SMTL ID : 5j06.1 (1 other biounit)

Structure of the immune receptor CD33 in complex with 3'-sialyllactose

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.66 Å

Oligo State

homo-dimer

Ligands

6 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG.1: 6 residues within 4Å: Chain A: L.21, L.76, G.77, R.81, N.83, S.85 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:N.83 NAG.2: 3 residues within 4Å: Chain A: N.143, P.172, I.181 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:N.143 NAG.3: 5 residues within 4Å: Chain A: G.190, T.191, N.192, T.209, Q.211 No protein-ligand interaction detected (PLIP) NAG.4: 7 residues within 4Å: Chain B: L.21, T.25, L.76, G.77, R.81, N.83, S.85 2 PLIP interactions: 2 interactions with chain B Hydrogen bonds: B:R.81, B:N.83 NAG.5: 4 residues within 4Å: Chain B: N.143, G.171, P.172, I.181 1 PLIP interactions: 1 interactions with chain B Hydrogen bonds: B:N.143 NAG.6: 6 residues within 4Å: Chain A: P.167, T.168 Chain B: N.192, E.207, T.209, Q.211 5 PLIP interactions: 3 interactions with chain B, 2 interactions with chain A Hydrogen bonds: B:N.192, B:T.209, B:Q.211, A:T.168 Hydrophobic interactions: A:P.167

1 x SIA: N-acetyl-alpha-neuraminic acid(Non-covalent)

SIA.7: 5 residues within 4Å: Chain B: R.102, K.109, Y.110, S.111, K.113 5 PLIP interactions: 5 interactions with chain B Hydrogen bonds: B:R.102, B:K.109, B:S.111, B:S.111 Salt bridges: B:R.102

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Dodd, R.B. et al., STRUCTURE OF LIGAND BOUND CD33 RECEPTOR ASSOCIATED WITH ALZHEIMER'S DISEASE. To Be Published

Release Date

2017-04-05

Peptides

Myeloid cell surface antigen CD33: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
D

Myeloid cell surface antigen CD33

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