HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011].

Protein name

CBM13-ppGalNAc-T12

Synonym(s)

Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)

HGNC gene name

GALNT12

HGNC name

polypeptide N-acetylgalactosaminyltransferase 12

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

Ricin-like

Known lectin group

R-Type Lectins

Lectin fold

b-trefoil

Glycan specificity

GalNAc / Mucin-type glycopeptide

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

Undefined

Reference

10.1074/jbc.M111.273722

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (581 amino acids) Download

MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q8IXK2-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for GALNT12 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Interaction between G ALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy. [33593824]

Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer. [29749045]

Role of GALNT12 in the genetic predisposition to attenuated adenomatous polyposis syndrome. [29095867]

Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings. [24038392]

GALNT12 is not a major contributor of familial colorectal cancer type X. [24115450]

Inherited deleterious variants in GALNT12 are associated with CRC susceptibility. [22461326]

Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. [19617566]

DNA sequence and analysis of human chromosome 9. [15164053]

Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-12 in gastric and colonic cancer cell lines and in human colorectal cancer. [15557789]

Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12. [12135769]

UniProt Main References (2 PubMed Identifiers)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

All isoforms of this gene containing a lectin domain

XP_006717350.1, XP_011517322.1, XP_024303441.1, XP_016870622.1, XP_011517320.1, NP_078918.3

RNA

RNA (Transcript ID: NM_024642.5)

RNA RefSeq ID

NM_024642.5

RNA name

polypeptide N-acetylgalactosaminyltransferase 12

Isoforms

All isoforms of GALNT12 containing a lectin domain

RNA Ensembl ID

ENST00000375011.4

Coding region

30..1775 (or 98807699.. 98849092)

