SMTL ID : 4pik.1 (1 other biounit)

Crystal Structure of Banana Lectin bound to dimannose

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.70 Å

Oligo State

homo-dimer

Ligands

1 x MAN- MAN: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose(Non-covalent)

MAN-MAN.1: 10 residues within 4Å: Chain B: G.14, G.15, H.84, G.85, A.86, V.88, G.129, K.130, F.131, D.133 7 PLIP interactions: 7 interactions with chain B Hydrogen bonds: B:G.15, B:G.129, B:K.130, B:F.131, B:F.131 Water bridges: B:G.15, B:V.87

3 x MAN: alpha-D-mannopyranose(Non-covalent)(Non-functional Binders)

MAN.2: 6 residues within 4Å: Chain A: G.14, G.15, G.129, K.130, F.131, D.133 6 PLIP interactions: 6 interactions with chain A Hydrogen bonds: A:G.15, A:G.129, A:K.130, A:F.131, A:F.131 Water bridges: A:G.14 MAN.3: 8 residues within 4Å: Chain A: G.34, D.35, V.36, D.38, G.59, G.60, Y.83, F.131 9 PLIP interactions: 9 interactions with chain A Hydrogen bonds: A:G.34, A:D.35, A:V.36, A:V.36, A:G.60, A:Y.83 Water bridges: A:G.34, A:D.35, A:T.61 MAN.5: 8 residues within 4Å: Chain B: G.34, D.35, V.36, D.38, G.59, G.60, Y.83, F.131 7 PLIP interactions: 7 interactions with chain B Hydrogen bonds: B:G.34, B:D.35, B:V.36, B:V.36, B:G.60, B:Y.83 Water bridges: B:G.59

2 x GOL: GLYCEROL(Non-covalent)

GOL.4: 9 residues within 4Å: Chain A: Y.24, R.25, I.26, L.67, Y.72, L.73, K.120, I.121, E.140 7 PLIP interactions: 7 interactions with chain A Hydrogen bonds: A:I.26, A:I.26, A:L.73, A:L.73, A:I.121, A:E.140, A:E.140 GOL.6: 8 residues within 4Å: Chain B: Y.24, R.25, I.26, L.67, Y.72, L.73, K.120, I.121 4 PLIP interactions: 4 interactions with chain B Hydrogen bonds: B:I.26, B:L.73, B:L.73 Water bridges: B:E.71

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Swanson, M.D. et al., Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity. Cell (2015)

Release Date

2015-11-04

Peptides

Ripening-associated protein: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Ripening-associated protein

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