NCBI Summary
This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
Protein
Protein (NP_079220)
Chondrolectin
Chondrolectin (Transmembrane protein MT75)
CHODL
chondrolectin
Undefined
Very low evidence
C-type lectin
Undefined
C-type - Type I receptors
a/b mixed / C-type lectin-like
Uncharacterised
NP_079220
140578
Q9H9P2
ENSP00000299295.2
Q9H9P2
0.297
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (273 amino acids) Download
MSRVVSLLLGAALLCGHGAFCRRVVSGQKVCFADFKHPCYKMAYFHELSSRVSFQEARLACESEGGVLLSLENEAEQKLIESMLQNLTKPGTGISDGDFWIGLWRNGDGQTSGACPDLYQWSDGSNSQYRNWYTDEPSCGSEKCVVMYHQPTANPGLGGPYLYQWNDDRCNMKHNYICKYEPEINPTAPVEKPYLTNQPGDTHQNVVVTEAGIIPNLIYVVIPTIPLLLLILVAFGTCCFQMLHKSKGRTKTSPNQSTLWISKSTRKESGMEV
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9H9P2-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.59, 2.06] ÅDownload
The location of the lectin domain structural model is: 35-182
We infer [1.59, 2.06] Å as the interval of error of this structural model.
Template 1: 3VYK chain: A, Q5YIR8, NP_001005860.1, sequence identity: 25.7%, coverage: 82.4%, location in sequence: 106-233, (106-233 in PDB).
Template 2: 7L67 chain: A, P22897, NP_002429.1, sequence identity: 25.7%, coverage: 81.8%, location in sequence: 659-779, (641-761 in PDB).
Template 3: 6LFJ chain: A, Q9D8Q7, NP_081494.1, sequence identity: 25.0%, coverage: 81.1%, location in sequence: 42-174, (75-207 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CHODL Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. [24529757]
  • Genetic variants associated with disordered eating. [23568457]
  • Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. [23648065]
  • Antibody-based protein profiling of the human chromosome 21. [22042635]
  • Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin. [17606388]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. [12621022]
  • Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. [12079284]
  • From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. [11707072]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence of human chromosome 21. [10830953]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_001191103.1, XP_016883762.1, XP_011527755.1, NP_079220.2, NP_001191104.1, NP_001191105.1, XP_011527759.1, NP_001191106.1, NP_001191107.1
RNA
RNA (Transcript ID: NM_024944.3)
NM_024944.3
chondrolectin, transcript variant 1
All isoforms of CHODL containing a lectin domain
ENST00000299295.7
392..1213 (or 18245224.. 18266038)
18244833.. 18267370
NCBI Matured mRNA sequence 2545 NTPDownload 
m7G-5')ppp(5'-GCUGCUGCUGUGAUCCAGGACCAGGGCGCACCGGCUCAGCCUCUCACUUGUCAGAGGCCGGGGAAGAGAAGCAAAGCGCAACGGUGUGGUCCAAGCCGGGGCUUCUGCUUCGCCUCUAGGACAUACACGGGACCCCCUAACUUCAGUCCCCCAAACGCGCACCCUCGAAGUCUUGAACUCCAGCCCCGCACAUCCACGCGCGGCACAGGCGCGGCAGGCGGCAGGUCCCGGCCGAAGGCGAUGCGCGCAGGGGGUCGGGCAGCUGGGCUCGGGCGGCGGGAGUAGGGCCCGGCAGGGAGGCAGGGAGGCUGCAGAGUCAGAGUCGCGGGCUGCGCCCUGGGCAGAGGCCGCCCUCGCUCCACGCAACACCUGCUGCUGCCACCGCGCCGCGAUGAGCCGCGUGGUCUCGCUGCUGCUGGGCGCCGCGCUGCUCUGCGGCCACGGAGCCUUCUGCCGCCGCGUGGUCAGCGGCCAAAAGGUGUGUUUUGCUGACUUCAAGCAUCCCUGCUACAAAAUGGCCUACUUCCAUGAACUGUCCAGCCGAGUGAGCUUUCAGGAGGCACGCCUGGCUUGUGAGAGUGAGGGAGGAGUCCUCCUCAGCCUUGAGAAUGAAGCAGAACAGAAGUUAAUAGAGAGCAUGUUGCAAAACCUGACAAAACCCGGGACAGGGAUUUCUGAUGGUGAUUUCUGGAUAGGGCUUUGGAGGAAUGGAGAUGGGCAAACAUCUGGUGCCUGCCCAGAUCUCUACCAGUGGUCUGAUGGAAGCAAUUCCCAGUACCGAAACUGGUACACAGAUGAACCUUCCUGCGGAAGUGAAAAGUGUGUUGUGAUGUAUCACCAACCAACUGCCAAUCCUGGCCUUGGGGGUCCCUACCUUUACCAGUGGAAUGAUGACAGGUGUAACAUGAAGCACAAUUAUAUUUGCAAGUAUGAACCAGAGAUUAAUCCAACAGCCCCUGUAGAAAAGCCUUAUCUUACAAAUCAACCAGGAGACACCCAUCAGAAUGUGGUUGUUACUGAAGCAGGUAUAAUUCCCAAUCUAAUUUAUGUUGUUAUACCAACAAUACCCCUGCUCUUACUGAUACUGGUUGCUUUUGGAACCUGUUGUUUCCAGAUGCUGCAUAAAAGUAAAGGAAGAACAAAAACUAGUCCAAACCAGUCUACACUGUGGAUUUCAAAGAGUACCAGAAAAGAAAGUGGCAUGGAAGUAUAAUAACUCAUUGACUUGGUUCCAGAAUUUUGUAAUUCUGGAUCUGUAUAAGGAAUGGCAUCAGAACAAUAGCUUGGAAUGGCUUGAAAUCACAAAGGAUCUGCAAGAUGAACUGUAAGCUCCCCCUUGAGGCAAAUAUUAAAGUAAUUUUUAUAUGUCUAUUAUUUCAUUUAAAGAAUAUGCUGUGCUAAUAAUGGAGUGAGACAUGCUUAUUUUGCUAAAGGAUGCACCCAAACUUCAAACUUCAAGCAAAUGAAAUGGACAAUGCAGAUAAAGUUGUUAUCAACACGUCGGGAGUAUGUGUGUUAGAAGCAAUUCCUUUUAUUUCUUUCACCUUUCAUAAGUUGUUAUCUAGUCAAUGUAAUGUAUAUUGUAUUGAAAUUUACAGUGUGCAAAAGUAUUUUACCUUUGCAUAAGUGUUUGAUAAAAAUGAACUGUUCUAAUAUUUAUUUUUAUGGCAUCUCAUUUUUCAAUACAUGCUCUUUUGAUUAAAGAAACUUAUUACUGUUGUCAACUGAAUUCACACACACACAAAUAUAGUACCAUAGAAAAAGUUUGUUUUCUCGAAAUAAUUCAUCUUUCAGCUUCUCUGCUUUUGGUCAAUGUCUAGGAAAUCUCUUCAGAAAUAAGAAGCUAUUUCAUUAAGUGUGAUAUAAACCUCCUCAAACAUUUUACUUAGAGGCAAGGAUUGUCUAAUUUCAAUUGUGCAAGACAUGUGCCUUAUAAUUAUUUUUAGCUUAAAAUUAAACAGAUUUUGUAAUAAUGUAACUUUGUUAAUAGGUGCAUAAACACUAAUGCAGUCAAUUUGAACAAAAGAAGUGACAUACACAAUAUAAAUCAUAUGUCUUCACACGUUGCCUAUAUAAUGAGAAGCAGCUCUCUGAGGGUUCUGAAAUCAAUGUGGUCCCUCUCUUGCCCACUAAACAAAGAUGGUUGUUCGGGGUUUGGGAUUGACACUGGAGGCAGAUAGUUGCAAAGUUAGUCUAAGGUUUCCCUAGCUGUAUUUAGCCUCUGACUAUAUUAGUAUACAAAGAGGUCAUGUGGUUGAGACCAGGUGAAUAGUCACUAUCAGUGUGGAGACAAGCACAGCACACAGACAUUUUAGGAAGGAAAGGAACUACGAAAUCGUGUGAAAAUGGGUUGGAACCCAUCAGUGAUCGCAUAUUCAUUGAUGAGGGUUUGCUUGAGAUAGAAAAUGGUGGCUCCUUUCUGUCUUAUCUCCUAGUUUCUUCAAUGCUUACGCCUUGUUCUUCUCAAGAGAAAGUUGUAACUCUCUGGUCUUCAUAUGUCCCUGUGCUCCUUUUAACCAAAUAAAGAGUUCUUGUUUCUGAAGAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 140578)
CHODL
chondrolectin
NC_000021.9
21  18245224.. 18266038
18245224.. 18266038
strand +
CCDS13570.1
MGI:2179069
ClinVar, dbVar
ENSG00000154645
FLJ12627, PRED12, MT75
uc002ykv.5
INSDC: AF257472
17807
607247
OTTHUMG00000074519
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (822 bp)
5'-ATGAGCCGCGTGGTCTCGCTGCTGCTGGGCGCCGCGCTGCTCTGCGGCCACGGAGCCTTCTGCCGCCGCGTGGTCAGCGGCCAAAAGGTGTGTTTTGCTGACTTCAAGCATCCCTGCTACAAAATGGCCTACTTCCATGAACTGTCCAGCCGAGTGAGCTTTCAGGAGGCACGCCTGGCTTGTGAGAGTGAGGGAGGAGTCCTCCTCAGCCTTGAGAATGAAGCAGAACAGAAGTTAATAGAGAGCATGTTGCAAAACCTGACAAAACCCGGGACAGGGATTTCTGATGGTGATTTCTGGATAGGGCTTTGGAGGAATGGAGATGGGCAAACATCTGGTGCCTGCCCAGATCTCTACCAGTGGTCTGATGGAAGCAATTCCCAGTACCGAAACTGGTACACAGATGAACCTTCCTGCGGAAGTGAAAAGTGTGTTGTGATGTATCACCAACCAACTGCCAATCCTGGCCTTGGGGGTCCCTACCTTTACCAGTGGAATGATGACAGGTGTAACATGAAGCACAATTATATTTGCAAGTATGAACCAGAGATTAATCCAACAGCCCCTGTAGAAAAGCCTTATCTTACAAATCAACCAGGAGACACCCATCAGAATGTGGTTGTTACTGAAGCAGGTATAATTCCCAATCTAATTTATGTTGTTATACCAACAATACCCCTGCTCTTACTGATACTGGTTGCTTTTGGAACCTGTTGTTTCCAGATGCTGCATAAAAGTAAAGGAAGAACAAAAACTAGTCCAAACCAGTCTACACTGTGGATTTCAAAGAGTACCAGAAAAGAAAGTGGCATGGAAGTATAA-3'
NCBI CDS gene sequence with introns (location: 18245224.. 18266038) (20815 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 18244833.. 18267370) (22538 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [18244833 - 1000].. 18267370) (23538 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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