NCBI Summary
This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011].
Protein
Protein (NP_078918)
CBM13-ppGalNAc-T12
Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)
GALNT12
polypeptide N-acetylgalactosaminyltransferase 12
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_078918
79695
Q8IXK2
ENSP00000364150.3
Q8IXK2
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (581 amino acids) Download
MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8IXK2-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
glycopeptide
GalNAc
6PXU
6PXU
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT12 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Interaction between G ALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy. [33593824]
  • Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer. [29749045]
  • Role of GALNT12 in the genetic predisposition to attenuated adenomatous polyposis syndrome. [29095867]
  • Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings. [24038392]
  • GALNT12 is not a major contributor of familial colorectal cancer type X. [24115450]
  • Inherited deleterious variants in GALNT12 are associated with CRC susceptibility. [22461326]
  • Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. [19617566]
  • DNA sequence and analysis of human chromosome 9. [15164053]
  • Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-12 in gastric and colonic cancer cell lines and in human colorectal cancer. [15557789]
  • Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12. [12135769]
UniProt Main References (2 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
All isoforms of this gene containing a lectin domain
XP_006717350.1, XP_011517322.1, XP_024303441.1, XP_016870622.1, XP_011517320.1, NP_078918.3
RNA
RNA (Transcript ID: NM_024642.5)
NM_024642.5
polypeptide N-acetylgalactosaminyltransferase 12
All isoforms of GALNT12 containing a lectin domain
ENST00000375011.4
30..1775 (or 98807699.. 98849092)
98807670.. 98850081
NCBI Matured mRNA sequence 2764 NTPDownload 
m7G-5')ppp(5'-GCAGAUCGCUGGCUGCAGUUGGCGGGCGCAUGUGGGGGCGCACGGCGCGGCGGCGCUGCCCGCGGGAACUGCGGCGCGGCCGGGAGGCGCUGUUGGUGCUCCUGGCGCUACUGGCGUUGGCCGGGCUGGGCUCGGUGCUGCGGGCGCAGCGUGGGGCCGGGGCCGGGGCUGCCGAGCCGGGACCCCCGCGCACCCCGCGCCCCGGGCGGCGCGAGCCGGUCAUGCCGCGGCCGCCGGUGCCGGCGAACGCGCUGGGCGCGCGGGGCGAGGCGGUGCGGCUGCAGCUGCAGGGCGAGGAGCUGCGGCUGCAGGAGGAGAGCGUGCGGCUGCACCAGAUUAACAUCUACCUCAGCGACCGCAUCUCACUGCACCGCCGCCUGCCCGAGCGCUGGAACCCGCUGUGCAAAGAGAAGAAAUAUGAUUAUGAUAAUUUGCCCAGGACAUCUGUUAUCAUAGCAUUUUAUAAUGAAGCCUGGUCAACUCUCCUUCGGACAGUUUACAGUGUCCUUGAGACAUCCCCGGAUAUCCUGCUAGAAGAAGUGAUCCUUGUAGAUGACUACAGUGAUAGAGAGCACCUGAAGGAGCGCUUGGCCAAUGAGCUUUCGGGACUGCCCAAGGUGCGCCUGAUCCGCGCCAACAAGAGAGAGGGCCUGGUGCGAGCCCGGCUGCUGGGGGCGUCUGCGGCGAGGGGCGAUGUUCUGACCUUCCUGGACUGUCACUGUGAGUGCCACGAAGGGUGGCUGGAGCCGCUGCUGCAGAGGAUCCAUGAAGAGGAGUCGGCAGUGGUGUGCCCGGUGAUUGAUGUGAUCGACUGGAACACCUUCGAAUACCUGGGGAACUCCGGGGAGCCCCAGAUCGGCGGUUUCGACUGGAGGCUGGUGUUCACGUGGCACACAGUUCCUGAGAGGGAGAGGAUACGGAUGCAAUCCCCCGUCGAUGUCAUCAGGUCUCCAACAAUGGCUGGUGGGCUGUUUGCUGUGAGUAAGAAAUAUUUUGAAUAUCUGGGGUCUUAUGAUACAGGAAUGGAAGUUUGGGGAGGAGAAAACCUCGAAUUUUCCUUUAGGAUCUGGCAGUGUGGUGGGGUUCUGGAAACACACCCAUGUUCCCAUGUUGGCCAUGUUUUCCCCAAGCAAGCUCCCUACUCCCGCAACAAGGCUCUGGCCAACAGUGUUCGUGCAGCUGAAGUAUGGAUGGAUGAAUUUAAAGAGCUCUACUACCAUCGCAACCCCCGUGCCCGCUUGGAACCUUUUGGGGAUGUGACAGAGAGGAAGCAGCUCCGGGACAAGCUCCAGUGUAAAGACUUCAAGUGGUUCUUGGAGACUGUGUAUCCAGAACUGCAUGUGCCUGAGGACAGGCCUGGCUUCUUCGGGAUGCUCCAGAACAAAGGACUAACAGACUACUGCUUUGACUAUAACCCUCCCGAUGAAAACCAGAUUGUGGGACACCAGGUCAUUCUGUACCUCUGUCAUGGGAUGGGCCAGAAUCAGUUUUUCGAGUACACGUCCCAGAAAGAAAUACGCUAUAACACCCACCAGCCUGAGGGCUGCAUUGCUGUGGAAGCAGGAAUGGAUACCCUUAUCAUGCAUCUCUGCGAAGAAACUGCCCCAGAGAAUCAGAAGUUCAUCUUGCAGGAGGAUGGAUCUUUAUUUCACGAACAGUCCAAGAAAUGUGUCCAGGCUGCGAGGAAGGAGUCGAGUGACAGUUUCGUUCCACUCUUACGAGACUGCACCAACUCGGAUCAUCAGAAAUGGUUCUUCAAAGAGCGCAUGUUAUGAAGCCUCGUGUAUCAAGGAGCCCAUCGAAGGAGACUGUGGAGCCAGGACUCUGCCCAACAAAGACUUAGCUAAGCAGUGACCAGAACCCACCAAAAACUAGGCUGCAUUGCUUUGAAGAGGCAAUCAUUUUGCCAUUUGUGAAAGUUGUGUUGGAUUUAGUAAAAAUGUGAAUAAGCUUUGUACUUAUUUUGAGAACUUUUUAAAUGUUCCAAAAUACCCUAUUUUCAAAGGGUAAUCGUAAGAUGUUAACCCUUGGUAUUUAGAAAAUUAAAACCUUAUAAUAUUUUUCUAUCAAGAUGUAUAUUUUACAGUCGUGCCUUUUACUCUCAUUAGCAAAAAAGAUAAAGAUUUUAUUUUGGUAUUUACAAGAAUUCCCAGGUACGAAGAUAUCUGCAUGGGUGGAAAUCAGGUUCAAGCAACGUACUUUGCAUUAACUGAUAAUACCUCAGCUGCGGGGUUAAAGUUUUCCCAGUAUAGAGAGACUGUCACUAGGAACAUUGUAUUGAUUUAUUCAGGUCAUUGAGAUCUUCUAGAUGUAUUUUAAAAAGAAUGCUUUUUGGUUAUGUGUUGCUACCACAGUUAACACUCCAUAAUGUUCAUGUCAGCCAAAGAGGACUAACCAAAGCUGAAAUCUCAGAGAACAAUUUGCUUUACUAAGCUGAGUCAACUUGAGAGCGAACUUCUAACAAUGCCGCACUGUAGUGUGGCUGGUUCUACCACUAUGACUUUAAAACAUGUUUAUAUCAUUUUUAAUUUUUAUGAUACGGUAGUGUCAGGGAGAAAUGUAAUGUUCUAUAUGAAAUUCCUUUUUCAAGUUUGUUCAUUAAUAACAGUUAUUAAUUUAAAUCAGCGUUAGAGUUUGUGCUGCUGCAACUGCUGUGAAAAUUUCUCUGAGUAAUUCUGAUUUGUGAAUGAUCCCAGACCAACCCUGAGAUUUUGUCAACCUGAUUAAGUCAAUAUGAAUGAUUAAAAAGAUGUGAGAACACUGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 79695)
