SMTL ID : 6qfy.1 (1 other biounit)

CRYSTAL STRUCTURE OF PORCINE HEMAGGLUTINATING ENCEPHALOMYELITIS VIRUS SPIKE PROTEIN LECTIN DOMAIN

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.97 Å

Oligo State

monomer

Ligands

2 x NAG- NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG-NAG.1: 5 residues within 4Å: Chain A: D.4, V.118, N.119, T.149, D.173 No protein-ligand interaction detected (PLIP) NAG-NAG.2: 6 residues within 4Å: Chain A: H.129, L.140, Q.142, K.182, R.183, N.184 No protein-ligand interaction detected (PLIP)

2 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)(Post Translational Modification)

NAG.3: 5 residues within 4Å: Chain A: N.8, S.10, Q.165, R.166, I.167 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:N.8, A:S.10, A:R.166 NAG.4: 2 residues within 4Å: Chain A: N.45, Q.262 2 PLIP interactions: 2 interactions with chain A Hydrophobic interactions: A:Q.262 Hydrogen bonds: A:N.45

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Hulswit, R.J.G. et al., Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A. Proc. Natl. Acad. Sci. U.S.A. (2019)

Release Date

2019-02-06

Peptides

Spike glycoprotein: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Spike glycoprotein

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