NCBI Summary
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011].
Protein
Protein (NP_659483)
Calreticulin 3
Calreticulin-3 (Calreticulin-2) (Calsperin)
CALR3
calreticulin 3
Undefined
Very low evidence
calnexin-calreticulin like
L-Type Lectins
b-sandwich / ConA-like
Uncharacterised
NP_659483
125972
Q96L12
ENSP00000269881.3
Q96L12
0.652
10.1007/s00418-011-0817-z
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (384 amino acids) Download
MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q96L12-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.15, 1.4] ÅDownload
The location of the lectin domain structural model is: 19-343
We infer [1.15, 1.4] Å as the interval of error of this structural model.
Template 1: 6ENY chain: G, P27797, NP_004334.1, sequence identity: 55.1%, coverage: 100.0%, location in sequence: 18-386, (18-386 in PDB).
Template 2: 3O0W chain: A, P14211, NP_031617.1, sequence identity: 54.5%, coverage: 100.0%, location in sequence: 18-362, (18-362 in PDB).
Template 3: 1JHN chain: A, P24643, NP_001003232.1, sequence identity: 31.4%, coverage: 96.9%, location in sequence: 61-458, (61-458 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CALR3 Gene
ProteomicsDB
References
NCBI References (7 PubMed Identifiers)
  • Lack of evidence for a causal role of CALR3 in monogenic cardiomyopathy. [29988065]
  • Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer. [26252478]
  • Multiple loci are associated with white blood cell phenotypes. [21738480]
  • Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein. [21590275]
  • Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis. [17975137]
  • Identification of a novel calreticulin isoform (Crt2) in human and mouse. [12384296]
  • Hypertrophic Cardiomyopathy Overview [20301725]
UniProt Main References (5 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. [17655857]
RNA
RNA (Transcript ID: NM_145046.5)
NM_145046.5
calreticulin 3
All isoforms of CALR3 containing a lectin domain
ENST00000269881.8
39..1193 (or 16479131.. 16496129)
16479061.. 16496167
NCBI Matured mRNA sequence 1263 NTPDownload 
m7G-5')ppp(5'-AAGGGGUGGCGGCGACCGGAAGCGCAGUGCACACCCCCAUGGCCCGGGCUUUGGUCCAGCUCUGGGCCAUAUGCAUGCUGCGAGUGGCGCUGGCUACCGUCUAUUUCCAAGAGGAAUUUCUAGACGGAGAGCAUUGGAGAAACCGAUGGUUGCAGUCCACCAAUGACUCCCGAUUUGGGCAUUUUAGACUUUCGUCGGGCAAGUUUUAUGGUCAUAAAGAGAAAGAUAAAGGUCUGCAAACCACUCAGAAUGGCCGAUUCUAUGCCAUCUCUGCACGCUUCAAACCGUUCAGCAAUAAAGGGAAAACUCUGGUUAUUCAGUACACAGUAAAACAUGAGCAGAAGAUGGACUGUGGAGGGGGCUACAUUAAGGUCUUUCCUGCAGACAUUGACCAGAAGAACCUGAAUGGAAAAUCGCAGUACUAUAUUAUGUUUGGACCCGAUAUUUGUGGAUUUGAUAUCAAGAAAGUUCAUGUUAUUUUACAUUUCAAGAAUAAGUAUCACGAAAACAAGAAACUGAUCAGGUGUAAGGUUGAUGGCUUCACACACCUGUACACUCUAAUUUUAAGACCAGAUCUUUCUUAUGAUGUGAAAAUUGAUGGUCAGUCAAUUGAAUCCGGCAGCAUAGAGUACGACUGGAACUUAACAUCACUCAAGAAGGAAACGUCCCCGGCAGAAUCGAAGGAUUGGGAACAGACUAAAGACAACAAAGCCCAGGACUGGGAGAAGCAUUUUCUGGACGCCAGCACCAGCAAGCAGAGCGACUGGAACGGUGACCUGGAUGGGGACUGGCCAGCGCCGAUGCUCCAGAAGCCCCCGUACCAGGAUGGCCUGAAACCAGAAGGUAUUCAUAAAGACGUCUGGCUCCACCGUAAGAUGAAGAAUACCGACUAUUUGACGCAGUAUGACCUCUCAGAAUUUGAGAACAUUGGUGCCAUUGGCCUGGAGCUUUGGCAGGUGAGAUCUGGAACCAUUUUUGAUAACUUUCUGAUCACAGAUGAUGAAGAGUACGCAGAUAAUUUUGGCAAGGCCACCUGGGGCGAAACCAAGGGUCCAGAAAGGGAGAUGGAUGCCAUACAGGCCAAGGAGGAAAUGAAGAAGGCCCGCGAGGAAGAGGAGGAAGAGCUGCUGUCGGGAAAAAUUAACAGGCACGAACAUUACUUCAAUCAAUUUCACAGAAGGAAUGAACUUUAGUGAUCCCCAUUGGAUAUAAGGAUGACUGGUAAAAUCUCAUUGCUACUUUAAUCUAUGUUUCAAACUCAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 125972)
CALR3
calreticulin 3
NC_000019.10
19  16479131.. 16496129
16479131.. 16496129
strand -
CCDS12344.1
MGI:1920566
ClinVar, dbVar
ENSG00000269058
CRT2, FLJ25355, MGC26577, CT93
uc002ned.3
INSDC: AK058084
20407
611414
OTTHUMG00000152571
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1155 bp)
5'-ATGGCCCGGGCTTTGGTCCAGCTCTGGGCCATATGCATGCTGCGAGTGGCGCTGGCTACCGTCTATTTCCAAGAGGAATTTCTAGACGGAGAGCATTGGAGAAACCGATGGTTGCAGTCCACCAATGACTCCCGATTTGGGCATTTTAGACTTTCGTCGGGCAAGTTTTATGGTCATAAAGAGAAAGATAAAGGTCTGCAAACCACTCAGAATGGCCGATTCTATGCCATCTCTGCACGCTTCAAACCGTTCAGCAATAAAGGGAAAACTCTGGTTATTCAGTACACAGTAAAACATGAGCAGAAGATGGACTGTGGAGGGGGCTACATTAAGGTCTTTCCTGCAGACATTGACCAGAAGAACCTGAATGGAAAATCGCAGTACTATATTATGTTTGGACCCGATATTTGTGGATTTGATATCAAGAAAGTTCATGTTATTTTACATTTCAAGAATAAGTATCACGAAAACAAGAAACTGATCAGGTGTAAGGTTGATGGCTTCACACACCTGTACACTCTAATTTTAAGACCAGATCTTTCTTATGATGTGAAAATTGATGGTCAGTCAATTGAATCCGGCAGCATAGAGTACGACTGGAACTTAACATCACTCAAGAAGGAAACGTCCCCGGCAGAATCGAAGGATTGGGAACAGACTAAAGACAACAAAGCCCAGGACTGGGAGAAGCATTTTCTGGACGCCAGCACCAGCAAGCAGAGCGACTGGAACGGTGACCTGGATGGGGACTGGCCAGCGCCGATGCTCCAGAAGCCCCCGTACCAGGATGGCCTGAAACCAGAAGGTATTCATAAAGACGTCTGGCTCCACCGTAAGATGAAGAATACCGACTATTTGACGCAGTATGACCTCTCAGAATTTGAGAACATTGGTGCCATTGGCCTGGAGCTTTGGCAGGTGAGATCTGGAACCATTTTTGATAACTTTCTGATCACAGATGATGAAGAGTACGCAGATAATTTTGGCAAGGCCACCTGGGGCGAAACCAAGGGTCCAGAAAGGGAGATGGATGCCATACAGGCCAAGGAGGAAATGAAGAAGGCCCGCGAGGAAGAGGAGGAAGAGCTGCTGTCGGGAAAAATTAACAGGCACGAACATTACTTCAATCAATTTCACAGAAGGAATGAACTTTAG-3'
NCBI CDS gene sequence with introns (location: 16479131.. 16496129) (16999 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 16479061.. 16496167) (17107 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [16479061.. 16496167 + 1000]) (18107 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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