NCBI Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_525126)
MCL - Macrophage C-type lectin
C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368)
CLEC4D
C-type lectin domain family 4 member D
CD368
Low evidence
C-type lectin
CLEC4D
C-type - Type II transmembrane receptors
a/b mixed / C-type lectin-like
Glycolipid weak
NP_525126
338339
Q8WXI8
ENSP00000299665.2
Q8WXI8
0.429
10.1073/pnas.1312649110
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (215 amino acids) Download
MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLSVCFIASCLVTHHNFSRCKRGTGVHKLEHHAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGENCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8WXI8-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC4D Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • The Mincle/Syk/NF-kappaB Signaling Circuit Is Essential for Maintaining the Protumoral Activities of Tumor-Associated Macrophages. [32532809]
  • A reference map of the human binary protein interactome. [32296183]
  • The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells. [29616019]
  • Widespread macromolecular interaction perturbations in human genetic disorders. [25910212]
  • Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. [24101491]
  • The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. [22689578]
  • Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. [15368084]
  • The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. [14971047]
  • Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. [12945048]
  • C-type lectin-like domains. [10508765]
UniProt Main References (3 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • C-type lectin MCL is an FcRgamma-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. [23602766]
  • C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. [23911656]
All isoforms of this gene containing a lectin domain
NP_525126.2, XP_011518934.1, XP_011518935.1
RNA
RNA (Transcript ID: NM_080387.5)
NM_080387.5
C-type lectin domain family 4 member D
All isoforms of CLEC4D containing a lectin domain
ENST00000299665.3
231..878 (or 8513733.. 8521271)
8513503.. 8522366
NCBI Matured mRNA sequence 1973 NTPDownload 
m7G-5')ppp(5'-GCCUCAUCUCCCGGAAUGUAUCAAAGGAAACCCCUGUCUUUGAAAAAGACUUCUUUUGAGCUAACUUUCUUAUACUGGUACCUUUCUAAUCUCACUACAAUAUGUAACAUUGGUGUUCGAUCUCAAGUAUUUCUGAAUAUAUUCCCCUAUCCACAGAAAUAUACUCUGGGGGAAAAAAAAUAGAACAAAUUCUUGCCGUCCUGACCAUUGAACAAGAGACUAAUUAGACAAUGGGGCUAGAAAAACCUCAAAGUAAACUGGAAGGAGGCAUGCAUCCCCAGCUGAUACCUUCGGUUAUUGCUGUAGUUUUCAUCUUACUUCUCAGUGUCUGUUUUAUUGCAAGUUGUUUGGUGACUCAUCACAACUUUUCACGCUGUAAGAGAGGCACAGGAGUGCACAAGUUAGAGCACCAUGCAAAGCUCAAAUGCAUCAAAGAGAAAUCAGAACUGAAAAGUGCUGAAGGGAGCACCUGGAACUGUUGUCCUAUUGACUGGAGAGCCUUCCAGUCCAACUGCUAUUUUCCUCUUACUGACAACAAGACGUGGGCUGAGAGUGAAAGGAACUGUUCAGGGAUGGGGGCCCAUCUGAUGACCAUCAGCACGGAAGCUGAGCAGAACUUUAUUAUUCAGUUUCUGGAUAGACGGCUUUCCUAUUUCCUUGGACUUAGAGAUGAGAAUGCCAAAGGUCAGUGGCGUUGGGUGGACCAGACGCCAUUUAACCCACGCAGAGUAUUCUGGCAUAAGAAUGAACCCGACAACUCUCAGGGAGAAAACUGUGUUGUUCUUGUUUAUAACCAAGAUAAAUGGGCCUGGAAUGAUGUUCCUUGUAACUUUGAAGCAAGUAGGAUUUGUAAAAUACCUGGAACAACAUUGAACUAGAAACUCAGAAAGUGGUCCUUGUGAUGGAAAGAGAAAAGAAAAACCAAUUAGAAUAAGGCAGAAUGUACGUGCGUCAUUGGAACACAGAAAACAUGCUGGUUCAUACAGCGUUUUUAGUCAUAAUGGUCUUUUUUAUUUUGUUUGAUUCAUUCGAGACAACAUGUGUGUAUGUGUGUGUGUGUGUGUGUAGAUAAUGUGGUUUUUGUAUGGUGUUUGAUGGAAGGAAUAAUCUUUCUUUGCUUUCUUAGUAGUAUUUCAAGGUGUUUACUUUUCAAUUGGUGUGCACUGAAUGCAUGUAUGGAAGAAUAGCGUGAAUAAUGCAAUCUCUUUGUCAUUUUUCCCCUUCUCAGACUCUUAGCUCUUAAAAUUCAAAGAUGGGAUAUUCUAACUGGUAGUGGUGCAUCAUUUUUAACCCAAAUAUUGCAAGCACUUUAAAGAUUUGAAACCACAUUUUUAUUGUUUGAUGUUUCAUUUUCAGACUUUUUAAUGUCAGUCAUUACAAUUACAUUGCAUGAGGAAAAUUUUUCCAGAACAACAGUGUGGAAUAGUUCUGAAUUAUGCUGUUCUACAGAUAGAAAAAAAGUCCAAAUGCCUUUAAAAAUUUACUUCUUACUCCACCCAACACGUUUUUGCAAAGCAAGAAGUCUUUGUAAGACACCUUAAACAAAGUCCUUCAAUUCUACAGCAGAGGAAAUAAAAUCCCCCAGAAGCCAAAGGGCUCACCUUCACAUUGUUAGUUCAUGACAGACCCAGGUGUGCUUCAUUAGAGAUAACAUACAUUCCCUUUGGUAUCACAGGAAGUUACUGGGGAUUACUCGACCUCAUUACUUAGCUAACGACUGGAUAAAAUUUCUUAAUUGUUUGAAGUAACAUUGUAUUCGUGUUUGCAUUAUUAAUUUGAAUAGAAAAUAAUCACAUUUUCAACCCAUUUAUACAAAUUGUUAAUGUUUCUUUAGAGCUGUAUAACUAUAGUUUGAACUAGCAAGGAAGUUAUUGUUUUGACAACCAGAAAUUAUGCUUUUCUGGUGCAUGAAACAUUAAUUGCAAAGGGCAGUCACAUCCAACUUUAAUAAAAUAUGGUGGUCUUUCUUAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 338339)
CLEC4D
C-type lectin domain family 4 member D
NC_000012.12
12  8513733.. 8521271
8513733.. 8521271
strand +
CCDS8593.1
MGI:1298389
ClinVar, dbVar
ENSG00000166527
Mpcl, CD368, MCL, Dectin-3
uc001qun.4
INSDC: AF411850
14554
609964
OTTHUMG00000168674
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (648 bp)
5'-ATGGGGCTAGAAAAACCTCAAAGTAAACTGGAAGGAGGCATGCATCCCCAGCTGATACCTTCGGTTATTGCTGTAGTTTTCATCTTACTTCTCAGTGTCTGTTTTATTGCAAGTTGTTTGGTGACTCATCACAACTTTTCACGCTGTAAGAGAGGCACAGGAGTGCACAAGTTAGAGCACCATGCAAAGCTCAAATGCATCAAAGAGAAATCAGAACTGAAAAGTGCTGAAGGGAGCACCTGGAACTGTTGTCCTATTGACTGGAGAGCCTTCCAGTCCAACTGCTATTTTCCTCTTACTGACAACAAGACGTGGGCTGAGAGTGAAAGGAACTGTTCAGGGATGGGGGCCCATCTGATGACCATCAGCACGGAAGCTGAGCAGAACTTTATTATTCAGTTTCTGGATAGACGGCTTTCCTATTTCCTTGGACTTAGAGATGAGAATGCCAAAGGTCAGTGGCGTTGGGTGGACCAGACGCCATTTAACCCACGCAGAGTATTCTGGCATAAGAATGAACCCGACAACTCTCAGGGAGAAAACTGTGTTGTTCTTGTTTATAACCAAGATAAATGGGCCTGGAATGATGTTCCTTGTAACTTTGAAGCAAGTAGGATTTGTAAAATACCTGGAACAACATTGAACTAG-3'
NCBI CDS gene sequence with introns (location: 8513733.. 8521271) (7539 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 8513503.. 8522366) (8864 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [8513503 - 1000].. 8522366) (9864 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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