NCBI Summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002].
Protein
Protein (NP_149121)
SIGLEC-10
Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Siglec-like protein 2)
SIGLEC10
sialic acid binding Ig like lectin 10
Undefined
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)Gal(b1-4)GlcNAc
NP_149121
89790
Q96LC7
ENSP00000345243.4
Q96LC7
0.516
10.1146/annurev-immunol-102419-035900
PFAM, InterPro
Protein sequence and protein families (fasta) (697 amino acids) Download
MLLPLLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQHVSLSLSVHYSPKLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQDSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCEAWNVHGAQSGSILQLPDKKGLISTAFSNGAFLGIGITALLFLCLALIIMKILPKRRTQTETPRPRFSRHSTILDYINVVPTAGPLAQKRNQKATPNSPRTPLPPGAPSPESKKNQKKQYQLPSFPEPKSSTQAPESQESQEELHYATLNFPGVRPRPEARMPKGTQADYAEVKFQ
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q96LC7-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.26, 1.53] ÅDownload
The location of the lectin domain structural model is: 18-146
We infer [1.26, 1.53] Å as the interval of error of this structural model.
Template 1: 2N7B chain: A, Q9NYZ4, NP_055257.2, sequence identity: 48.8%, coverage: 94.6%, location in sequence: 26-152, (10-136 in PDB).
Template 2: 2ZG1 chain: A, O15389, NP_003821.1, sequence identity: 47.3%, coverage: 94.6%, location in sequence: 20-141, (25-146 in PDB).
Template 3: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 45.0%, coverage: 96.1%, location in sequence: 18-141, (18-141 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Oligomerization and Known Interactions
Interacts with PTPN6/SHP-1 upon phosphorylation (PubMed:12163025). Interacts with NCF1 (By similarity). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with HMGB1; the interaction is dependent on CD24 (PubMed:19264983). Interacts with RIGI, CBL and PTPN11 (By similarity). Source: UniProt
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Novel insights into the function of CD24: A driving force in cancer. [32790899]
  • Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. [32915505]
  • Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10. [32765491]
  • Siglec-10 expression is up-regulated in activated human CD4+ T cells. [32046870]
  • CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. [31367043]
  • Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. [17672918]
  • Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. [12163025]
  • Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells. [11358961]
  • Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. [11409878]
  • Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. [11284738]
UniProt Main References (6 PubMed Identifiers)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. [19264983]
  • Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma. [25450598]
All isoforms of this gene containing a lectin domain
NP_149121.2, NP_001164628.1, XP_005259423.1, NP_001309034.1, NP_001164629.1, NP_001164630.1, NP_001164627.1, NP_001164632.1, XP_005259424.1
RNA
RNA (Transcript ID: NM_033130.5)
NM_033130.5
sialic acid binding Ig like lectin 10, transcript variant 1
All isoforms of SIGLEC10 containing a lectin domain
ENST00000339313.10
62..2155 (or 51411099.. 51417581)
51410020.. 51417642
NCBI Matured mRNA sequence 3234 NTPDownload 
m7G-5')ppp(5'-ACUCACAGCACGACCAGAGAACAGGCCUGUCUCAGGCAGGCCCUGCGCCUCCUAUGCGGAGAUGCUACUGCCACUGCUGCUGUCCUCGCUGCUGGGCGGGUCCCAGGCUAUGGAUGGGAGAUUCUGGAUACGAGUGCAGGAGUCAGUGAUGGUGCCGGAGGGCCUGUGCAUCUCUGUGCCCUGCUCUUUCUCCUACCCCCGACAGGACUGGACAGGGUCUACCCCAGCUUAUGGCUACUGGUUCAAAGCAGUGACUGAGACAACCAAGGGUGCUCCUGUGGCCACAAACCACCAGAGUCGAGAGGUGGAAAUGAGCACCCGGGGCCGAUUCCAGCUCACUGGGGAUCCCGCCAAGGGGAACUGCUCCUUGGUGAUCAGAGACGCGCAGAUGCAGGAUGAGUCACAGUACUUCUUUCGGGUGGAGAGAGGAAGCUAUGUGAGAUAUAAUUUCAUGAACGAUGGGUUCUUUCUAAAAGUAACAGCCCUGACUCAGAAGCCUGAUGUCUACAUCCCCGAGACCCUGGAGCCCGGGCAGCCGGUGACGGUCAUCUGUGUGUUUAACUGGGCCUUUGAGGAAUGUCCACCCCCUUCUUUCUCCUGGACGGGGGCUGCCCUCUCCUCCCAAGGAACCAAACCAACGACCUCCCACUUCUCAGUGCUCAGCUUCACGCCCAGACCCCAGGACCACAACACCGACCUCACCUGCCAUGUGGACUUCUCCAGAAAGGGUGUGAGCGCACAGAGGACCGUCCGACUCCGUGUGGCCUAUGCCCCCAGAGACCUUGUUAUCAGCAUUUCACGUGACAACACGCCAGCCCUGGAGCCCCAGCCCCAGGGAAAUGUCCCAUACCUGGAAGCCCAAAAAGGCCAGUUCCUGCGGCUCCUCUGUGCUGCUGACAGCCAGCCCCCUGCCACACUGAGCUGGGUCCUGCAGAACAGAGUCCUCUCCUCGUCCCAUCCCUGGGGCCCUAGACCCCUGGGGCUGGAGCUGCCCGGGGUGAAGGCUGGGGAUUCAGGGCGCUACACCUGCCGAGCGGAGAACAGGCUUGGCUCCCAGCAGCGAGCCCUGGACCUCUCUGUGCAGUAUCCUCCAGAGAACCUGAGAGUGAUGGUUUCCCAAGCAAACAGGACAGUCCUGGAAAACCUUGGGAACGGCACGUCUCUCCCAGUACUGGAGGGCCAAAGCCUGUGCCUGGUCUGUGUCACACACAGCAGCCCCCCAGCCAGGCUGAGCUGGACCCAGAGGGGACAGGUUCUGAGCCCCUCCCAGCCCUCAGACCCCGGGGUCCUGGAGCUGCCUCGGGUUCAAGUGGAGCACGAAGGAGAGUUCACCUGCCACGCUCGGCACCCACUGGGCUCCCAGCACGUCUCUCUCAGCCUCUCCGUGCACUACUCCCCGAAGCUGCUGGGCCCCUCCUGCUCCUGGGAGGCUGAGGGUCUGCACUGCAGCUGCUCCUCCCAGGCCAGCCCGGCCCCCUCUCUGCGCUGGUGGCUUGGGGAGGAGCUGCUGGAGGGGAACAGCAGCCAGGACUCCUUCGAGGUCACCCCCAGCUCAGCCGGGCCCUGGGCCAACAGCUCCCUGAGCCUCCAUGGAGGGCUCAGCUCCGGCCUCAGGCUCCGCUGUGAGGCCUGGAACGUCCAUGGGGCCCAGAGUGGAUCCAUCCUGCAGCUGCCAGAUAAGAAGGGACUCAUCUCAACGGCAUUCUCCAACGGAGCGUUUCUGGGAAUCGGCAUCACGGCUCUUCUUUUCCUCUGCCUGGCCCUGAUCAUCAUGAAGAUUCUACCGAAGAGACGGACUCAGACAGAAACCCCGAGGCCCAGGUUCUCCCGGCACAGCACGAUCCUGGAUUACAUCAAUGUGGUCCCGACGGCUGGCCCCCUGGCUCAGAAGCGGAAUCAGAAAGCCACACCAAACAGUCCUCGGACCCCUCUUCCACCAGGUGCUCCCUCCCCAGAAUCAAAGAAGAACCAGAAAAAGCAGUAUCAGUUGCCCAGUUUCCCAGAACCCAAAUCAUCCACUCAAGCCCCAGAAUCCCAGGAGAGCCAAGAGGAGCUCCAUUAUGCCACGCUCAACUUCCCAGGCGUCAGACCCAGGCCUGAGGCCCGGAUGCCCAAGGGCACCCAGGCGGAUUAUGCAGAAGUCAAGUUCCAAUGAGGGUCUCUUAGGCUUUAGGACUGGGACUUCGGCUAGGGAGGAAGGUAGAGUAAGAGGUUGAAGAUAACAGAGUGCAAAGUUUCCUUCUCUCCCUCUCUCUCUCUCUUUCUCUCUCUCUCUCUCUUUCUCUCUCUUUUAAAAAAACAUCUGGCCAGGGCACAGUGGCUCACGCCUGUAAUCCCAGCACUUUGGGAGGUUGAGGUGGGCAGAUCGCCUGAGGUCGGGAGUUCGAGACCAGCCUGGCCAACUUGGUGAAACCCCGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCAUGGUGGCAGGCGCCUGUAAUCCUACCUACUUGGGAAGCUGAGGCAGGAGAAUCACUUGAACCUGGGAGACGGAGGUUGCAGUGAGCCAAGAUCACACCAUUGCACGCCAGCCUGGGCAACAAAGCGAGACUCCAUCUCAAAAAAAAAAUCCUCCAAAUGGGUUGGGUGUCUGUAAUCCCAGCACUUUGGGAGGCUAAGGUGGGUGGAUUGCUUGAGCCCAGGAGUUCGAGACCAGCCUGGGCAACAUGGUGAAACCCCAUCUCUACAAAAAAUACAAAACAUAGCUGGGCUUGGUGGUGUGUGCCUGUAGUCCCAGCUGUCAGACAUUUAAACCAGAGCAACUCCAUCUGGAAUAGGAGCUGAAUAAAAUGAGGCUGAGACCUACUGGGCUGCAUUCUCAGACAGUGGAGGCAUUCUAAGUCACAGGAUGAGACAGGAGGUCCGUACAAGAUACAGGUCAUAAAGACUUUGCUGAUAAAACAGAUUGCAGUAAAGAAGCCAACCAAAUCCCACCAAAACCAAGUUGGCCACGAGAGUGACCUCUGGUCGUCCUCACUGCUACACUCCUGACAGCACCAUGACAGUUUACAAAUGCCAUGGCAACAUCAGGAAGUUACCCGAUAUGUCCCAAAAGGGGGAGGAAUGAAUAAUCCACCCCUUGUUUAGCAAAUAAGCAAGAAAUAACCAUAAAAGUGGGCAACCAGCAGCUCUAGGCGCUGCUCUUGUCUAUGGAGUAGCCAUUCUUUUGUUCCUUUACUUUCUUAAUAAACUUGCUUUCACCUUAC-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 89790)
SIGLEC10
sialic acid binding Ig like lectin 10
NC_000019.10
19  51411099.. 51417581
51411099.. 51417581
strand -
CCDS12832.1
MGI:2443630
ClinVar, dbVar
ENSG00000142512
SIGLEC-10, SLG2, PRO940, MGC126774
uc002pwo.4
INSDC: AF310233
15620
606091
OTTHUMG00000165521
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (2094 bp)
