NCBI Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012].
Protein
Protein (NP_778230)
C-type lectin domain containing 14A
C-type lectin domain family 14 member A (Epidermal growth factor receptor 5) (EGFR-5)
CLEC14A
C-type lectin domain containing 14A
Undefined
Very low evidence
C-type lectin
Undefined
C-type - Endosialin
a/b mixed / C-type lectin-like
Uncharacterised
NP_778230
161198
Q86T13
ENSP00000353013.2
Q86T13
Undefined
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (490 amino acids) Download
MRPAFALCLLWQALWPGPGGGEHPTADRAGCSASGACYSLHHATMKRQAAEEACILRGGALSTVRAGAELRAVLALLRAGPGPGGGSKDLLFWVALERRRSHCTLENEPLRGFSWLSSDPGGLESDTLQWVEEPQRSCTARRCAVLQATGGVEPAGWKEMRCHLRANGYLCKYQFEVLCPAPRPGAASNLSYRAPFQLHSAALDFSPPGTEVSALCRGQLPISVTCIADEIGARWDKLSGDVLCPCPGRYLRAGKCAELPNCLDDLGGFACECATGFELGKDGRSCVTSGEGQPTLGGTGVPTRRPPATATSPVPQRTWPIRVDEKLGETPLVPEQDNSVTSIPEIPRWGSQSTMSTLQMSLQAESKATITPSGSVISKFNSTTSSATPQAFDSSSAVVFIFVSTAVVVLVILTMTVLGLVKLCFHESPSSQPRKESMGPPGLESDPEPAALGSSSAHCTNNGVKVGDCDLRDRAEGALLAESPLGSSDA
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q86T13-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.6, 2.09] ÅDownload
The location of the lectin domain structural model is: 33-174
We infer [1.6, 2.09] Å as the interval of error of this structural model.
Template 1: 4MTH chain: A, Q06141, NP_002571.1, sequence identity: 24.6%, coverage: 89.4%, location in sequence: 40-175, (40-175 in PDB).
Template 2: 3L9J chain: C, P05452, NP_003269.2, sequence identity: 23.2%, coverage: 85.2%, location in sequence: 67-201, (46-180 in PDB).
Template 3: 7L67 chain: A, P22897, NP_002429.1, sequence identity: 20.4%, coverage: 82.4%, location in sequence: 659-779, (641-761 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC14A Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • An evaluation of the tumour endothelial marker CLEC14A as a therapeutic target in solid tumours. [32696621]
  • A reference map of the human binary protein interactome. [32296183]
  • Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein. [31964714]
  • Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7. [31852888]
  • Methylation of CLEC14A is associated with its expression and lung adenocarcinoma progression. [30191970]
  • Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. [23319000]
  • Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro. [23644659]
  • Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. [21706054]
