SMTL ID : 4xbl.1

Crystal Structure of Human Galectin-1 in Complex with Type 1 N-acetyllactosamine

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.93 Å

Oligo State

homo-dimer

Ligands

2 x NAG- GAL: beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)

NAG-GAL.1: 8 residues within 4Å: Chain A: H.64, N.66, R.68, H.72, N.81, W.88, E.91, R.93 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:R.68, A:H.72, A:N.81, A:R.68, A:R.68, A:R.93 Water bridges: A:N.66 NAG-GAL.2: 8 residues within 4Å: Chain B: H.64, N.66, R.68, H.72, N.81, W.88, E.91, R.93 3 PLIP interactions: 3 interactions with chain B Hydrogen bonds: B:R.68, B:H.72, B:N.81, B:R.68, B:R.68, B:R.93 Water bridges: B:N.66

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Hsieh, T.J. et al., Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Gal beta 1-3/4GlcNAc. Plos One (2015)

Release Date

2015-05-20

Peptides

Galectin-1: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Galectin-1