GALNT12
polypeptide N-acetylgalactosaminyltransferase 12
NC_000009.12
9  98807699.. 98849092
98807699.. 98849092
strand +
CCDS6737.1
MGI:2444664
ClinVar, dbVar
ENSG00000119514
GalNAc-T12
uc004ayz.3
INSDC: AB078146
19877
610290
OTTHUMG00000020348
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1746 bp)
5'-ATGTGGGGGCGCACGGCGCGGCGGCGCTGCCCGCGGGAACTGCGGCGCGGCCGGGAGGCGCTGTTGGTGCTCCTGGCGCTACTGGCGTTGGCCGGGCTGGGCTCGGTGCTGCGGGCGCAGCGTGGGGCCGGGGCCGGGGCTGCCGAGCCGGGACCCCCGCGCACCCCGCGCCCCGGGCGGCGCGAGCCGGTCATGCCGCGGCCGCCGGTGCCGGCGAACGCGCTGGGCGCGCGGGGCGAGGCGGTGCGGCTGCAGCTGCAGGGCGAGGAGCTGCGGCTGCAGGAGGAGAGCGTGCGGCTGCACCAGATTAACATCTACCTCAGCGACCGCATCTCACTGCACCGCCGCCTGCCCGAGCGCTGGAACCCGCTGTGCAAAGAGAAGAAATATGATTATGATAATTTGCCCAGGACATCTGTTATCATAGCATTTTATAATGAAGCCTGGTCAACTCTCCTTCGGACAGTTTACAGTGTCCTTGAGACATCCCCGGATATCCTGCTAGAAGAAGTGATCCTTGTAGATGACTACAGTGATAGAGAGCACCTGAAGGAGCGCTTGGCCAATGAGCTTTCGGGACTGCCCAAGGTGCGCCTGATCCGCGCCAACAAGAGAGAGGGCCTGGTGCGAGCCCGGCTGCTGGGGGCGTCTGCGGCGAGGGGCGATGTTCTGACCTTCCTGGACTGTCACTGTGAGTGCCACGAAGGGTGGCTGGAGCCGCTGCTGCAGAGGATCCATGAAGAGGAGTCGGCAGTGGTGTGCCCGGTGATTGATGTGATCGACTGGAACACCTTCGAATACCTGGGGAACTCCGGGGAGCCCCAGATCGGCGGTTTCGACTGGAGGCTGGTGTTCACGTGGCACACAGTTCCTGAGAGGGAGAGGATACGGATGCAATCCCCCGTCGATGTCATCAGGTCTCCAACAATGGCTGGTGGGCTGTTTGCTGTGAGTAAGAAATATTTTGAATATCTGGGGTCTTATGATACAGGAATGGAAGTTTGGGGAGGAGAAAACCTCGAATTTTCCTTTAGGATCTGGCAGTGTGGTGGGGTTCTGGAAACACACCCATGTTCCCATGTTGGCCATGTTTTCCCCAAGCAAGCTCCCTACTCCCGCAACAAGGCTCTGGCCAACAGTGTTCGTGCAGCTGAAGTATGGATGGATGAATTTAAAGAGCTCTACTACCATCGCAACCCCCGTGCCCGCTTGGAACCTTTTGGGGATGTGACAGAGAGGAAGCAGCTCCGGGACAAGCTCCAGTGTAAAGACTTCAAGTGGTTCTTGGAGACTGTGTATCCAGAACTGCATGTGCCTGAGGACAGGCCTGGCTTCTTCGGGATGCTCCAGAACAAAGGACTAACAGACTACTGCTTTGACTATAACCCTCCCGATGAAAACCAGATTGTGGGACACCAGGTCATTCTGTACCTCTGTCATGGGATGGGCCAGAATCAGTTTTTCGAGTACACGTCCCAGAAAGAAATACGCTATAACACCCACCAGCCTGAGGGCTGCATTGCTGTGGAAGCAGGAATGGATACCCTTATCATGCATCTCTGCGAAGAAACTGCCCCAGAGAATCAGAAGTTCATCTTGCAGGAGGATGGATCTTTATTTCACGAACAGTCCAAGAAATGTGTCCAGGCTGCGAGGAAGGAGTCGAGTGACAGTTTCGTTCCACTCTTACGAGACTGCACCAACTCGGATCATCAGAAATGGTTCTTCAAAGAGCGCATGTTATGA-3'
NCBI CDS gene sequence with introns (location: 98807699.. 98849092) (41394 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 98807670.. 98850081) (42412 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [98807670 - 1000].. 98850081) (43412 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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