  • Shear stress, tip cells and regulators of endothelial migration. [22103489]
  • Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion. [21095181]
UniProt Main References (6 PubMed Identifiers)
  • [Cloning and characterization of a novel human ceg1 gene cDNA]. [15636369]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • The DNA sequence and analysis of human chromosome 14. [12508121]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
RNA
RNA (Transcript ID: NM_175060.3)
NM_175060.3
C-type lectin domain containing 14A
All isoforms of CLEC14A containing a lectin domain
ENST00000342213.3
72..1544 (or 38254550.. 38256022)
38254000.. 38256093
NCBI Matured mRNA sequence 2094 NTPDownload 
m7G-5')ppp(5'-AGACACAGCUCUGCGUCCUCGAGCGGGACAGAUCCAAGUUGGGAGCAGCUCUGCGUGCGGGGCCUCAGAGAAUGAGGCCGGCGUUCGCCCUGUGCCUCCUCUGGCAGGCGCUCUGGCCCGGGCCGGGCGGCGGCGAACACCCCACUGCCGACCGUGCUGGCUGCUCGGCCUCGGGGGCCUGCUACAGCCUGCACCACGCUACCAUGAAGCGGCAGGCGGCCGAGGAGGCCUGCAUCCUGCGAGGUGGGGCGCUCAGCACCGUGCGUGCGGGCGCCGAGCUGCGCGCUGUGCUCGCGCUCCUGCGGGCAGGCCCAGGGCCCGGAGGGGGCUCCAAAGACCUGCUGUUCUGGGUCGCACUGGAGCGCAGGCGUUCCCACUGCACCCUGGAGAACGAGCCUUUGCGGGGUUUCUCCUGGCUGUCCUCCGACCCCGGCGGUCUCGAAAGCGACACGCUGCAGUGGGUGGAGGAGCCCCAACGCUCCUGCACCGCGCGGAGAUGCGCGGUACUCCAGGCCACCGGUGGGGUCGAGCCCGCAGGCUGGAAGGAGAUGCGAUGCCACCUGCGCGCCAACGGCUACCUGUGCAAGUACCAGUUUGAGGUCUUGUGUCCUGCGCCGCGCCCCGGGGCCGCCUCUAACUUGAGCUAUCGCGCGCCCUUCCAGCUGCACAGCGCCGCUCUGGACUUCAGUCCACCUGGGACCGAGGUGAGUGCGCUCUGCCGGGGACAGCUCCCGAUCUCAGUUACUUGCAUCGCGGACGAAAUCGGCGCUCGCUGGGACAAACUCUCGGGCGAUGUGUUGUGUCCCUGCCCCGGGAGGUACCUCCGUGCUGGCAAAUGCGCAGAGCUCCCUAACUGCCUAGACGACUUGGGAGGCUUUGCCUGCGAAUGUGCUACGGGCUUCGAGCUGGGGAAGGACGGCCGCUCUUGUGUGACCAGUGGGGAAGGACAGCCGACCCUUGGGGGGACCGGGGUGCCCACCAGGCGCCCGCCGGCCACUGCAACCAGCCCCGUGCCGCAGAGAACAUGGCCAAUCAGGGUCGACGAGAAGCUGGGAGAGACACCACUUGUCCCUGAACAAGACAAUUCAGUAACAUCUAUUCCUGAGAUUCCUCGAUGGGGAUCACAGAGCACGAUGUCUACCCUUCAAAUGUCCCUUCAAGCCGAGUCAAAGGCCACUAUCACCCCAUCAGGGAGCGUGAUUUCCAAGUUUAAUUCUACGACUUCCUCUGCCACUCCUCAGGCUUUCGACUCCUCCUCUGCCGUGGUCUUCAUAUUUGUGAGCACAGCAGUAGUAGUGUUGGUGAUCUUGACCAUGACAGUACUGGGGCUUGUCAAGCUCUGCUUUCACGAAAGCCCCUCUUCCCAGCCAAGGAAGGAGUCUAUGGGCCCGCCGGGCCUGGAGAGUGAUCCUGAGCCCGCUGCUUUGGGCUCCAGUUCUGCACAUUGCACAAACAAUGGGGUGAAAGUCGGGGACUGUGAUCUGCGGGACAGAGCAGAGGGUGCCUUGCUGGCGGAGUCCCCUCUUGGCUCUAGUGAUGCAUAGGGAAACAGGGGACAUGGGCACUCCUGUGAACAGUUUUUCACUUUUGAUGAAACGGGGAACCAAGAGGAACUUACUUGUGUAACUGACAAUUUCUGCAGAAAUCCCCCUUCCUCUAAAUUCCCUUUACUCCACUGAGGAGCUAAAUCAGAACUGCACACUCCUUCCCUGAUGAUAGAGGAAGUGGAAGUGCCUUUAGGAUGGUGAUACUGGGGGACCGGGUAGUGCUGGGGAGAGAUAUUUUCUUAUGUUUAUUCGGAGAAUUUGGAGAAGUGAUUGAACUUUUCAAGACAUUGGAAACAAAUAGAACACAAUAUAAUUUACAUUAAAAAAUAAUUUCUACCAAAAUGGAAAGGAAAUGUUCUAUGUUGUUCAGGCUAGGAGUAUAUUGGUUCGAAAUCCCAGGGAAAAAAAUAAAAAUAAAAAAUUAAAGGAUUGUUGAUAACCCAGACUCAAAUAUCAUUGCCUUCCUCCAGGAGUAAUUAGGAACAGCUGAGGGCAUGCUGGGAGUAAGCAGCAAGAGUGCAUUCUGCUUUUAGAUUGAGGGAGAGGU-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 161198)
