SMTL ID : 4y20.1

Complex of human Galectin-1 and NeuAcalpha2-3Galbeta1-4Glc

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.20 Å

Oligo State

homo-dimer

Ligands

2 x GLC- GAL- SIA: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose(Non-covalent)

GLC-GAL-SIA.1: 9 residues within 4Å: Chain A: H.64, N.66, R.68, H.72, N.81, W.88, E.91, R.93, D.143 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:R.68, A:H.72, A:N.81, A:R.68, A:R.68, A:R.93, A:D.143 Water bridges: A:N.66 Salt bridges: A:H.64, A:K.83 GLC-GAL-SIA.2: 8 residues within 4Å: Chain B: H.64, N.66, R.68, H.72, N.81, W.88, E.91, R.93 1 PLIP interactions: 1 interactions with chain B Hydrogen bonds: B:R.68, B:H.72, B:N.81, B:R.68, B:R.68, B:E.91, B:R.93 Salt bridges: B:H.64

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Lin, H.Y. et al., Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range. To Be Published

Release Date

2016-04-06

Peptides

Galectin-1: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Galectin-1

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