SMTL ID : 4lbl.1

Crystal structure of Human galectin-3 CRD K176L mutant in complex with a-GM3

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.58 Å

Oligo State

monomer

Ligands

1 x BGC- GAL- SIA: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose

BGC-GAL-SIA.1: 7 residues within 4Å: Chain A: H.46, N.48, R.50, N.62, W.69, E.72, R.74 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:R.50, A:R.50, A:R.74, A:R.50, A:N.62, A:E.72 Water bridges: A:E.53, A:E.53, A:E.72, A:R.74, A:N.48, A:H.46

2 x CL: CHLORIDE ION(Non-functional Binders)

CL.2: 3 residues within 4Å: Chain A: V.113, K.114, K.115 Ligand excluded by PLIP CL.3: 6 residues within 4Å: Chain A: Q.38, R.39, G.40, E.118, S.120, K.121 Ligand excluded by PLIP

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Collins, P.M. et al., Galectin-3 interactions with glycosphingolipids. J.Mol.Biol. (2014)

Release Date

2014-01-22

Peptides

Galectin-3: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Galectin-3

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