NCBI Summary
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Protein
Protein (NP_443116)
SIGLEC-11
Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11)
SIGLEC11
sialic acid binding Ig like lectin 11
Undefined
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-8)Neu5Ac(a2-3)Gal
NP_443116
114132
Q96RL6
ENSP00000412361.2
Q96RL6
0.513
10.1146/annurev-immunol-102419-035900
PFAM, InterPro
Protein sequence and protein families (fasta) (698 amino acids) Download
MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSVFQLLPGKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQDVPSTLGPISQGHQHECSAGSSQDHPPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEAPSTTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q96RL6-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.27, 1.54] ÅDownload
The location of the lectin domain structural model is: 31-159
We infer [1.27, 1.54] Å as the interval of error of this structural model.
Template 1: 2N7B chain: A, Q9NYZ4, NP_055257.2, sequence identity: 48.1%, coverage: 94.6%, location in sequence: 26-152, (10-136 in PDB).
Template 2: 2ZG1 chain: A, O15389, NP_003821.1, sequence identity: 47.3%, coverage: 94.6%, location in sequence: 20-141, (25-146 in PDB).
Template 3: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 43.4%, coverage: 96.1%, location in sequence: 18-141, (18-141 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Oligomerization and Known Interactions
Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (6 PubMed Identifiers)
  • Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. [28100677]
  • Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology. [21467073]
  • Alleviation of neurotoxicity by microglial human Siglec-11. [20203208]
  • SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. [18629938]
  • A human-specific gene in microglia. [16151003]
  • Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. [11986327]
UniProt Main References (2 PubMed Identifiers)
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
All isoforms of this gene containing a lectin domain
XP_005258533.2, NP_443116.2, XP_005258534.2, NP_001128635.1
RNA
RNA (Transcript ID: NM_052884.3)
NM_052884.3
sialic acid binding Ig like lectin 11, transcript variant 1
All isoforms of SIGLEC11 containing a lectin domain
ENST00000447370.6
92..2188 (or 49949970.. 49961081)
49948985.. 49961172
NCBI Matured mRNA sequence 3173 NTPDownload 