mRNA location

98807670.. 98850081

NCBI Matured mRNA sequence 2764 NTP Download

m⁷G-5')ppp(5'-GCAGAUCGCUGGCUGCAGUUGGCGGGCGCAUGUGGGGGCGCACGGCGCGGCGGCGCUGCCCGCGGGAACUGCGGCGCGGCCGGGAGGCGCUGUUGGUGCUCCUGGCGCUACUGGCGUUGGCCGGGCUGGGCUCGGUGCUGCGGGCGCAGCGUGGGGCCGGGGCCGGGGCUGCCGAGCCGGGACCCCCGCGCACCCCGCGCCCCGGGCGGCGCGAGCCGGUCAUGCCGCGGCCGCCGGUGCCGGCGAACGCGCUGGGCGCGCGGGGCGAGGCGGUGCGGCUGCAGCUGCAGGGCGAGGAGCUGCGGCUGCAGGAGGAGAGCGUGCGGCUGCACCAGAUUAACAUCUACCUCAGCGACCGCAUCUCACUGCACCGCCGCCUGCCCGAGCGCUGGAACCCGCUGUGCAAAGAGAAGAAAUAUGAUUAUGAUAAUUUGCCCAGGACAUCUGUUAUCAUAGCAUUUUAUAAUGAAGCCUGGUCAACUCUCCUUCGGACAGUUUACAGUGUCCUUGAGACAUCCCCGGAUAUCCUGCUAGAAGAAGUGAUCCUUGUAGAUGACUACAGUGAUAGAGAGCACCUGAAGGAGCGCUUGGCCAAUGAGCUUUCGGGACUGCCCAAGGUGCGCCUGAUCCGCGCCAACAAGAGAGAGGGCCUGGUGCGAGCCCGGCUGCUGGGGGCGUCUGCGGCGAGGGGCGAUGUUCUGACCUUCCUGGACUGUCACUGUGAGUGCCACGAAGGGUGGCUGGAGCCGCUGCUGCAGAGGAUCCAUGAAGAGGAGUCGGCAGUGGUGUGCCCGGUGAUUGAUGUGAUCGACUGGAACACCUUCGAAUACCUGGGGAACUCCGGGGAGCCCCAGAUCGGCGGUUUCGACUGGAGGCUGGUGUUCACGUGGCACACAGUUCCUGAGAGGGAGAGGAUACGGAUGCAAUCCCCCGUCGAUGUCAUCAGGUCUCCAACAAUGGCUGGUGGGCUGUUUGCUGUGAGUAAGAAAUAUUUUGAAUAUCUGGGGUCUUAUGAUACAGGAAUGGAAGUUUGGGGAGGAGAAAACCUCGAAUUUUCCUUUAGGAUCUGGCAGUGUGGUGGGGUUCUGGAAACACACCCAUGUUCCCAUGUUGGCCAUGUUUUCCCCAAGCAAGCUCCCUACUCCCGCAACAAGGCUCUGGCCAACAGUGUUCGUGCAGCUGAAGUAUGGAUGGAUGAAUUUAAAGAGCUCUACUACCAUCGCAACCCCCGUGCCCGCUUGGAACCUUUUGGGGAUGUGACAGAGAGGAAGCAGCUCCGGGACAAGCUCCAGUGUAAAGACUUCAAGUGGUUCUUGGAGACUGUGUAUCCAGAACUGCAUGUGCCUGAGGACAGGCCUGGCUUCUUCGGGAUGCUCCAGAACAAAGGACUAACAGACUACUGCUUUGACUAUAACCCUCCCGAUGAAAACCAGAUUGUGGGACACCAGGUCAUUCUGUACCUCUGUCAUGGGAUGGGCCAGAAUCAGUUUUUCGAGUACACGUCCCAGAAAGAAAUACGCUAUAACACCCACCAGCCUGAGGGCUGCAUUGCUGUGGAAGCAGGAAUGGAUACCCUUAUCAUGCAUCUCUGCGAAGAAACUGCCCCAGAGAAUCAGAAGUUCAUCUUGCAGGAGGAUGGAUCUUUAUUUCACGAACAGUCCAAGAAAUGUGUCCAGGCUGCGAGGAAGGAGUCGAGUGACAGUUUCGUUCCACUCUUACGAGACUGCACCAACUCGGAUCAUCAGAAAUGGUUCUUCAAAGAGCGCAUGUUAUGAAGCCUCGUGUAUCAAGGAGCCCAUCGAAGGAGACUGUGGAGCCAGGACUCUGCCCAACAAAGACUUAGCUAAGCAGUGACCAGAACCCACCAAAAACUAGGCUGCAUUGCUUUGAAGAGGCAAUCAUUUUGCCAUUUGUGAAAGUUGUGUUGGAUUUAGUAAAAAUGUGAAUAAGCUUUGUACUUAUUUUGAGAACUUUUUAAAUGUUCCAAAAUACCCUAUUUUCAAAGGGUAAUCGUAAGAUGUUAACCCUUGGUAUUUAGAAAAUUAAAACCUUAUAAUAUUUUUCUAUCAAGAUGUAUAUUUUACAGUCGUGCCUUUUACUCUCAUUAGCAAAAAAGAUAAAGAUUUUAUUUUGGUAUUUACAAGAAUUCCCAGGUACGAAGAUAUCUGCAUGGGUGGAAAUCAGGUUCAAGCAACGUACUUUGCAUUAACUGAUAAUACCUCAGCUGCGGGGUUAAAGUUUUCCCAGUAUAGAGAGACUGUCACUAGGAACAUUGUAUUGAUUUAUUCAGGUCAUUGAGAUCUUCUAGAUGUAUUUUAAAAAGAAUGCUUUUUGGUUAUGUGUUGCUACCACAGUUAACACUCCAUAAUGUUCAUGUCAGCCAAAGAGGACUAACCAAAGCUGAAAUCUCAGAGAACAAUUUGCUUUACUAAGCUGAGUCAACUUGAGAGCGAACUUCUAACAAUGCCGCACUGUAGUGUGGCUGGUUCUACCACUAUGACUUUAAAACAUGUUUAUAUCAUUUUUAAUUUUUAUGAUACGGUAGUGUCAGGGAGAAAUGUAAUGUUCUAUAUGAAAUUCCUUUUUCAAGUUUGUUCAUUAAUAACAGUUAUUAAUUUAAAUCAGCGUUAGAGUUUGUGCUGCUGCAACUGCUGUGAAAAUUUCUCUGAGUAAUUCUGAUUUGUGAAUGAUCCCAGACCAACCCUGAGAUUUUGUCAACCUGAUUAAGUCAAUAUGAAUGAUUAAAAAGAUGUGAGAACACUGA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 79695)

HGNC Gene symbol

GALNT12

HGNC Gene name

polypeptide N-acetylgalactosaminyltransferase 12

Chr. RefSeq ID

NC_000009.12

Chromosome N°

9 98807699.. 98849092

CDS location

98807699.. 98849092

DNA strand

strand +

CCDS ID

CCDS6737.1

Mouse ortholog gene

MGI:2444664

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000119514

HGNC other symbol

GalNAc-T12

UCSC ID

uc004ayz.3

GeneBank

INSDC: AB078146

GeneCards

19877

MIM

610290

VEGA ID

OTTHUMG00000020348

Other links

ENA, DDBJ, Monarch

NCBI CDS Gene viewer

More about the NCBI sViewer.

