Protein
Protein (NP_775806)
Kupffer Cell receptor
C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13)
CLEC4F
C-type lectin domain family 4 member F
Undefined
Curated
C-type lectin
Undefined
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
Gal, Fuc, GlcNAc
NP_775806
165530
Q8N1N0
ENSP00000272367.2
Q8N1N0
0.345
10.1371/journal.pone.0065070
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (589 amino acids) Download
MDGEAVRFCTDNQCVSLHPQEVDSVAMAPAAPKIPRLVQATPAFMAVTLVFSLVTLFVVVQQQTRPVPKPVQAVILGDNITGHLPFEPNNHHHFGREAEMRELIQTFKGHMENSSAWVVEIQMLKCRVDNVNSQLQVLGDHLGNTNADIQMVKGVLKDATTLSLQTQMLRSSLEGTNAEIQRLKEDLEKADALTFQTLNFLKSSLENTSIELHVLSRGLENANSEIQMLNASLETANTQAQLANSSLKNANAEIYVLRGHLDSVNDLRTQNQVLRNSLEGANAEIQGLKENLQNTNALNSQTQAFIKSSFDNTSAEIQFLRGHLERAGDEIHVLKRDLKMVTAQTQKANGRLDQTDTQIQVFKSEMENVNTLNAQIQVLNGHMKNASREIQTLKQGMKNASALTSQTQMLDSNLQKASAEIQRLRGDLENTKALTMEIQQEQSRLKTLHVVITSQEQLQRTQSQLLQMVLQGWKFNGGSLYYFSSVKKSWHEAEQFCVSQGAHLASVASKEEQAFLVEFTSKVYYWIGLTDRGTEGSWRWTDGTPFNAAQNKAPGSKGSCPLRKYIIVNSGMGACSFIDTPPCPWILSN
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q8N1N0-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.31, 1.6] ÅDownload
The location of the lectin domain structural model is: 436-589
We infer [1.31, 1.6] Å as the interval of error of this structural model.
Template 1: 6BBD chain: A, Q9N1X4, NP_999275.1, sequence identity: 22.1%, coverage: 91.6%, location in sequence: 225-378, (205-358 in PDB).
Template 2: 6JJJ chain: A, P70194, NP_058031.2, sequence identity: 45.5%, coverage: 89.6%, location in sequence: 393-543, (393-543 in PDB).
Template 3: 5M62 chain: A, Q8VBX4, NP_659192.2, sequence identity: 33.1%, coverage: 80.5%, location in sequence: 192-327, (192-327 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC4F Gene
ProteomicsDB
References
NCBI References (3 PubMed Identifiers)
  • Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. [24927181]
  • A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. [16713569]
  • Structure of the gene for a carbohydrate-binding receptor unique to rat kupffer cells. [1846367]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [15815621]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
XP_011530945.1, XP_011530944.1, NP_775806.2, XP_011530937.1, XP_011530939.1, XP_016859008.1, NP_001244956.1, NP_001308237.1, XP_011530942.1, XP_011530940.1, XP_011530941.1
RNA
RNA (Transcript ID: NM_173535.3)
NM_173535.3
C-type lectin domain family 4 member F, transcript variant 1
All isoforms of CLEC4F containing a lectin domain
ENST00000272367.7