m7G-5')ppp(5'-CGAGGCUCCUCCUCUGUGGAUGGUCACUGCCCCUCCACCAGGCUUCCUGCUGGAGGAGUUUCCUUCCCAGCCAGGCCGGCCCAGAAGCCAGAUGGUCCCGGGACAGGCCCAGCCCCAGAGCCCAGAGAUGCUGCUGCUGCCCCUGCUGCUGCCCGUGCUGGGGGCGGGGUCCCUGAACAAGGAUCCCAGUUACAGUCUUCAAGUGCAGAGGCAGGUGCCGGUGCCGGAGGGCCUGUGUGUCAUCGUGUCUUGCAACCUCUCCUACCCCCGGGAUGGCUGGGACGAGUCUACUGCUGCUUAUGGCUACUGGUUCAAAGGACGGACCAGCCCAAAGACGGGUGCUCCUGUGGCCACUAACAACCAGAGUCGAGAGGUGGAAAUGAGCACCCGGGACCGAUUCCAGCUCACUGGGGAUCCCGGCAAAGGGAGCUGCUCCUUGGUGAUCAGAGACGCGCAGAGGGAGGAUGAGGCAUGGUACUUCUUUCGGGUGGAGAGAGGAAGCCGUGUGAGACAUAGUUUCCUGAGCAAUGCGUUCUUUCUAAAAGUAACAGCCCUGACUAAGAAGCCUGAUGUCUACAUCCCCGAGACCCUGGAGCCCGGGCAGCCGGUGACGGUCAUCUGUGUGUUUAACUGGGCUUUCAAGAAAUGUCCAGCCCCUUCUUUCUCCUGGACGGGGGCUGCCCUCUCCCCUAGAAGAACCAGACCAAGCACCUCCCACUUCUCAGUGCUCAGCUUCACGCCCAGCCCCCAGGACCACGACACCGACCUCACCUGCCAUGUGGACUUCUCCAGAAAGGGUGUGAGCGCACAGAGGACCGUCCGACUCCGUGUGGCCUAUGCCCCCAAAGACCUUAUUAUCAGCAUUUCACAUGACAACACGUCAGCCCUGGAACUCCAGGGAAACGUCAUAUAUCUGGAAGUUCAGAAAGGCCAGUUCCUGCGGCUCCUCUGUGCUGCUGACAGCCAGCCCCCUGCCACGCUGAGCUGGGUCCUGCAGGACAGAGUCCUCUCCUCGUCCCACCCCUGGGGCCCCAGAACCCUGGGGCUGGAGCUGCGUGGGGUAAGGGCCGGGGAUUCAGGGCGCUACACCUGCCGAGCGGAGAACAGGCUUGGCUCCCAGCAGCAAGCCCUGGACCUCUCUGUGCAGUAUCCUCCAGAGAACCUGAGAGUGAUGGUUUCCCAAGCAAACAGGACAGUCCUGGAAAACCUCGGGAACGGCACAUCCCUCCCGGUCCUGGAGGGCCAAAGCCUGCGCCUGGUCUGUGUCACCCACAGCAGCCCCCCAGCCAGGCUGAGCUGGACCCGGUGGGGACAGACCGUGGGCCCCUCCCAGCCCUCAGACCCCGGGGUCCUGGAGCUGCCACCCAUUCAAAUGGAGCACGAAGGAGAGUUCACCUGCCACGCUCAGCACCCUCUGGGCUCCCAGCACGUCUCUCUCAGCCUCUCCGUGCACUACCCUCCACAGCUGCUGGGCCCCUCCUGCUCCUGGGAGGCUGAGGGUCUGCACUGCAGCUGCUCCUCCCAGGCCAGCCCGGCCCCCUCUCUGCGCUGGUGGCUUGGGGAGGAGCUGCUGGAGGGGAACAGCAGUCAGGGCUCCUUCGAGGUCACCCCCAGCUCAGCCGGGCCCUGGGCCAACAGCUCCCUGAGCCUCCAUGGAGGGCUCAGCUCCGGCCUCAGGCUCCGCUGUAAGGCCUGGAACGUCCACGGGGCCCAGAGUGGCUCUGUCUUCCAGCUGCUACCAGGGAAGCUGGAGCAUGGGGGAGGACUUGGCCUGGGGGCUGCCCUGGGAGCUGGCGUCGCUGCCCUGCUCGCUUUCUGUUCCUGCCUUGUCGUCUUCAGGGUGAAGAUCUGCAGGAAGGAAGCUCGCAAGAGGGCAGCAGCUGAGCAGGACGUGCCCUCCACCCUGGGACCCAUCUCCCAGGGUCACCAGCAUGAAUGCUCGGCAGGCAGCUCCCAAGACCACCCGCCCCCAGGUGCAGCCACCUACACCCCGGGGAAGGGGGAAGAGCAGGAGCUCCACUAUGCCUCCCUCAGCUUCCAGGGCCUGAGGCUCUGGGAGCCUGCGGACCAGGAGGCCCCCAGCACCACCGAGUACUCGGAGAUCAAGAUCCACACAGGACAGCCCCUGAGGGGCCCAGGCUUUGGGCUUCAAUUGGAGAGGGAGAUGUCAGGGAUGGUUCCAAAGUGAAGAGGUCUCCAUGGCAACAGGACACCAGCAAGUGUGUGGGAGUCGCACUGGUGUGACGGCCAGAACUGGACUCAGAUUUCAGCCCCAUCCCCAAUGAAGAGCUUGAGUUUGAAGAUUAUACUUUUUUUGAGACAGGGUCUGACUCUGUCCUCCAGGCCAGAGUCCAGUGGUGCAAUCUCAGCUCACUGUAGCCUCAACCUGCCAGGUUGAAGUGAGCCUCCCAUUUCAGCCUCCCAAGUAGCUGGGACUACAAUUGUGAGCCACCAUGCCAGGCUCAUUGUUAUAUUUUUAGUAGAGACAGGGUUUUGCCAUGUUUCCCUGGCUGGUCUCAGACUCCUGGGCUCAAGCAAUCUGCCCGCCUCUGCCUCCCAAAGUGCUGGGAUUACAGACGUGAGCCACCACAGCUGGCUGAAGAUUAUACUUUCAAUUCAGAGCGAGUUUGAAGAUGACACUUUGAGGCAUCGUGUCUAUGGUUCAUUACUACAGAAGCUUCUCUGGAUGUGUAAAGCACAGGAAACCAGGCAGAGGAGGCACAGGGUGCUCUCCAGAACGAGAAGCCAGCUCCUGGAGUUGUUUGCUGCAACUGCCAUUCCCCGUUGAUGACCAUGCUCUUCCUUCAGAAGAGGGAGAGUGAGAGGACCAAGUCCAAGUGGUUCCCAUUUGAACAUUUAAAAAAAAAAAAAAGGCUGGGCAUGGUGGCUCACGCCUGUAAUCUCAACACUUUGGGAGGCUGAAGUGGGUGGAUCACAAGUCAGGAGUUCAAGACCAGCCUGGGCAAGAUGGUGAAACCCCAUCUCUACUAAAAAUACAAAAAUUAGCCGGGCAUGGUGGCGGGCGCCUAAAAUCCCAGCUACUCGGGAGACUAGGCAGAGAAUUGGUUGAACCCGGGAGGUGGAGGUUGCAGUGAGCCGAGAUCGUCCCACUGCACUCCAGCCUGGGCAACAGAGUGAGACUCUGUUUCUAAAUAAAUAAAUGAAUAAAUAAA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 114132)
