SMTL ID : 4wr9.1

Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D)

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.30 Å

Oligo State

homo-trimer

Ligands

9 x CA: CALCIUM ION(Non-covalent)

CA.1: 5 residues within 4Å: Chain A: E.115, R.117, E.122, N.134, D.135 5 PLIP interactions: 3 interactions with chain A, 2 Ligand-Water interactions Metal complexes: A:E.115, A:D.135, A:D.135, H2O.1, H2O.2 CA.2: 5 residues within 4Å: Chain A: D.91, E.95, Q.119, E.122, D.123 4 PLIP interactions: 4 interactions with chain A Metal complexes: A:D.91, A:D.91, A:Q.119, A:E.122 CA.3: 3 residues within 4Å: Chain A: E.95, G.120, D.123 3 PLIP interactions: 3 interactions with chain A Metal complexes: A:G.120, A:D.123, A:D.123 CA.4: 5 residues within 4Å: Chain B: E.115, R.117, E.122, N.134, D.135 5 PLIP interactions: 3 interactions with chain B, 2 Ligand-Water interactions Metal complexes: B:E.115, B:D.135, B:D.135, H2O.4, H2O.5 CA.5: 5 residues within 4Å: Chain B: D.91, E.95, Q.119, E.122, D.123 4 PLIP interactions: 4 interactions with chain B Metal complexes: B:D.91, B:D.91, B:Q.119, B:E.122 CA.6: 3 residues within 4Å: Chain B: E.95, G.120, D.123 3 PLIP interactions: 3 interactions with chain B Metal complexes: B:G.120, B:D.123, B:D.123 CA.7: 5 residues within 4Å: Chain C: E.115, R.117, E.122, N.134, D.135 5 PLIP interactions: 3 interactions with chain C, 2 Ligand-Water interactions Metal complexes: C:E.115, C:D.135, C:D.135, H2O.6, H2O.7 CA.8: 5 residues within 4Å: Chain C: D.91, E.95, Q.119, E.122, D.123 4 PLIP interactions: 4 interactions with chain C Metal complexes: C:D.91, C:D.91, C:Q.119, C:E.122 CA.9: 3 residues within 4Å: Chain C: E.95, G.120, D.123 3 PLIP interactions: 3 interactions with chain C Metal complexes: C:G.120, C:D.123, C:D.123

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Rynkiewicz, M.J. et al., Differential ligand binding specificities of the pulmonary collectins are determined by the conformational freedom of a surface loop. To be published

Release Date

2016-02-10

Peptides

Pulmonary surfactant-associated protein A: ABC

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
A

C
A

Pulmonary surfactant-associated protein A

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