NCBI Summary
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].
Protein
Protein (NP_569057)
SRCL - Scavenger receptor with CTLD
Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin)
COLEC12
collectin subfamily member 12
Undefined
Curated
C-type lectin
COLEC12
C-type - Collectins
a/b mixed / C-type lectin-like
Fuc / Lewis x / Gal(b1-4)[Fuc(a1-3)]GlcNAc
0.406
MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGYKVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAISTNSELSTFRSDILDLRQQLREITEKTSKNKDTLEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQNQMYSHNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLEDMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIKFNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDTLTKHTDDLTSLNNTLANIRLDSVSLRMQQDLMRSRLDTEVANLSVIMEEMKLVDSKHGQLIKNFTILQGPPGPRGPRGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKPGPQGSSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAVVPLALQNEPTPAPEDNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRESHWIGLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLIYAGQWNDFQCEDVNNFICEKDRETVLSSAL
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- COLEC12 regulates apoptosis of osteosarcoma through Toll-like receptor 4-activated inflammation. [32822099]
- Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement. [32909942]
- Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases. [29491476]
- Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes. [28317919]
- Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes. [25819896]
- Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands. [15845541]
- SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen. [12761161]
- Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene. [12601552]
- The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells. [11564734]
- Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family. [11162630]
UniProt Main References (5 PubMed Identifiers)
- DNA sequence and analysis of human chromosome 18. [16177791]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- The full-ORF clone resource of the German cDNA Consortium. [17974005]
- Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease. [16868960]
- Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism. [17420244]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_130386.3)
m7G-5')ppp(5'-AGCAGAGCGCGGAGCCGGGAGCGCGGGGAGCGCGGGCCGGCGGCGGCGAGGGAGGACGGGGGCGCAGACGGCCGGCGCGCGGCGCGGCUACCAUGGGCGUGCGGUGAGCAGCCGCUCGGGACGACUUCCUCGGCUGCGCGGCGCUCGCGCGGAGCUCCCCGGCCGGCGGUGCGUCCCCACGGUCACCAUGAAAGACGACUUCGCAGAGGAGGAGGAGGUGCAAUCCUUCGGUUACAAGCGGUUUGGUAUUCAGGAAGGAACACAAUGUACCAAAUGUAAAAAUAACUGGGCACUGAAGUUUUCUAUCAUAUUAUUAUACAUUUUGUGUGCCUUGCUAACAAUCACAGUAGCCAUUUUGGGAUAUAAAGUUGUAGAGAAAAUGGACAAUGUCACAGGUGGCAUGGAAACAUCUCGCCAAACCUAUGAUGACAAGCUCACAGCAGUGGAAAGUGACCUGAAAAAAUUAGGUGACCAAACUGGGAAGAAAGCUAUCAGCACCAACUCAGAACUCUCCACCUUCAGAUCAGACAUUCUAGAUCUCCGUCAGCAACUUCGUGAGAUUACAGAAAAAACCAGCAAGAACAAGGAUACGCUGGAGAAGUUACAGGCGAGCGGGGAUGCUCUGGUGGACAGGCAGAGUCAAUUGAAAGAAACUUUGGAGAAUAACUCUUUCCUCAUCACCACUGUAAACAAAACCCUCCAGGCGUAUAAUGGCUAUGUCACGAAUCUGCAGCAAGAUACCAGCGUGCUCCAGGGCAAUCUGCAGAACCAAAUGUAUUCUCAUAAUGUGGUCAUCAUGAACCUCAACAACCUGAACCUGACCCAGGUGCAGCAGAGGAACCUCAUCACGAAUCUGCAGCGGUCUGUGGAUGACACAAGCCAGGCUAUCCAGCGAAUCAAGAACGACUUUCAAAAUCUGCAGCAGGUUUUUCUUCAAGCCAAGAAGGACACGGAUUGGCUGAAGGAGAAAGUGCAGAGCUUGCAGACGCUGGCUGCCAACAACUCUGCGUUGGCCAAAGCCAACAACGACACCCUGGAGGAUAUGAACAGCCAGCUCAACUCAUUCACAGGUCAGAUGGAGAACAUCACCACUAUCUCUCAAGCCAACGAGCAGAACCUGAAAGACCUGCAGGACUUACACAAAGAUGCAGAGAAUAGAACAGCCAUCAAGUUCAACCAACUGGAGGAACGCUUCCAGCUCUUUGAGACGGAUAUUGUGAACAUCAUUAGCAAUAUCAGUUACACAGCCCACCACCUGCGGACGCUGACCAGCAAUCUAAAUGAAGUCAGGACCACUUGCACAGAUACCCUUACCAAACACACAGAUGAUCUGACCUCCUUGAAUAAUACCCUGGCCAACAUCCGUUUGGAUUCUGUUUCUCUCAGGAUGCAACAAGAUUUGAUGAGGUCGAGGUUAGACACUGAAGUAGCCAACUUAUCAGUGAUUAUGGAAGAAAUGAAGCUAGUAGACUCCAAGCAUGGUCAGCUCAUCAAGAAUUUUACAAUACUACAAGGUCCACCGGGCCCCAGGGGUCCAAGAGGUGACAGAGGAUCCCAGGGACCCCCUGGCCCAACUGGCAACAAGGGACAGAAAGGAGAGAAGGGGGAGCCUGGACCACCUGGCCCUGCGGGUGAGAGAGGCCCAAUUGGACCAGCUGGUCCCCCCGGAGAGCGUGGCGGCAAAGGAUCUAAAGGCUCCCAGGGCCCCAAAGGCUCCCGUGGUUCCCCUGGGAAGCCCGGCCCUCAGGGCUCCAGUGGGGACCCAGGCCCCCCGGGCCCACCAGGCAAAGAGGGACUCCCCGGCCCUCAGGGCCCUCCUGGCUUCCAGGGACUUCAGGGCACCGUUGGGGAGCCUGGGGUGCCUGGACCUCGGGGACUGCCAGGCUUGCCUGGGGUACCAGGCAUGCCAGGCCCCAAGGGCCCCCCCGGCCCUCCUGGCCCAUCAGGAGCGGUGGUGCCCCUGGCCCUGCAGAAUGAGCCAACCCCAGCACCGGAGGACAAUGGCUGCCCGCCUCACUGGAAGAACUUCACAGACAAAUGCUACUAUUUUUCAGUUGAGAAAGAAAUUUUUGAGGAUGCAAAGCUUUUCUGUGAAGACAAGUCUUCACAUCUUGUUUUCAUAAACACUAGAGAGGAACAGCAAUGGAUAAAAAAACAGAUGGUAGGGAGAGAGAGCCACUGGAUCGGCCUCACAGACUCAGAGCGUGAAAAUGAAUGGAAGUGGCUGGAUGGGACAUCUCCAGACUACAAAAAUUGGAAAGCUGGACAGCCGGAUAACUGGGGUCAUGGCCAUGGGCCAGGAGAAGACUGUGCUGGGUUGAUUUAUGCUGGGCAGUGGAACGAUUUCCAAUGUGAAGACGUCAAUAACUUCAUUUGCGAAAAAGACAGGGAGACAGUACUGUCAUCUGCAUUAUAACGGACUGUGAUGGGAUCACAUGAGCAAAUUUUCAGCUCUCAAAGGCAAAGGACACUCCUUUCUAAUUGCAUCACCUUCUCAUCAGAUUGAAAAAAAAAAAGCACUGAAAACCAAUUACUGAAAAAAAAUUGACAGCUAGUGUUUUUUACCAUCCGUCAUUACCCAAAGACUUGGGAACUAAAAUGUUCCCCAGGGUGAUAUGCUGAUUUUCAUUGUGCACAUGGACUGAAUCACAUAGAUUCUCCUCCGUCAGUAACCGUGCGAUUAUACAAAUUAUGUCUUCCAAAGUAUGGAACACUCCAAUCAGAAAAAGGUUAUCAUUGGUCGUUGAGUUAUGGGAAGAACUUAAGCAUAUACUGUGUAAACAGUGCCAUACAUUUCUAAAAUCCCAAGUGUAGGAAAAAUAUGCAGACAUACAGAUAUAUAGGCCAACUAUUAGUAAUAAUAUGAAAUAUACUUAAAGAGCUUUUAAAACUUUGUAUUUUUGUACAAAAUAUUUGUCUUUUACAAUUUUUUUCCUUUUUUUUUUUUUGUCAUUUUACCGACAUAAUACAUGGAGCCAAAGAAAACAAUAAUGGUACUAAUAAAAACUCCUAGGGUUUCCUGUCAGAUUUAAUUCUACCCAGUGGCAAAGAAUUUUUUCAAUUGUGGCUUUAAAAAAAUAAUUAAAUAUACAUGUGUAUAUAUAUAUAUAUAUAUAUAUUUUUUUUUUUUUUUUUUUUUAAUGUUUCAUUUCCUCAGAGGAACCAAUCACUUGGAAUGUCUAGAAAUAUCCUUGCAGAUUUUGCCAGUGUCAAUCAAGCCUGCACACAUGCACAGUGAAGCGGGCUGUGCCUGCCUUGAGCCCAUCACCAGCCAACAUUCUUGACGUGUGCCUGACCAGACACAGAAGAAAUGGGCAACUCAAGACGUGCUUCCACUUCAUUUUGGUGGAGUCGGGAGGUGUGGGGGAUGGAGAGGCAUCUGUUGGGAAGGGCACUGAAUCUGGCCUAUCUGGAAGGCCCUGUGUCAUGGCUGAGCUAUGACUGUACUUGGCAUCAGAUCCCUACAGAGCCAACAUUAACUGUCAGGAACGUAUGGCGUCACAUCAGCCAAAGGCAGAGAUGCUAGAAAGAUGGGAACCGGCUACGUGUUACCUGGAAAGUUUGUUUUCUUAAGUCAUAUUCCAAAAACAUAACUCCAAGGCAUACGCAUGAUAAAAUGCAAGAAUAAACUUUUGGCCACUUUGUGGAACUCUUAAAAGAACCUUUCCAGCCGGGCGCAGUGGCUCAUGCCUGUAAUCCCAGCACUUUGGGAGGCCGAGGCAGGCAGAUGACUUGAGGUCAGGAGUUCGAGACCAGCCUGGCCAACGUGGCAAAACCCCAUCUCUACUAAAAAUAAGAAAAUUAGCCGGGUGUAGUGGCACAUGCCUGUAAUCCCAGCUACUCAGGAGGCUGAGGCAGGAGAAUCGCUUGAGCCCAGGAGGCAGAGAUUGCAGUGAGCCAAGAUCGCACCACUGCACUCCAGCCUCGGUGACAGAGCAAGACUCCAUCUCAAAAAAAAAAAAAAAAAAAAAACCUUUCCUCUGAGCCCAUCUUCCUUUCGCUCCUUGACUUUCCUUGACUUGCUGUUGGAAAGUCUAAUAUGAAAAGGGCUGAAACUAGGCAUUAAAUAUAACUGAUGCUCAAAGGUAAGAUUUCCAUCCAACAGAUUCCUUCUCCCUCCCAAGGGUCUUCCCAGGCAGUGCUGCUACUUAUCCCAAAUAAAAUGGUAAAAGAAUAAAGACAGCCGGGCGCGGUGGCUCACGCCUGUAAUCCCAGCACUUUGGGAGGCCGAGGCGGACGGAUCACAAGGUCAGGAGAUCGAGACCAUCCUGGCUAACACGGUGAAACCCCGUCUCUACUAAAAAUACAAAAAAAAAAUUAGCCGGGCGCGGUGGCGGGCGCCUGUAGUCCCAGCUACUCGGGAGGCUGAGGCAGGAGAAUGGCGUGAACCCAGGAAGCGGAGCUUGCAGUGAGCCGAGAUCGCGCCACUGCACUCCAGCCUGGGCGACAGAGCGAGACUCAUCUCAAAAAGAAAAAAAAAAAAGAAUAAAGACAGAGUUUGACUUUCCCACCUGCGAACAAGUGGACUGUACUGCUUUGCCCACAGUCUCCAUUCCCCAUUCAUGCUGUUUUCACAGCCCAGUAAUGGCCAACUGCUCAGCACCUGUGUGCCCUGCUGUCAGGCAGGUGGGACCCACAGUCCUCUGGGCCUAAACUGCUGAAGCCUGCACCACAAGGCGGGCACGGCAUUCCAACACCUCUUCAGGCUCAACAGCCUUUAGAGGCUACACUGAGUCCUCUUUUUCAUGCUCUUCCUGGUUUUCAAGUGUCAAUUAAAAUUUGUCUUCAGAAGAAACUUGAAAAUAAGUAUCUGAUGCCGUCAUCAGGAUAGACUAGUAUUAGCUUUCGCAGCUGAAGUUAUUGCUCUCCCAGCCCUAAUAAUAACUUACCAAGUGCUUAUUAUUUAUCAGGCACUGGUCCAAGUCCUUCAAUCAGAUUGUCUCACCUGAUCCUCCCAACAGCCCUAGGAAGCAGGUCUUACUACACUCCCCAUUUCACAGGGACUGGGGCUUGGGGAGGUGAUGCGGUUUCCUGGGUCACUCCAUUACUGAGUAGUGAGACAGGAUUCAGACGCAAGCUUUGAAAAUGUUCUAAUUUUCUUUAGAAGGAAGGGCCCUUCUUAAUAGCACACUGAAUAAAAUCAAAUGAAUAAUCACACAUUACAAGAUGCCUCCUAUACGUCUCUAUAUUUAGCUACUUACAUACCAGGUUUCUUUUUUGUUUGUUUUUGUUUUUAAGACAGAGUCUCGCUCUGUCACCCAGGCUGGAGUGCGGUGGCGCGAUCUCGGCUCACUGCAAUCUCUGCCUCCCAGGUUCAAGCGACUCUCCCGCCUCAGCCUCUGCAGUAGCUUAGGGACUACAGGUGCGUGCCACCAUGCCAGGCUAAUUUUUGUGUUUUUAGUAGAGACACGGUUUCGCCAUUUUGGCCAGGCUGGUCUCAAACUCCUGACCUCAGGUGAUCCACCCGCCUUGGCCUCCCAAAGUGCUGGGAUUACAGGUGUGAGCCACCGUGCCCGGCCUACACACCAGCUUUCUAUUCACCUACACACAACUGAUGCUCUUUUGGAGUGGAGAGUUUUAGUAAAAUAUGAUGGGGUCUUCAGGCACCUGAGUUGCUACUUACUACUAUGAGAAGAUAGAAAAUGUUUUUUCCUCUAAACAGCUUUUGAAAGAAUGAAUGCACAACAAGGCAAAAAAUAAAAACUUUCUUUUCCUUUUCUACGA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 81035)
collectin subfamily member 12
strand -
SRCL, CL-P1, SCARA4
NCBI CDS gene sequence (2229 bp)
