SMTL ID : 4y1u.1

Complex of human Galectin-1 and Galbeta1-4GlcNAc

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.76 Å

Oligo State

homo-dimer

Ligands

2 x MAG- GAL: beta-D-galactopyranose-(1-4)-methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside(Non-covalent)

MAG-GAL.1: 7 residues within 4Å: Chain A: H.64, N.66, R.68, H.72, N.81, E.91, R.93 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:R.68, A:N.81, A:R.68, A:R.68, A:H.72, A:R.93 Water bridges: A:N.66, A:N.66 MAG-GAL.2: 7 residues within 4Å: Chain B: H.64, N.66, R.68, N.81, W.88, E.91, R.93 5 PLIP interactions: 5 interactions with chain B Hydrogen bonds: B:R.68, B:N.81, B:R.68, B:R.68, B:E.91, B:R.93 Water bridges: B:N.66, B:D.74

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Lin, H.Y. et al., Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range. To Be Published

Release Date

2016-04-06

Peptides

Galectin-1: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
B

B
A

Galectin-1

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