NCBI Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_001035972)
Galectin 7
Galectin-7 (Gal-7) (HKL-14) (PI7) (p53-induced gene 1 protein)
LGALS7B
galectin 7B
Undefined
Curated
Galectin
S-Type Lectins - Prototypical
b-sandwich / ConA-like
Gal / Gal(b1-3)GlcNAc / Fucosylated blood group
NP_001035972
653499
P47929
ENSP00000313571.3
P47929
0.445
10.1016/j.isci.2022.104482
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (136 amino acids) Download
MSNVPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P47929-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
GalN
GalN
3GAL
3GAL
GlyConnect Structures
3-deoxy-3-(4-[m-fluorophenyl]-1H-1, Gal, thiodigalactoside derivative, bGal-O-R, galactose-benzylphosphate
Gal
2GAL, 3ZXE, 4UW3, 4UW4, 4UW5, 4UW6, 5H9Q, 5H9S
2GAL, 3ZXE, 4UW3, 4UW4, 4UW5, 4UW6, 5H9Q, 5H9S
GlyConnect Structures
bGal14GlcNAc
Gal(b1-4)GlcNAc
5GAL
5GAL
GlyConnect Structures
2, bGal13GlcNAc
Gal(b1-3)GlcNAc
4XBQ, 4Y26
4XBQ, 4Y26
GlyConnect Structures
bGal14Glc
Gal(b1-4)Glc
4GAL
4GAL
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS7B Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. [32915505]
  • A reference map of the human binary protein interactome. [32296183]
  • Galectin-7 serum levels are altered prior to the onset of pre-eclampsia. [24534543]
  • Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). [19199708]
  • Increased expression and altered intracellular distribution of adhesion/growth-regulatory lectins galectins-1 and -7 during tumour progression in hypopharyngeal and laryngeal squamous cell carcinomas. [18315601]
  • Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. [13679866]
  • Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. [11706006]
  • Structural basis for the recognition of carbohydrates by human galectin-7. [9760227]
  • Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. [7729568]
  • Cloning, expression, and chromosome mapping of human galectin-7. [7534301]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_001042507.4)
NM_001042507.4
galectin 7B
All isoforms of LGALS7B containing a lectin domain
ENST00000314980.5
28..438 (or 38789227.. 38791693)
38789200.. 38791754
NCBI Matured mRNA sequence 499 NTPDownload 
m7G-5')ppp(5'-CCACGGCUGCCCAACCCGGUCCCAGCCAUGUCCAACGUCCCCCACAAGUCCUCACUGCCCGAGGGCAUCCGCCCUGGCACGGUGCUGAGAAUUCGCGGCUUGGUUCCUCCCAAUGCCAGCAGGUUCCAUGUAAACCUGCUGUGCGGGGAGGAGCAGGGCUCCGAUGCCGCCCUGCAUUUCAACCCCCGGCUGGACACGUCGGAGGUGGUCUUCAACAGCAAGGAGCAAGGCUCCUGGGGCCGCGAGGAGCGCGGGCCGGGCGUUCCUUUCCAGCGCGGGCAGCCCUUCGAGGUGCUCAUCAUCGCGUCAGACGACGGCUUCAAGGCCGUGGUUGGGGACGCCCAGUACCACCACUUCCGCCACCGCCUGCCGCUGGCGCGCGUGCGCCUGGUGGAGGUGGGCGGGGACGUGCAGCUGGACUCCGUGAGGAUCUUCUGAGCAGAAGCCCAGGCGGGCCCGGGGCCUUGGCUGGCAAAUAAAGCGUUAGCCCGCAGCGCGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 653499)
LGALS7B
galectin 7B
NC_000019.10
19  38789227.. 38791693
38789227.. 38791693
strand +
CCDS42565.1
MGI:1316742
ClinVar, dbVar
ENSG00000178934
GAL7
uc002ojf.5
INSDC:
34447
617139
OTTHUMG00000182607
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (411 bp)
5'-ATGTCCAACGTCCCCCACAAGTCCTCACTGCCCGAGGGCATCCGCCCTGGCACGGTGCTGAGAATTCGCGGCTTGGTTCCTCCCAATGCCAGCAGGTTCCATGTAAACCTGCTGTGCGGGGAGGAGCAGGGCTCCGATGCCGCCCTGCATTTCAACCCCCGGCTGGACACGTCGGAGGTGGTCTTCAACAGCAAGGAGCAAGGCTCCTGGGGCCGCGAGGAGCGCGGGCCGGGCGTTCCTTTCCAGCGCGGGCAGCCCTTCGAGGTGCTCATCATCGCGTCAGACGACGGCTTCAAGGCCGTGGTTGGGGACGCCCAGTACCACCACTTCCGCCACCGCCTGCCGCTGGCGCGCGTGCGCCTGGTGGAGGTGGGCGGGGACGTGCAGCTGGACTCCGTGAGGATCTTCTGA-3'
NCBI CDS gene sequence with introns (location: 38789227.. 38791693) (2467 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 38789200.. 38791754) (2555 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [38789200 - 1000].. 38791754) (3555 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905