SMTL ID : 6lik.1

Crystal Structure of Lectin from Pleurotus ostreatus in complex with Galactose

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.40 Å

Oligo State

monomer

Ligands

3 x NAG- NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG-NAG.1: 8 residues within 4Å: Chain A: R.108, I.109, G.110, T.111, L.121, F.122, L.313, N.321 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:R.108, A:R.108, A:T.111, A:T.111 NAG-NAG.2: 6 residues within 4Å: Chain A: N.78, T.80, T.128, W.129, L.131, P.183 No protein-ligand interaction detected (PLIP) NAG-NAG.3: 6 residues within 4Å: Chain A: S.235, R.261, N.298, T.300, I.336, F.340 No protein-ligand interaction detected (PLIP)

2 x CA: CALCIUM ION(Non-covalent)

CA.4: 6 residues within 4Å: Chain A: D.259, D.260, N.301, G.303, P.305 Ligands: GLA.8 4 PLIP interactions: 4 interactions with chain A Metal complexes: A:D.259, A:D.260, A:G.303, A:P.305 CA.5: 6 residues within 4Å: Chain A: D.97, D.98, N.138, S.143, P.144 Ligands: GOL.7 4 PLIP interactions: 4 interactions with chain A Metal complexes: A:D.97, A:D.98, A:S.143, A:P.144

2 x GOL: GLYCEROL(Non-functional Binders)

GOL.6: 6 residues within 4Å: Chain A: R.239, K.240, T.241, S.329, K.331, E.347 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:R.239, A:T.241, A:T.241, A:S.329, A:E.347 GOL.7: 6 residues within 4Å: Chain A: D.97, D.98, V.140, S.143, P.144 Ligands: CA.5 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:D.97, A:S.143

1 x GLA: alpha-D-galactopyranose(Non-covalent)

GLA.8: 6 residues within 4Å: Chain A: D.259, D.260, Y.277, G.303, P.305 Ligands: CA.4 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:D.259, A:Y.277

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Vajravijayan, S. et al., Crystallographic and calorimetric analysis on Pleurotus ostreatus lectin and its sugar complexes - promiscuous binding driven by geometry. Int.J.Biol.Macromol. (2020)

Release Date

2020-08-05

Peptides

Lectin: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Lectin

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