NCBI CDS gene sequence (1746 bp)

5'-ATGTGGGGGCGCACGGCGCGGCGGCGCTGCCCGCGGGAACTGCGGCGCGGCCGGGAGGCGCTGTTGGTGCTCCTGGCGCTACTGGCGTTGGCCGGGCTGGGCTCGGTGCTGCGGGCGCAGCGTGGGGCCGGGGCCGGGGCTGCCGAGCCGGGACCCCCGCGCACCCCGCGCCCCGGGCGGCGCGAGCCGGTCATGCCGCGGCCGCCGGTGCCGGCGAACGCGCTGGGCGCGCGGGGCGAGGCGGTGCGGCTGCAGCTGCAGGGCGAGGAGCTGCGGCTGCAGGAGGAGAGCGTGCGGCTGCACCAGATTAACATCTACCTCAGCGACCGCATCTCACTGCACCGCCGCCTGCCCGAGCGCTGGAACCCGCTGTGCAAAGAGAAGAAATATGATTATGATAATTTGCCCAGGACATCTGTTATCATAGCATTTTATAATGAAGCCTGGTCAACTCTCCTTCGGACAGTTTACAGTGTCCTTGAGACATCCCCGGATATCCTGCTAGAAGAAGTGATCCTTGTAGATGACTACAGTGATAGAGAGCACCTGAAGGAGCGCTTGGCCAATGAGCTTTCGGGACTGCCCAAGGTGCGCCTGATCCGCGCCAACAAGAGAGAGGGCCTGGTGCGAGCCCGGCTGCTGGGGGCGTCTGCGGCGAGGGGCGATGTTCTGACCTTCCTGGACTGTCACTGTGAGTGCCACGAAGGGTGGCTGGAGCCGCTGCTGCAGAGGATCCATGAAGAGGAGTCGGCAGTGGTGTGCCCGGTGATTGATGTGATCGACTGGAACACCTTCGAATACCTGGGGAACTCCGGGGAGCCCCAGATCGGCGGTTTCGACTGGAGGCTGGTGTTCACGTGGCACACAGTTCCTGAGAGGGAGAGGATACGGATGCAATCCCCCGTCGATGTCATCAGGTCTCCAACAATGGCTGGTGGGCTGTTTGCTGTGAGTAAGAAATATTTTGAATATCTGGGGTCTTATGATACAGGAATGGAAGTTTGGGGAGGAGAAAACCTCGAATTTTCCTTTAGGATCTGGCAGTGTGGTGGGGTTCTGGAAACACACCCATGTTCCCATGTTGGCCATGTTTTCCCCAAGCAAGCTCCCTACTCCCGCAACAAGGCTCTGGCCAACAGTGTTCGTGCAGCTGAAGTATGGATGGATGAATTTAAAGAGCTCTACTACCATCGCAACCCCCGTGCCCGCTTGGAACCTTTTGGGGATGTGACAGAGAGGAAGCAGCTCCGGGACAAGCTCCAGTGTAAAGACTTCAAGTGGTTCTTGGAGACTGTGTATCCAGAACTGCATGTGCCTGAGGACAGGCCTGGCTTCTTCGGGATGCTCCAGAACAAAGGACTAACAGACTACTGCTTTGACTATAACCCTCCCGATGAAAACCAGATTGTGGGACACCAGGTCATTCTGTACCTCTGTCATGGGATGGGCCAGAATCAGTTTTTCGAGTACACGTCCCAGAAAGAAATACGCTATAACACCCACCAGCCTGAGGGCTGCATTGCTGTGGAAGCAGGAATGGATACCCTTATCATGCATCTCTGCGAAGAAACTGCCCCAGAGAATCAGAAGTTCATCTTGCAGGAGGATGGATCTTTATTTCACGAACAGTCCAAGAAATGTGTCCAGGCTGCGAGGAAGGAGTCGAGTGACAGTTTCGTTCCACTCTTACGAGACTGCACCAACTCGGATCATCAGAAATGGTTCTTCAAAGAGCGCATGTTATGA-3'

NCBI CDS gene sequence with introns (location: 98807699.. 98849092) (41394 bp)Download

NCBI Gene Viewer (CDS + introns)

NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 98807670.. 98850081) (42412 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions)

NCBI gene sequence (location: [98807670 - 1000].. 98850081) (43412 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)