5'-ATGAAAGACGACTTCGCAGAGGAGGAGGAGGTGCAATCCTTCGGTTACAAGCGGTTTGGTATTCAGGAAGGAACACAATGTACCAAATGTAAAAATAACTGGGCACTGAAGTTTTCTATCATATTATTATACATTTTGTGTGCCTTGCTAACAATCACAGTAGCCATTTTGGGATATAAAGTTGTAGAGAAAATGGACAATGTCACAGGTGGCATGGAAACATCTCGCCAAACCTATGATGACAAGCTCACAGCAGTGGAAAGTGACCTGAAAAAATTAGGTGACCAAACTGGGAAGAAAGCTATCAGCACCAACTCAGAACTCTCCACCTTCAGATCAGACATTCTAGATCTCCGTCAGCAACTTCGTGAGATTACAGAAAAAACCAGCAAGAACAAGGATACGCTGGAGAAGTTACAGGCGAGCGGGGATGCTCTGGTGGACAGGCAGAGTCAATTGAAAGAAACTTTGGAGAATAACTCTTTCCTCATCACCACTGTAAACAAAACCCTCCAGGCGTATAATGGCTATGTCACGAATCTGCAGCAAGATACCAGCGTGCTCCAGGGCAATCTGCAGAACCAAATGTATTCTCATAATGTGGTCATCATGAACCTCAACAACCTGAACCTGACCCAGGTGCAGCAGAGGAACCTCATCACGAATCTGCAGCGGTCTGTGGATGACACAAGCCAGGCTATCCAGCGAATCAAGAACGACTTTCAAAATCTGCAGCAGGTTTTTCTTCAAGCCAAGAAGGACACGGATTGGCTGAAGGAGAAAGTGCAGAGCTTGCAGACGCTGGCTGCCAACAACTCTGCGTTGGCCAAAGCCAACAACGACACCCTGGAGGATATGAACAGCCAGCTCAACTCATTCACAGGTCAGATGGAGAACATCACCACTATCTCTCAAGCCAACGAGCAGAACCTGAAAGACCTGCAGGACTTACACAAAGATGCAGAGAATAGAACAGCCATCAAGTTCAACCAACTGGAGGAACGCTTCCAGCTCTTTGAGACGGATATTGTGAACATCATTAGCAATATCAGTTACACAGCCCACCACCTGCGGACGCTGACCAGCAATCTAAATGAAGTCAGGACCACTTGCACAGATACCCTTACCAAACACACAGATGATCTGACCTCCTTGAATAATACCCTGGCCAACATCCGTTTGGATTCTGTTTCTCTCAGGATGCAACAAGATTTGATGAGGTCGAGGTTAGACACTGAAGTAGCCAACTTATCAGTGATTATGGAAGAAATGAAGCTAGTAGACTCCAAGCATGGTCAGCTCATCAAGAATTTTACAATACTACAAGGTCCACCGGGCCCCAGGGGTCCAAGAGGTGACAGAGGATCCCAGGGACCCCCTGGCCCAACTGGCAACAAGGGACAGAAAGGAGAGAAGGGGGAGCCTGGACCACCTGGCCCTGCGGGTGAGAGAGGCCCAATTGGACCAGCTGGTCCCCCCGGAGAGCGTGGCGGCAAAGGATCTAAAGGCTCCCAGGGCCCCAAAGGCTCCCGTGGTTCCCCTGGGAAGCCCGGCCCTCAGGGCTCCAGTGGGGACCCAGGCCCCCCGGGCCCACCAGGCAAAGAGGGACTCCCCGGCCCTCAGGGCCCTCCTGGCTTCCAGGGACTTCAGGGCACCGTTGGGGAGCCTGGGGTGCCTGGACCTCGGGGACTGCCAGGCTTGCCTGGGGTACCAGGCATGCCAGGCCCCAAGGGCCCCCCCGGCCCTCCTGGCCCATCAGGAGCGGTGGTGCCCCTGGCCCTGCAGAATGAGCCAACCCCAGCACCGGAGGACAATGGCTGCCCGCCTCACTGGAAGAACTTCACAGACAAATGCTACTATTTTTCAGTTGAGAAAGAAATTTTTGAGGATGCAAAGCTTTTCTGTGAAGACAAGTCTTCACATCTTGTTTTCATAAACACTAGAGAGGAACAGCAATGGATAAAAAAACAGATGGTAGGGAGAGAGAGCCACTGGATCGGCCTCACAGACTCAGAGCGTGAAAATGAATGGAAGTGGCTGGATGGGACATCTCCAGACTACAAAAATTGGAAAGCTGGACAGCCGGATAACTGGGGTCATGGCCATGGGCCAGGAGAAGACTGTGCTGGGTTGATTTATGCTGGGCAGTGGAACGATTTCCAATGTGAAGACGTCAATAACTTCATTTGCGAAAAAGACAGGGAGACAGTACTGTCATCTGCATTATAA-3'
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