Protein
Protein (NP_543154)
Intelectin 2
Intelectin-2 (Endothelial lectin HL-2)
ITLN2
intelectin 2
Undefined
Low evidence
Ficolin-like
X-Type Lectins
a/b mixed with b-sheet / Fibrinogen C-ter like
b-glucans
NP_543154
142683
Q8WWU7
ENSP00000357008.3
Q8WWU7
0.481
10.1016/j.fsi.2022.03.025
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (325 amino acids) Download
MLSMLRTMTRLCFLLFFSVATSGCSAAAASSLEMLSREFETCAFSFSSLPRSCKEIKERCHSAGDGLYFLRTKNGVVYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGNKADYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSALLRYRTNTGFLQRLGHNLFGIYQKYPVKYRSGKCWNDNGPAIPVVYDFGDAKKTASYYSPYGQREFVAGFVQFRVFNNERAANALCAGIKVTGCNTEHHCIGGGGFFPQGKPRQCGDFSAFDWDGYGTHVKSSCSREITEAAVLLFYR
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q8WWU7-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [ err > 2 Å]Download
The location of the lectin domain structural model is: 44-323
We infer [ err > 2 Å] as the interval of error of this structural model.
Template 1: 2J5Z chain: A, O75636, NP_003656.2, sequence identity: 16.4%, coverage: 74.3%, location in sequence: 86-299, (63-276 in PDB).
Template 2: 2J3U chain: B, Q15485, NP_004099.2, sequence identity: 14.3%, coverage: 71.8%, location in sequence: 96-313, (71-288 in PDB).
Template 3: 6ZQX chain: A, Q8N539, NP_116232.3, sequence identity: 11.8%, coverage: 72.5%, location in sequence: 239-457, (239-457 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for ITLN2 Gene
ProteomicsDB
References
NCBI References (6 PubMed Identifiers)
  • Comparative genomic and phylogenetic analyses of the intelectin gene family: implications for their origin and evolution. [23643964]
  • Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. [20682687]
  • Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. [20628086]
  • Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. [19913121]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Human homologs of the Xenopus oocyte cortical granule lectin XL35. [11181563]
UniProt Main References (2 PubMed Identifiers)
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
XP_024309089.1, NP_543154.1, XP_011507512.1
RNA
RNA (Transcript ID: NM_080878.3)
NM_080878.3
intelectin 2
All isoforms of ITLN2 containing a lectin domain
ENST00000368029.4
69..1046 (or 160945140.. 160954741)
160945025.. 160954809
NCBI Matured mRNA sequence 1161 NTPDownload 