SIGLEC11
sialic acid binding Ig like lectin 11
NC_000019.10
19  49949970.. 49961081
49949970.. 49961081
strand -
CCDS12790.2
MGI:2443630
ClinVar, dbVar
ENSG00000161640
uc010ybh.3
INSDC: AF337818
15622
607157
OTTHUMG00000157077
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (2097 bp)
5'-ATGGTCCCGGGACAGGCCCAGCCCCAGAGCCCAGAGATGCTGCTGCTGCCCCTGCTGCTGCCCGTGCTGGGGGCGGGGTCCCTGAACAAGGATCCCAGTTACAGTCTTCAAGTGCAGAGGCAGGTGCCGGTGCCGGAGGGCCTGTGTGTCATCGTGTCTTGCAACCTCTCCTACCCCCGGGATGGCTGGGACGAGTCTACTGCTGCTTATGGCTACTGGTTCAAAGGACGGACCAGCCCAAAGACGGGTGCTCCTGTGGCCACTAACAACCAGAGTCGAGAGGTGGAAATGAGCACCCGGGACCGATTCCAGCTCACTGGGGATCCCGGCAAAGGGAGCTGCTCCTTGGTGATCAGAGACGCGCAGAGGGAGGATGAGGCATGGTACTTCTTTCGGGTGGAGAGAGGAAGCCGTGTGAGACATAGTTTCCTGAGCAATGCGTTCTTTCTAAAAGTAACAGCCCTGACTAAGAAGCCTGATGTCTACATCCCCGAGACCCTGGAGCCCGGGCAGCCGGTGACGGTCATCTGTGTGTTTAACTGGGCTTTCAAGAAATGTCCAGCCCCTTCTTTCTCCTGGACGGGGGCTGCCCTCTCCCCTAGAAGAACCAGACCAAGCACCTCCCACTTCTCAGTGCTCAGCTTCACGCCCAGCCCCCAGGACCACGACACCGACCTCACCTGCCATGTGGACTTCTCCAGAAAGGGTGTGAGCGCACAGAGGACCGTCCGACTCCGTGTGGCCTATGCCCCCAAAGACCTTATTATCAGCATTTCACATGACAACACGTCAGCCCTGGAACTCCAGGGAAACGTCATATATCTGGAAGTTCAGAAAGGCCAGTTCCTGCGGCTCCTCTGTGCTGCTGACAGCCAGCCCCCTGCCACGCTGAGCTGGGTCCTGCAGGACAGAGTCCTCTCCTCGTCCCACCCCTGGGGCCCCAGAACCCTGGGGCTGGAGCTGCGTGGGGTAAGGGCCGGGGATTCAGGGCGCTACACCTGCCGAGCGGAGAACAGGCTTGGCTCCCAGCAGCAAGCCCTGGACCTCTCTGTGCAGTATCCTCCAGAGAACCTGAGAGTGATGGTTTCCCAAGCAAACAGGACAGTCCTGGAAAACCTCGGGAACGGCACATCCCTCCCGGTCCTGGAGGGCCAAAGCCTGCGCCTGGTCTGTGTCACCCACAGCAGCCCCCCAGCCAGGCTGAGCTGGACCCGGTGGGGACAGACCGTGGGCCCCTCCCAGCCCTCAGACCCCGGGGTCCTGGAGCTGCCACCCATTCAAATGGAGCACGAAGGAGAGTTCACCTGCCACGCTCAGCACCCTCTGGGCTCCCAGCACGTCTCTCTCAGCCTCTCCGTGCACTACCCTCCACAGCTGCTGGGCCCCTCCTGCTCCTGGGAGGCTGAGGGTCTGCACTGCAGCTGCTCCTCCCAGGCCAGCCCGGCCCCCTCTCTGCGCTGGTGGCTTGGGGAGGAGCTGCTGGAGGGGAACAGCAGTCAGGGCTCCTTCGAGGTCACCCCCAGCTCAGCCGGGCCCTGGGCCAACAGCTCCCTGAGCCTCCATGGAGGGCTCAGCTCCGGCCTCAGGCTCCGCTGTAAGGCCTGGAACGTCCACGGGGCCCAGAGTGGCTCTGTCTTCCAGCTGCTACCAGGGAAGCTGGAGCATGGGGGAGGACTTGGCCTGGGGGCTGCCCTGGGAGCTGGCGTCGCTGCCCTGCTCGCTTTCTGTTCCTGCCTTGTCGTCTTCAGGGTGAAGATCTGCAGGAAGGAAGCTCGCAAGAGGGCAGCAGCTGAGCAGGACGTGCCCTCCACCCTGGGACCCATCTCCCAGGGTCACCAGCATGAATGCTCGGCAGGCAGCTCCCAAGACCACCCGCCCCCAGGTGCAGCCACCTACACCCCGGGGAAGGGGGAAGAGCAGGAGCTCCACTATGCCTCCCTCAGCTTCCAGGGCCTGAGGCTCTGGGAGCCTGCGGACCAGGAGGCCCCCAGCACCACCGAGTACTCGGAGATCAAGATCCACACAGGACAGCCCCTGAGGGGCCCAGGCTTTGGGCTTCAATTGGAGAGGGAGATGTCAGGGATGGTTCCAAAGTGA-3'
NCBI CDS gene sequence with introns (location: 49949970.. 49961081) (11112 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 49948985.. 49961172) (12188 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [49948985.. 49961172 + 1000]) (13188 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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