SMTL ID : 6x7h.1

Cyanovirin-N Mutation I34Y with Dimannose bound

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.25 Å

Oligo State

homo-dimer

Ligands

2 x MAN- MAN: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose(Non-covalent)

MAN-MAN.1: 14 residues within 4Å: Chain A: E.41, N.42, V.43, D.44, G.45, S.52, N.53, F.54, E.56, T.57, K.74, T.75, R.76, Q.78 8 PLIP interactions: 8 interactions with chain A Hydrogen bonds: A:E.41, A:N.42, A:S.52, A:N.53, A:T.57, A:T.57 Water bridges: A:S.52, A:E.56 MAN-MAN.2: 14 residues within 4Å: Chain B: E.41, N.42, V.43, D.44, G.45, S.52, N.53, F.54, E.56, T.57, K.74, T.75, R.76, Q.78 7 PLIP interactions: 7 interactions with chain B Hydrogen bonds: B:N.42, B:S.52, B:S.52, B:N.53, B:E.56, B:T.57, B:T.57

Links

RCSB   PDBe   PDBe-KB   PDBj   PDBsum   CATH   PLIP

Citation

Kazan, I.C. et al., Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations. Elife (2022)

Release Date

2021-06-02

Peptides

Cyanovirin-N: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Cyanovirin-N