HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011].

Protein name

C-type lectin domain family 12 member A

Synonym(s)

C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)

HGNC gene name

CLEC12A

HGNC name

C-type lectin domain family 12 member A

Protein_CD_name

CD371

Lectin confidence

Very low evidence

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - Natural Killer NK

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Uncharacterised

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.375

Reference

10.3390/ijms24043891

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (265 amino acids) Download

MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVLASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRELYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFIKSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHCTYKKRMICEKMANPVQLGSTYFREA

No structure currently available in the PDB RCSB Databank.

Structural models

AlphaFold v2: AF-Q5QGZ9-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models

SWISS-MODEL structural model

Modeller structural model (Homology modelling pipeline), Error: [1.61, 2.1] Å Download

The location of the lectin domain structural model is: 105-256
We infer [1.61, 2.1] Å as the interval of error of this structural model.
Template 1: 4ZES chain: A, Q8WTT0, NP_569708.1, sequence identity: 24.3%, coverage: 90.8%, location in sequence: 67-213, (67-213 in PDB).
Template 2: 3WHD chain: C, Q8WXI8, NP_525126.2, sequence identity: 22.4%, coverage: 95.4%, location in sequence: 63-215, (63-215 in PDB).
Template 3: 5VYB chain: A, Q6EIG7, NP_001007034.1, sequence identity: 21.7%, coverage: 90.8%, location in sequence: 63-209, (63-209 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for CLEC12A Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Regulation of the Expression, Oligomerisation and Signaling of the Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk Region. [34638548]

The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release. [34234773]

C-Type Lectin-Like Molecule-1 as a Biomarker for Diagnosis and Prognosis in Acute Myeloid Leukemia: A Preliminary Study. [33778076]

CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy. [33094319]

Blast cells in acute megakaryoblastic leukaemia with Down syndrome are characterized by low CLEC12A expression. [33095915]

Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. [16838277]

KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. [15238421]

Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. [14739280]

Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. [12945048]

C-type lectin-like domains. [10508765]

UniProt Main References (6 PubMed Identifiers)

C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia. [15548716]

Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production. [16239426]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The finished DNA sequence of human chromosome 12. [16541075]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]

All isoforms of this gene containing a lectin domain

NP_963917.2, XP_011518873.2, NP_612210.4, XP_005253381.1, XP_011518872.1, NP_001193939.1, XP_006719096.1, XP_011518875.1, NP_001287659.1, XP_006719098.1, XP_006719099.1

RNA

RNA (Transcript ID: NM_138337.6)

RNA RefSeq ID

NM_138337.6

RNA name

C-type lectin domain family 12 member A, transcript variant 1

Isoforms

All isoforms of CLEC12A containing a lectin domain

RNA Ensembl ID

ENST00000304361.9

Coding region

189..986 (or 9971597.. 9985026)

mRNA location

9971409.. 9985595

NCBI Matured mRNA sequence 1555 NTP Download

m⁷G-5')ppp(5'-GGCUCAUUUGCAGACAUAUGGGUGAUUGGUACAGUAGGUUUAUAAACAGAAGUUUAAACUUGUAAGCUUAAGCUUCCGUUUAUAAACAGAAGUUUAAAAUUAUAGGUCCUGUUUAACAUUCAGCUCUGUUAACUCACUCAUCUUUUUGUGUUUUUACACUUUGUCAAGAUUUCUUUACAUAUUCAUCAAUGUCUGAAGAAGUUACUUAUGCAGAUCUUCAAUUCCAGAACUCCAGUGAGAUGGAAAAAAUCCCAGAAAUUGGCAAAUUUGGGGAAAAAGCACCUCCAGCUCCCUCUCAUGUAUGGCGUCCAGCAGCCUUGUUUCUGACUCUUCUGUGCCUUCUGUUGCUCAUUGGAUUGGGAGUCUUGGCAAGCAUGUUUCACGUAACUUUGAAGAUAGAAAUGAAAAAAAUGAACAAACUACAAAACAUCAGUGAAGAGCUCCAGAGAAAUAUUUCUCUACAACUGAUGAGUAACAUGAAUAUCUCCAACAAGAUCAGGAACCUCUCCACCACACUGCAAACAAUAGCCACCAAAUUAUGUCGUGAGCUAUAUAGCAAAGAACAAGAGCACAAAUGUAAGCCUUGUCCAAGGAGAUGGAUUUGGCAUAAGGACAGCUGUUAUUUCCUAAGUGAUGAUGUCCAAACAUGGCAGGAGAGUAAAAUGGCCUGUGCUGCUCAGAAUGCCAGCCUGUUGAAGAUAAACAACAAAAAUGCAUUGGAAUUUAUAAAAUCCCAGAGUAGAUCAUAUGACUAUUGGCUGGGAUUAUCUCCUGAAGAAGAUUCCACUCGUGGUAUGAGAGUGGAUAAUAUAAUCAACUCCUCUGCCUGGGUUAUAAGAAACGCACCUGACUUAAAUAACAUGUAUUGUGGAUAUAUAAAUAGACUAUAUGUUCAAUAUUAUCACUGCACUUAUAAAAAAAGAAUGAUAUGUGAGAAGAUGGCCAAUCCAGUGCAGCUUGGUUCUACAUAUUUUAGGGAGGCAUGAGGCAUCAAUCAAAUACAUUUAAGGAGUGUAGGGGGUGGGGGUUCUAGGCUAUAGGUAAAUUUAAAUAUUUUCUGGUUGACAAUUAGUUGAGUUUGUCUGAAGACCUGGGAUUUUAUCAUGCAGAUGAAACAUCCAGGUAGCAAGCUUCAGAGAGAAUAGACUGUGAAUGUUAAUGCCAGAGAGGUAUAAUGAAGCAUGUCCCACCUCCCACUUUCCAUCAUGGCCUGAACCCUGGAGGAAGAGGAAGUCCAUUCAGAUAGUUGUGGGGGGCCUUCGAAUUUUCAUUUUCAUUUACGUUCUUCCCCUUCUGGCCAAGAUUUGCCAGAGGCAACAUCAAAAACCAGCAAAUUUUAAUUUUGUCCCACAGCGUUGCUAGGGUGGCAUGGCUCCCCAUCUCGGGUCCAUCCUAUACUUCCAUGGGACUCCCUAUGGCUGAAGGCCUUAUGAGUCAAAGGACUUAUAGCCAAUUGAUUGUUCUAGGCCAGGUAAGAAUGGAUAUGGACAUGCAUUUAUUACCUCUUAAAAUUAUUAUUUUAAGUAAAAGCCAAUAAACAAAAACGAAAAGGCAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 160364)

HGNC Gene symbol

CLEC12A

HGNC Gene name

C-type lectin domain family 12 member A

Chr. RefSeq ID

NC_000012.12

Chromosome N°

12 9971597.. 9985026

CDS location

9971597.. 9985026

DNA strand

strand +

CCDS ID

CCDS8608.1

Mouse ortholog gene

MGI:3040968

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000172322

HGNC other symbol

CLL-1, MICL, CD371, DCAL-2

UCSC ID

uc001qwq.3

GeneBank

INSDC: AY498550

GeneCards

31713

MIM

612088

VEGA ID

OTTHUMG00000168396

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