SMTL ID : 7r55.1 (1 other biounit)

B-trefoil lectin from Salpingoeca rosetta in complex with Gb3

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.84 Å

Oligo State

monomer

Ligands

2 x GLC- GAL- GLA: alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose

GLC-GAL-GLA.1: 11 residues within 4Å: Chain A: K.91, E.92, H.129, P.130, H.131, G.132, G.133, V.144, Y.146, R.150, L.153 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:E.92, A:G.132, A:H.129, A:H.131, A:G.132, A:R.150, A:R.150, A:K.91 Salt bridges: A:K.91 GLC-GAL-GLA.2: 12 residues within 4Å: Chain A: N.42, D.43, H.83, P.84, K.85, G.86, G.87, V.96, H.98, S.100, R.103, T.106 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:D.43, A:G.86, A:H.98, A:D.43, A:H.83, A:G.86, A:S.100, A:R.103, A:R.103, A:N.42, A:D.43, A:H.98 Water bridges: A:D.43, A:K.85, A:N.42, A:N.42

Links

RCSB   PDBe   PDBe-KB   PDBj   PDBsum   CATH   PLIP

Citation

Notova, S. et al., The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3. Commun Biol (2022)

Release Date

2022-09-14

Peptides

Sarol-1: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Sarol-1

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