NCBI Summary
This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011].
Protein
Protein (NP_078918)
CBM13-ppGalNAc-T12
Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)
GALNT12
polypeptide N-acetylgalactosaminyltransferase 12
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML
Mol* PDB structure viewerUniLectin3D
References
NCBI References (10 PubMed Identifiers)
- Interaction between G ALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy. [33593824]
- Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer. [29749045]
- Role of GALNT12 in the genetic predisposition to attenuated adenomatous polyposis syndrome. [29095867]
- Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings. [24038392]
- GALNT12 is not a major contributor of familial colorectal cancer type X. [24115450]
- Inherited deleterious variants in GALNT12 are associated with CRC susceptibility. [22461326]
- Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. [19617566]
- DNA sequence and analysis of human chromosome 9. [15164053]
- Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-12 in gastric and colonic cancer cell lines and in human colorectal cancer. [15557789]
- Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12. [12135769]
UniProt Main References (2 PubMed Identifiers)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_024642.5)
polypeptide N-acetylgalactosaminyltransferase 12
m7G-5')ppp(5'-GCAGAUCGCUGGCUGCAGUUGGCGGGCGCAUGUGGGGGCGCACGGCGCGGCGGCGCUGCCCGCGGGAACUGCGGCGCGGCCGGGAGGCGCUGUUGGUGCUCCUGGCGCUACUGGCGUUGGCCGGGCUGGGCUCGGUGCUGCGGGCGCAGCGUGGGGCCGGGGCCGGGGCUGCCGAGCCGGGACCCCCGCGCACCCCGCGCCCCGGGCGGCGCGAGCCGGUCAUGCCGCGGCCGCCGGUGCCGGCGAACGCGCUGGGCGCGCGGGGCGAGGCGGUGCGGCUGCAGCUGCAGGGCGAGGAGCUGCGGCUGCAGGAGGAGAGCGUGCGGCUGCACCAGAUUAACAUCUACCUCAGCGACCGCAUCUCACUGCACCGCCGCCUGCCCGAGCGCUGGAACCCGCUGUGCAAAGAGAAGAAAUAUGAUUAUGAUAAUUUGCCCAGGACAUCUGUUAUCAUAGCAUUUUAUAAUGAAGCCUGGUCAACUCUCCUUCGGACAGUUUACAGUGUCCUUGAGACAUCCCCGGAUAUCCUGCUAGAAGAAGUGAUCCUUGUAGAUGACUACAGUGAUAGAGAGCACCUGAAGGAGCGCUUGGCCAAUGAGCUUUCGGGACUGCCCAAGGUGCGCCUGAUCCGCGCCAACAAGAGAGAGGGCCUGGUGCGAGCCCGGCUGCUGGGGGCGUCUGCGGCGAGGGGCGAUGUUCUGACCUUCCUGGACUGUCACUGUGAGUGCCACGAAGGGUGGCUGGAGCCGCUGCUGCAGAGGAUCCAUGAAGAGGAGUCGGCAGUGGUGUGCCCGGUGAUUGAUGUGAUCGACUGGAACACCUUCGAAUACCUGGGGAACUCCGGGGAGCCCCAGAUCGGCGGUUUCGACUGGAGGCUGGUGUUCACGUGGCACACAGUUCCUGAGAGGGAGAGGAUACGGAUGCAAUCCCCCGUCGAUGUCAUCAGGUCUCCAACAAUGGCUGGUGGGCUGUUUGCUGUGAGUAAGAAAUAUUUUGAAUAUCUGGGGUCUUAUGAUACAGGAAUGGAAGUUUGGGGAGGAGAAAACCUCGAAUUUUCCUUUAGGAUCUGGCAGUGUGGUGGGGUUCUGGAAACACACCCAUGUUCCCAUGUUGGCCAUGUUUUCCCCAAGCAAGCUCCCUACUCCCGCAACAAGGCUCUGGCCAACAGUGUUCGUGCAGCUGAAGUAUGGAUGGAUGAAUUUAAAGAGCUCUACUACCAUCGCAACCCCCGUGCCCGCUUGGAACCUUUUGGGGAUGUGACAGAGAGGAAGCAGCUCCGGGACAAGCUCCAGUGUAAAGACUUCAAGUGGUUCUUGGAGACUGUGUAUCCAGAACUGCAUGUGCCUGAGGACAGGCCUGGCUUCUUCGGGAUGCUCCAGAACAAAGGACUAACAGACUACUGCUUUGACUAUAACCCUCCCGAUGAAAACCAGAUUGUGGGACACCAGGUCAUUCUGUACCUCUGUCAUGGGAUGGGCCAGAAUCAGUUUUUCGAGUACACGUCCCAGAAAGAAAUACGCUAUAACACCCACCAGCCUGAGGGCUGCAUUGCUGUGGAAGCAGGAAUGGAUACCCUUAUCAUGCAUCUCUGCGAAGAAACUGCCCCAGAGAAUCAGAAGUUCAUCUUGCAGGAGGAUGGAUCUUUAUUUCACGAACAGUCCAAGAAAUGUGUCCAGGCUGCGAGGAAGGAGUCGAGUGACAGUUUCGUUCCACUCUUACGAGACUGCACCAACUCGGAUCAUCAGAAAUGGUUCUUCAAAGAGCGCAUGUUAUGAAGCCUCGUGUAUCAAGGAGCCCAUCGAAGGAGACUGUGGAGCCAGGACUCUGCCCAACAAAGACUUAGCUAAGCAGUGACCAGAACCCACCAAAAACUAGGCUGCAUUGCUUUGAAGAGGCAAUCAUUUUGCCAUUUGUGAAAGUUGUGUUGGAUUUAGUAAAAAUGUGAAUAAGCUUUGUACUUAUUUUGAGAACUUUUUAAAUGUUCCAAAAUACCCUAUUUUCAAAGGGUAAUCGUAAGAUGUUAACCCUUGGUAUUUAGAAAAUUAAAACCUUAUAAUAUUUUUCUAUCAAGAUGUAUAUUUUACAGUCGUGCCUUUUACUCUCAUUAGCAAAAAAGAUAAAGAUUUUAUUUUGGUAUUUACAAGAAUUCCCAGGUACGAAGAUAUCUGCAUGGGUGGAAAUCAGGUUCAAGCAACGUACUUUGCAUUAACUGAUAAUACCUCAGCUGCGGGGUUAAAGUUUUCCCAGUAUAGAGAGACUGUCACUAGGAACAUUGUAUUGAUUUAUUCAGGUCAUUGAGAUCUUCUAGAUGUAUUUUAAAAAGAAUGCUUUUUGGUUAUGUGUUGCUACCACAGUUAACACUCCAUAAUGUUCAUGUCAGCCAAAGAGGACUAACCAAAGCUGAAAUCUCAGAGAACAAUUUGCUUUACUAAGCUGAGUCAACUUGAGAGCGAACUUCUAACAAUGCCGCACUGUAGUGUGGCUGGUUCUACCACUAUGACUUUAAAACAUGUUUAUAUCAUUUUUAAUUUUUAUGAUACGGUAGUGUCAGGGAGAAAUGUAAUGUUCUAUAUGAAAUUCCUUUUUCAAGUUUGUUCAUUAAUAACAGUUAUUAAUUUAAAUCAGCGUUAGAGUUUGUGCUGCUGCAACUGCUGUGAAAAUUUCUCUGAGUAAUUCUGAUUUGUGAAUGAUCCCAGACCAACCCUGAGAUUUUGUCAACCUGAUUAAGUCAAUAUGAAUGAUUAAAAAGAUGUGAGAACACUGA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 79695)
