NCBI Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_525126)
MCL - Macrophage C-type lectin
C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368)
CLEC4D
C-type lectin domain family 4 member D
CD368
Low evidence
C-type lectin
CLEC4D
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
Glycolipid weak
NP_525126
338339
Q8WXI8
ENSP00000299665.2
Q8WXI8
0.429
10.1073/pnas.1312649110
PFAM, InterPro
Protein sequence and protein families (fasta) (215 amino acids) Download
MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLSVCFIASCLVTHHNFSRCKRGTGVHKLEHHAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGENCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8WXI8-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Heterodimer with CLEC4E; disulfide-linked (By similarity). CLEC4E acts as a bridge for interaction between CLEC4D and FCER1G to form a functional complex (By similarity). Heterodimer with CLEC6A; this heterodimer forms a pattern recognition receptor (PRR) against fungal infection (PubMed:23911656)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • The Mincle/Syk/NF-kappaB Signaling Circuit Is Essential for Maintaining the Protumoral Activities of Tumor-Associated Macrophages. [32532809]
  • A reference map of the human binary protein interactome. [32296183]
  • The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells. [29616019]
  • Widespread macromolecular interaction perturbations in human genetic disorders. [25910212]
  • Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. [24101491]
  • The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. [22689578]
  • Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. [15368084]
  • The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. [14971047]
  • Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. [12945048]
  • C-type lectin-like domains. [10508765]
UniProt Main References (3 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • C-type lectin MCL is an FcRgamma-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. [23602766]
  • C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. [23911656]
All isoforms of this gene containing a lectin domain
NP_525126.2, XP_011518934.1, XP_011518935.1
RNA
RNA (Transcript ID: NM_080387.5)
NM_080387.5
C-type lectin domain family 4 member D
All isoforms of CLEC4D containing a lectin domain
ENST00000299665.3
231..878 (or 8513733.. 8521271)
8513503.. 8522366
NCBI Matured mRNA sequence 1973 NTPDownload 
m7G-5')ppp(5'-GCCUCAUCUCCCGGAAUGUAUCAAAGGAAACCCCUGUCUUUGAAAAAGACUUCUUUUGAGCUAACUUUCUUAUACUGGUACCUUUCUAAUCUCACUACAAUAUGUAACAUUGGUGUUCGAUCUCAAGUAUUUCUGAAUAUAUUCCCCUAUCCACAGAAAUAUACUCUGGGGGAAAAAAAAUAGAACAAAUUCUUGCCGUCCUGACCAUUGAACAAGAGACUAAUUAGACAAUGGGGCUAGAAAAACCUCAAAGUAAACUGGAAGGAGGCAUGCAUCCCCAGCUGAUACCUUCGGUUAUUGCUGUAGUUUUCAUCUUACUUCUCAGUGUCUGUUUUAUUGCAAGUUGUUUGGUGACUCAUCACAACUUUUCACGCUGUAAGAGAGGCACAGGAGUGCACAAGUUAGAGCACCAUGCAAAGCUCAAAUGCAUCAAAGAGAAAUCAGAACUGAAAAGUGCUGAAGGGAGCACCUGGAACUGUUGUCCUAUUGACUGGAGAGCCUUCCAGUCCAACUGCUAUUUUCCUCUUACUGACAACAAGACGUGGGCUGAGAGUGAAAGGAACUGUUCAGGGAUGGGGGCCCAUCUGAUGACCAUCAGCACGGAAGCUGAGCAGAACUUUAUUAUUCAGUUUCUGGAUAGACGGCUUUCCUAUUUCCUUGGACUUAGAGAUGAGAAUGCCAAAGGUCAGUGGCGUUGGGUGGACCAGACGCCAUUUAACCCACGCAGAGUAUUCUGGCAUAAGAAUGAACCCGACAACUCUCAGGGAGAAAACUGUGUUGUUCUUGUUUAUAACCAAGAUAAAUGGGCCUGGAAUGAUGUUCCUUGUAACUUUGAAGCAAGUAGGAUUUGUAAAAUACCUGGAACAACAUUGAACUAGAAACUCAGAAAGUGGUCCUUGUGAUGGAAAGAGAAAAGAAAAACCAAUUAGAAUAAGGCAGAAUGUACGUGCGUCAUUGGAACACAGAAAACAUGCUGGUUCAUACAGCGUUUUUAGUCAUAAUGGUCUUUUUUAUUUUGUUUGAUUCAUUCGAGACAACAUGUGUGUAUGUGUGUGUGUGUGUGUGUAGAUAAUGUGGUUUUUGUAUGGUGUUUGAUGGAAGGAAUAAUCUUUCUUUGCUUUCUUAGUAGUAUUUCAAGGUGUUUACUUUUCAAUUGGUGUGCACUGAAUGCAUGUAUGGAAGAAUAGCGUGAAUAAUGCAAUCUCUUUGUCAUUUUUCCCCUUCUCAGACUCUUAGCUCUUAAAAUUCAAAGAUGGGAUAUUCUAACUGGUAGUGGUGCAUCAUUUUUAACCCAAAUAUUGCAAGCACUUUAAAGAUUUGAAACCACAUUUUUAUUGUUUGAUGUUUCAUUUUCAGACUUUUUAAUGUCAGUCAUUACAAUUACAUUGCAUGAGGAAAAUUUUUCCAGAACAACAGUGUGGAAUAGUUCUGAAUUAUGCUGUUCUACAGAUAGAAAAAAAGUCCAAAUGCCUUUAAAAAUUUACUUCUUACUCCACCCAACACGUUUUUGCAAAGCAAGAAGUCUUUGUAAGACACCUUAAACAAAGUCCUUCAAUUCUACAGCAGAGGAAAUAAAAUCCCCCAGAAGCCAAAGGGCUCACCUUCACAUUGUUAGUUCAUGACAGACCCAGGUGUGCUUCAUUAGAGAUAACAUACAUUCCCUUUGGUAUCACAGGAAGUUACUGGGGAUUACUCGACCUCAUUACUUAGCUAACGACUGGAUAAAAUUUCUUAAUUGUUUGAAGUAACAUUGUAUUCGUGUUUGCAUUAUUAAUUUGAAUAGAAAAUAAUCACAUUUUCAACCCAUUUAUACAAAUUGUUAAUGUUUCUUUAGAGCUGUAUAACUAUAGUUUGAACUAGCAAGGAAGUUAUUGUUUUGACAACCAGAAAUUAUGCUUUUCUGGUGCAUGAAACAUUAAUUGCAAAGGGCAGUCACAUCCAACUUUAAUAAAAUAUGGUGGUCUUUCUUAAAA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 338339)
CLEC4D
C-type lectin domain family 4 member D
NC_000012.12
12  8513733.. 8521271
8513733.. 8521271
strand +
CCDS8593.1
MGI:1298389
ClinVar, dbVar
ENSG00000166527
Mpcl, CD368, MCL, Dectin-3
uc001qun.4
INSDC: AF411850
14554
609964
OTTHUMG00000168674
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (648 bp)
5'-ATGGGGCTAGAAAAACCTCAAAGTAAACTGGAAGGAGGCATGCATCCCCAGCTGATACCTTCGGTTATTGCTGTAGTTTTCATCTTACTTCTCAGTGTCTGTTTTATTGCAAGTTGTTTGGTGACTCATCACAACTTTTCACGCTGTAAGAGAGGCACAGGAGTGCACAAGTTAGAGCACCATGCAAAGCTCAAATGCATCAAAGAGAAATCAGAACTGAAAAGTGCTGAAGGGAGCACCTGGAACTGTTGTCCTATTGACTGGAGAGCCTTCCAGTCCAACTGCTATTTTCCTCTTACTGACAACAAGACGTGGGCTGAGAGTGAAAGGAACTGTTCAGGGATGGGGGCCCATCTGATGACCATCAGCACGGAAGCTGAGCAGAACTTTATTATTCAGTTTCTGGATAGACGGCTTTCCTATTTCCTTGGACTTAGAGATGAGAATGCCAAAGGTCAGTGGCGTTGGGTGGACCAGACGCCATTTAACCCACGCAGAGTATTCTGGCATAAGAATGAACCCGACAACTCTCAGGGAGAAAACTGTGTTGTTCTTGTTTATAACCAAGATAAATGGGCCTGGAATGATGTTCCTTGTAACTTTGAAGCAAGTAGGATTTGTAAAATACCTGGAACAACATTGAACTAG-3'
NCBI CDS gene sequence with introns (location: 8513733.. 8521271) (7539 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 8513503.. 8522366) (8864 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [8513503 - 1000].. 8522366) (9864 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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