m7G-5')ppp(5'-AGGAUCCUCUGCAGGGGAGCUCCGAGUGUCCACAGGAAGGGAACUAUCAGCUCCUGGCAUCUGUAAGGAUGCUGUCCAUGCUGAGGACAAUGACCAGACUCUGCUUCCUGUUAUUCUUCUCUGUGGCCACCAGUGGGUGCAGUGCAGCAGCAGCCUCUUCUCUUGAGAUGCUCUCGAGGGAAUUCGAAACCUGUGCCUUCUCCUUUUCUUCCCUGCCUAGAAGCUGCAAAGAAAUCAAGGAACGCUGCCAUAGUGCAGGUGAUGGCCUGUAUUUUCUCCGCACCAAGAAUGGUGUUGUCUACCAGACCUUCUGUGACAUGACUUCUGGGGGUGGCGGCUGGACCCUGGUGGCCAGCGUGCACGAGAAUGACAUGCGUGGGAAGUGCACGGUGGGUGAUCGCUGGUCCAGUCAGCAGGGCAACAAAGCAGACUACCCAGAGGGGGAUGGCAACUGGGCCAACUACAACACCUUUGGAUCUGCAGAGGCGGCCACGAGCGAUGACUACAAGAACCCUGGCUACUACGACAUCCAGGCCAAGGACCUGGGCAUCUGGCAUGUGCCCAACAAGUCCCCCAUGCAGCAUUGGAGAAACAGCGCCCUGCUGAGGUACCGCACCAACACUGGCUUCCUCCAGAGACUGGGACAUAAUCUGUUUGGCAUCUACCAGAAAUACCCAGUGAAAUACAGAUCAGGGAAAUGUUGGAAUGACAAUGGCCCAGCCAUACCUGUGGUCUAUGACUUUGGUGAUGCUAAGAAGACUGCAUCUUAUUACUCACCGUAUGGUCAACGGGAAUUUGUUGCAGGAUUCGUUCAGUUCCGGGUGUUUAAUAACGAGAGAGCAGCCAACGCCCUUUGUGCUGGGAUAAAAGUUACUGGCUGUAACACUGAGCAUCACUGCAUCGGUGGAGGAGGGUUCUUCCCACAGGGCAAACCCCGUCAGUGUGGGGACUUCUCCGCCUUUGACUGGGAUGGAUAUGGAACUCACGUUAAGAGCAGCUGCAGUCGGGAGAUAACGGAGGCGGCUGUACUCUUGUUCUAUAGAUGAGACAGAGCUCUGCGGUGUCAGGGCGAGAACCCAUCUUCCAACCCCGGCUAUUUGGAGACGGAAAAACUGGAAUUCUAACAAGGAGGAGAGGAGACUAAAUCACAUCAAUUUGCAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 142683)
ITLN2
intelectin 2
NC_000001.11
1  160945140.. 160954741
160945140.. 160954741
strand -
CCDS1212.1
MGI:1333831
ClinVar, dbVar
ENSG00000158764
HL-2
uc001fxd.4
INSDC: AY065973
20599
609874
OTTHUMG00000028605
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (978 bp)
5'-ATGCTGTCCATGCTGAGGACAATGACCAGACTCTGCTTCCTGTTATTCTTCTCTGTGGCCACCAGTGGGTGCAGTGCAGCAGCAGCCTCTTCTCTTGAGATGCTCTCGAGGGAATTCGAAACCTGTGCCTTCTCCTTTTCTTCCCTGCCTAGAAGCTGCAAAGAAATCAAGGAACGCTGCCATAGTGCAGGTGATGGCCTGTATTTTCTCCGCACCAAGAATGGTGTTGTCTACCAGACCTTCTGTGACATGACTTCTGGGGGTGGCGGCTGGACCCTGGTGGCCAGCGTGCACGAGAATGACATGCGTGGGAAGTGCACGGTGGGTGATCGCTGGTCCAGTCAGCAGGGCAACAAAGCAGACTACCCAGAGGGGGATGGCAACTGGGCCAACTACAACACCTTTGGATCTGCAGAGGCGGCCACGAGCGATGACTACAAGAACCCTGGCTACTACGACATCCAGGCCAAGGACCTGGGCATCTGGCATGTGCCCAACAAGTCCCCCATGCAGCATTGGAGAAACAGCGCCCTGCTGAGGTACCGCACCAACACTGGCTTCCTCCAGAGACTGGGACATAATCTGTTTGGCATCTACCAGAAATACCCAGTGAAATACAGATCAGGGAAATGTTGGAATGACAATGGCCCAGCCATACCTGTGGTCTATGACTTTGGTGATGCTAAGAAGACTGCATCTTATTACTCACCGTATGGTCAACGGGAATTTGTTGCAGGATTCGTTCAGTTCCGGGTGTTTAATAACGAGAGAGCAGCCAACGCCCTTTGTGCTGGGATAAAAGTTACTGGCTGTAACACTGAGCATCACTGCATCGGTGGAGGAGGGTTCTTCCCACAGGGCAAACCCCGTCAGTGTGGGGACTTCTCCGCCTTTGACTGGGATGGATATGGAACTCACGTTAAGAGCAGCTGCAGTCGGGAGATAACGGAGGCGGCTGTACTCTTGTTCTATAGATGA-3'
NCBI CDS gene sequence with introns (location: 160945140.. 160954741) (9602 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 160945025.. 160954809) (9785 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [160945025.. 160954809 + 1000]) (10785 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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