SMTL ID : 5eq4.1 (2 other biounits)

Crystal structure of the SrpA adhesin R347E mutant from Streptococcus sanguinis

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.30 Å

Oligo State

homo-dimer

Ligands

5 x CA: CALCIUM ION(Non-covalent)

CA.1: 5 residues within 4Å: Chain A: D.5, T.7, D.33, D.34, D.105 5 PLIP interactions: 5 interactions with chain A Metal complexes: A:D.5, A:T.7, A:D.33, A:D.34, A:D.105 CA.2: 3 residues within 4Å: Chain A: T.124, Y.127, D.186 5 PLIP interactions: 4 interactions with chain A, 1 Ligand-Water interactions Metal complexes: A:T.124, A:T.124, A:Y.127, A:D.186, H2O.5 CA.3: 2 residues within 4Å: Chain A: E.152 Chain B: E.152 5 PLIP interactions: 1 interactions with chain A, 1 interactions with chain B, 3 Ligand-Water interactions Metal complexes: A:E.152, B:E.152, H2O.2, H2O.3, H2O.8 CA.6: 6 residues within 4Å: Chain B: D.5, T.7, D.33, D.34, D.105, N.109 5 PLIP interactions: 5 interactions with chain B Metal complexes: B:D.5, B:T.7, B:D.33, B:D.34, B:D.105 CA.7: 3 residues within 4Å: Chain B: T.124, Y.127, D.186 5 PLIP interactions: 4 interactions with chain B, 1 Ligand-Water interactions Metal complexes: B:T.124, B:T.124, B:Y.127, B:D.186, H2O.11

2 x ACT: ACETATE ION(Non-functional Binders)

ACT.4: 5 residues within 4Å: Chain A: R.167, T.169 Chain B: T.169, V.170 Ligands: ACT.5 5 PLIP interactions: 3 interactions with chain B, 2 interactions with chain A Hydrogen bonds: B:V.170 Water bridges: B:K.148, B:K.148, A:R.167 Salt bridges: A:R.167 ACT.5: 5 residues within 4Å: Chain A: T.169, V.170 Chain B: R.167, T.169 Ligands: ACT.4 4 PLIP interactions: 2 interactions with chain B, 2 interactions with chain A Water bridges: B:R.167 Salt bridges: B:R.167, A:K.148 Hydrogen bonds: A:V.170

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Bensing, B.A. et al., Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J.Biol.Chem. (2016)

Release Date

2016-01-27

Peptides

Platelet-binding glycoprotein: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Platelet-binding glycoprotein

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