5'-ATGCTACTGCCACTGCTGCTGTCCTCGCTGCTGGGCGGGTCCCAGGCTATGGATGGGAGATTCTGGATACGAGTGCAGGAGTCAGTGATGGTGCCGGAGGGCCTGTGCATCTCTGTGCCCTGCTCTTTCTCCTACCCCCGACAGGACTGGACAGGGTCTACCCCAGCTTATGGCTACTGGTTCAAAGCAGTGACTGAGACAACCAAGGGTGCTCCTGTGGCCACAAACCACCAGAGTCGAGAGGTGGAAATGAGCACCCGGGGCCGATTCCAGCTCACTGGGGATCCCGCCAAGGGGAACTGCTCCTTGGTGATCAGAGACGCGCAGATGCAGGATGAGTCACAGTACTTCTTTCGGGTGGAGAGAGGAAGCTATGTGAGATATAATTTCATGAACGATGGGTTCTTTCTAAAAGTAACAGCCCTGACTCAGAAGCCTGATGTCTACATCCCCGAGACCCTGGAGCCCGGGCAGCCGGTGACGGTCATCTGTGTGTTTAACTGGGCCTTTGAGGAATGTCCACCCCCTTCTTTCTCCTGGACGGGGGCTGCCCTCTCCTCCCAAGGAACCAAACCAACGACCTCCCACTTCTCAGTGCTCAGCTTCACGCCCAGACCCCAGGACCACAACACCGACCTCACCTGCCATGTGGACTTCTCCAGAAAGGGTGTGAGCGCACAGAGGACCGTCCGACTCCGTGTGGCCTATGCCCCCAGAGACCTTGTTATCAGCATTTCACGTGACAACACGCCAGCCCTGGAGCCCCAGCCCCAGGGAAATGTCCCATACCTGGAAGCCCAAAAAGGCCAGTTCCTGCGGCTCCTCTGTGCTGCTGACAGCCAGCCCCCTGCCACACTGAGCTGGGTCCTGCAGAACAGAGTCCTCTCCTCGTCCCATCCCTGGGGCCCTAGACCCCTGGGGCTGGAGCTGCCCGGGGTGAAGGCTGGGGATTCAGGGCGCTACACCTGCCGAGCGGAGAACAGGCTTGGCTCCCAGCAGCGAGCCCTGGACCTCTCTGTGCAGTATCCTCCAGAGAACCTGAGAGTGATGGTTTCCCAAGCAAACAGGACAGTCCTGGAAAACCTTGGGAACGGCACGTCTCTCCCAGTACTGGAGGGCCAAAGCCTGTGCCTGGTCTGTGTCACACACAGCAGCCCCCCAGCCAGGCTGAGCTGGACCCAGAGGGGACAGGTTCTGAGCCCCTCCCAGCCCTCAGACCCCGGGGTCCTGGAGCTGCCTCGGGTTCAAGTGGAGCACGAAGGAGAGTTCACCTGCCACGCTCGGCACCCACTGGGCTCCCAGCACGTCTCTCTCAGCCTCTCCGTGCACTACTCCCCGAAGCTGCTGGGCCCCTCCTGCTCCTGGGAGGCTGAGGGTCTGCACTGCAGCTGCTCCTCCCAGGCCAGCCCGGCCCCCTCTCTGCGCTGGTGGCTTGGGGAGGAGCTGCTGGAGGGGAACAGCAGCCAGGACTCCTTCGAGGTCACCCCCAGCTCAGCCGGGCCCTGGGCCAACAGCTCCCTGAGCCTCCATGGAGGGCTCAGCTCCGGCCTCAGGCTCCGCTGTGAGGCCTGGAACGTCCATGGGGCCCAGAGTGGATCCATCCTGCAGCTGCCAGATAAGAAGGGACTCATCTCAACGGCATTCTCCAACGGAGCGTTTCTGGGAATCGGCATCACGGCTCTTCTTTTCCTCTGCCTGGCCCTGATCATCATGAAGATTCTACCGAAGAGACGGACTCAGACAGAAACCCCGAGGCCCAGGTTCTCCCGGCACAGCACGATCCTGGATTACATCAATGTGGTCCCGACGGCTGGCCCCCTGGCTCAGAAGCGGAATCAGAAAGCCACACCAAACAGTCCTCGGACCCCTCTTCCACCAGGTGCTCCCTCCCCAGAATCAAAGAAGAACCAGAAAAAGCAGTATCAGTTGCCCAGTTTCCCAGAACCCAAATCATCCACTCAAGCCCCAGAATCCCAGGAGAGCCAAGAGGAGCTCCATTATGCCACGCTCAACTTCCCAGGCGTCAGACCCAGGCCTGAGGCCCGGATGCCCAAGGGCACCCAGGCGGATTATGCAGAAGTCAAGTTCCAATGA-3'
NCBI CDS gene sequence with introns (location: 51411099.. 51417581) (6483 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51410020.. 51417642) (7623 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51410020.. 51417642 + 1000]) (8623 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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