SMTL ID : 5h9s.1

Crystal Structure of Human Galectin-7 in Complex with TAZTDG

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.82 Å

Oligo State

homo-dimer

Ligands

1 x TGZ: (2~{S},3~{R},4~{S},5~{R},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol(Non-covalent)

TGZ.1: 8 residues within 4Å: Chain B: H.69, N.71, R.73, V.80, N.82, W.89, E.92, R.94 6 PLIP interactions: 6 interactions with chain B Hydrogen bonds: B:H.69, B:R.73, B:R.73, B:N.82, B:R.94 pi-Cation interactions: B:R.94

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Hsieh, T.J. et al., Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors. Sci Rep (2016)

Release Date

2016-06-29

Peptides

Galectin-7: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Galectin-7

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