SMTL ID : 8jpg.1

Cryo-EM structure of full-length ERGIC-53 with MCFD2

Coordinates

PDB Format Compare

Method

ELECTRON MICROSCOPY

Oligo State

hetero-4-4-mer

Ligands

16 x CA: CALCIUM ION(Non-covalent)

CA.1: 5 residues within 4Å: Chain A: D.152, F.154, N.156, H.178, D.181 4 PLIP interactions: 4 interactions with chain A Metal complexes: A:D.152, A:D.152, A:F.154, A:D.181 CA.2: 5 residues within 4Å: Chain A: D.155, D.157, N.161, N.162, D.181 4 PLIP interactions: 4 interactions with chain A Metal complexes: A:D.155, A:D.157, A:D.157, A:D.181 CA.3: 6 residues within 4Å: Chain B: D.152, F.154, D.155, N.156, N.162, D.181 4 PLIP interactions: 4 interactions with chain B Metal complexes: B:D.152, B:D.152, B:F.154, B:D.181 CA.4: 5 residues within 4Å: Chain B: D.155, D.157, N.161, N.162, D.181 4 PLIP interactions: 4 interactions with chain B Metal complexes: B:D.155, B:D.157, B:D.157, B:D.181 CA.5: 6 residues within 4Å: Chain C: D.152, F.154, D.155, N.156, H.178, D.181 4 PLIP interactions: 4 interactions with chain C Metal complexes: C:D.152, C:D.152, C:F.154, C:D.181 CA.6: 5 residues within 4Å: Chain C: D.155, D.157, N.161, N.162, D.181 4 PLIP interactions: 4 interactions with chain C Metal complexes: C:D.155, C:D.157, C:D.157, C:D.181 CA.7: 5 residues within 4Å: Chain D: D.152, F.154, N.156, H.178, D.181 5 PLIP interactions: 5 interactions with chain D Metal complexes: D:D.152, D:D.152, D:F.154, D:H.178, D:D.181 CA.8: 6 residues within 4Å: Chain D: D.155, D.157, N.161, N.162, N.180, D.181 4 PLIP interactions: 4 interactions with chain D Metal complexes: D:D.155, D:D.157, D:D.157, D:D.181 CA.9: 7 residues within 4Å: Chain E: D.107, N.109, D.111, Y.113, I.114, D.115, E.118 5 PLIP interactions: 5 interactions with chain E Metal complexes: E:D.111, E:D.111, E:Y.113, E:E.118, E:E.118 CA.10: 6 residues within 4Å: Chain E: D.59, D.61, N.63, L.65, L.66, E.70 5 PLIP interactions: 5 interactions with chain E Metal complexes: E:D.59, E:D.61, E:L.65, E:E.70, E:E.70 CA.12: 7 residues within 4Å: Chain F: D.107, N.109, D.111, Y.113, I.114, D.115, E.118 5 PLIP interactions: 5 interactions with chain F Metal complexes: F:D.107, F:D.111, F:Y.113, F:E.118, F:E.118 CA.13: 6 residues within 4Å: Chain F: D.59, D.61, N.63, L.65, L.66, E.70 5 PLIP interactions: 5 interactions with chain F Metal complexes: F:D.59, F:D.61, F:D.61, F:L.65, F:E.70 CA.15: 6 residues within 4Å: Chain G: D.107, K.108, N.109, D.111, Y.113, E.118 5 PLIP interactions: 5 interactions with chain G Metal complexes: G:D.107, G:D.111, G:Y.113, G:E.118, G:E.118 CA.16: 6 residues within 4Å: Chain G: D.59, D.61, N.63, L.65, L.66, E.70 5 PLIP interactions: 5 interactions with chain G Metal complexes: G:D.59, G:D.61, G:D.61, G:L.65, G:E.70 CA.18: 5 residues within 4Å: Chain H: D.107, N.109, D.111, Y.113, E.118 5 PLIP interactions: 5 interactions with chain H Metal complexes: H:D.111, H:D.111, H:Y.113, H:E.118, H:E.118 CA.19: 6 residues within 4Å: Chain H: D.59, D.61, N.63, L.65, L.66, E.70 5 PLIP interactions: 5 interactions with chain H Metal complexes: H:D.59, H:D.61, H:D.61, H:L.65, H:E.70

4 x ZN: ZINC ION(Non-covalent)

ZN.11: 4 residues within 4Å: Chain E: H.29, H.33, H.77, H.79 5 PLIP interactions: 5 interactions with chain E Metal complexes: E:H.29, E:H.33, E:H.33, E:H.77, E:H.79 ZN.14: 4 residues within 4Å: Chain F: H.29, H.33, H.77, H.79 5 PLIP interactions: 5 interactions with chain F Metal complexes: F:H.29, F:H.33, F:H.33, F:H.77, F:H.79 ZN.17: 4 residues within 4Å: Chain G: H.29, H.33, H.77, H.79 5 PLIP interactions: 5 interactions with chain G Metal complexes: G:H.29, G:H.29, G:H.33, G:H.77, G:H.79 ZN.20: 4 residues within 4Å: Chain H: H.29, H.33, H.77, H.79 5 PLIP interactions: 5 interactions with chain H Metal complexes: H:H.29, H:H.29, H:H.33, H:H.77, H:H.79

Links

RCSB   PDBe   PDBe-KB   PDBj   PDBsum   CATH   PLIP

Citation

Watanabe, S. et al., Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport. Nat Commun (2024)

Release Date

2024-04-17

Peptides

Protein ERGIC-53: ABCD
Multiple coagulation factor deficiency protein 2: EFGH

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

C
E

D
F

E
C

F
G

G
D

H
H

Membrane

We predict this structure to be a membrane protein.
Show / Hide

Protein ERGIC-53

Multiple coagulation factor deficiency protein 2

Related Entries With Identical Sequence