SMTL ID : 5lfr.1 (1 other biounit)

Crystal structure of glycosylated Myelin-associated glycoprotein (MAG) Ig1-3

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.12 Å

Oligo State

monomer

Ligands

1 x NAG- NAG- BMA- MAN- MAN: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG-NAG-BMA-MAN-MAN.1: 8 residues within 4Å: Chain A: S.22, L.75, G.76, N.82, T.84, P.149, R.152 Ligands: GOL.8 3 PLIP interactions: 3 interactions with chain A Hydrophobic interactions: A:L.75, A:P.149 Hydrogen bonds: A:S.22

1 x MAN: alpha-D-mannopyranose(Post Translational Modification)

MAN.2: 3 residues within 4Å: Chain A: H.4, W.5, P.30 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:W.5, A:W.5

3 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)(Non-functional Binders)

NAG.3: 1 residues within 4Å: Chain A: N.206 No protein-ligand interaction detected (PLIP) NAG.4: 7 residues within 4Å: Chain A: E.227, N.229, V.232, V.240, S.241, L.243, Y.272 7 PLIP interactions: 7 interactions with chain A Hydrophobic interactions: A:V.232, A:V.240 Hydrogen bonds: A:E.227, A:N.229, A:S.241, A:S.241, A:Y.272 NAG.5: 1 residues within 4Å: Chain A: N.298 No protein-ligand interaction detected (PLIP)

3 x GOL: GLYCEROL(Non-covalent)(Post Translational Modification)

GOL.6: 5 residues within 4Å: Chain A: V.37, V.38, D.77, L.78, G.79 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:V.38, A:V.38, A:L.78, A:G.79 GOL.7: 1 residues within 4Å: Chain A: H.115 No protein-ligand interaction detected (PLIP) GOL.8: 3 residues within 4Å: Chain A: P.149 Ligands: NAG-NAG-BMA-MAN-MAN.1, NAG-NAG-BMA-MAN-MAN.1 No protein-ligand interaction detected (PLIP)

2 x SO4: SULFATE ION(Post Translational Modification)(Non-functional Binders)

SO4.9: 3 residues within 4Å: Chain A: V.226, M.228, R.299 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:M.228 Salt bridges: A:R.299 SO4.10: 3 residues within 4Å: Chain A: A.134, T.190, R.191 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:R.191 Salt bridges: A:R.191

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Pronker, M.F. et al., Structural basis of myelin-associated glycoprotein adhesion and signalling. Nat Commun (2016)

Release Date

2016-12-14

Peptides

Myelin-associated glycoprotein: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Myelin-associated glycoprotein

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