAAACUAUAUUUCCUCAUGUGCUGAUUUGUCUUAUUUUUUUCAUACUUUCCCACUGGUGCUAUUUUUAUUUCCAAUGGAUAUUUCUGUAUUACUAGGGAGGCAUUUACAGUCCUCUAAUGUUGAUUAAUAUGUGAAAAGAAAUUGUACCAAUUUUACUAAAUUAUGCAGUUUAAAAUGGAUGAUUUUAUGUUAUGUGGAUUUCAUUUCAAUAAAAAAAAACUCUUAUCAAAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 64581)
CLEC7A
C-type lectin domain containing 7A
NC_000012.12
12  10118458.. 10130082
10118458.. 10130082
strand -
CCDS41753.1
MGI:1861431
ClinVar, dbVar
ENSG00000172243
DECTIN-1, hDectin-1, CD369, SCARE2
uc001qxf.4
INSDC: AY009090
14558
606264
OTTHUMG00000133597
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (744 bp)
5'-ATGGAATATCATCCTGATTTAGAAAATTTGGATGAAGATGGATATACTCAATTACACTTCGACTCTCAAAGCAATACCAGGATAGCTGTTGTTTCAGAGAAAGGATCGTGTGCTGCATCTCCTCCTTGGCGCCTCATTGCTGTAATTTTGGGAATCCTATGCTTGGTAATACTGGTGATAGCTGTGGTCCTGGGTACCATGGCTATTTGGAGATCCAATTCAGGAAGCAACACATTGGAGAATGGCTACTTTCTATCAAGAAATAAAGAGAACCACAGTCAACCCACACAATCATCTTTAGAAGACAGTGTGACTCCTACCAAAGCTGTCAAAACCACAGGGGTTCTTTCCAGCCCTTGTCCTCCTAATTGGATTATATATGAGAAGAGCTGTTATCTATTCAGCATGTCACTAAATTCCTGGGATGGAAGTAAAAGACAATGCTGGCAACTGGGCTCTAATCTCCTAAAGATAGACAGCTCAAATGAATTGGGATTTATAGTAAAACAAGTGTCTTCCCAACCTGATAATTCATTTTGGATAGGCCTTTCTCGGCCCCAGACTGAGGTACCATGGCTCTGGGAGGATGGATCAACATTCTCTTCTAACTTATTTCAGATCAGAACCACAGCTACCCAAGAAAACCCATCTCCAAATTGTGTATGGATTCACGTGTCAGTCATTTATGACCAACTGTGTAGTGTGCCCTCATATAGTATTTGTGAGAAGAAGTTTTCAATGTAA-3'
NCBI CDS gene sequence with introns (location: 10118458.. 10130082) (11625 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 10116777.. 10130199) (13423 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [10116777.. 10130199 + 1000]) (14423 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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