NCBI Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_878910)
MGL - Macrophage Galactose C-type lectin
C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (Macrophage lectin 2) (CD antigen CD301)
CLEC10A
C-type lectin domain containing 10A
CD301
Curated
C-type lectin
CLEC10A
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
Gal, GalNAc
NP_878910
10462
Q8IUN9
Undefined
Q8IUN9
0.438
10.1021/acs.biochem.1c00009
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (316 amino acids) Download
MTRTYENFQYLENKVKVQGFKNGPLPLQSLLQRLCSGPCHLLLSLGLGLLLLVIICVVGFQNSKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAGVSELQEHTTQKAHLGHCPHCPSVCVPVHSEMLLRVQQLVQDLKKLTCQVATLNNNASTEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMGLSDPEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHFHPDGRWNDDVCQRPYHWVCEAGLGQTSQESH
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8IUN9-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
GalNAc, Tn antigen, thio-derivative of GalNAc
GalNAc
6PY1, 6XIY, 6W12
6PY1, 6XIY, 6W12
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC10A Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. [32915505]
  • N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity. [32752259]
  • A reference map of the human binary protein interactome. [32296183]
  • Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines. [31911241]
  • The C-type lectin receptor MGL senses N-acetylgalactosamine on the unique Staphylococcus aureus ST395 wall teichoic acid. [31219660]
  • Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. [22531918]
  • New genetic associations detected in a host response study to hepatitis B vaccine. [20237496]
  • Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. [19776380]
  • Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses. [19834553]
  • Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. [8598452]
UniProt Main References (2 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_878910.1, XP_011521915.1, NP_001316999.1, NP_006335.2, XP_011521917.1
RNA
RNA (Transcript ID: NM_182906.4)
NM_182906.4
C-type lectin domain containing 10A, transcript variant 1
All isoforms of CLEC10A containing a lectin domain
274..1224 (or 7075054.. 7078812)
7074537.. 7080251
NCBI Matured mRNA sequence 1741 NTPDownload 
m7G-5')ppp(5'-CUCAUUUACUGUCUAAAGUUGAGGAGAUGGGAUGUCCCAGAUGAUAGGGCUCCUGGGAUUUCAGACCCAAGACCAGCAGGACUCCAGUCACCUCUACCCCAGCUCUCCAGGACACAGCGCUCCCAACUCUGAGUGACGUCCCACCUCUGGUCCUUGCAGCACAACCAACGUGGGAAUCACACCCUCCAGACCUCCCACAGCUCCACCCCAGACUGGGCGCCGGCCCUGCCUCCAUUUCAGCUGUGACAACCUCAGAGCCGUGUUGGCCCAAGCAUGACAAGGACGUAUGAAAACUUCCAGUACUUGGAGAAUAAGGUGAAAGUCCAGGGGUUUAAAAAUGGGCCACUUCCUCUCCAGUCCCUCCUGCAGCGUCUCUGCUCUGGGCCCUGCCAUCUCCUGCUGUCCCUGGGCCUCGGCCUCCUGCUGCUGGUCAUCAUCUGUGUGGUUGGAUUCCAAAAUUCCAAAUUUCAGAGGGACCUGGUGACCCUGAGAACAGAUUUUAGCAACUUCACCUCAAACACUGUGGCGGAGAUCCAGGCACUGACUUCCCAGGGCAGCAGCUUGGAAGAAACGAUAGCAUCUCUGAAAGCUGAGGUGGAGGGUUUCAAGCAGGAACGGCAGGCAGGGGUAUCUGAGCUCCAGGAACACACUACGCAGAAGGCACACCUAGGCCACUGUCCCCACUGCCCAUCUGUGUGUGUCCCAGUUCAUUCUGAAAUGCUCCUGCGAGUCCAGCAGCUGGUGCAAGACCUGAAGAAACUGACCUGCCAGGUGGCUACUCUCAACAACAAUGCCUCCACUGAAGGGACCUGCUGCCCUGUCAACUGGGUGGAGCACCAAGACAGCUGCUACUGGUUCUCUCACUCUGGGAUGUCCUGGGCCGAGGCUGAGAAGUACUGCCAGCUGAAGAACGCCCACCUGGUGGUCAUCAACUCCAGGGAGGAGCAGAAUUUUGUCCAGAAAUAUCUAGGCUCCGCAUACACCUGGAUGGGCCUCAGUGACCCUGAAGGAGCCUGGAAGUGGGUGGAUGGAACAGACUAUGCGACCGGCUUCCAGAACUGGAAGCCAGGCCAGCCAGACGACUGGCAGGGGCACGGGCUGGGUGGAGGCGAGGACUGUGCUCACUUCCAUCCAGACGGCAGGUGGAAUGACGACGUCUGCCAGAGGCCCUACCACUGGGUCUGCGAGGCUGGCCUGGGUCAGACCAGCCAGGAGAGUCACUGAGCUGCCUUUGGUGGGACCACCCGGCCACAGAAAUGGCGGUGGGAGGAGGACUCUUCUCACGACCUCCUCGCAAGACCGCUCUGGGAGAGAAAUAAGCACUGGGAGAUUGGAAGCACUGCUAACAUUUUGAAUUUUUUUCUCUUUAAUUUUAAAAAGAUGGUAUAGUGUUCUUAAGCUUUUAUUUUUUUUCCAACUUUUGAAAGUCAACUUCAUGAAGGUAUAAUUUUUACAUAAUAAAAAUGCACUCAUUUAAAGAGUAGAGAUGACUUUGACAAAUAUGCAUGCCUAGGUGACUACCACUCCGAUCGCAAUAGAUAACAUUGCCAUCGCCCCCACCAGUCCCCUCAUGCCUCUGGGCAGUCCAACCACUUCCCUGUUUCCAGGCCAGUGAUCUACUUCUUUUUCACUAUUUAUUGGCCUUGCCUCUUCUAGAGCUUCUAGAACUUCAUAUAAGUGAAAUCAUACACUCUCGUGUAUAUACUUCAUAUAAGUGAAUAUAUACUCUCGUGAGAACUUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 10462)
CLEC10A
C-type lectin domain containing 10A
NC_000017.11
17  7075054.. 7078812
7075054.. 7078812
strand -
CCDS11087.1
MGI:96975;MGI:2385729
ClinVar, dbVar
ENSG00000132514
HML2, HML, CD301
uc002gej.4
INSDC: D50532
16916
605999
OTTHUMG00000177939
ENA, DDBJ, Monarch
CD301
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (951 bp)
5'-ATGACAAGGACGTATGAAAACTTCCAGTACTTGGAGAATAAGGTGAAAGTCCAGGGGTTTAAAAATGGGCCACTTCCTCTCCAGTCCCTCCTGCAGCGTCTCTGCTCTGGGCCCTGCCATCTCCTGCTGTCCCTGGGCCTCGGCCTCCTGCTGCTGGTCATCATCTGTGTGGTTGGATTCCAAAATTCCAAATTTCAGAGGGACCTGGTGACCCTGAGAACAGATTTTAGCAACTTCACCTCAAACACTGTGGCGGAGATCCAGGCACTGACTTCCCAGGGCAGCAGCTTGGAAGAAACGATAGCATCTCTGAAAGCTGAGGTGGAGGGTTTCAAGCAGGAACGGCAGGCAGGGGTATCTGAGCTCCAGGAACACACTACGCAGAAGGCACACCTAGGCCACTGTCCCCACTGCCCATCTGTGTGTGTCCCAGTTCATTCTGAAATGCTCCTGCGAGTCCAGCAGCTGGTGCAAGACCTGAAGAAACTGACCTGCCAGGTGGCTACTCTCAACAACAATGCCTCCACTGAAGGGACCTGCTGCCCTGTCAACTGGGTGGAGCACCAAGACAGCTGCTACTGGTTCTCTCACTCTGGGATGTCCTGGGCCGAGGCTGAGAAGTACTGCCAGCTGAAGAACGCCCACCTGGTGGTCATCAACTCCAGGGAGGAGCAGAATTTTGTCCAGAAATATCTAGGCTCCGCATACACCTGGATGGGCCTCAGTGACCCTGAAGGAGCCTGGAAGTGGGTGGATGGAACAGACTATGCGACCGGCTTCCAGAACTGGAAGCCAGGCCAGCCAGACGACTGGCAGGGGCACGGGCTGGGTGGAGGCGAGGACTGTGCTCACTTCCATCCAGACGGCAGGTGGAATGACGACGTCTGCCAGAGGCCCTACCACTGGGTCTGCGAGGCTGGCCTGGGTCAGACCAGCCAGGAGAGTCACTGA-3'
NCBI CDS gene sequence with introns (location: 7075054.. 7078812) (3759 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 7074537.. 7080251) (5715 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [7074537.. 7080251 + 1000]) (6715 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905