77..1846 (or 70809271.. 70820523)
70808643.. 70820599
NCBI Matured mRNA sequence 2474 NTPDownload 
m7G-5')ppp(5'-ACUGCCAUUGGUCCACGGGACGGCCCUUCCAGGAGCCAGUGGCUGGGAGCAGUGCUGGAGGAUCAAGGAAGCAGAGAUGGACGGUGAGGCAGUCCGCUUCUGCACAGAUAACCAGUGUGUCUCCCUGCACCCCCAAGAGGUGGACUCUGUGGCAAUGGCUCCUGCAGCCCCCAAGAUACCGAGGCUCGUUCAGGCUACCCCGGCAUUUAUGGCUGUGACCUUGGUCUUCUCUCUUGUGACUCUCUUUGUAGUGGUUCAACAGCAGACAAGACCUGUUCCGAAGCCUGUGCAAGCCGUAAUUCUGGGAGACAACAUUACUGGGCAUUUACCUUUUGAACCCAACAAUCAUCACCACUUUGGCAGGGAGGCAGAAAUGCGAGAGCUUAUCCAGACAUUUAAAGGCCACAUGGAGAAUUCCAGUGCCUGGGUAGUAGAAAUCCAGAUGUUGAAGUGCAGAGUGGACAAUGUCAAUUCGCAGCUCCAGGUGCUCGGUGAUCAUCUGGGAAACACCAAUGCUGACAUCCAGAUGGUAAAAGGAGUUCUAAAGGAUGCCACUACAUUGAGUUUGCAGACACAGAUGUUAAGGAGUUCCCUGGAGGGAACCAAUGCUGAGAUCCAGAGGCUCAAGGAAGACCUUGAAAAGGCAGAUGCUUUAACUUUCCAGACGCUGAAUUUCUUAAAAAGCAGUUUAGAAAACACCAGCAUUGAGCUCCACGUGCUAAGCAGAGGCUUAGAAAAUGCAAACUCUGAAAUUCAGAUGUUGAAUGCCAGUUUGGAAACGGCAAAUACCCAGGCUCAGUUAGCCAAUAGCAGUUUAAAGAACGCUAAUGCUGAGAUCUAUGUUUUGAGAGGCCAUCUAGAUAGUGUCAAUGACUUGAGGACCCAGAACCAGGUUUUAAGAAAUAGUUUGGAAGGAGCCAAUGCUGAGAUCCAGGGACUAAAGGAAAAUUUGCAGAACACAAAUGCUUUAAACUCCCAGACCCAGGCCUUUAUAAAAAGCAGUUUUGACAACACUAGUGCUGAGAUCCAGUUCUUAAGAGGUCAUUUGGAAAGAGCUGGUGAUGAAAUUCACGUGUUAAAAAGGGAUUUGAAAAUGGUCACAGCCCAGACCCAAAAAGCAAAUGGCCGUCUGGACCAGACAGAUACUCAGAUUCAGGUAUUCAAGUCAGAGAUGGAAAAUGUGAAUACCUUAAAUGCCCAGAUUCAGGUCUUAAAUGGUCAUAUGAAAAAUGCCAGCAGAGAGAUACAGACCCUAAAACAAGGAAUGAAGAAUGCUUCAGCCUUAACUUCCCAGACCCAGAUGUUAGACAGCAAUCUGCAGAAGGCCAGUGCCGAGAUCCAGAGGUUAAGAGGGGAUCUAGAGAACACCAAAGCUCUAACCAUGGAAAUCCAGCAGGAGCAGAGUCGCCUGAAGACCCUCCAUGUGGUCAUUACUUCACAGGAACAGCUACAAAGAACCCAAAGUCAGCUUCUCCAGAUGGUCCUGCAAGGCUGGAAGUUCAAUGGUGGAAGCUUAUAUUAUUUUUCUAGUGUCAAGAAGUCUUGGCAUGAGGCUGAGCAGUUCUGCGUGUCCCAGGGAGCCCAUCUGGCAUCUGUGGCCUCCAAGGAGGAGCAGGCAUUUCUGGUAGAGUUCACAAGUAAAGUGUACUACUGGAUCGGUCUCACUGACAGGGGCACAGAGGGCUCCUGGCGCUGGACAGAUGGGACACCAUUCAACGCCGCCCAGAACAAAGCGCCUGGUUCCAAGGGAUCCUGCCCACUCAGAAAGUAUAUUAUUGUGAAUUCUGGGAUGGGAGCUUGCAGCUUCAUAGACACCCCUCCCUGUCCCUGGAUCCUCAGUAACUAAGAGCAACCUGAGCACAGACACCCUCAGGGUACUCCUUCUCCCAGCCCUGUCCUCAUCCUAGGGCCACUAGGGGAUGAAGGACCCAUCUCAAGUCAGCUCCCUAGACUCAUCCCAUGUCAGCUCCCUAGGAGCCACAGCACCAGGAAGGGAUGCUGCCUUCAUCUAACAGUAUAAAGCCCUGUUGUCUUCGGGUUUUGGGAAAAGAAUCAGUCUGACAACUGGCGGCACAAGAAUGGGCAGACUGAAGACUGUGUCCAAAUUCAGCAGAAGUGGAAUGACAUGACCUGUGACACCCCCUAUCAGUGGGUGUGCAAGAAGCCCAUGGGCCAGGGUGUGGCCUGAGGGCAGGCCAGAGCUGAGGGGCUGCUCCUGCUUGCCAAUACUGACCCUCCUCCUCGAUGCCUUCGGAGCCUCUGAGCUCUGCUUGUUCUCUGGGACCUUCCGUUGGCCUUGUGGACUUCCUGCCUUGUUCUUUGAUUCAGCCCUUUCAAACAUGCUUACCUCGAGUGACCCAGUGACAUCAGUGGCUUCUCAAGGGAAGAGCCUUGCUGUGCCCCUGUAGCCUCAGCACCCAGCACAGGCCUGUCAGACAGCAGGUCCUCAAUAAAUACUCGCUGGAUCAACAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 165530)
