SMTL ID : 5ik8.1 (1 other biounit)

Laminin A2LG45 I-form, G6/7 bound.

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.00 Å

Oligo State

monomer

Ligands

2 x CA: CALCIUM ION(Non-covalent)

CA.1: 4 residues within 4Å: Chain A: D.71, L.88, I.137, D.139 4 PLIP interactions: 4 interactions with chain A Metal complexes: A:D.71, A:L.88, A:I.137, A:D.139 CA.2: 7 residues within 4Å: Chain A: D.245, N.262, G.263, S.316, A.317, D.318 Ligands: FLC.4 5 PLIP interactions: 4 interactions with chain A, 1 Ligand-Water interactions Metal complexes: A:D.245, A:N.262, A:S.316, A:D.318, H2O.2

1 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG.3: 2 residues within 4Å: Chain A: I.151, N.152 No protein-ligand interaction detected (PLIP)

2 x FLC: CITRATE ANION(Non-covalent)

FLC.4: 7 residues within 4Å: Chain A: N.262, A.313, S.314, T.315, S.316, D.318 Ligands: CA.2 6 PLIP interactions: 6 interactions with chain A Hydrogen bonds: A:N.262, A:N.262, A:S.314, A:T.315, A:S.316, A:D.318 FLC.5: 9 residues within 4Å: Chain A: A.1, P.2, L.3, A.4, M.5, E.13, S.14, E.15, R.344 8 PLIP interactions: 8 interactions with chain A Hydrophobic interactions: A:P.2 Hydrogen bonds: A:L.3, A:L.3, A:M.5, A:E.15, A:E.15 Water bridges: A:A.4, A:R.344

5 x EDO: 1,2-ETHANEDIOL(Non-functional Binders)

EDO.6: 4 residues within 4Å: Chain A: P.16, A.17, L.18, T.20 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:L.18, A:T.20 Water bridges: A:P.16, A:T.20 EDO.7: 8 residues within 4Å: Chain A: Y.202, R.228, T.229, T.230, G.282, G.345, C.346, P.379 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:R.228 Water bridges: A:S.14, A:R.344 EDO.8: 9 residues within 4Å: Chain A: D.253, E.254, K.255, D.272, A.273, E.274, I.275, P.276, G.277 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:K.255, A:D.272 EDO.9: 6 residues within 4Å: Chain A: F.194, Y.202, D.204, G.372, V.373, Q.374 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:D.204, A:D.204 EDO.10: 5 residues within 4Å: Chain A: D.204, G.205, T.206, R.231, R.344 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:D.204, A:R.231, A:R.231, A:R.344

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Briggs, D.C. et al., Structural basis of laminin binding to the LARGE glycans on dystroglycan. Nat.Chem.Biol. (2016)

Release Date

2016-08-10

Peptides

Laminin subunit alpha-2: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Laminin subunit alpha-2

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