SMTL ID : 4p6a.1

Crystal structure of a potent anti-HIV lectin actinohivin in complex with alpha-1,2-mannotriose

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.40 Å

Oligo State

monomer

Ligands

3 x MAN- MAN- MAN: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose(Non-covalent)

MAN-MAN-MAN.1: 8 residues within 4Å: Chain A: D.15, S.16, Y.23, L.25, N.28, G.30, Y.32, Q.33 1 PLIP interactions: 1 interactions with chain A Water bridges: A:N.31 MAN-MAN-MAN.2: 8 residues within 4Å: Chain A: D.53, S.54, Y.61, L.63, N.66, G.68, Y.70, Q.71 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:S.69 Water bridges: A:N.66, A:N.66 MAN-MAN-MAN.3: 9 residues within 4Å: Chain A: D.91, S.92, N.93, Y.99, L.101, N.104, G.106, Y.108, Q.109 No protein-ligand interaction detected (PLIP)

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Zhang, F. et al., The characteristic structure of anti-HIV actinohivin in complex with three HMTG D1 chains of HIV-gp120. Chembiochem (2014)

Release Date

2015-03-04

Peptides

Actinohivin: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Actinohivin

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