SMTL ID : 6x3q.1

Hsa Siglec and Unique domains in complex with 3'sialyl-N-acetyllactosamine trisaccharide

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.15 Å

Oligo State

monomer

Ligands

1 x NAG- GAL- SIA: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose

NAG-GAL-SIA.1: 12 residues within 4Å: Chain A: N.65, V.66, E.67, S.76, S.117, Y.118, Y.119, T.120, R.121, Y.122, D.137, R.146 10 PLIP interactions: 10 interactions with chain A Hydrogen bonds: A:Y.122, A:Y.122, A:D.137, A:N.65, A:S.76, A:S.76, A:Y.118, A:T.120, A:T.120, A:R.121, A:R.121 Water bridges: A:V.66, A:T.120, A:T.120 Hydrophobic interactions: A:Y.119

2 x NA: SODIUM ION(Non-functional Binders)

NA.2: 8 residues within 4Å: Chain A: D.26, E.28, A.29, D.53, N.54, S.55, D.127, N.131 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:D.26, A:D.127 NA.3: 5 residues within 4Å: Chain A: N.155, E.156, Y.158, P.160, D.217 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:D.217

Links

RCSB   PDBe   PDBe-KB   PDBj   PDBsum   CATH   PLIP

Citation

Bensing, B.A. et al., Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation. Nat Commun (2022)

Release Date

2021-11-17

Peptides

Streptococcal hemagglutinin: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Streptococcal hemagglutinin

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