NCBI Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_001035972)
Galectin 7
Galectin-7 (Gal-7) (HKL-14) (PI7) (p53-induced gene 1 protein)
LGALS7B
galectin 7B
Undefined
Curated
galectin-like
S-Type Lectins - Prototypical
b-sandwich / ConA-like
Gal / Gal(b1-3)GlcNAc / Fucosylated blood group
NP_001035972
653499
P47929
ENSP00000313571.3
P47929
0.445
10.1016/j.isci.2022.104482
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (136 amino acids) Download
MSNVPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVRLVEVGGDVQLDSVRIF
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P47929-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.
Ligand
Glycan ligands from structural data
GalN
GalN
3GAL
3GAL
GlyConnect Structures
3-deoxy-3-(4-[m-fluorophenyl]-1H-1, Gal, thiodigalactoside derivative, bGal-O-R, galactose-benzylphosphate
Gal
2GAL, 3ZXE, 4UW3, 4UW4, 4UW5, 4UW6, 5H9Q, 5H9S
2GAL, 3ZXE, 4UW3, 4UW4, 4UW5, 4UW6, 5H9Q, 5H9S
GlyConnect Structures
bGal14GlcNAc
Gal(b1-4)GlcNAc
5GAL
5GAL
GlyConnect Structures
2, bGal13GlcNAc
Gal(b1-3)GlcNAc
4XBQ, 4Y26
4XBQ, 4Y26
GlyConnect Structures
bGal14Glc
Gal(b1-4)Glc
4GAL
4GAL
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS7B Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. [32915505]
  • A reference map of the human binary protein interactome. [32296183]
  • Galectin-7 serum levels are altered prior to the onset of pre-eclampsia. [24534543]
  • Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). [19199708]
  • Increased expression and altered intracellular distribution of adhesion/growth-regulatory lectins galectins-1 and -7 during tumour progression in hypopharyngeal and laryngeal squamous cell carcinomas. [18315601]
  • Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. [13679866]
  • Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. [11706006]
  • Structural basis for the recognition of carbohydrates by human galectin-7. [9760227]
  • Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. [7729568]
  • Cloning, expression, and chromosome mapping of human galectin-7. [7534301]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_001042507.4)
NM_001042507.4
galectin 7B
All isoforms of LGALS7B containing a lectin domain
ENST00000314980.5
28..438 (or 38789227.. 38791693)
38789200.. 38791754
NCBI Matured mRNA sequence 499 NTPDownload 
m7G-5')ppp(5'-CCACGGCUGCCCAACCCGGUCCCAGCCAUGUCCAACGUCCCCCACAAGUCCUCACUGCCCGAGGGCAUCCGCCCUGGCACGGUGCUGAGAAUUCGCGGCUUGGUUCCUCCCAAUGCCAGCAGGUUCCAUGUAAACCUGCUGUGCGGGGAGGAGCAGGGCUCCGAUGCCGCCCUGCAUUUCAACCCCCGGCUGGACACGUCGGAGGUGGUCUUCAACAGCAAGGAGCAAGGCUCCUGGGGCCGCGAGGAGCGCGGGCCGGGCGUUCCUUUCCAGCGCGGGCAGCCCUUCGAGGUGCUCAUCAUCGCGUCAGACGACGGCUUCAAGGCCGUGGUUGGGGACGCCCAGUACCACCACUUCCGCCACCGCCUGCCGCUGGCGCGCGUGCGCCUGGUGGAGGUGGGCGGGGACGUGCAGCUGGACUCCGUGAGGAUCUUCUGAGCAGAAGCCCAGGCGGGCCCGGGGCCUUGGCUGGCAAAUAAAGCGUUAGCCCGCAGCGCGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 653499)
LGALS7B
galectin 7B
NC_000019.10
19  38789227.. 38791693
38789227.. 38791693
strand +
CCDS42565.1
MGI:1316742
ClinVar, dbVar
ENSG00000178934
GAL7
uc002ojf.5
INSDC:
34447
617139
OTTHUMG00000182607
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (411 bp)
5'-ATGTCCAACGTCCCCCACAAGTCCTCACTGCCCGAGGGCATCCGCCCTGGCACGGTGCTGAGAATTCGCGGCTTGGTTCCTCCCAATGCCAGCAGGTTCCATGTAAACCTGCTGTGCGGGGAGGAGCAGGGCTCCGATGCCGCCCTGCATTTCAACCCCCGGCTGGACACGTCGGAGGTGGTCTTCAACAGCAAGGAGCAAGGCTCCTGGGGCCGCGAGGAGCGCGGGCCGGGCGTTCCTTTCCAGCGCGGGCAGCCCTTCGAGGTGCTCATCATCGCGTCAGACGACGGCTTCAAGGCCGTGGTTGGGGACGCCCAGTACCACCACTTCCGCCACCGCCTGCCGCTGGCGCGCGTGCGCCTGGTGGAGGTGGGCGGGGACGTGCAGCTGGACTCCGTGAGGATCTTCTGA-3'
NCBI CDS gene sequence with introns (location: 38789227.. 38791693) (2467 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 38789200.. 38791754) (2555 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [38789200 - 1000].. 38791754) (3555 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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