NCBI Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_569708)
BDCA-2 - Blood Dendritic Cell Antigen 2
C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303)
CLEC4C
C-type lectin domain family 4 member C
CD303
Curated
C-type lectin
CLEC4C
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
Gal / Asialo N-glycans
NP_569708
170482
Q8WTT0
Undefined
Q8WTT0
0.396
10.1074/jbc.M115.660613
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (213 amino acids) Download
MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERCAIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8WTT0-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
bGal14bGlcNAc12Man
Gal(b1-4)GlcNAc(b1-2)Man
4ZET
4ZET
GlyConnect Structures
aMeMan
Man
4ZES
4ZES
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC4C Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Zika Virus Inhibits IFN-alpha Response by Human Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering of CD303 (BDCA-2) Signaling. [33193389]
  • A reference map of the human binary protein interactome. [32296183]
  • Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation. [31845972]
  • Effect of in vivo Hydroxychloroquine and ex vivo Anti-BDCA2 mAb Treatment on pDC IFNalpha Production From Patients Affected With Cutaneous Lupus Erythematosus. [30846987]
  • Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2. [29796630]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. [11748283]
  • Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells. [11536172]
  • BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. [11086035]
  • Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12. [11031109]
UniProt Main References (4 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. [21880719]
  • Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer. [24425442]
  • A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2. [25995448]
All isoforms of this gene containing a lectin domain
NP_987099.1, NP_001358319.1, NP_569708.1, XP_024304640.1, XP_024304641.1, NP_001358320.1, XP_016874429.1
RNA
RNA (Transcript ID: NM_130441.3)
NM_130441.3
C-type lectin domain family 4 member C, transcript variant 1
All isoforms of CLEC4C containing a lectin domain
560..1201 (or 7729596.. 7747348)
7729445.. 7749541
NCBI Matured mRNA sequence 1352 NTPDownload 
m7G-5')ppp(5'-ACUCUGUCACCCAGGCUGGAGUGAAGUGGUACGAUUACGGCUCACUGCAAUCCCUGCCUCCCAAAUUCCAGUGAUUCUCGUGCCUCAGCCUCCUGAGUAGCCGAAAUUACAGACGUGUGCCACCAUGCUUGGCUAAUUUUUUGGAUUUUUAGUAGAGAUGGGGUUUCACUAUGUUGGCCAGGCUAGUCUUGAACUCCUGGCCUGAAGCAAUCCGCCCACCUCAGCCUCCCAAAGUGCUGAGAUUAUAGGCACGAGCCACUACACCUGGCCACAAAAUUCUUUAAAGAAGCCAAUCCCAUCCUCCCUCAAGAGCCAAGGGGCCACCUCACCCUCUUGUUACAGCAGAUCCUGCCUCCCACAGUCACCCUGCUCCCAAGUGCAACCUCUGUCUGACCCUGCAUGGUGUGCGGUGCCCUCCUGCCUCAGGCCGCGAAGAAGGAUCUAAGGGCUUGGCUUGUUUGAAAGAACCACACCCCGAAAGUAACAUCUUUGGAGAAAGUGAUACAAGAGCUUCUGCACCCACCUGAUAGAGGAAGUCCAAAGGGUGUGCGCACACACAAUGGUGCCUGAAGAAGAGCCUCAAGACCGAGAGAAAGGACUCUGGUGGUUCCAGUUGAAGGUCUGGUCCAUGGCAGUCGUAUCCAUCUUGCUCCUCAGUGUCUGUUUCACUGUGAGUUCUGUGGUGCCUCACAAUUUUAUGUAUAGCAAAACUGUCAAGAGGCUGUCCAAGUUACGAGAGUAUCAACAGUAUCAUCCAAGCCUGACCUGCGUCAUGGAAGGAAAGGACAUAGAAGAUUGGAGCUGCUGCCCAACCCCUUGGACUUCAUUUCAGUCUAGUUGCUACUUUAUUUCUACUGGGAUGCAAUCUUGGACUAAGAGUCAAAAGAACUGUUCUGUGAUGGGGGCUGAUCUGGUGGUGAUCAACACCAGGGAAGAACAGGAUUUCAUCAUUCAGAAUCUGAAAAGAAAUUCUUCUUAUUUUCUGGGGCUGUCAGAUCCAGGGGGUCGGCGACAUUGGCAAUGGGUUGACCAGACACCAUACAAUGAAAAUGUCACAUUCUGGCACUCAGGUGAACCCAAUAACCUUGAUGAGCGUUGUGCGAUAAUAAAUUUCCGUUCUUCAGAAGAAUGGGGCUGGAAUGACAUUCACUGUCAUGUACCUCAGAAGUCAAUUUGCAAGAUGAAGAAGAUCUACAUAUAAAUGAAAUAUUCUCCCUGGAAAUGUGUUUGGGUUGGCAUCCACCGUUGUAGAAAGCUAAAUUGAUUUUUUAAUUUAUGUGUAAGUUUUGUACAAGGAAUGCCCCUAAAAUGUUUCAGCAGGCUGUCACCUAUUACACUUAUGAUAUAAUCCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 170482)
CLEC4C
C-type lectin domain family 4 member C
NC_000012.12
12  7729596.. 7747348
7729596.. 7747348
strand -
CCDS8583.1
MGI:1917060
ClinVar, dbVar
ENSG00000198178
HECL, DLEC, BDCA2, CD303
uc001qth.1
INSDC: AF325460
13258
606677
OTTHUMG00000168441
ENA, DDBJ, Monarch
CD303
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (642 bp)
5'-ATGGTGCCTGAAGAAGAGCCTCAAGACCGAGAGAAAGGACTCTGGTGGTTCCAGTTGAAGGTCTGGTCCATGGCAGTCGTATCCATCTTGCTCCTCAGTGTCTGTTTCACTGTGAGTTCTGTGGTGCCTCACAATTTTATGTATAGCAAAACTGTCAAGAGGCTGTCCAAGTTACGAGAGTATCAACAGTATCATCCAAGCCTGACCTGCGTCATGGAAGGAAAGGACATAGAAGATTGGAGCTGCTGCCCAACCCCTTGGACTTCATTTCAGTCTAGTTGCTACTTTATTTCTACTGGGATGCAATCTTGGACTAAGAGTCAAAAGAACTGTTCTGTGATGGGGGCTGATCTGGTGGTGATCAACACCAGGGAAGAACAGGATTTCATCATTCAGAATCTGAAAAGAAATTCTTCTTATTTTCTGGGGCTGTCAGATCCAGGGGGTCGGCGACATTGGCAATGGGTTGACCAGACACCATACAATGAAAATGTCACATTCTGGCACTCAGGTGAACCCAATAACCTTGATGAGCGTTGTGCGATAATAAATTTCCGTTCTTCAGAAGAATGGGGCTGGAATGACATTCACTGTCATGTACCTCAGAAGTCAATTTGCAAGATGAAGAAGATCTACATATAA-3'
NCBI CDS gene sequence with introns (location: 7729596.. 7747348) (17753 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 7729445.. 7749541) (20097 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [7729445.. 7749541 + 1000]) (21097 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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