CLEC4F
C-type lectin domain family 4 member F
NC_000002.12
2  70809271.. 70820523
70809271.. 70820523
strand -
CCDS1910.1
MGI:1859834
ClinVar, dbVar
ENSG00000152672
FLJ39110, KCLR
uc002shf.4
INSDC: AK096429
25357
OTTHUMG00000129713
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1770 bp)
5'-ATGGACGGTGAGGCAGTCCGCTTCTGCACAGATAACCAGTGTGTCTCCCTGCACCCCCAAGAGGTGGACTCTGTGGCAATGGCTCCTGCAGCCCCCAAGATACCGAGGCTCGTTCAGGCTACCCCGGCATTTATGGCTGTGACCTTGGTCTTCTCTCTTGTGACTCTCTTTGTAGTGGTTCAACAGCAGACAAGACCTGTTCCGAAGCCTGTGCAAGCCGTAATTCTGGGAGACAACATTACTGGGCATTTACCTTTTGAACCCAACAATCATCACCACTTTGGCAGGGAGGCAGAAATGCGAGAGCTTATCCAGACATTTAAAGGCCACATGGAGAATTCCAGTGCCTGGGTAGTAGAAATCCAGATGTTGAAGTGCAGAGTGGACAATGTCAATTCGCAGCTCCAGGTGCTCGGTGATCATCTGGGAAACACCAATGCTGACATCCAGATGGTAAAAGGAGTTCTAAAGGATGCCACTACATTGAGTTTGCAGACACAGATGTTAAGGAGTTCCCTGGAGGGAACCAATGCTGAGATCCAGAGGCTCAAGGAAGACCTTGAAAAGGCAGATGCTTTAACTTTCCAGACGCTGAATTTCTTAAAAAGCAGTTTAGAAAACACCAGCATTGAGCTCCACGTGCTAAGCAGAGGCTTAGAAAATGCAAACTCTGAAATTCAGATGTTGAATGCCAGTTTGGAAACGGCAAATACCCAGGCTCAGTTAGCCAATAGCAGTTTAAAGAACGCTAATGCTGAGATCTATGTTTTGAGAGGCCATCTAGATAGTGTCAATGACTTGAGGACCCAGAACCAGGTTTTAAGAAATAGTTTGGAAGGAGCCAATGCTGAGATCCAGGGACTAAAGGAAAATTTGCAGAACACAAATGCTTTAAACTCCCAGACCCAGGCCTTTATAAAAAGCAGTTTTGACAACACTAGTGCTGAGATCCAGTTCTTAAGAGGTCATTTGGAAAGAGCTGGTGATGAAATTCACGTGTTAAAAAGGGATTTGAAAATGGTCACAGCCCAGACCCAAAAAGCAAATGGCCGTCTGGACCAGACAGATACTCAGATTCAGGTATTCAAGTCAGAGATGGAAAATGTGAATACCTTAAATGCCCAGATTCAGGTCTTAAATGGTCATATGAAAAATGCCAGCAGAGAGATACAGACCCTAAAACAAGGAATGAAGAATGCTTCAGCCTTAACTTCCCAGACCCAGATGTTAGACAGCAATCTGCAGAAGGCCAGTGCCGAGATCCAGAGGTTAAGAGGGGATCTAGAGAACACCAAAGCTCTAACCATGGAAATCCAGCAGGAGCAGAGTCGCCTGAAGACCCTCCATGTGGTCATTACTTCACAGGAACAGCTACAAAGAACCCAAAGTCAGCTTCTCCAGATGGTCCTGCAAGGCTGGAAGTTCAATGGTGGAAGCTTATATTATTTTTCTAGTGTCAAGAAGTCTTGGCATGAGGCTGAGCAGTTCTGCGTGTCCCAGGGAGCCCATCTGGCATCTGTGGCCTCCAAGGAGGAGCAGGCATTTCTGGTAGAGTTCACAAGTAAAGTGTACTACTGGATCGGTCTCACTGACAGGGGCACAGAGGGCTCCTGGCGCTGGACAGATGGGACACCATTCAACGCCGCCCAGAACAAAGCGCCTGGTTCCAAGGGATCCTGCCCACTCAGAAAGTATATTATTGTGAATTCTGGGATGGGAGCTTGCAGCTTCATAGACACCCCTCCCTGTCCCTGGATCCTCAGTAACTAA-3'
NCBI CDS gene sequence with introns (location: 70809271.. 70820523) (11253 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 70808643.. 70820599) (11957 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [70808643.. 70820599 + 1000]) (12957 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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