polypeptide N-acetylgalactosaminyltransferase 12
strand +
GalNAc-T12
NCBI CDS gene sequence (1746 bp)
5'-ATGTGGGGGCGCACGGCGCGGCGGCGCTGCCCGCGGGAACTGCGGCGCGGCCGGGAGGCGCTGTTGGTGCTCCTGGCGCTACTGGCGTTGGCCGGGCTGGGCTCGGTGCTGCGGGCGCAGCGTGGGGCCGGGGCCGGGGCTGCCGAGCCGGGACCCCCGCGCACCCCGCGCCCCGGGCGGCGCGAGCCGGTCATGCCGCGGCCGCCGGTGCCGGCGAACGCGCTGGGCGCGCGGGGCGAGGCGGTGCGGCTGCAGCTGCAGGGCGAGGAGCTGCGGCTGCAGGAGGAGAGCGTGCGGCTGCACCAGATTAACATCTACCTCAGCGACCGCATCTCACTGCACCGCCGCCTGCCCGAGCGCTGGAACCCGCTGTGCAAAGAGAAGAAATATGATTATGATAATTTGCCCAGGACATCTGTTATCATAGCATTTTATAATGAAGCCTGGTCAACTCTCCTTCGGACAGTTTACAGTGTCCTTGAGACATCCCCGGATATCCTGCTAGAAGAAGTGATCCTTGTAGATGACTACAGTGATAGAGAGCACCTGAAGGAGCGCTTGGCCAATGAGCTTTCGGGACTGCCCAAGGTGCGCCTGATCCGCGCCAACAAGAGAGAGGGCCTGGTGCGAGCCCGGCTGCTGGGGGCGTCTGCGGCGAGGGGCGATGTTCTGACCTTCCTGGACTGTCACTGTGAGTGCCACGAAGGGTGGCTGGAGCCGCTGCTGCAGAGGATCCATGAAGAGGAGTCGGCAGTGGTGTGCCCGGTGATTGATGTGATCGACTGGAACACCTTCGAATACCTGGGGAACTCCGGGGAGCCCCAGATCGGCGGTTTCGACTGGAGGCTGGTGTTCACGTGGCACACAGTTCCTGAGAGGGAGAGGATACGGATGCAATCCCCCGTCGATGTCATCAGGTCTCCAACAATGGCTGGTGGGCTGTTTGCTGTGAGTAAGAAATATTTTGAATATCTGGGGTCTTATGATACAGGAATGGAAGTTTGGGGAGGAGAAAACCTCGAATTTTCCTTTAGGATCTGGCAGTGTGGTGGGGTTCTGGAAACACACCCATGTTCCCATGTTGGCCATGTTTTCCCCAAGCAAGCTCCCTACTCCCGCAACAAGGCTCTGGCCAACAGTGTTCGTGCAGCTGAAGTATGGATGGATGAATTTAAAGAGCTCTACTACCATCGCAACCCCCGTGCCCGCTTGGAACCTTTTGGGGATGTGACAGAGAGGAAGCAGCTCCGGGACAAGCTCCAGTGTAAAGACTTCAAGTGGTTCTTGGAGACTGTGTATCCAGAACTGCATGTGCCTGAGGACAGGCCTGGCTTCTTCGGGATGCTCCAGAACAAAGGACTAACAGACTACTGCTTTGACTATAACCCTCCCGATGAAAACCAGATTGTGGGACACCAGGTCATTCTGTACCTCTGTCATGGGATGGGCCAGAATCAGTTTTTCGAGTACACGTCCCAGAAAGAAATACGCTATAACACCCACCAGCCTGAGGGCTGCATTGCTGTGGAAGCAGGAATGGATACCCTTATCATGCATCTCTGCGAAGAAACTGCCCCAGAGAATCAGAAGTTCATCTTGCAGGAGGATGGATCTTTATTTCACGAACAGTCCAAGAAATGTGTCCAGGCTGCGAGGAAGGAGTCGAGTGACAGTTTCGTTCCACTCTTACGAGACTGCACCAACTCGGATCATCAGAAATGGTTCTTCAAAGAGCGCATGTTATGA-3'
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