CLEC14A
C-type lectin domain containing 14A
NC_000014.9
14  38254550.. 38256022
38254550.. 38256022
strand -
CCDS9667.1
MGI:1914114
ClinVar, dbVar
ENSG00000176435
uc001wum.3
INSDC:
19832
616845
OTTHUMG00000140248
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1473 bp)
5'-ATGAGGCCGGCGTTCGCCCTGTGCCTCCTCTGGCAGGCGCTCTGGCCCGGGCCGGGCGGCGGCGAACACCCCACTGCCGACCGTGCTGGCTGCTCGGCCTCGGGGGCCTGCTACAGCCTGCACCACGCTACCATGAAGCGGCAGGCGGCCGAGGAGGCCTGCATCCTGCGAGGTGGGGCGCTCAGCACCGTGCGTGCGGGCGCCGAGCTGCGCGCTGTGCTCGCGCTCCTGCGGGCAGGCCCAGGGCCCGGAGGGGGCTCCAAAGACCTGCTGTTCTGGGTCGCACTGGAGCGCAGGCGTTCCCACTGCACCCTGGAGAACGAGCCTTTGCGGGGTTTCTCCTGGCTGTCCTCCGACCCCGGCGGTCTCGAAAGCGACACGCTGCAGTGGGTGGAGGAGCCCCAACGCTCCTGCACCGCGCGGAGATGCGCGGTACTCCAGGCCACCGGTGGGGTCGAGCCCGCAGGCTGGAAGGAGATGCGATGCCACCTGCGCGCCAACGGCTACCTGTGCAAGTACCAGTTTGAGGTCTTGTGTCCTGCGCCGCGCCCCGGGGCCGCCTCTAACTTGAGCTATCGCGCGCCCTTCCAGCTGCACAGCGCCGCTCTGGACTTCAGTCCACCTGGGACCGAGGTGAGTGCGCTCTGCCGGGGACAGCTCCCGATCTCAGTTACTTGCATCGCGGACGAAATCGGCGCTCGCTGGGACAAACTCTCGGGCGATGTGTTGTGTCCCTGCCCCGGGAGGTACCTCCGTGCTGGCAAATGCGCAGAGCTCCCTAACTGCCTAGACGACTTGGGAGGCTTTGCCTGCGAATGTGCTACGGGCTTCGAGCTGGGGAAGGACGGCCGCTCTTGTGTGACCAGTGGGGAAGGACAGCCGACCCTTGGGGGGACCGGGGTGCCCACCAGGCGCCCGCCGGCCACTGCAACCAGCCCCGTGCCGCAGAGAACATGGCCAATCAGGGTCGACGAGAAGCTGGGAGAGACACCACTTGTCCCTGAACAAGACAATTCAGTAACATCTATTCCTGAGATTCCTCGATGGGGATCACAGAGCACGATGTCTACCCTTCAAATGTCCCTTCAAGCCGAGTCAAAGGCCACTATCACCCCATCAGGGAGCGTGATTTCCAAGTTTAATTCTACGACTTCCTCTGCCACTCCTCAGGCTTTCGACTCCTCCTCTGCCGTGGTCTTCATATTTGTGAGCACAGCAGTAGTAGTGTTGGTGATCTTGACCATGACAGTACTGGGGCTTGTCAAGCTCTGCTTTCACGAAAGCCCCTCTTCCCAGCCAAGGAAGGAGTCTATGGGCCCGCCGGGCCTGGAGAGTGATCCTGAGCCCGCTGCTTTGGGCTCCAGTTCTGCACATTGCACAAACAATGGGGTGAAAGTCGGGGACTGTGATCTGCGGGACAGAGCAGAGGGTGCCTTGCTGGCGGAGTCCCCTCTTGGCTCTAGTGATGCATAG-3'
NCBI CDS gene sequence with introns (location: 38254550.. 38256022) (1473 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 38254000.. 38256093) (2094 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [38254000.. 38256093 + 1000]) (3094 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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